Gene Page:SMO

Summary?
GeneID 6608
Symbol SMO
Synonyms FZD11|Gx|SMOH
Description smoothened, frizzled class receptor
Reference MIM:601500|HGNC:HGNC:11119|Ensembl:ENSG00000128602|HPRD:03294|Vega:OTTHUMG00000158421
Gene type protein-coding
Map location 7q32.3
Pascal p-value 0.744
Fetal beta 1.173
DMG 1 (# studies)
eGene Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccur High-throughput literature-search 系统搜索PubMedfor genes co-occurring with SCZ keywords. A total of 3027 genes were included.
文学 High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg19015909 7 128828512 SMO 6.97E-8 0.006 1.69E-5 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL类型
rs11080561 chr18 12257229 SMO 6608 0 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CD99L2 0.88 0.86
MAP7D2 0.87 0.87
PLEKHB2 0.87 0.86
AARS 0.86 0.85
DDHD2 0.86 0.85
MAP1A 0.86 0.84
RNF157 0.86 0.84
NSF 0.86 0.86
EHD3 0.86 0.85
ATP6V0A1 0.86 0.85
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
C1orf61 -0.42 -0.43
RPL35 -0.41 -0.47
IL32 -0.41 -0.38
SIGIRR -0.41 -0.48
CLEC3B -0.41 -0.47
BCL7C -0.41 -0.51
FAM159B -0.40 -0.60
AC006276.2 -0.40 -0.41
GNG11 -0.40 -0.33
RAMP2 -0.40 -0.46

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0004872 receptor activity TAS 9422511
GO:0004930 G-protein coupled receptor activity IEA -
GO:0005515 protein binding TAS 8906787
GO:0004926 non-G-protein coupled 7TM receptor activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0021953 central nervous system neuron differentiation IEA neuron (GO term level: 9) -
GO:0001755 neural crest cell migration IEA -
GO:0001570 vasculogenesis IEA -
GO:0001649 osteoblast differentiation IEA -
GO:0002052 positive regulation of neuroblast proliferation IEA -
GO:0003007 心morphogenesis IEA -
GO:0007186 G-protein coupled receptor protein signaling pathway IEA -
GO:0007368 determination of left/right symmetry IEA -
GO:0009953 dorsal/ventral pattern formation IEA -
GO:0048468 cell development IEA -
GO:0007389 pattern specification process IEA -
GO:0043066 negative regulation of apoptosis IEA -
GO:0042475 odontogenesis of dentine-containing tooth IEA -
GO:0021938 smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation IEA -
GO:0043392 negative regulation of DNA binding IEA -
GO:0021696 cerebellar cortex morphogenesis IEA -
GO:0048589 developmental growth IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0016020 membrane IEA -
GO:0016021 integral to membrane TAS 9422511
GO:0005929 cilium IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG HEDGEHOG SIGNALING PATHWAY 56 42 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG BASAL CELL CARCINOMA 55 44 All SZGR 2.0 genes in this pathway
BIOCARTA SHH PATHWAY 16 15 All SZGR 2.0 genes in this pathway
PID HEDGEHOG 2PATHWAY 22 17 All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 48 35 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS 88 58 All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408 246 All SZGR 2.0 genes in this pathway
DOANE BREAST CANCER CLASSES DN 34 26 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 6HR DN 21 13 All SZGR 2.0 genes in this pathway
VERRECCHIA RESPONSE TO TGFB1 C5 21 11 All SZGR 2.0 genes in this pathway
VERRECCHIA DELAYED RESPONSE TO TGFB1 39 26 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR 681 420 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 24HR 20 13 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T7 98 63 All SZGR 2.0 genes in this pathway
STEARMAN LUNG CANCER EARLY VS LATE UP 125 89 All SZGR 2.0 genes in this pathway
LEE METASTASIS AND ALTERNATIVE SPLICING UP 74 51 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593 372 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591 366 All SZGR 2.0 genes in this pathway
BREDEMEYER RAG SIGNALING VIA ATM NOT VIA NFKB UP 49 32 All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264 159 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
MURAKAMI UV RESPONSE 1HR DN 10 8 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA CLASSICAL 162 122 All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS DN 315 215 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION TOP20 DN 18 12 All SZGR 2.0 genes in this pathway
TORCHIA TARGETS OF EWSR1 FLI1 FUSION DN 321 200 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

microrna的家庭 Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-381 1086 1092 1A hsa-miR-381 UAUACAAGGGCAAGCUCUCUGU