Gene Page:SFRP1

Summary？
基因 6422
象征 SFRP1
Synonyms FRP|FRP-1|FRP1|FrzA|SARP2
Description secreted frizzled-related protein 1
Reference MIM：604156|HGNC:HGNC:10776|ENSEMBL：ENSG00000104332|HPRD:09165|Vega：Otthumg00000164074
基因类型 蛋白质编码
Map location 8p11.21
Pascal p-value 0.218
Sherlock p-value 0.348
胎儿β 2.805
主持人 海马
Putamen basal ganglia

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:PGCnp 全基因组关联研究 GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
协会 A combined odds ratio method (Sun等。2008), association studies 1 Link to SZGene
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS1374585 8 41225456 SFRP1 ENSG00000104332.7 1.66838E-6 0.04 -58440 gtex_brain_putamen_basal
RS78623944 8 41227207 SFRP1 ENSG00000104332.7 1.63225E-6 0.04 -60191 gtex_brain_putamen_basal
RS4736805 8 41231323 SFRP1 ENSG00000104332.7 2.41864E-6 0.04 -64307 gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

Not available

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005515 蛋白质结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0001756 somitogenesis IEA -
GO：0016055 Wnt receptor signaling pathway IEA -
GO:0007165 信号转导 TAS 9192640
去：0009653 解剖结构形态发生 TAS 9192640
GO:0006916 抗凋亡 TAS 9391078
GO:0007275 multicellular organismal development IEA -
GO:0030154 细胞分化 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IEA -
去：0005615 细胞外空间 TAS 9192640

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG WNT SIGNALING PATHWAY 151 112 All SZGR 2.0 genes in this pathway
wnt信令 89 71 All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY 34 28 All SZGR 2.0 genes in this pathway
PID MYC REPRESS PATHWAY 63 52 All SZGR 2.0 genes in this pathway
turashvili乳房导管癌与导管正常DN 198 110 All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS LOBULAR NORMAL DN 69 43 All SZGR 2.0 genes in this pathway
turashvili乳房小叶癌与导管正常DN 91 53 All SZGR 2.0 genes in this pathway
turashvili乳房小叶癌与小叶正常 94 59 All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS TOP50 DN 45 26 All SZGR 2.0 genes in this pathway
CHARAFE乳房CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
Doane乳腺癌ESR1 DN 48 28 All SZGR 2.0 genes in this pathway
ROY WOUND BLOOD VESSEL DN 22 14 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
剑麻结肠直肠腺瘤DN 291 176 All SZGR 2.0 genes in this pathway
ENK UV响应表皮增强 293 179 All SZGR 2.0 genes in this pathway
ENK UV响应角质形成细胞DN 485 334 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232 154 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向E 97 60 All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房3 4WK 214 144 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP 271 175 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN 79 54 All SZGR 2.0 genes in this pathway
哈马凋亡通过小径dn 186 107 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 62 44 All SZGR 2.0 genes in this pathway
Streicher LSM1靶向DN 19 13 All SZGR 2.0 genes in this pathway
MCBRYAN TERMINAL END BUD UP 12 12 All SZGR 2.0 genes in this pathway
埃尔南德斯有丝分裂逮捕Docetaxel 1 Up 36 18 All SZGR 2.0 genes in this pathway
YANG BREAST CANCER ESR1 DN 25 15 All SZGR 2.0 genes in this pathway
HUI MAPK14 TARGETS UP 21 11 All SZGR 2.0 genes in this pathway
结肠癌中的施莱辛格甲基化 10 7 All SZGR 2.0 genes in this pathway
Schlesinger甲基化的癌症 88 64 All SZGR 2.0 genes in this pathway
OHM METHYLATED IN ADULT CANCERS 27 23 All SZGR 2.0 genes in this pathway
OHM EMBRYONIC CARCINOMA UP 6 5 All SZGR 2.0 genes in this pathway
Ingram SHH靶向DN 64 41 All SZGR 2.0 genes in this pathway
Bertucci侵入性癌导管与小叶DN 46 34 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发12小时DN 57 45 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发和癌症Box5 11 7 All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN 45 33 All SZGR 2.0 genes in this pathway
里克曼头颈癌 100 63 All SZGR 2.0 genes in this pathway
Benporath ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
Benporath Oct4目标 290 172 All SZGR 2.0 genes in this pathway
Benporath SOX2目标 734 436 All SZGR 2.0 genes in this pathway
Benporath NOS目标 179 105 All SZGR 2.0 genes in this pathway
Benporath Suz12目标 1038 678 All SZGR 2.0 genes in this pathway
Benporath EED目标 1062 725 All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118 744 All SZGR 2.0 genes in this pathway
Benporath PRC2目标 652 441 All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU UP 53 37 All SZGR 2.0 genes in this pathway
Nikolsky乳腺癌8p12 P11扩增子 57 32 All SZGR 2.0 genes in this pathway
Onder CDH1目标2 DN 464 276 All SZGR 2.0 genes in this pathway
Shepard BMYB Morpholino DN 200 112 All SZGR 2.0 genes in this pathway
Shepard BMYB目标 74 41 All SZGR 2.0 genes in this pathway
Shepard粉碎和燃烧突变体DN 185 111 All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者 555 346 All SZGR 2.0 genes in this pathway
LEI MYB目标 318 215 All SZGR 2.0 genes in this pathway
RORIE TARGETS OF EWSR1 FLI1 FUSION DN 30 23 All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 23 16 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病初期 390 242 All SZGR 2.0 genes in this pathway
KAAB HEART ATRIUM VS VENTRICLE UP 249 170 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 2 50 34 All SZGR 2.0 genes in this pathway
阿尔茨海默氏症疾病 1691 1088 All SZGR 2.0 genes in this pathway
大脑衰老 262 186 All SZGR 2.0 genes in this pathway
Sato在胰腺癌中表观遗传沉默 49 30 All SZGR 2.0 genes in this pathway
杰克逊DNMT1靶向 77 57 All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN 287 208 All SZGR 2.0 genes in this pathway
Nielsen Gist和滑膜肉瘤 20 15 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
结肠癌中甲基化的甲基化 27 20 All SZGR 2.0 genes in this pathway
癌症中的甲基化 56 45 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BRAIN UP 39 20 All SZGR 2.0 genes in this pathway
骨骼DN中的Smid乳腺癌复发 315 197 All SZGR 2.0 genes in this pathway
SMID乳腺癌腔B DN 564 326 All SZGR 2.0 genes in this pathway
Smid乳腺癌正常 476 285 All SZGR 2.0 genes in this pathway
Smid乳腺癌基础 648 398 All SZGR 2.0 genes in this pathway
麦加维因结肠癌的甲基化沉默 42 29 All SZGR 2.0 genes in this pathway
Mirlet7a3 DN的Brueckner目标 78 49 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN 70 43 All SZGR 2.0 genes in this pathway
CROMER TUMORIGENESIS DN 51 29 All SZGR 2.0 genes in this pathway
Yauch刺猬信号传导旁分泌 149 85 All SZGR 2.0 genes in this pathway
VART KSHV感染血管生成标记DN 138 92 All SZGR 2.0 genes in this pathway
Meissner Brain HCP带有H3K4ME3和H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA1 DN 74 47 All SZGR 2.0 genes in this pathway
Nakayama软组织肿瘤PCA2 DN 80 51 All SZGR 2.0 genes in this pathway
钱德兰转移DN 306 191 All SZGR 2.0 genes in this pathway
Mikkelsen NPC HCP带有H3K27ME3 341 243 All SZGR 2.0 genes in this pathway
Nielsen Gist vs滑膜肉瘤DN 20 17 All SZGR 2.0 genes in this pathway
尼尔森平滑肌肉瘤DN 18 11 All SZGR 2.0 genes in this pathway
Hirsch细胞转化特征dn 103 67 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567 365 All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到 1137 655 All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化 121 70 All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN 553 343 All SZGR 2.0 genes in this pathway
Wang MLL目标 289 188 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway
lim乳腺腔内成熟DN 99 74 All SZGR 2.0 genes in this pathway
NABA分泌因素 344 197 All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753 411 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-1/206 3046 3053 1A，M8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ Uggaauguaaggaagugugugg
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-128 3030 3036 1a hsa-miR-128a ucacagugaaccggucuuuu
hsa-miR-128b ucacagugaaccggucuuc
miR-144 3028 3034 M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-27 3030 3037 1A，M8 HSA-MIR-27Abrain uucacaguggcuaaguuccgc
HSA-MIR-27Bbrain uucacaguggcuaaguucugc
mir-30-3p 1939年 1945 M8 HSA-MIR-30A-3P CUUUCAGUCGGAUGUUUGCAGC
HSA-MIR-30E-3P cuuucagucggauguauacagc