SZGR2 - Beplay体育中心

概括?

基因	6633
象征	SNRPD2
Synonyms	SMD2\|SNRPD1\|Sm-D2
Description	small nuclear ribonucleoprotein D2 polypeptide
Reference	MIM:601061\|HGNC:HGNC:11159\|Ensembl:ENSG00000125743\|HPRD:03038\|Vega:OTTHUMG00000182130
Gene type	protein-coding
Map location	19q13.2
Pascal p-value	0.179
Sherlock p-value	0.828
Fetal beta	0.362
DMG	1 (# studies)
eGene	Myers' cis & trans

数据源中的基因

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:vanEijk_2014	Genome-wide DNA methylation analysis	This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250).	2
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2

第一节遗传学和表观遗传学注释

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg08130813	19	46195655	QPCTL;SNRPD2	1.799E-4	-0.237	0.034	DMG:Wockner_2014
cg19154438	19	45825730	SNRPD2	4.192E-4	-4.336		DMG:vanEijk_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	EQTL类型
snp_a-1856993		0	SNRPD2	6633		0.18		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

第四节。蛋白质蛋白相互作用注释

Interactors	Aliases B	Official full name B	Experimental	资源	PubMed ID
CLNS1A	CLCI \| CLNS1B \| ICln	chloride channel, nucleotide-sensitive, 1A	Affinity Capture-Western	BioGRID	11713266
DDX20	DKFZp434H052 \| DP103 \| GEMIN3	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	-	HPRD,BioGRID	10601333
E2F4	E2F-4	E2F转录因子4，P107/P130结合	E2F4interacts with SNRPD2 promoter.	BIND	15782160
EEF1G	EF1G \| GIG35	真核翻译伸长因子1伽玛	两个杂交	BioGRID	16169070
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD	12577067
GEMIN5	DKFZP586M1824 \|MGC142174	gem (nuclear organelle) associated protein 5	-	HPRD,BioGRID	11714716
GEMIN6	FLJ23459	gem (nuclear organelle) associated protein 6	Gemin6 interacts with SmD2	BIND	11748230
GEMIN6	FLJ23459	gem (nuclear organelle) associated protein 6	Gemin6 interacts with SNRPD2 (SmD2)	BIND	15939020
GEMIN6	FLJ23459	gem (nuclear organelle) associated protein 6	-	HPRD	11748230
GEMIN7	SIP3	gem (nuclear organelle) associated protein 7	GEMIN7 interacts with SNRPD2 (SmD2)	BIND	12065586
KAT5	ESA1 \| HTATIP \| HTATIP1 \| PLIP \| TIP \| TIP60 \| cPLA2	K(lysine) acetyltransferase 5	两个杂交	BioGRID	16169070
LSM10	MGC15749 \|MST074 \|MSTP074	LSM10, U7 small nuclear RNA associated	亲和力捕获ms	BioGRID	12975319
LSM11	FLJ38273	LSM11, U7 small nuclear RNA associated	-	HPRD	12975319
LSM6	YDR378C	LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)	-	HPRD,BioGRID	15231747
RNU11	U11	RNA，U11小核	亲和力捕获ms	BioGRID	15146077
RNU12	U12	RNA，U12小核	亲和力捕获ms	BioGRID	15146077
SF3A2	prp11 \|PRPF11 \|SAP62 \|SF3A66	剪接因子3a，亚基2，66KDA	亲和力捕获ms	BioGRID	12234937
SMN1	BCD541 \| SMA \| SMA1 \| SMA2 \| SMA3 \| SMA4 \| SMA@ \| SMN \| SMNT \| T-BCD541	survival of motor neuron 1, telomeric	共同分级共纯化	BioGRID	10942426
SMN2	BCD541 \| C-BCD541 \| FLJ76644 \| MGC20996 \| MGC5208 \| SMNC	运动神经元2的存活率，丝粒	-	HPRD	9323129\|10942426
SNRPD1	HsT2456 \| SMD1 \| SNRPD	小型核核糖核蛋白D1多肽16 kDa	Co-crystal Structure 两个杂交	BioGRID	9417867\|10025403
SNRPD1	HsT2456 \| SMD1 \| SNRPD	小型核核糖核蛋白D1多肽16 kDa	SNRPD2 interacts with SNRPD1.	BIND	9417867
SNRPE	B-raf \| SME	small nuclear ribonucleoprotein polypeptide E	SNRPD2 interacts with SNRPE.	BIND	9417867
SNRPE	B-raf \| SME	small nuclear ribonucleoprotein polypeptide E	两个杂交	BioGRID	9417867
SNRPF	SMF	small nuclear ribonucleoprotein polypeptide F	-	HPRD,BioGRID	9417867\|11226169
SNRPF	SMF	small nuclear ribonucleoprotein polypeptide F	SNRPD2 interacts with SNRPF.	BIND	9417867
STXBP3	MUNC18-3 \| MUNC18C \| PSP \| UNC-18C	syntaxin binding protein 3	-	HPRD	12065586
WDR77	HKMT1069 \| MEP50 \| MGC2722 \| Nbla10071 \| RP11-552M11.3 \| p44	WD repeat domain 77	-	HPRD,BioGRID	11756452

V.途径注释

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF NON CODING RNA	49	29	该途径中的所有SZGR 2.0基因
REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA	140	77	该途径中的所有SZGR 2.0基因
REACTOME MRNA PROCESSING	161	86	该途径中的所有SZGR 2.0基因
REACTOME MRNA SPLICING	111	58	该途径中的所有SZGR 2.0基因
REACTOME MRNA SPLICING MINOR PATHWAY	45	19	该途径中的所有SZGR 2.0基因
REACTOME METABOLISM OF RNA	330	155	该途径中的所有SZGR 2.0基因
RHEIN ALL GLUCOCORTICOID THERAPY DN	362	238	该途径中的所有SZGR 2.0基因
BERENJENO TRANSFORMED BY RHOA UP	536	340	该途径中的所有SZGR 2.0基因
LI AMPLIFIED IN LUNG CANCER	178	108	该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK	1652	1023	该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK	779	480	该途径中的所有SZGR 2.0基因
NUYTTEN NIPP1 TARGETS UP	769	437	该途径中的所有SZGR 2.0基因
KOYAMA SEMA3B TARGETS UP	292	168	该途径中的所有SZGR 2.0基因
STARK PREFRONTAL CORTEX 22Q11 DELETION DN	517	309	该途径中的所有SZGR 2.0基因
SANA RESPONSE TO IFNG DN	85	56	该途径中的所有SZGR 2.0基因
Pomeroy髓母细胞瘤预后DN	43	28	该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE DN	1237	837	该途径中的所有SZGR 2.0基因
Creighton内分泌疗法抗性1	528	324	该途径中的所有SZGR 2.0基因
GRADE METASTASIS DN	45	31	该途径中的所有SZGR 2.0基因
GRADE COLON CANCER UP	871	505	该途径中的所有SZGR 2.0基因
WANG TUMOR INVASIVENESS UP	374	247	该途径中的所有SZGR 2.0基因
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	该途径中的所有SZGR 2.0基因
HSIAO HOUSEKEEPING GENES	389	245	该途径中的所有SZGR 2.0基因
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	该途径中的所有SZGR 2.0基因
清肝癌亚类未注释的DN	193	112	该途径中的所有SZGR 2.0基因
Nakayama FGF2目标	29	17	该途径中的所有SZGR 2.0基因
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	该途径中的所有SZGR 2.0基因
DANG REGULATED BY MYC UP	72	53	该途径中的所有SZGR 2.0基因
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13	172	107	该途径中的所有SZGR 2.0基因
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	该途径中的所有SZGR 2.0基因
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	该途径中的所有SZGR 2.0基因

Gene Page:SNRPD2