Gene Page:SNRNP70
概括?
| 基因 | 6625 |
| Symbol | SNRNP70 |
| Synonyms | RNPU1Z|RPU1|SNRP70|Snp1|U1-70K|U170K|U1AP|U1RNP |
| Description | 小型核ribonucleoprotein U1 subunit 70 |
| Reference | MIM:180740|HGNC:HGNC:11150|Ensembl:ENSG00000104852|HPRD：01617|织女:OTTHUMG00000183344 |
| Gene type | protein-coding |
| Map location | 19q13.3 |
| Pascal p-value | 0.007 |
| Sherlock p-value | 0.095 |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | SNRNP70 | 6625 | 0 | trans | ||
| rs3845734 | chr2 | 171125572 | SNRNP70 | 6625 | 0.16 | trans | ||
| RS4114866 | chr6 | 6257660 | SNRNP70 | 6625 | 0.12 | trans | ||
| rs3851513 | chr6 | 6274160 | SNRNP70 | 6625 | 0.09 | trans | ||
| rs16955618 | chr15 | 29937543 | SNRNP70 | 6625 | 4.14E-4 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COQ4 | 0.87 | 0.86 |
| MOSPD3 | 0.84 | 0.84 |
| ACD | 0.82 | 0.83 |
| TADA3L | 0.82 | 0.81 |
| ADCK4 | 0.81 | 0.82 |
| MRPL43 | 0.81 | 0.81 |
| UNC119 | 0.81 | 0.82 |
| VPS28 | 0.81 | 0.82 |
| LRRC24 | 0.81 | 0.81 |
| AP4M1 | 0.81 | 0.80 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.59 | -0.64 |
| MT-CYB | -0.58 | -0.65 |
| AF347015.27 | -0.58 | -0.64 |
| AF347015.31 | -0.58 | -0.63 |
| AF347015.8 | -0.57 | -0.63 |
| AF347015.15 | -0.55 | -0.63 |
| AF347015.2 | -0.55 | -0.63 |
| AF347015.33 | -0.55 | -0.59 |
| AF347015.26 | -0.53 | -0.62 |
| GBP2 | -0.50 | -0.54 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CRP | MGC149895 | MGC88244 | PTX1 | C-reactive protein, pentraxin-related | - | HPRD,BioGRID | 2477447 |
| CTDP1 | CCFDN | FCP1 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 | - | HPRD | 12560496 |
| DDX17 | DKFZp761H2016 | P72 | RH70 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 | - | HPRD,BioGRID | 12193588 |
| FUSIP1 | FUSIP2 | NSSR | SFRS13 | SRp38 | SRrp40 | TASR | TASR1 | TASR2 | FUS相互作用蛋白（丝氨酸/精氨酸富含）1 | Dephosphorylated SRp38 interacts with U1-70K | BIND | 14765198 |
| GSK3B | - | glycogen synthase kinase 3 beta | Affinity Capture-MS | BioGRID | 17353931 |
| HNRNPA2B1 | DKFZp779B0244 | FLJ22720 | HNRNPA2 | HNRNPB1 | HNRPA2 | HNRPA2B1 | HNRPB1 | RNPA2 | SNRPB1 | heterogeneous nuclear ribonucleoprotein A2/B1 | - | HPRD | 1833625 |
| NUDT21 | CFIM25 | CPSF5 | DKFZp686H1588 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | Reconstituted Complex | BioGRID | 14561889 |
| RNPS1 | E5.1 | MGC117332 | RNA结合蛋白S1，富含丝氨酸的结构域 | Affinity Capture-MS | BioGRID | 17353931 |
| SFRS1 | ASF | MGC5228 | SF2 | SF2p33 | SRp30a | splicing factor, arginine/serine-rich 1 | - | HPRD,BioGRID | 9799243 |
| SFRS11 | DKFZp686M13204 | dJ677H15.2 | p54 | splicing factor, arginine/serine-rich 11 | - | HPRD | 8816452 |
| SFRS2 | PR264 | SC-35 | SC35 | SFRS2A | SRp30b | splicing factor, arginine/serine-rich 2 | - | HPRD | 8261509 |
| SFRS2IP | CASP11 | SIP1 | SRRP129 | splicing factor, arginine/serine-rich 2, interacting protein | - | HPRD | 9447963 |
| SIP1 | GEMIN2 | SIP1-delta | survival of motor neuron protein interacting protein 1 | - | HPRD | 9447963 |
| SNRPC | FLJ20302 | 小型核ribonucleoprotein polypeptide C | - | HPRD,BioGRID | 9826776 |
| SRPK1 | SFRSK1 | SFRS protein kinase 1 | Affinity Capture-Western Biochemical Activity |
BioGRID | 9472028|12417631 |
| SRPK2 | FLJ36101 | SFRSK2 | SFRS protein kinase 2 | Biochemical Activity | BioGRID | 9472028 |
| ZRANB2 | DKFZp686J1831 | DKFZp686N09117 | FLJ41119 | ZIS | ZIS1 | ZIS2 | ZNF265 | zinc finger, RAN-binding domain containing 2 | - | HPRD,BioGRID | 11448987 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG SPLICEOSOME | 128 | 72 | 该途径中的所有SZGR 2.0基因 |
| REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | 140 | 77 | 该途径中的所有SZGR 2.0基因 |
| REACTOME MRNA PROCESSING | 161 | 86 | 该途径中的所有SZGR 2.0基因 |
| REACTOME MRNA SPLICING | 111 | 58 | 该途径中的所有SZGR 2.0基因 |
| PARENT MTOR SIGNALING UP | 567 | 375 | 该途径中的所有SZGR 2.0基因 |
| GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID UP | 25 | 18 | 该途径中的所有SZGR 2.0基因 |
| CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | 该途径中的所有SZGR 2.0基因 |
| Huttmann B Cll生存不佳 | 276 | 187 | 该途径中的所有SZGR 2.0基因 |
| GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN | 335 | 193 | 该途径中的所有SZGR 2.0基因 |
| HAHTOLA MYCOSIS FUNGOIDES SKIN UP | 177 | 113 | 该途径中的所有SZGR 2.0基因 |
| DAIRKEE TERT TARGETS UP | 380 | 213 | 该途径中的所有SZGR 2.0基因 |
| WEI MYCN TARGETS WITH E BOX | 795 | 478 | 该途径中的所有SZGR 2.0基因 |
| Schaeffer前列腺开发6小时DN | 514 | 330 | 该途径中的所有SZGR 2.0基因 |
| SCHAEFFER PROSTATE DEVELOPMENT AND CANCER BOX1 DN | 10 | 7 | 该途径中的所有SZGR 2.0基因 |
| Benporath Nanog目标 | 988 | 594 | 该途径中的所有SZGR 2.0基因 |
| LIN APC TARGETS | 77 | 55 | 该途径中的所有SZGR 2.0基因 |
| NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP | 157 | 105 | 该途径中的所有SZGR 2.0基因 |
| PENG GLUTAMINE DEPRIVATION DN | 337 | 230 | 该途径中的所有SZGR 2.0基因 |
| BLALOCK ALZHEIMERS DISEASE UP | 1691年 | 1088 | 该途径中的所有SZGR 2.0基因 |
| BURTON ADIPOGENESIS PEAK AT 24HR | 43 | 30 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | 该途径中的所有SZGR 2.0基因 |
| WELCSH BRCA1 TARGETS DN | 141 | 92 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR DN | 911 | 527 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR DN | 1011 | 592 | 该途径中的所有SZGR 2.0基因 |
| HELLER HDAC TARGETS UP | 317 | 208 | 该途径中的所有SZGR 2.0基因 |
| TOYOTA TARGETS OF MIR34B AND MIR34C | 463 | 262 | 该途径中的所有SZGR 2.0基因 |
| CHNG MULTIPLE MYELOMA HYPERPLOID UP | 52 | 25 | 该途径中的所有SZGR 2.0基因 |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | 该途径中的所有SZGR 2.0基因 |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | 该途径中的所有SZGR 2.0基因 |
| HSIAO HOUSEKEEPING GENES | 389 | 245 | 该途径中的所有SZGR 2.0基因 |
| JISON SICKLE CELL DISEASE DN | 181 | 97 | 该途径中的所有SZGR 2.0基因 |
| DANG REGULATED BY MYC UP | 72 | 53 | 该途径中的所有SZGR 2.0基因 |
| FIGUEROA AML METHYLATION CLUSTER 6 UP | 140 | 81 | 该途径中的所有SZGR 2.0基因 |
| FIGUEROA AML METHYLATION CLUSTER 7 UP | 118 | 68 | 该途径中的所有SZGR 2.0基因 |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | 该途径中的所有SZGR 2.0基因 |