Gene Page:年代LC3A2

年代ummary?
GeneID 6520
年代ymbol 年代LC3A2
年代ynonyms 4F2|4F2HC|4T2HC|CD98|CD98HC|MDU1|NACAE
Description solute carrier family 3 member 2
Reference MIM:158070|HGNC:HGNC:11026|Ensembl:ENSG00000168003|HPRD:01148|Vega:OTTHUMG00000074091
Gene type protein-coding
Map location 11q13
Pascal p-value 0.139
年代herlock p-value 0.199
Fetal beta -0.266
DMG 1 (# studies)
年代upport CELL METABOLISM

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
DNM:McCarthy_2014 Whole Exome Sequencing analysis Whole exome sequencing of 57 trios with sporadic or familial schizophrenia.
PMID:cooccur High-throughput literature-search 年代ystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details

年代ection I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type 年代ift CG46 Trait 年代tudy
年代LC3A2 chr11 62623787 C A NM_001012662 p.P16T missense SNV N D 年代chizophrenia DNM:McCarthy_2014

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) 年代tudy
cg27629023 11 62648823 年代LC3A2 2.243E-4 -0.22 0.036 DMG:Wockner_2014


年代ection II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
年代C: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
年代T1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
年代ERPINA1 0.73 0.53
FPR1 0.72 0.54
C1QB 0.66 0.41
年代ERPINA3 0.63 0.27
BCL2A1 0.61 0.38
TLR2 0.61 0.40
MT1M 0.61 0.24
年代100A9 0.60 0.50
HMOX1 0.60 0.43
CSF3R 0.59 0.52
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 年代pearman's Correlation
C10orf118 -0.22 -0.24
ARID4A -0.22 -0.23
GNAI1 -0.21 -0.23
C1orf96 -0.21 -0.20
PPIG -0.21 -0.25
LMO7 -0.20 -0.21
年代EC62 -0.20 -0.29
LEMD3 -0.20 -0.22
年代MARCA2 -0.20 -0.19
WDR89 -0.20 -0.22

年代ection V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID NFAT TFPATHWAY 47 39 All SZGR 2.0 genes in this pathway
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL 91 65 All SZGR 2.0 genes in this pathway
REACTOME BASIGIN INTERACTIONS 30 23 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE 31 21 All SZGR 2.0 genes in this pathway
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 All SZGR 2.0 genes in this pathway
REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT 241 157 All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES 94 65 All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS 49 36 All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466 331 All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 90 65 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS DN 352 225 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 136 80 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214 133 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
PACHER TARGETS OF IGF1 AND IGF2 UP 35 27 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239 157 All SZGR 2.0 genes in this pathway
TANAKA METHYLATED IN ESOPHAGEAL CARCINOMA 103 58 All SZGR 2.0 genes in this pathway
年代CHLOSSER MYC TARGETS REPRESSED BY SERUM 159 93 All SZGR 2.0 genes in this pathway
WANG METHYLATED IN BREAST CANCER 35 25 All SZGR 2.0 genes in this pathway
TSUNODA CISPLATIN RESISTANCE DN 51 38 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP 33 20 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 DN 59 35 All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206 136 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
年代HEPARD CRUSH AND BURN MUTANT UP 197 110 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 142 93 All SZGR 2.0 genes in this pathway
JECHLINGER上皮间充质转变 71 51 All SZGR 2.0 genes in this pathway
KANNAN TP53 TARGETS UP 58 40 All SZGR 2.0 genes in this pathway
FLECHNER PBL KIDNEY TRANSPLANT REJECTED VS OK DN 51 35 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245 154 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 138 91 All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA DN 18 16 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311 205 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 113 71 All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 49 34 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953 554 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783 442 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 105 67 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292 189 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281 179 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 33 22 All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 147 98 All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 60 44 All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242 168 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 51 32 All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION A 67 52 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF UP 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN 50 33 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 67 51 All SZGR 2.0 genes in this pathway
年代HAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 81 66 All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721 492 All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 34 24 All SZGR 2.0 genes in this pathway
金所有障碍少突细胞数量。柯尔 756 494 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658 397 All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770 480 All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517 302 All SZGR 2.0 genes in this pathway