Gene Page:MRPS6

Summary?
GeneID 64968
Symbol MRPS6
Synonyms C21orf101|MRP-S6|RPMS6|S6mt
Description mitochondrial ribosomal protein S6
Reference MIM:611973|HGNC:HGNC:14051|Ensembl:ENSG00000243927|HPRD:11374|Vega:OTTHUMG00000065820
Gene type protein-coding
Map location 21q22.11
Pascal p-value 0.01
Sherlock p-value 0.412
Fetal beta 0.602
DMG 1 (# studies)
eGene Anterior cingulate cortex BA24
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 3
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 3

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg06728306 21 35445589 MRPS6;SLC5A3 5.58E-5 0.355 0.022 DMG:Wockner_2014
cg10599571 21 35445161 MRPS6;SLC5A3 4.198E-4 0.344 0.045 DMG:Wockner_2014
cg04096688 21 35574180 MRPS6 6.21E-9 -0.018 3.28E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs17049408 chr2 58431128 MRPS6 64968 0.19 trans
rs11850361 chr14 24220154 MRPS6 64968 0.16 trans
rs17793479 chr20 59328916 MRPS6 64968 0.2 trans
rs2300390 21 35969515 MRPS6 ENSG00000243927.1 4.72385E-7 0.02 523991 gtex_brain_ba24
rs12482676 21 35970712 MRPS6 ENSG00000243927.1 8.6745E-7 0.02 525188 gtex_brain_ba24
rs915540 21 35985895 MRPS6 ENSG00000243927.1 7.79706E-7 0.02 540371 gtex_brain_ba24
rs12483565 21 35989970 MRPS6 ENSG00000243927.1 5.81351E-7 0.02 544446 gtex_brain_ba24

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
OSMAN BLADDER CANCER DN 406 230 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537 339 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487 286 All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 138 91 All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566 371 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN 270 181 All SZGR 2.0 genes in this pathway
IZADPANAH STEM CELL ADIPOSE VS BONE UP 126 92 All SZGR 2.0 genes in this pathway
HONMA DOCETAXEL RESISTANCE 34 23 All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS 47 28 All SZGR 2.0 genes in this pathway
MALONEY RESPONSE TO 17AAG UP 41 26 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS EARLY UP 66 44 All SZGR 2.0 genes in this pathway
NAKAMURA ADIPOGENESIS LATE UP 104 67 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 34 24 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT 572 352 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
GHANDHI DIRECT IRRADIATION DN 33 23 All SZGR 2.0 genes in this pathway