Gene Page:BMP6

概括?
基因 654
象征 BMP6
Synonyms VGR|VGR1
Description bone morphogenetic protein 6
Reference MIM:112266|HGNC:HGNC:1073|Ensembl:ENSG00000153162|HPRD:00211|Vega:OTTHUMG00000014217
Gene type protein-coding
Map location 6p24-p23
Pascal p-value 0.11
Sherlock p-value 0.66
Fetal beta -0.136
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.0159
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

第一节遗传学和表观遗传学注释

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs546975 chr1 91963738 BMP6 654 0.03 trans
rs4236095 chr6 47368686 BMP6 654 0.02 trans
snp_a-2266657 0 BMP6 654 0.15 trans
rs2430483 chr7 104548631 BMP6 654 0.07 trans
rs2061799 chr9 97795003 BMP6 654 0.01 trans
rs10149864 chr14 86719683 BMP6 654 0 trans
rs5029382 chr18 45981525 BMP6 654 0.11 trans
rs1877412 chr18 45987674 BMP6 654 0.09 trans
rs11873703 chr18 61448702 BMP6 654 0.19 trans
rs16999569 chr19 22902709 BMP6 654 0.09 trans
RS12973782 chr19 22905126 BMP6 654 0.09 trans
SNP_A-2090370 0 BMP6 654 0.09 trans
rs12980129 chr19 22908910 BMP6 654 0.02 trans
rs2194111 chr19 22922548 BMP6 654 0.09 trans
rs6095741 chr20 48666589 BMP6 654 0.02 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
SLC4A4 0.86 0.79
PPAP2B 0.86 0.85
ATP13A4 0.85 0.77
ACSS3 0.84 0.81
AQP4 0.83 0.77
SSPN 0.83 0.75
SLC1A3 0.83 0.84
PDLIM5 0.82 0.80
ITPR2 0.82 0.73
add3 0.82 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MED19 -0.36 -0.39
AC011491.1 -0.35 -0.37
RAB33A -0.34 -0.37
DCTPP1 -0.33 -0.36
DPF1 -0.33 -0.30
BZW2 -0.32 -0.33
GPR21 -0.32 -0.29
POLB -0.32 -0.34
ACTL6B -0.31 -0.31
ARL4D -0.31 -0.29

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005125 cytokine activity IEA -
GO:0005515 protein binding IEA -
去：0008083 生长factor activity IEA -
生物过程 GO term Evidence Neuro keywords PubMed ID
GO:0006955 immune response IMP 16886151
GO:0006954 inflammatory response IEA -
GO:0007275 multicellular organismal development IEA -
GO:0030501 positive regulation of bone mineralization IDA 18436533
GO:0030509 BMP signaling pathway IEA -
GO：0051216 cartilage development IEA -
GO:0032349 positive regulation of aldosterone biosynthetic process IDA 16527843
GO:0040007 生长 IEA -
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 16527843
GO:0045669 成骨细胞分化的阳性调节 IDA 18436533
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region IEA -
GO:0005615 extracellular space IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 该途径中的所有SZGR 2.0基因
KEGG TGF BETA SIGNALING PATHWAY 86 64 该途径中的所有SZGR 2.0基因
PID BMP PATHWAY 42 31 该途径中的所有SZGR 2.0基因
UDAYAKUMAR MED1 TARGETS DN 240 171 该途径中的所有SZGR 2.0基因
BENPORATH EED TARGETS 1062 725 该途径中的所有SZGR 2.0基因
BENPORATH ES WITH H3K27ME3 1118 744 该途径中的所有SZGR 2.0基因
SHEN SMARCA2 TARGETS DN 357 212 该途径中的所有SZGR 2.0基因
STOSSI RESPONSE TO ESTRADIOL 50 35 该途径中的所有SZGR 2.0基因
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 该途径中的所有SZGR 2.0基因
AFFAR YY1 TARGETS UP 214 133 该途径中的所有SZGR 2.0基因
PETROVA PROX1 TARGETS DN 64 38 该途径中的所有SZGR 2.0基因
Jazaeri乳腺癌BRCA1 vs BRCA2 DN 43 31 该途径中的所有SZGR 2.0基因
击倒卡路里限制肌肉DN 87 59 该途径中的所有SZGR 2.0基因
CHIBA RESPONSE TO TSA UP 52 33 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 48HR UP 180 125 该途径中的所有SZGR 2.0基因
WESTON VEGFA TARGETS 108 71 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 14HR UP 156 101 该途径中的所有SZGR 2.0基因
tseng irs1靶向 113 71 该途径中的所有SZGR 2.0基因
WESTON VEGFA TARGETS 3HR 74 47 该途径中的所有SZGR 2.0基因
Tseng成脂潜力 30 19 该途径中的所有SZGR 2.0基因
RIZKI TUMOR INVASIVENESS 3D UP 210 124 该途径中的所有SZGR 2.0基因
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 该途径中的所有SZGR 2.0基因
SWEET LUNG CANCER KRAS DN 435 289 该途径中的所有SZGR 2.0基因
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 101 76 该途径中的所有SZGR 2.0基因
SHAFFER IRF4 TARGETS IN PLASMA CELL VS MATURE B LYMPHOCYTE 67 51 该途径中的所有SZGR 2.0基因
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 81 66 该途径中的所有SZGR 2.0基因
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 该途径中的所有SZGR 2.0基因
ZHAN LATE DIFFERENTIATION GENES UP 33 24 该途径中的所有SZGR 2.0基因
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349 234 该途径中的所有SZGR 2.0基因
MIKKELSEN MCV6 HCP WITH H3K27ME3 435 318 该途径中的所有SZGR 2.0基因
MIKKELSEN NPC HCP WITH H3K27ME3 341 243 该途径中的所有SZGR 2.0基因
LU EZH2 TARGETS DN 414 237 该途径中的所有SZGR 2.0基因
FORTSCHEGGER PHF8 TARGETS UP 279 155 该途径中的所有SZGR 2.0基因
NABA SECRETED FACTORS 344 197 该途径中的所有SZGR 2.0基因
NABA MATRISOME ASSOCIATED 753 411 该途径中的所有SZGR 2.0基因
NABA MATRISOME 1028 559 该途径中的所有SZGR 2.0基因

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-124.1 55 62 1A,m8 hsa-miR-124a UUAAGGCACGCGGUGAAUGCCA
miR-124/506 55 61 1A hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brain UAAGGCACGCGGUGAAUGCC
miR-219 1015 1021 1A hsa-miR-219brain UGAUUGUCCAAACGCAAUUCU