Gene Page:BNIP1
Summary?
| GeneID | 662 |
| Symbol | BNIP1 |
| Synonyms | NIP1|SEC20|TRG-8 |
| Description | BCL2/adenovirus E1B 19kDa interacting protein 1 |
| Reference | MIM:603291|HGNC:HGNC:1082|Ensembl:ENSG00000113734|HPRD:04480|Vega:OTTHUMG00000130521 |
| Gene type | protein-coding |
| Map location | 5q35.1 |
| Pascal p-value | 0.002 |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Nucleus accumbens basal ganglia Putamen basal ganglia Myers' cis & trans 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.0276 | |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs17703470 | chr5 | 171812351 | BNIP1 | 662 | 0.14 | cis | ||
| rs13356223 | chr5 | 171821670 | BNIP1 | 662 | 0.14 | cis | ||
| rs13436547 | chr5 | 171840724 | BNIP1 | 662 | 0.2 | cis | ||
| rs17729841 | 5 | 172472573 | BNIP1 | ENSG00000113734.13 | 1.178E-6 | 0.02 | -98872 | gtex_brain_ba24 |
| rs141178159 | 5 | 172475940 | BNIP1 | ENSG00000113734.13 | 1.069E-6 | 0.02 | -95505 | gtex_brain_ba24 |
| rs72814167 | 5 | 172478593 | BNIP1 | ENSG00000113734.13 | 1.064E-6 | 0.02 | -92852 | gtex_brain_ba24 |
| rs375292338 | 5 | 172482903 | BNIP1 | ENSG00000113734.13 | 1.028E-6 | 0.02 | -88542 | gtex_brain_ba24 |
| rs72814178 | 5 | 172486739 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -84706年 | gtex_brain_ba24 |
| rs72814179 | 5 | 172489416 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -82029 | gtex_brain_ba24 |
| rs58066026 | 5 | 172494772 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -76673 | gtex_brain_ba24 |
| rs36001173 | 5 | 172500586 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -70859 | gtex_brain_ba24 |
| rs145543953 | 5 | 172509306 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -62139 | gtex_brain_ba24 |
| rs72816110 | 5 | 172509839 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -61606 | gtex_brain_ba24 |
| rs72816112 | 5 | 172511550 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -59895 | gtex_brain_ba24 |
| rs149007571 | 5 | 172512513 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -58932 | gtex_brain_ba24 |
| rs72816115 | 5 | 172515179 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -56266 | gtex_brain_ba24 |
| rs72816117 | 5 | 172516765 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -54680 | gtex_brain_ba24 |
| rs72816119 | 5 | 172519608 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -51837 | gtex_brain_ba24 |
| rs60418095 | 5 | 172522096 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -49349 | gtex_brain_ba24 |
| rs72816122 | 5 | 172524035 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -47410 | gtex_brain_ba24 |
| rs72816124 | 5 | 172524537 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -46908 | gtex_brain_ba24 |
| rs72816126 | 5 | 172524845 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -46600 | gtex_brain_ba24 |
| rs57858557 | 5 | 172531348 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -40097 | gtex_brain_ba24 |
| rs17662639 | 5 | 172534347 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -37098 | gtex_brain_ba24 |
| rs112356729 | 5 | 172544816 | BNIP1 | ENSG00000113734.13 | 1.612E-6 | 0.02 | -26629 | gtex_brain_ba24 |
| rs138114144 | 5 | 172547600 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -23845 | gtex_brain_ba24 |
| rs72816142 | 5 | 172549449 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -21996 | gtex_brain_ba24 |
| rs72816146 | 5 | 172552315 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -19130 | gtex_brain_ba24 |
| rs72816147 | 5 | 172552330 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -19115 | gtex_brain_ba24 |
| rs112024751 | 5 | 172557038 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -14407 | gtex_brain_ba24 |
| rs35387209 | 5 | 172560793 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -10652 | gtex_brain_ba24 |
| rs17730451 | 5 | 172566698 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -4747 | gtex_brain_ba24 |
| rs72816155 | 5 | 172569032 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -2413 | gtex_brain_ba24 |
| rs5745098 | 5 | 172570687 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | -758 | gtex_brain_ba24 |
| rs5745110 | 5 | 172572954 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 1509 | gtex_brain_ba24 |
| rs5745114 | 5 | 172574252 | BNIP1 | ENSG00000113734.13 | 1.081E-6 | 0.02 | 2807 | gtex_brain_ba24 |
| rs5745116 | 5 | 172575703 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 4258 | gtex_brain_ba24 |
| rs5745118 | 5 | 172576100 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 4655 | gtex_brain_ba24 |
| rs5745120 | 5 | 172576255 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 4810 | gtex_brain_ba24 |
| rs5745127 | 5 | 172577864 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 6419 | gtex_brain_ba24 |
| rs5745135 | 5 | 172580933 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 9488 | gtex_brain_ba24 |
| rs397843711 | 5 | 172585210 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 13765 | gtex_brain_ba24 |
| rs8543 | 5 | 172591337 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 19892 | gtex_brain_ba24 |
| rs72816168 | 5 | 172595024 | BNIP1 | ENSG00000113734.13 | 1.073E-6 | 0.02 | 23579 | gtex_brain_ba24 |
| rs72816171 | 5 | 172595998 | BNIP1 | ENSG00000113734.13 | 1.072E-6 | 0.02 | 24553 | gtex_brain_ba24 |
| rs17729841 | 5 | 172472573 | BNIP1 | ENSG00000113734.13 | 2.152E-6 | 0.01 | -98872 | gtex_brain_putamen_basal |
| rs141178159 | 5 | 172475940 | BNIP1 | ENSG00000113734.13 | 7.17E-7 | 0.01 | -95505 | gtex_brain_putamen_basal |
| rs72814167 | 5 | 172478593 | BNIP1 | ENSG00000113734.13 | 7.194E-7 | 0.01 | -92852 | gtex_brain_putamen_basal |
| rs375292338 | 5 | 172482903 | BNIP1 | ENSG00000113734.13 | 7.285E-7 | 0.01 | -88542 | gtex_brain_putamen_basal |
| rs72814178 | 5 | 172486739 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -84706年 | gtex_brain_putamen_basal |
| rs72814179 | 5 | 172489416 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -82029 | gtex_brain_putamen_basal |
| rs112427077 | 5 | 172490001 | BNIP1 | ENSG00000113734.13 | 1.564E-7 | 0.01 | -81444 | gtex_brain_putamen_basal |
| rs58066026 | 5 | 172494772 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -76673 | gtex_brain_putamen_basal |
| rs36001173 | 5 | 172500586 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -70859 | gtex_brain_putamen_basal |
| rs145543953 | 5 | 172509306 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -62139 | gtex_brain_putamen_basal |
| rs72816110 | 5 | 172509839 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -61606 | gtex_brain_putamen_basal |
| rs72816112 | 5 | 172511550 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -59895 | gtex_brain_putamen_basal |
| rs149007571 | 5 | 172512513 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -58932 | gtex_brain_putamen_basal |
| rs72816115 | 5 | 172515179 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -56266 | gtex_brain_putamen_basal |
| rs72816117 | 5 | 172516765 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -54680 | gtex_brain_putamen_basal |
| rs72816119 | 5 | 172519608 | BNIP1 | ENSG00000113734.13 | 6.945E-7 | 0.01 | -51837 | gtex_brain_putamen_basal |
| rs60418095 | 5 | 172522096 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -49349 | gtex_brain_putamen_basal |
| rs72816122 | 5 | 172524035 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -47410 | gtex_brain_putamen_basal |
| rs72816124 | 5 | 172524537 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -46908 | gtex_brain_putamen_basal |
| rs72816126 | 5 | 172524845 | BNIP1 | ENSG00000113734.13 | 7.2E-7 | 0.01 | -46600 | gtex_brain_putamen_basal |
| rs57858557 | 5 | 172531348 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -40097 | gtex_brain_putamen_basal |
| rs17662639 | 5 | 172534347 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -37098 | gtex_brain_putamen_basal |
| rs112356729 | 5 | 172544816 | BNIP1 | ENSG00000113734.13 | 2.063E-6 | 0.01 | -26629 | gtex_brain_putamen_basal |
| rs138114144 | 5 | 172547600 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -23845 | gtex_brain_putamen_basal |
| rs72816142 | 5 | 172549449 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -21996 | gtex_brain_putamen_basal |
| rs72816146 | 5 | 172552315 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -19130 | gtex_brain_putamen_basal |
| rs72816147 | 5 | 172552330 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -19115 | gtex_brain_putamen_basal |
| rs112024751 | 5 | 172557038 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -14407 | gtex_brain_putamen_basal |
| rs35387209 | 5 | 172560793 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -10652 | gtex_brain_putamen_basal |
| rs17730451 | 5 | 172566698 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -4747 | gtex_brain_putamen_basal |
| rs72816155 | 5 | 172569032 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -2413 | gtex_brain_putamen_basal |
| rs5745098 | 5 | 172570687 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | -758 | gtex_brain_putamen_basal |
| rs5745110 | 5 | 172572954 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 1509 | gtex_brain_putamen_basal |
| rs5745114 | 5 | 172574252 | BNIP1 | ENSG00000113734.13 | 5.867E-7 | 0.01 | 2807 | gtex_brain_putamen_basal |
| rs5745116 | 5 | 172575703 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 4258 | gtex_brain_putamen_basal |
| rs5745118 | 5 | 172576100 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 4655 | gtex_brain_putamen_basal |
| rs5745120 | 5 | 172576255 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 4810 | gtex_brain_putamen_basal |
| rs5745127 | 5 | 172577864 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 6419 | gtex_brain_putamen_basal |
| rs5745135 | 5 | 172580933 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 9488 | gtex_brain_putamen_basal |
| rs8543 | 5 | 172591337 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 19892 | gtex_brain_putamen_basal |
| rs72816168 | 5 | 172595024 | BNIP1 | ENSG00000113734.13 | 7.251E-7 | 0.01 | 23579 | gtex_brain_putamen_basal |
| rs72816171 | 5 | 172595998 | BNIP1 | ENSG00000113734.13 | 7.269E-7 | 0.01 | 24553 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13- 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| CDKN1C | 0.80 | 0.82 |
| NAGLU | 0.74 | 0.72 |
| CDC42EP2 | 0.74 | 0.76 |
| C22orf9 | 0.72 | 0.73 |
| RGS19 | 0.71 | 0.62 |
| TESK1 | 0.70 | 0.69 |
| CHST2 | 0.69 | 0.63 |
| SLC25A10 | 0.69 | 0.63 |
| NR2F6 | 0.68 | 0.64 |
| MVK | 0.68 | 0.67 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.39 | -0.39 |
| AF347015.21 | -0.39 | -0.41 |
| MT-ATP8 | -0.38 | -0.43 |
| AF347015.8 | -0.38 | -0.39 |
| AF347015.27 | -0.38 | -0.37 |
| MT-CO2 | -0.37 | -0.37 |
| AF347015.2 | -0.35 | -0.36 |
| AF347015.33 | -0.35 | -0.34 |
| AF347015.15 | -0.34 | -0.36 |
| MT-CYB | -0.34 | -0.36 |
Section III. Gene Ontology annotation
| Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005515 | protein binding | 新闻学会 | 7954800 | |
| Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0006917 | induction of apoptosis | IMP | 15272311 | |
| GO:0007029 | endoplasmic reticulum organization | IMP | 15272311 | |
| GO:0006916 | anti-apoptosis | TAS | 7954800 | |
| GO:0006915 | apoptosis | IDA | 7954800 | |
| GO:0016192 | vesicle-mediated transport | IEA | - | |
| GO:0016320 | endoplasmic reticulum membrane fusion | IMP | 15272311 | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0031201 | SNARE complex | IDA | neuron, Synap (GO term level: 6) | 15272311 |
| GO:0005789 | endoplasmic reticulum membrane | IEA | - | |
| GO:0005635 | nuclear envelope | IDA | 7954800 | |
| GO:0005737 | cytoplasm | IDA | 7954800 | |
| GO:0005783 | endoplasmic reticulum | IDA | 15272311 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0030176 | integral to endoplasmic reticulum membrane | TAS | 15272311 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT | 38 | 25 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| SABATES COLORECTAL ADENOMA SIZE DN | 14 | 8 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN | 770 | 415 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | All SZGR 2.0 genes in this pathway |
| BENPORATH NANOG TARGETS | 988 | 594 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP | 314 | 201 | All SZGR 2.0 genes in this pathway |