Gene Page:ST3GAL3

Summary?
GeneID 6487
Symbol ST3GAL3
Synonyms EIEE15|MRT12|SIAT6|ST3GALII|ST3GalIII|ST3N
Description ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Reference MIM:606494|HGNC:HGNC:10866|Ensembl:ENSG00000126091|HPRD:05930|Vega:OTTHUMG00000007561
Gene type protein-coding
Map location 1p34.1
Pascal p-value 3.806E-5
Sherlock p-value 0.269
Fetal beta 0.112
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs1249912 chr3 112390577 ST3GAL3 6487 0.12 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
KRT222P 0.49 0.53
SNX10 0.48 0.51
AUH 0.48 0.49
GHITM 0.48 0.52
CCDC110 0.48 0.47
SCOC 0.47 0.51
CISD1 0.47 0.51
HPRT1 0.47 0.52
MAL2 0.46 0.48
PPP4R4 0.46 0.46
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CDC42EP4 -0.29 -0.30
SMTN -0.28 -0.29
SEMA4B -0.27 -0.29
FADS2 -0.26 -0.26
NFKBIA -0.26 -0.26
PRX -0.26 -0.25
SH3BP2 -0.26 -0.32
PDLIM7 -0.26 -0.26
SLC38A5 -0.26 -0.27
AC006028.3 -0.26 -0.28

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG GLYCOSAMINOGLYCAN BIOSYNTHESIS KERATAN SULFATE 15 11 All SZGR 2.0 genes in this pathway
KEGG GLYCOSPHINGOLIPID BIOSYNTHESIS LACTO AND NEOLACTO SERIES 26 19 All SZGR 2.0 genes in this pathway
REACTOME O LINKED GLYCOSYLATION OF MUCINS 59 29 All SZGR 2.0 genes in this pathway
REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS 24 12 All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 44 24 All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH PROCESSING IN GOLGI 16 10 All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE BIOSYNTHESIS 26 18 All SZGR 2.0 genes in this pathway
REACTOME KERATAN SULFATE KERATIN METABOLISM 30 21 All SZGR 2.0 genes in this pathway
REACTOME GLYCOSAMINOGLYCAN METABOLISM 111 69 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF PROTEINS 518 242 All SZGR 2.0 genes in this pathway
REACTOME POST TRANSLATIONAL PROTEIN MODIFICATION 188 116 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 103 64 All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF CARBOHYDRATES 247 154 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP 423 283 All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA DN 284 156 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821 933 All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN 121 79 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway