Gene Page:EPS8L2

Summary?
GeneID 64787
Symbol EPS8L2
Synonyms EPS8R2
Description EPS8 like 2
Reference MIM:614988|HGNC:HGNC:21296|Ensembl:ENSG00000177106|HPRD:10940|Vega:OTTHUMG00000165165
Gene type protein-coding
Map location 11p15.5
Pascal p-value 0.574
Sherlock p-value 0.19
Fetal beta -0.875
DMG 1 (# studies)
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Putamen basal ganglia
Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg04587886 11 719633 EPS8L2 4.78E-5 0.428 0.021 DMG:Wockner_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17392743 chr1 54764240 EPS8L2 64787 0.17 trans
rs4655567 chr1 68101639 EPS8L2 64787 0.2 trans
rs1170050 chr1 116004969 EPS8L2 64787 0.15 trans
rs6687849 chr1 175904808 EPS8L2 64787 1.572E-4 trans
rs2481653 chr1 176044120 EPS8L2 64787 0.07 trans
rs2502827 chr1 176044216 EPS8L2 64787 1.057E-6 trans
rs12405921 chr1 206695730 EPS8L2 64787 0.17 trans
rs17572651 chr1 218943612 EPS8L2 64787 0.08 trans
rs882011 chr2 22711668 EPS8L2 64787 0.01 trans
rs16829545 chr2 151977407 EPS8L2 64787 9.945E-4 trans
rs16841750 chr2 158288461 EPS8L2 64787 0.07 trans
rs3845734 chr2 171125572 EPS8L2 64787 0.15 trans
rs7584986 chr2 184111432 EPS8L2 64787 0 trans
rs2322831 chr3 4799093 EPS8L2 64787 0.15 trans
rs6807632 chr3 111395567 EPS8L2 64787 0.01 trans
rs10013482 chr4 82552047 EPS8L2 64787 0.11 trans
rs17762315 chr5 76807576 EPS8L2 64787 0.16 trans
rs7729096 chr5 76835927 EPS8L2 64787 0.12 trans
rs1368303 chr5 147672388 EPS8L2 64787 2.324E-6 trans
rs3779491 chr7 95120635 EPS8L2 64787 0.03 trans
rs6989594 chr8 126303866 EPS8L2 64787 3.644E-4 trans
rs17263352 chr9 124811572 EPS8L2 64787 0.01 trans
rs17036489 chr12 105292283 EPS8L2 64787 0.18 trans
rs457696 chr13 32581313 EPS8L2 64787 0.02 trans
rs1629937 chr14 77059671 EPS8L2 64787 0.09 trans
rs17104720 chr14 77127308 EPS8L2 64787 3.661E-5 trans
rs6574467 chr14 79179744 EPS8L2 64787 0.01 trans
rs10146003 chr14 79191170 EPS8L2 64787 0.01 trans
rs16955618 chr15 29937543 EPS8L2 64787 6.504E-17 trans
snp_a-1830894 0 EPS8L2 64787 0 trans
rs1420984 chr16 51408733 EPS8L2 64787 0.18 trans
rs16968252 chr17 31692447 EPS8L2 64787 0 trans
rs17823633 chr17 68851458 EPS8L2 64787 0 trans
rs17085767 chr18 69839397 EPS8L2 64787 0.1 trans
rs5955025 chrX 142542997 EPS8L2 64787 0.07 trans
rs7928943 11 698253 EPS8L2 ENSG00000177106.10 4.164E-7 0.01 3815 gtex_brain_putamen_basal
rs11246269 11 698626 EPS8L2 ENSG00000177106.10 3.592E-7 0.01 4188 gtex_brain_putamen_basal
rs7107522 11 703175 EPS8L2 ENSG00000177106.10 3.295E-7 0.01 8737 gtex_brain_putamen_basal
rs11246277 11 706310 EPS8L2 ENSG00000177106.10 4.559E-7 0.01 11872 gtex_brain_putamen_basal
rs11246278 11 706510 EPS8L2 ENSG00000177106.10 2.318E-7 0.01 12072 gtex_brain_putamen_basal
rs73407148 11 707152 EPS8L2 ENSG00000177106.10 7.014E-7 0.01 12714 gtex_brain_putamen_basal
rs10902203 11 711149 EPS8L2 ENSG00000177106.10 1.387E-6 0.01 16711 gtex_brain_putamen_basal
rs11605373 11 711970 EPS8L2 ENSG00000177106.10 5.271E-7 0.01 17532 gtex_brain_putamen_basal
rs113249763 11 712611 EPS8L2 ENSG00000177106.10 1.041E-6 0.01 18173 gtex_brain_putamen_basal
rs11246286 11 715420 EPS8L2 ENSG00000177106.10 9.194E-7 0.01 20982 gtex_brain_putamen_basal
rs28648977 11 772235 EPS8L2 ENSG00000177106.10 1.929E-6 0.01 77797 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
COLDREN GEFITINIB RESISTANCE DN 230 115 All SZGR 2.0 genes in this pathway
KERLEY RESPONSE TO CISPLATIN UP 44 30 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
FERREIRA EWINGS SARCOMA UNSTABLE VS STABLE DN 98 59 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
CHUANG OXIDATIVE STRESS RESPONSE UP 28 18 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 720 440 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536 296 All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE DN 138 99 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO DOXORUBICIN 17 10 All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857 456 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway