Gene Page:REEP1

概括?
GeneID 65055
Symbol REEP1
Synonyms C2orf23|HMN5B|SPG31|Yip2a
描述 receptor accessory protein 1
参考 MIM:609139|HGNC:HGNC:25786|Ensembl：ENSG0000000068615|HPRD:07810|Vega:OTTHUMG00000130205
Gene type protein-coding
Map location 2p11.2
Pascal p-value 0.305
Sherlock P值 0.795
Fetal beta 1.081
DMG 1（＃研究）
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
额叶皮质BA9
Hippocampus
Nucleus accumbens basal ganglia
梭子基底神经节
迈尔斯的顺式和跨性别

数据源中的基因
Gene set name Method of gene set 描述 Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GSMA_I 基因组扫描荟萃分析 Psr: 0.0004

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) beta（dis） FDR (dis) Study
cg21569844 2 86564582 REEP1 3.37E-8 -0.016 1.01E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs10994209 chr10 61877705 REEP1 65055 0.17 trans
RS71377068 2 86477840 REEP1 ENSG00000068615.12 3.588E-6 0.02 87366 gtex_brain_putamen_basal
rs397873792 2 86494130 REEP1 ENSG00000068615.12 3.307E-6 0.02 71076 gtex_brain_putamen_basal
rs2367233 2 86541666 REEP1 ENSG00000068615.12 1.065E-6 0.02 23540 gtex_brain_putamen_basal
RS6746198 2 86542113 REEP1 ENSG00000068615.12 1.314E-6 0.02 23093 gtex_brain_putamen_basal
rs11691122 2 86543595 REEP1 ENSG00000068615.12 2.841E-6 0.02 21611 gtex_brain_putamen_basal
rs10200619 2 86548848 REEP1 ENSG00000068615.12 1.314E-6 0.02 16358 gtex_brain_putamen_basal
rs7593440 2 86550657 REEP1 ENSG00000068615.12 1.314E-6 0.02 14549 gtex_brain_putamen_basal
rs4392258 2 86552577 REEP1 ENSG00000068615.12 1.314E-6 0.02 12629 gtex_brain_putamen_basal
rs6547674 2 86552919 REEP1 ENSG00000068615.12 2.836E-6 0.02 12287 gtex_brain_putamen_basal
rs11685863 2 86554484 REEP1 ENSG00000068615.12 1.314E-6 0.02 10722 gtex_brain_putamen_basal
RS11127029 2 86554625 REEP1 ENSG00000068615.12 2.97E-6 0.02 10581 gtex_brain_putamen_basal
rs1863051 2 86559148 REEP1 ENSG00000068615.12 2.374E-6 0.02 6058 gtex_brain_putamen_basal
rs1863052 2 86559358 REEP1 ENSG00000068615.12 1.313E-6 0.02 5848 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0031849 olfactory receptor binding 小鬼 15550249
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0051205 protein insertion into membrane IDA 15550249
细胞分量 去的术语 Evidence Neuro keywords PubMed ID
GO:0005737 细胞质 IDA 15550249
GO:0005739 mitochondrion IEA -
GO:0016020 膜 IEA -
GO:0016021 integral to membrane IEA -
GO:0031966 mitochondrial membrane IEA -

V.途径注释

Pathway name Pathway size ＃szgr 2.0基因 Info
ONKEN UVEAL MELANOMA UP 783 507 该途径中的所有SZGR 2.0基因
WATANABE COLON CANCER MSI VS MSS DN 81 42 该途径中的所有SZGR 2.0基因
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS DN 68 49 该途径中的所有SZGR 2.0基因
ZHOU INFLAMMATORY RESPONSE FIMA DN 284 156 该途径中的所有SZGR 2.0基因
SCIBETTA KDM5B TARGETS DN 81 55 该途径中的所有SZGR 2.0基因
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 该途径中的所有SZGR 2.0基因
多德鼻咽癌 1821 933 该途径中的所有SZGR 2.0基因
PAX3 FOXO1融合的Ebauer目标 207 128 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 该途径中的所有SZGR 2.0基因
SCHLOSSER SERUM RESPONSE UP 134 93 该途径中的所有SZGR 2.0基因
KANG GIST WITH PDGFRA UP 50 27 该途径中的所有SZGR 2.0基因
RICKMAN HEAD AND NECK CANCER C 113 47 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
BENPORATH CYCLING GENES 648 385 该途径中的所有SZGR 2.0基因
GEORGES TARGETS OF MIR192 AND MIR215 893 528 该途径中的所有SZGR 2.0基因
CERVERA SDHB TARGETS 1 UP 118 66 该途径中的所有SZGR 2.0基因
LE EGR2目标 108 75 该途径中的所有SZGR 2.0基因
BYSTRYKH造血干细胞QTL Trans 882 572 该途径中的所有SZGR 2.0基因
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 该途径中的所有SZGR 2.0基因
IVANOVA HEMATOPOIESIS LATE PROGENITOR 544 307 该途径中的所有SZGR 2.0基因
MCLACHLAN DENTAL CARIES DN 245 144 该途径中的所有SZGR 2.0基因
麦克拉克兰牙科龋齿 253 147 该途径中的所有SZGR 2.0基因
BILD E2F3 ONCOGENIC SIGNATURE 246 153 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性2 473 224 该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性5 482 296 该途径中的所有SZGR 2.0基因
riggi ewing肉瘤祖先 430 288 该途径中的所有SZGR 2.0基因
SMID BREAST CANCER BASAL DN 701 446 该途径中的所有SZGR 2.0基因
WHITFIELD CELL CYCLE S 162 86 该途径中的所有SZGR 2.0基因
金所有障碍OLIGODENDROCYTE NUMBER CORR UP 756 494 该途径中的所有SZGR 2.0基因
金所有障碍CALB1 CORR UP 548 370 该途径中的所有SZGR 2.0基因
verhaak胶质母细胞瘤pro 177 132 该途径中的所有SZGR 2.0基因
QI HYPOXIA 140 96 该途径中的所有SZGR 2.0基因
BHAT ESR1目标不是通过AKT1向上的 211 131 该途径中的所有SZGR 2.0基因
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN 1080 713 该途径中的所有SZGR 2.0基因
PEDERSEN METASTASIS BY ERBB2 ISOFORM 1 46 33 该途径中的所有SZGR 2.0基因
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position mirna id miRNA seq
UTR start UTR end Match method
let-7/98 31 37 1A HSA-LET-7A脑 UGAGGUAGUAGGUUGUAUAGUU
HSA-LET-7B脑 UGAGGUAGUAGGUUGUGUGGUU
HSA-LET-7C脑 UGAGGUAGUAGGUUGUAUGGUU
HSA-LET-7D脑 agagguaguagguugcauagu
HSA-LET-7E脑 UGAGGUAGGAGGUUGUAUAGU
HSA-LET-7F脑 UGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98脑 UGAGGUAGUAAGUUGUAUUGUU
HSA-LET-7GSZ UGAGGUAGUAGUUUGUACAGU
HSA-LET-7I脑 UGAGGUAGUAGUUUGUGCUGU
miR-124.1 106 113 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 106 112 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124脑 UAAGGCACGCGGUGAAUGCC
mir-140 51 57 m8 hsa-miR-140脑 agugguuuuacccuaugguag
miR-182 2231 2237 1A hsa-miR-182 UUUGGCAAUGGUAGAACUCACA
MiR-200BC/429 2848 2854 m8 HSA-MIR-200B UAAUACUGCCUGGUAAUGAUGAC
HSA-MIR-200C uaauacugccggguaaugaugg
HSA-MIR-429 uaauacuguguguguguguaaaaaccgu
miR-204/211 259 266 1A,m8 HSA-MIR-204脑 UUCCCUUUGUCAUCCUAUGCCU
HSA-MIR-211 UUCCCUUUGUCAUCCUUCGCCU
miR-208 3083 3089 1A HSA-MIR-208 AUAAGACGAGCAAAAAGCUUGU
miR-214 386 392 1A HSA-MIR-214脑 ACAGCAGGCACAGACAGGCAG
miR-23 2482 2489 1A,m8 hsa-miR-23a脑 aucacauugccagggauucc
hsa-miR-23b脑 AUCACAUUGCCAGGGAUUACC
miR-24 1460 1466 m8 HSA-MIR-24SZ UGGCUCAGUUCAGCAGGAACAG
HSA-MIR-24SZ UGGCUCAGUUCAGCAGGAACAG
mir-377 2719 2726 1A,m8 hsa-miR-377 AUCACACAAAGGCAACUUUUGU
mir-493-5p 394 400 m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU
mir-495 3049 3055 1A hsa-miR-495脑 AAACAAACAUGGUGCACUUCUUU
mir-499 3082 3089 1A,m8 hsa-miR-499 uuaagacuugcagugauguuaa
miR-96 2231 2237 1A hsa-miR-96脑 UUUGGCACUAGCACAUUUUUGC