Gene Page:SLC15A1
Summary?
| GeneID | 6564 |
| Symbol | SLC15A1 |
| Synonyms | HPECT1|HPEPT1|PEPT1 |
| Description | solute carrier family 15 member 1 |
| Reference | MIM:600544|HGNC:HGNC:10920|Ensembl:ENSG00000088386|HPRD:02768|Vega:OTTHUMG00000017255 |
| Gene type | protein-coding |
| Map location | 13q32.3 |
| Pascal p-value | 0.98 |
| Fetal beta | -0.331 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed co-o基因ccurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RP11-544M22.1 | 0.81 | 0.85 |
| NME2 | 0.81 | 0.83 |
| PHPT1 | 0.80 | 0.84 |
| NME1-NME2 | 0.79 | 0.79 |
| NT5C3L | 0.79 | 0.77 |
| C12orf73 | 0.77 | 0.79 |
| HTRA2 | 0.77 | 0.79 |
| ARD1A | 0.77 | 0.78 |
| C14orf179 | 0.77 | 0.85 |
| CUTA | 0.77 | 0.77 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MYH14 | -0.58 | -0.65 |
| PTRF | -0.54 | -0.60 |
| FOXO4 | -0.53 | -0.62 |
| ZBTB7B | -0.53 | -0.59 |
| KIF1C | -0.53 | -0.61 |
| MUC5B | -0.53 | -0.60 |
| DAAM2 | -0.52 | -0.57 |
| SYNM | -0.52 | -0.51 |
| AF347015.26 | -0.52 | -0.58 |
| EPAS1 | -0.52 | -0.58 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity | IEA | - | |
| GO:0005215 | transporter activity | IEA | - | |
| GO:0015333 | peptide:hydrogen symporter activity | TAS | 7896779 | |
| GO:0015293 | symporter activity | IEA | - | |
| GO:0015198 | oligopeptide transporter activity | IEA | - | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0007586 | digestion | TAS | 7896779 | |
| GO:0006857 | oligopeptide transport | IEA | - | |
| GO:0015031 | protein transport | IEA | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | - | |
| GO:0005624 | membrane fraction | TAS | 7896779 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 7896779 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | 94 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | 49 | 36 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER EARLY DN | 367 | 220 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA DN | 291 | 176 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| MATSUDA NATURAL KILLER DIFFERENTIATION | 475 | 313 | All SZGR 2.0 genes in this pathway |
| ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP | 174 | 96 | All SZGR 2.0 genes in this pathway |
| ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE DN | 274 | 165 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL UP | 648 | 398 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING | 246 | 152 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| CHIANG LIVER CANCER SUBCLASS CTNNB1 DN | 170 | 105 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |