Gene Page:SMARCA4

Summary?
GeneID 6597
Symbol SMARCA4
Synonyms BAF190|BAF190A|BRG1|MRD16|RTPS2|SNF2|SNF2L4|SNF2LB|SWI2|hSNF2b
Description 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily a, member 4
Reference MIM:603254|HGNC:HGNC:11100|Ensembl:ENSG00000127616|HPRD:04459|Vega:OTTHUMG00000169272
Gene type protein-coding
Map location 19p13.2
Pascal p-value 0.598
Sherlock p-value 0.021
Fetal beta 0.751
DMG 2 (# studies)
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets
Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis 作者调查了甲基化配置文件of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 2
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 3
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0172

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg12411068 19 11072235 SMARCA4 -0.048 0.27 DMG:Nishioka_2013
cg25397562 19 11616711 SMARCA4 0.001 3.654 DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TPRKB 0.89 0.81
CETN3 0.85 0.76
RPL35A 0.84 0.83
CCDC58 0.81 0.68
PSMA2 0.81 0.73
SNRPE 0.81 0.66
TBCA 0.81 0.73
RPL23 0.80 0.82
RPL24 0.80 0.76
TPT1 0.79 0.77
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
ZBTB47 -0.54 -0.63
TMEM184B -0.53 -0.68
PK4P -0.53 -0.64
BCL2L2 -0.52 -0.69
ATP10A -0.52 -0.65
VASN -0.51 -0.65
GAS2L1 -0.50 -0.57
TNS1 -0.50 -0.70
SYNM -0.50 -0.67
PEAR1 -0.50 -0.64

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0003677 DNA binding IEA -
GO:0003682 chromatin binding IEA -
GO:0003700 transcription factor activity TAS 8208605
GO:0003713 transcription coactivator activity TAS 8208605
GO:0005524 ATP binding IEA -
GO:0004386 helicase activity IEA -
GO:0004386 helicase activity TAS 8208605
GO:0016787 hydrolase activity IEA -
GO:0008134 transcription factor binding IEA -
GO:0042802 identical protein binding 新闻学会 12917342
GO:0047485 protein N-terminus binding 新闻学会 12917342
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0007403 glial cell fate determination IEA Glial (GO term level: 10) -
GO:0030902 hindbrain development IEA Brain (GO term level: 8) -
GO:0030900 forebrain development IEA Brain (GO term level: 8) -
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA -
GO:0001835 blastocyst hatching IEA -
GO:0001832 blastocyst growth IEA -
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8208605
GO:0006350 transcription IEA -
GO:0006346 methylation-dependent chromatin silencing IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0000792 heterochromatin IEA -
GO:0005634 nucleus IEA -
GO:0005634 nucleus TAS 8232556
GO:0005654 nucleoplasm TAS 8208605

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ACTB PS1TP5BP1 actin, beta - HPRD,BioGRID 9845365
ACTL6A ACTL6 | Arp4 | BAF53A | INO80K | MGC5382 actin-like 6A - HPRD,BioGRID 9845365
AHR - aryl hydrocarbon receptor - HPRD,BioGRID 11805098
ALB DKFZp779N1935 | PRO0883 | PRO0903 | PRO1341 albumin Brg-1 interactis with the Albumin gene. BIND 15616580
AR AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM androgen receptor Affinity Capture-Western BioGRID 14966121
ARID1A B120 | BAF250 | BAF250a | BM029 | C1orf4 | P270 | SMARCF1 AT rich interactive domain 1A (SWI-like) Affinity Capture-Western
Co-purification		 BioGRID 8895581|9845365
ARID1B 6A3-5 | BAF250b | BRIGHT | DAN15 | ELD/OSA1 | KIAA1235 | p250R AT rich interactive domain 1B (SWI1-like) ELD/OSA1 interacts with BRG1. BIND 11988099
ARID1B 6A3-5 | BAF250b | BRIGHT | DAN15 | ELD/OSA1 | KIAA1235 | p250R AT rich interactive domain 1B (SWI1-like) - HPRD,BioGRID 11988099|12200431
BAZ1B WBSCR10 | WBSCR9 | WSTF bromodomain adjacent to zinc finger domain, 1B - HPRD 12837248
BRCA1 BRCAI | BRCC1 | IRIS | PSCP | RNF53 breast cancer 1, early onset - HPRD,BioGRID 10943845
BRWD1 C21orf107 | FLJ43918 | N143 | WDR9 bromodomain and WD repeat domain containing 1 - HPRD 12889071
CBX5 HP1 | HP1A chromobox homolog 5 (HP1 alpha homolog, Drosophila) - HPRD,BioGRID 12411497
CCNE1 CCNE cyclin E1 - HPRD,BioGRID 9891079
CDKN1A CAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) BRG1 interacts with p21 promoter. BIND 15780937
CEBPB C/EBP-beta | CRP2 | IL6DBP | LAP | MGC32080 | NF-IL6 | TCF5 CCAAT/enhancer binding protein (C/EBP), beta - HPRD 10619021
CREBBP CBP | KAT3A | RSTS CREB binding protein Phenotypic Enhancement BioGRID 11003650
CSF1 MCSF | MGC31930 colony stimulating factor 1 (macrophage) BRG1 interacts with CSF1 promoter. BIND 15780937
CTNNB1 CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 catenin (cadherin-associated protein), beta 1, 88kDa - HPRD,BioGRID 11532957
ESR1 DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 estrogen receptor 1 - HPRD,BioGRID 9099865
ETS2 ETS2IT1 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) ETS2 (Ets-2) interacts with SMARCA4 (Brg-1). This interaction was modeled on a demonstrated interaction between ETS2 from an unspecified species and SMARCA4 from an unspecified species. BIND 12637547
FANCA FA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158 Fanconi anemia, complementation group A - HPRD,BioGRID 11726552
GATA1 ERYF1 | GF-1 | GF1 | NFE1 GATA binding protein 1 (globin transcription factor 1) Reconstituted Complex BioGRID 11018012
GRM2 GLUR2 | GPRC1B | MGLUR2 | mGlu2 glutamate receptor, metabotropic 2 BRG1 interacts with mGluR2 promoter. BIND 15035981
H3F3A H3.3A | H3F3 | MGC87782 | MGC87783 H3 histone, family 3A H3F3A (Histone 3) interacts with SMARCA4 (BRG-1). BIND 15616580
HDAC2 RPD3 | YAF1 histone deacetylase 2 Co-purification BioGRID 11238380
HDAC3 HD3 | RPD3 | RPD3-2 histone deacetylase 3 - HPRD 10944117
HNF1A HNF1 | LFB1 | MODY3 | TCF1 HNF1 homeobox A Brg-1 interacts with the HNF-1 gene. BIND 15616580
HNF4A FLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14 hepatocyte nuclear factor 4, alpha Brg-1 interacts with the HNF-4 gene. BIND 15616580
HSF1 HSTF1 heat shock transcription factor 1 Affinity Capture-Western
in vitro		 BioGRID 8856972|11486022
HSF1 HSTF1 heat shock transcription factor 1 - HPRD 8856972|9222609
|11486022
HSP90B1 ECGP | GP96 | GRP94 | TRA1 heat shock protein 90kDa beta (Grp94), member 1 Affinity Capture-Western BioGRID 11726552
ING1 p24ING1c | p33 | p33ING1 | p33ING1b | p47 | p47ING1a inhibitor of growth family, member 1 Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11784859
KLF1 EKLF Kruppel-like factor 1 (erythroid) Reconstituted Complex BioGRID 11018012
MED17 CRSP6 | CRSP77 | DRIP80 | FLJ10812 | TRAP80 mediator complex subunit 17 Co-purification BioGRID 12154023
MPHOSPH6 MPP | MPP-6 | MPP6 M-phase phosphoprotein 6 - HPRD 15231747
MPP6 PALS2 | VAM-1 | VAM1 | p55T membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) - HPRD,BioGRID 15231747
MYC bHLHe39 | c-Myc v-myc myelocytomatosis viral oncogene homolog (avian) Affinity Capture-MS
Affinity Capture-Western		 BioGRID 11839798|17353931
NCOA1 F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42 nuclear receptor coactivator 1 Phenotypic Enhancement BioGRID 11003650
NCOR1 KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoR nuclear receptor co-repressor 1 Co-purification BioGRID 11013263
NCOR2 CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1 nuclear receptor co-repressor 2 Co-fractionation BioGRID 10944117
NR3C1 GCCR | GCR | GR | GRL nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Affinity Capture-Western
Reconstituted Complex		 BioGRID 10688647|12917342
PABPN1 OPMD | PAB2 | PABP2 poly(A) binding protein, nuclear 1 Two-hybrid BioGRID 11371506
PHB PHB1 prohibitin - HPRD,BioGRID 12065415
PHB PHB1 prohibitin Prohibitin interacts with Brg-1 BIND 12065415
POLR2A MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa Affinity Capture-Western
Co-purification
in vitro		 BioGRID 8895581|9443979
|9845365|11238380
POLR2A MGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1 polymerase (RNA) II (DNA directed) polypeptide A, 220kDa - HPRD 9443979|12154023
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 - HPRD,BioGRID 7923370
RBBP4 NURF55 | RBAP48 retinoblastoma binding protein 4 Co-purification BioGRID 11238380
RELB I-REL | IREL v-rel reticuloendotheliosis viral oncogene homolog B Affinity Capture-MS BioGRID 14743216
SIN3A DKFZp434K2235 | FLJ90319 | KIAA0700 SIN3 homolog A, transcription regulator (yeast) Affinity Capture-Western
Co-purification
Reconstituted Complex		 BioGRID 11238380|11784859
SMARCB1 BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily b, member 1 - HPRD,BioGRID 8895581
SMARCC1 BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily c, member 1 Affinity Capture-Western
Co-purification		 BioGRID 8895581|9845365
|11238380|11726552
SMARCC1 BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily c, member 1 - HPRD 9891079
SMARCC2 BAF170 | CRACC2 | Rsc8 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily c, member 2 Affinity Capture-Western
Co-purification		 BioGRID 8895581|9845365
|11726552
SMARCD1 BAF60A | CRACD1 | Rsc6p 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily d, member 1 Affinity Capture-Western BioGRID 12917342
SMARCE1 BAF57 瑞士/ SNF相关,关联矩阵,肌动蛋白dependent regulator of chromatin, subfamily e, member 1 Affinity Capture-Western
Co-purification		 BioGRID 8895581|9845365
SP1 - Sp1 transcription factor Reconstituted Complex BioGRID 11018012
SS18 MGC116875 | SSXT | SYT | SYT-SSX1 | SYT-SSX2 synovial sarcoma translocation, chromosome 18 - HPRD 11734557|14603256
STAT2 ISGF-3 | MGC59816 | P113 | STAT113 signal transducer and activator of transcription 2, 113kDa - HPRD,BioGRID 12244326
STK11 LKB1 | PJS serine/threonine kinase 11 - HPRD,BioGRID 11445556
STMN2 SCG10 | SCGN10 | SGC10 stathmin-like 2 BRG1 interacts with SCG10 promoter. BIND 15035981
TP53 FLJ92943 | LFS1 | TRP53 | p53 tumor protein p53 Affinity Capture-Western
Co-fractionation
Reconstituted Complex		 BioGRID 11950834
VDR NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor Affinity Capture-Western BioGRID 12837248


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID REG GR PATHWAY 82 60 All SZGR 2.0 genes in this pathway
PID ERB GENOMIC PATHWAY 15 8 All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 137 94 All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY 80 60 All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 65 46 All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA PROGENITOR DN 66 42 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335 193 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP 95 64 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION MONOCYTE UP 204 140 All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA UP 43 27 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
MAYBURD RESPONSE TO L663536 UP 29 18 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 DN 378 231 All SZGR 2.0 genes in this pathway
NADERI BREAST CANCER PROGNOSIS UP 50 26 All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION UP 67 37 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN 137 97 All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP 197 135 All SZGR 2.0 genes in this pathway
MATTIOLI MGUS VS PCL 116 62 All SZGR 2.0 genes in this pathway
MATTIOLI MULTIPLE MYELOMA SUBGROUPS 16 7 All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER 747 453 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 100 68 All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE UP 86 49 All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE DN 90 55 All SZGR 2.0 genes in this pathway
MORI MATURE B LYMPHOCYTE DN 75 43 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 110 69 All SZGR 2.0 genes in this pathway
GOLUB ALL VS AML UP 24 20 All SZGR 2.0 genes in this pathway
CHANG POU5F1 TARGETS UP 15 10 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309 206 All SZGR 2.0 genes in this pathway
GILDEA METASTASIS 30 14 All SZGR 2.0 genes in this pathway
MUNSHI MULTIPLE MYELOMA DN 11 6 All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293 193 All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI DN 172 107 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
RHODES CANCER META SIGNATURE 64 47 All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS UP 56 35 All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 86 66 All SZGR 2.0 genes in this pathway
MEDINA SMARCA4 TARGETS 44 29 All SZGR 2.0 genes in this pathway
MCCLUNG COCAIN REWARD 4WK 75 47 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
HOWLIN CITED1 TARGETS 2 UP 17 10 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS DN 366 257 All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE DN 50 33 All SZGR 2.0 genes in this pathway
SHEDDEN肺通过R GOOD SURVIVAL A5 70 32 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA UP 207 143 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14 143 86 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO GONADOTROPHINS DN 87 66 All SZGR 2.0 genes in this pathway
SASSON RESPONSE TO FORSKOLIN UP 90 58 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC2 39 25 All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 146 75 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 7 14 1A,m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-101 358 364 1A hsa-miR-101 UACAGUACUGUGAUAACUGAAG
miR-139 313 319 m8 hsa-miR-139brain UCUACAGUGCACGUGUCU
miR-144 358 364 1A hsa-miR-144 UACAGUAUAGAUGAUGUACUAG
miR-155 204 211 1A,m8 hsa-miR-155 UUAAUGCUAAUCGUGAUAGGGG
miR-199 417 423 1A hsa-miR-199a CCCAGUGUUCAGACUACCUGUUC
hsa-miR-199b CCCAGUGUUUAGACUAUCUGUUC
miR-324-5p 328 334 1A hsa-miR-324-5p CGCAUCCCCUAGGGCAUUGGUGU