Gene Page:SNRPN

Summary?
GeneID 6638
Symbol SNRPN
Synonyms HCERN3|PWCR|RT-LI|SM-D|SMN|SNRNP-N|SNURF-SNRPN|sm-N
Description small nuclear ribonucleoprotein polypeptide N
Reference MIM:182279|HGNC:HGNC:11164|Ensembl:ENSG00000128739|HPRD:01653|Vega:OTTHUMG00000129180
Gene type protein-coding
Map location 15q11.2
Pascal p-value 0.21
Sherlock p-value 0.914
Fetal beta -1.583

Gene in Data Sources
Gene set name Method of gene set Description Info
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search Co-occurance和Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0278

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
LIX1 0.69 0.69
TMEM47 0.69 0.69
MDFIC 0.68 0.66
FIBIN 0.67 0.63
SULT1C4 0.66 0.60
ABHD4 0.66 0.61
SNTB1 0.65 0.64
SLC40A1 0.65 0.59
ANXA5 0.65 0.59
ST5 0.64 0.60
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AC132872.1 -0.29 -0.36
RP9P -0.26 -0.34
IER5L -0.26 -0.15
AC135724.1 -0.25 -0.26
AC005921.3 -0.24 -0.30
SNHG12 -0.24 -0.25
NEUROD2 -0.23 -0.07
FAM159B -0.23 -0.27
AC010300.1 -0.22 -0.13
TBR1 -0.22 -0.08

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0003674 molecular_function ND -
GO:0003723 RNA binding IEA -
GO:0042802 identical protein binding 新闻学会 14715275
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0008380 RNA splicing TAS 1533223
GO:0008150 biological_process ND -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005575 cellular_component ND -
GO:0005634 nucleus IEA -
GO:0005681 spliceosome TAS 1533223
GO:0030532 small nuclear ribonucleoprotein complex TAS 7512861

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
LIU SOX4 TARGETS DN 309 191 All SZGR 2.0 genes in this pathway
BERTUCCI MEDULLARY VS DUCTAL BREAST CANCER DN 169 118 All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE DN 244 147 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS DN 384 230 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY DN 367 220 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 DN 229 142 All SZGR 2.0 genes in this pathway
ABDULRAHMAN KIDNEY CANCER VHL DN 14 9 All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS 1174 695 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203 134 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344 180 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179 105 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA UP 64 46 All SZGR 2.0 genes in this pathway
SUZUKI RESPONSE TO TSA AND DECITABINE 1A 23 16 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911 527 All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011 592 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 307 185 All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 69 45 All SZGR 2.0 genes in this pathway
LEIN LOCALIZED TO PROXIMAL DENDRITES 37 26 All SZGR 2.0 genes in this pathway
霍克甲基化在癌症 56 45 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 40 31 All SZGR 2.0 genes in this pathway
RAY TARGETS OF P210 BCR ABL FUSION DN 16 11 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP 397 206 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918 550 All SZGR 2.0 genes in this pathway
BRIDEAU IMPRINTED GENES 63 47 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308 187 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway