Gene Page:SLC6A9

概括?
基因 6536
象征 SLC6A9
Synonyms GLYT1
Description solute carrier family 6 member 9
Reference MIM:601019|HGNC:HGNC:11056|Ensembl:ENSG00000196517|HPRD:03010|Vega:OTTHUMG00000008294
Gene type protein-coding
Map location 1p33
Pascal p-value 0.007
Fetal beta -0.662
DMG 1（＃研究）
Support NEUROTRANSMITTER METABOLISM

数据源中的基因
Gene set name Method of gene set Description Info
CV：GWASDB Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias 点击to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 与神经相关关键字的命中：3

第一节遗传学和表观遗传学注释

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg25605771 1 44466601 SLC6A9 1.781E-4 0.291 0.034 DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CHAT 0.72 0.57
SLC5A7 0.67 0.53
NTRK1 0.67 0.41
ECEL1 0.63 0.56
CHODL 0.54 0.60
S100A10 0.53 0.17
ASPG 0.51 0.27
LMO1 0.48 0.44
TACR1 0.48 0.32
GYG2 0.48 0.44
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC26A4 -0.20 -0.16
FBXW7 -0.19 -0.16
ANKRD56 -0.18 -0.21
C6orf105 -0.18 -0.16
PRSS16 -0.17 -0.33
FBXO32 -0.17 -0.14
MEF2C -0.17 0.01
MCHR2 -0.17 -0.18
AC016910.1 -0.17 -0.06
C6orf142 -0.17 -0.21

Section III. Gene Ontology annotation

分子功能 GO term Evidence Neuro keywords PubMed ID
GO:0005328 neurotransmitter:sodium symporter activity IEA Neurotransmitter (GO term level: 9) -
去：0005283 sodium:amino acid symporter activity IEA glutamate (GO term level: 10) -
GO:0015375 glycine:sodium symporter activity TAS 8183239
GO：0015293 分类者活动 IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0006836 neurotransmitter transport IEA neuron, Neurotransmitter (GO term level: 5) -
GO:0006865 amino acid transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005624 membrane fraction TAS 8183239
去：0016020 membrane IEA -
GO:0005887 integral to plasma membrane IEA -
GO:0005887 integral to plasma membrane TAS 8183239

V.途径注释

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES 413 270 该途径中的所有SZGR 2.0基因
Reactome SLC介导的跨膜运输 241 157 该途径中的所有SZGR 2.0基因
REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS 89 54 该途径中的所有SZGR 2.0基因
REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS 17 12 该途径中的所有SZGR 2.0基因
REACTOME AMINE COMPOUND SLC TRANSPORTERS 27 16 该途径中的所有SZGR 2.0基因
ENK UV RESPONSE EPIDERMIS DN 508 354 该途径中的所有SZGR 2.0基因
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 该途径中的所有SZGR 2.0基因
LEIN MEDULLA MARKERS 81 48 该途径中的所有SZGR 2.0基因
Yoshimura mapk8靶向 1305 895 该途径中的所有SZGR 2.0基因
VALK AML CLUSTER 7 28 16 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 该途径中的所有SZGR 2.0基因
WIERENGA STAT5A TARGETS UP 217 131 该途径中的所有SZGR 2.0基因
WIERENGA STAT5A TARGETS GROUP1 136 76 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS UP 745 475 该途径中的所有SZGR 2.0基因
PARK OSTEOBLAST DIFFERENTIATION BY PHENYLAMIL UP 13 11 该途径中的所有SZGR 2.0基因
HUANG GATA2 TARGETS DN 72 52 该途径中的所有SZGR 2.0基因
FOSTER KDM1A TARGETS DN 211 119 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

mirna家族 Target position mirna id miRNA seq
UTR start UTR end Match method
mir-137 969 975 1A hsa-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-141/200a 166 172 m8 hsa-miR-141 uaacacugucugugugugugaugg
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
hsa-miR-141 uaacacugucugugugugugaugg
HSA-MIR-200A UAACACUGUCUGGUAACGAUGU
miR-17-5p/20/93.mr/106/519.d 245 251 m8 hsa-miR-17-5p caaagugcuuacugcagguagu
hsa-miR-20abrain uaaagugcuuauagugcagguag
hsa-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZ uaaagugcugacagugcagau
hsa-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
HSA-MIR-519D caaagugccucccuuuagugugu
miR-182 831 837 1A hsa-miR-182 uuuggcaaugguagaacucaca
miR-184 918 924 m8 hsa-miR-184 UGGACGGAGAACUGAUAAGGGU
miR-221/222 966 972 1A HSA-MIR-221brain AGCUACAUUGUCUGCUGGGUUUC
HSA-MIR-222brain agcuacaucuggcuacugggucuc
miR-30-5p 169 176 1A,m8 HSA-MIR-30A-5P UGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrain uguaaacauccuacucucucucucagc
hsa-miR-30dSZ uguaaacauccccgacuggaag
hsa-miR-30bSZ UGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5p UGUAAACAUCCUUGACUGGA
miR-7 568 575 1A,m8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
miR-93.hd/291-3p/294/295/302/372/373/520 244 250 m8 hsa-miR-93brain aaagugcuguucgugcagguag
hsa-miR-302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302c uaagugcuuccauguucagugg
hsa-miR-302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520e Aaagugcuuuuuugaggg
hsa-miR-520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR-520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR-520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520d AAAGUGCUUCUCUUUGGUGGGUU
mir-96 830 837 1A,m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC