Gene Page:SOS2

Summary?
GeneID 6655
Symbol SOS2
Synonyms NS9
Description SOS Ras/Rho guanine nucleotide exchange factor 2
Reference MIM:601247|HGNC:HGNC:11188|Ensembl:ENSG00000100485|HPRD:03149|Vega:OTTHUMG00000140292
Gene type protein-coding
Map location 14q21
Pascal p-value 0.362
Fetal beta 0.678
eGene Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Gulsuner_2013 Whole Exome Sequencing analysis 155 DNMs identified by exome sequencing of quads or trios of schizophrenia individuals and their parents.

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
SOS2 chr14 50585249 G A NM_006939 p.1271P>L missense Schizophrenia DNM:Gulsuner_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CADPS 0.89 0.89
ATP2A2 0.87 0.89
MTMR7 0.87 0.85
DNAJC6 0.86 0.91
PALM2-AKAP2 0.85 0.84
SV2A 0.84 0.88
PRKAR1A 0.84 0.86
SNAP91 0.84 0.87
ADAM23 0.84 0.85
RAB6B 0.83 0.86
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RAB34 -0.54 -0.63
C1orf61 -0.51 -0.64
GNG11 -0.50 -0.53
AP002478.3 -0.48 -0.54
C1orf54 -0.47 -0.54
AF347015.21 -0.47 -0.44
HIGD1B -0.47 -0.48
DBI -0.47 -0.56
ACSF2 -0.47 -0.51
AL138743.2 -0.46 -0.52

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG DORSO VENTRAL AXIS FORMATION 25 21 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 90 68 All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155 105 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY 108 89 All SZGR 2.0 genes in this pathway
KEGG B CELL RECEPTOR SIGNALING PATHWAY 75 56 All SZGR 2.0 genes in this pathway
KEGG FC EPSILON RI SIGNALING PATHWAY 79 58 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG GNRH SIGNALING PATHWAY 101 77 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
KEGG GLIOMA 65 56 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 73 59 All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 60 47 All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 54 47 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES 67 54 All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY 35 29 All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES 27 23 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES 51 41 All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 45 33 All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY 46 38 All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR 40 32 All SZGR 2.0 genes in this pathway
ST INTERLEUKIN 4 PATHWAY 26 18 All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY 37 29 All SZGR 2.0 genes in this pathway
PID RAS PATHWAY 30 22 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396 292 All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 43 33 All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME AXON GUIDANCE 251 188 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF RAC 14 11 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ROBO RECEPTOR 30 26 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526 357 All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332 228 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275 168 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN 64 39 All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN 75 50 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 XPCS DN 88 71 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712 443 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
HASINA NOL7 TARGETS UP 13 11 All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811 508 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION 171 102 All SZGR 2.0 genes in this pathway
GOLDRATH IMMUNE MEMORY 65 42 All SZGR 2.0 genes in this pathway
SCHURINGA STAT5A TARGETS UP 21 13 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN 128 90 All SZGR 2.0 genes in this pathway
JIANG AGING CEREBRAL CORTEX UP 36 27 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830 547 All SZGR 2.0 genes in this pathway
MARIADASON RESPONSE TO BUTYRATE CURCUMIN SULINDAC TSA 8 16 7 All SZGR 2.0 genes in this pathway
XU GH1 EXOGENOUS TARGETS UP 85 50 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL DN 66 42 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS DN 19 10 All SZGR 2.0 genes in this pathway