Gene Page:SOAT1
Summary?
| GeneID | 6646 |
| Symbol | SOAT1 |
| Synonyms | ACACT|ACAT|ACAT-1|ACAT1|SOAT|STAT |
| Description | sterol O-acyltransferase 1 |
| Reference | MIM:102642|HGNC:HGNC:11177|Ensembl:ENSG00000057252|HPRD:00033|Vega:OTTHUMG00000035253 |
| Gene type | protein-coding |
| Map location | 1q25 |
| eGene | Putamen basal ganglia |
| Support | CompositeSet |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DNM:Fromer_2014 | Whole Exome Sequencing analysis | This study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA. |
Section I. Genetics and epigenetics annotation
DNM table
DNM table| Gene | Chromosome | Position | Ref | Alt | Transcript | AA change | Mutation type | Sift | CG46 | Trait | Study |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SOAT1 | chr1 | 179304780 | A | G | NM_001252511 NM_001252512 NM_003101 NR_045530 |
p.48N>S p.41N>S p.106N>S . |
missense missense missense npcRNA |
Schizophrenia | DNM:Fromer_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs6696464 | 1 | 179265075 | SOAT1 | ENSG00000057252.8 | 4.743E-6 | 0.01 | 2150 | gtex_brain_putamen_basal |
| rs6680899 | 1 | 179285624 | SOAT1 | ENSG00000057252.8 | 3.519E-6 | 0.01 | 22699 | gtex_brain_putamen_basal |
| rs185676837 | 1 | 179421824 | SOAT1 | ENSG00000057252.8 | 4.355E-6 | 0.01 | 158899 | gtex_brain_putamen_basal |
| rs61826000 | 1 | 179423953 | SOAT1 | ENSG00000057252.8 | 9.553E-7 | 0.01 | 161028 | gtex_brain_putamen_basal |
| rs4652391 | 1 | 179431386 | SOAT1 | ENSG00000057252.8 | 6.768E-7 | 0.01 | 168461 | gtex_brain_putamen_basal |
| rs4372213 | 1 | 179440019 | SOAT1 | ENSG00000057252.8 | 1.668E-6 | 0.01 | 177094 | gtex_brain_putamen_basal |
| rs12133017 | 1 | 179442337 | SOAT1 | ENSG00000057252.8 | 1.491E-6 | 0.01 | 179412 | gtex_brain_putamen_basal |
| rs11806918 | 1 | 179443390 | SOAT1 | ENSG00000057252.8 | 1.425E-6 | 0.01 | 180465 | gtex_brain_putamen_basal |
| rs34929015 | 1 | 179443937 | SOAT1 | ENSG00000057252.8 | 1.444E-6 | 0.01 | 181012 | gtex_brain_putamen_basal |
| rs6671451 | 1 | 179444549 | SOAT1 | ENSG00000057252.8 | 1.426E-6 | 0.01 | 181624 | gtex_brain_putamen_basal |
| rs12138700 | 1 | 179445467 | SOAT1 | ENSG00000057252.8 | 1.401E-6 | 0.01 | 182542 | gtex_brain_putamen_basal |
| rs11808270 | 1 | 179446396 | SOAT1 | ENSG00000057252.8 | 1.425E-6 | 0.01 | 183471 | gtex_brain_putamen_basal |
| rs11808664 | 1 | 179446755 | SOAT1 | ENSG00000057252.8 | 1.398E-6 | 0.01 | 183830 | gtex_brain_putamen_basal |
| rs12732770 | 1 | 179446964 | SOAT1 | ENSG00000057252.8 | 1.446E-6 | 0.01 | 184039 | gtex_brain_putamen_basal |
| rs12734672 | 1 | 179447347 | SOAT1 | ENSG00000057252.8 | 5.119E-7 | 0.01 | 184422 | gtex_brain_putamen_basal |
| rs10913786 | 1 | 179447956 | SOAT1 | ENSG00000057252.8 | 1.416E-6 | 0.01 | 185031 | gtex_brain_putamen_basal |
| rs6681518 | 1 | 179449389 | SOAT1 | ENSG00000057252.8 | 8.32E-7 | 0.01 | 186464 | gtex_brain_putamen_basal |
| rs10913793 | 1 | 179450913 | SOAT1 | ENSG00000057252.8 | 1.385E-6 | 0.01 | 187988 | gtex_brain_putamen_basal |
| rs12141674 | 1 | 179451316 | SOAT1 | ENSG00000057252.8 | 5.073E-7 | 0.01 | 188391 | gtex_brain_putamen_basal |
| rs11585043 | 1 | 179453321 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 190396 | gtex_brain_putamen_basal |
| rs36027796 | 1 | 179453992 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 191067 | gtex_brain_putamen_basal |
| rs139938400 | 1 | 179454882 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 191957 | gtex_brain_putamen_basal |
| rs6693261 | 1 | 179455110 | SOAT1 | ENSG00000057252.8 | 5.057E-6 | 0.01 | 192185 | gtex_brain_putamen_basal |
| rs12119573 | 1 | 179458334 | SOAT1 | ENSG00000057252.8 | 1.62E-6 | 0.01 | 195409 | gtex_brain_putamen_basal |
| rs10913797 | 1 | 179458648 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 195723 | gtex_brain_putamen_basal |
| rs2225213 | 1 | 179458821 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 195896 | gtex_brain_putamen_basal |
| rs6425566 | 1 | 179459122 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 196197 | gtex_brain_putamen_basal |
| rs4652402 | 1 | 179461158 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 198233 | gtex_brain_putamen_basal |
| rs4652403 | 1 | 179461212 | SOAT1 | ENSG00000057252.8 | 1.383E-6 | 0.01 | 198287 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception一周s), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG STEROID BIOSYNTHESIS | 17 | 12 | All SZGR 2.0 genes in this pathway |
| ST JAK STAT PATHWAY | 9 | 8 | All SZGR 2.0 genes in this pathway |
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| IGARASHI ATF4 TARGETS DN | 90 | 65 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP | 579 | 346 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS DN | 431 | 263 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS BASAL DN | 455 | 304 | All SZGR 2.0 genes in this pathway |
| CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN | 460 | 312 | All SZGR 2.0 genes in this pathway |
| WANG LMO4 TARGETS UP | 372 | 227 | All SZGR 2.0 genes in this pathway |
| KINSEY TARGETS OF EWSR1 FLII FUSION UP | 1278 | 748 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP | 633 | 376 | All SZGR 2.0 genes in this pathway |
| LINDGREN BLADDER CANCER CLUSTER 3 UP | 329 | 196 | All SZGR 2.0 genes in this pathway |
| XU AKT1 TARGETS 6HR | 27 | 18 | All SZGR 2.0 genes in this pathway |
| TERAMOTO OPN TARGETS CLUSTER 6 | 27 | 17 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA HIF1A DN | 110 | 78 | All SZGR 2.0 genes in this pathway |
| GROSS HYPOXIA VIA ELK3 AND HIF1A UP | 142 | 104 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| LIAO METASTASIS | 539 | 324 | All SZGR 2.0 genes in this pathway |
| GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
| MORI LARGE PRE BII LYMPHOCYTE DN | 58 | 39 | All SZGR 2.0 genes in this pathway |
| BROWN MYELOID CELL DEVELOPMENT UP | 165 | 100 | All SZGR 2.0 genes in this pathway |
| VISALA AGING LYMPHOCYTE DN | 19 | 10 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY NO BLOOD UP | 222 | 139 | All SZGR 2.0 genes in this pathway |
| CHANG IMMORTALIZED BY HPV31 UP | 84 | 55 | All SZGR 2.0 genes in this pathway |
| CUI TCF21 TARGETS 2 UP | 428 | 266 | All SZGR 2.0 genes in this pathway |
| DOUGLAS BMI1 TARGETS DN | 314 | 188 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 3 | 720 | 440 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P4 | 100 | 62 | All SZGR 2.0 genes in this pathway |
| ZHANG GATA6 TARGETS DN | 64 | 46 | All SZGR 2.0 genes in this pathway |
| COATES MACROPHAGE M1 VS M2 DN | 78 | 44 | All SZGR 2.0 genes in this pathway |
| IWANAGA CARCINOGENESIS BY KRAS UP | 170 | 107 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C CLUSTER DN | 32 | 21 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C DN | 59 | 39 | All SZGR 2.0 genes in this pathway |
| SWEET LUNG CANCER KRAS UP | 491 | 316 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR DN | 277 | 166 | All SZGR 2.0 genes in this pathway |
| CHEN METABOLIC SYNDROM NETWORK | 1210 | 725 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS DN | 668 | 419 | All SZGR 2.0 genes in this pathway |
| POOLA INVASIVE BREAST CANCER UP | 288 | 168 | All SZGR 2.0 genes in this pathway |
| CHEN LIVER METABOLISM QTL CIS | 93 | 40 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER SUBCLASS S3 | 266 | 180 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 2 DN | 336 | 211 | All SZGR 2.0 genes in this pathway |
| MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS DN | 229 | 135 | All SZGR 2.0 genes in this pathway |
| PASINI SUZ12 TARGETS DN | 315 | 215 | All SZGR 2.0 genes in this pathway |
| BAKKER FOXO3 TARGETS DN | 187 | 109 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| YANG BCL3 TARGETS UP | 364 | 236 | All SZGR 2.0 genes in this pathway |
| PLASARI TGFB1 SIGNALING VIA NFIC 1HR UP | 33 | 25 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |