Gene Page:SKIL

Summary?
GeneID 6498
Symbol SKIL
Synonyms SNO|SnoA|SnoI|SnoN
Description SKI-like proto-oncogene
Reference MIM:165340|HGNC:HGNC:10897|Ensembl:ENSG00000136603|HPRD:01319|Vega:OTTHUMG00000158831
Gene type protein-coding
Map location 3q26
Pascal p-value 0.498
Fetal beta 0.665

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0108

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
GALNT9 0.86 0.89
FSTL4 0.86 0.79
SYT7 0.86 0.84
SYNGR1 0.85 0.84
ABCG4 0.84 0.88
KNDC1 0.84 0.82
AC013418.1 0.84 0.80
AC135048.1 0.84 0.79
DNM1 0.83 0.88
MCHR1 0.83 0.84
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
FAM36A -0.43 -0.35
GTF3C6 -0.43 -0.38
C9orf46 -0.43 -0.43
RPS20 -0.40 -0.49
RBMX2 -0.40 -0.40
RPL27A -0.39 -0.49
RPS6 -0.39 -0.42
EXOSC8 -0.39 -0.32
RPL35 -0.39 -0.44
RPL31 -0.39 -0.40

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003714 transcription corepressor activity TAS 10531062
GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity TAS 10531062
GO:0005515 protein binding TAS 10531062
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006366 transcription from RNA polymerase II promoter TAS 10531062
GO:0007165 signal transduction TAS 10531062
GO:0007275 multicellular organismal development NAS 9207045
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CDC16 APC6 cell division cycle 16 homolog (S. cerevisiae) - HPRD 11691834
CDC27 APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC cell division cycle 27 homolog (S. cerevisiae) - HPRD 11691834
CPNE1 COPN1 | CPN1 | MGC1142 copine我 - HPRD 12522145
CPNE2 COPN2 | CPN2 | DKFZp686E06199 | MGC16924 copine我I - HPRD 12522145
CPNE4 COPN4 | CPN4 | MGC15604 copine我V - HPRD 12522145
FZR1 CDC20C | CDH1 | FZR | FZR2 | HCDH | HCDH1 | KIAA1242 fizzy/cell division cycle 20 related 1 (Drosophila) - HPRD,BioGRID 11691834
SKI SKV v-ski sarcoma viral oncogene homolog (avian) - HPRD,BioGRID 9927733
SKIL SNO | SnoA | SnoN SKI-like oncogene Reconstituted Complex BioGRID 9927733
SMAD1 BSP1 | JV4-1 | JV41 | MADH1 | MADR1 SMAD family member 1 Smad1 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad1. BIND 12426322
SMAD2 JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 SMAD family member 2 Smad2 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad2. BIND 12426322
SMAD2 JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2 SMAD family member 2 - HPRD,BioGRID 10531062|11691834
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 Smad3 interacts with SnoN. This interaction was modeled on a demonstrated interaction between SnoN from an unspecified source and human Smad3. BIND 12426322
SMAD3 DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 SMAD family member 3 - HPRD,BioGRID 10531062
SMAD4 DPC4 | JIP | MADH4 SMAD家庭成员4 Smad4 interacts with SnoN. This interaction was modeled on a demonstrated interaction between human Smad4 and SnoN from an unspecified species. BIND 15761153
SMAD4 DPC4 | JIP | MADH4 SMAD家庭成员4 - HPRD,BioGRID 10531062
SMURF2 DKFZp686F0270 | MGC138150 SMAD specific E3 ubiquitin protein ligase 2 - HPRD,BioGRID 11389444
SNW1 Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIP SNW domain containing 1 Phenotypic Suppression BioGRID 11278756


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BIOCARTA TGFB PATHWAY 19 14 All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 82 63 All SZGR 2.0 genes in this pathway
PID TGFBR PATHWAY 55 38 All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER 38 26 All SZGR 2.0 genes in this pathway
REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY 20 14 All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352 181 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY TGF BETA RECEPTOR COMPLEX 63 42 All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA UP 183 119 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156 106 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A DN 110 78 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 AND HIF1A DN 103 71 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283 177 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179 105 All SZGR 2.0 genes in this pathway
STOSSI RESPONSE TO ESTRADIOL 50 35 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA DN 11 6 All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND UP 77 52 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR UP 180 125 All SZGR 2.0 genes in this pathway
SARTIPY BLUNTED BY INSULIN RESISTANCE UP 19 17 All SZGR 2.0 genes in this pathway
VISALA RESPONSE TO HEAT SHOCK AND AGING DN 14 12 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE UP 578 341 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA DN 100 63 All SZGR 2.0 genes in this pathway
COULOUARN颞TGFB1签名UP 109 68 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222 147 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
BAKKER FOXO3 TARGETS DN 187 109 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
KOINUMA TARGETS OF SMAD2 OR SMAD3 824 528 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367 231 All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 48 33 All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462 273 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-330 58 64 m8 hsa-miR-330brain GCAAAGCACACGGCCUGCAGAGA
miR-410 145 151 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU