Gene Page:dst
Summary？
| GeneID | 667 |
| 象征 | dst |
| Synonyms | BP240|BPA|BPAG1|CATX-15|CATX15|D6S1101|DMH|DT|EBSB2|HSAN6|MACF2 |
| Description | dystonin |
| Reference | MIM：113810|HGNC:HGNC:1090|Ensembl:ENSG00000151914|HPRD:00222|Vega：Otthumg0000000014913 |
| 基因类型 | 蛋白质编码 |
| Map location | 6p12.1 |
| Pascal p-value | 3.458E-6 |
| Sherlock p-value | 0.942 |
| 胎儿β | -1.064 |
| DMG | 1 (# studies) |
| 主持人 | Myers' cis & trans |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS CompositeSet Darnell FMRP targets Ascano FMRP targets |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 2 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| gsma_iie | Genome scan meta-analysis (European-ancestry samples) | PSR：0.04433 | |
| Literature | High-throughput literature-search | 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症，精神分裂症，精神分裂症 | 点击显示详细信息 |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关关键字的命中：2 | |
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | PPI网络中最短路径的贡献：1.9568 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| CG05022673 | 6 | 56819429 | dst; bend6 | 6.58e-5 | -0.26 | 0.024 | DMG：Wockner_2014 |
| CG12152867 | 6 | 56708725 | dst | 9.43E-5 | -0.27 | 0.027 | DMG：Wockner_2014 |
eQTL annotation
| SNP ID | 染色体 | 位置 | 主持人 | Gene Entrez ID | pvalue | QVALUE | TSS距离 | EQTL类型 |
|---|---|---|---|---|---|---|---|---|
| rs10915848 | CHR1 | 225788919 | dst | 667 | 0.16 | 反式 | ||
| RS17029291 | CHR3 | 32402138 | dst | 667 | 0 | 反式 | ||
| RS1610001 | CHR13 | 100484419 | dst | 667 | 0.06 | 反式 | ||
| rs1324669 | CHR13 | 107872446 | dst | 667 | 0.02 | 反式 | ||
| RS3742829 | CHR14 | 73489267 | dst | 667 | 0.19 | 反式 | ||
| RS16958358 | CHR17 | 55502410 | dst | 667 | 0.02 | 反式 | ||
| RS6015314 | chr20 | 57167224 | dst | 667 | 0.12 | 反式 | ||
| RS17145698 | Chrx | 40218345 | dst | 667 | 0.08 | 反式 |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| COL15A1 | 0.58 | 0.18 |
| COL6A3 | 0.57 | 0.26 |
| RP11-291I6.1 | 0.56 | 0.29 |
| ITIH2 | 0.56 | 0.21 |
| NID2 | 0.55 | 0.21 |
| MMRN1 | 0.55 | 0.33 |
| NID1 | 0.55 | 0.28 |
| COL4A1 | 0.54 | 0.27 |
| SLCO2A1 | 0.53 | 0.20 |
| OSR1 | 0.53 | 0.28 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| TCEAL3 | -0.28 | -0.18 |
| AL132868.3 | -0.27 | -0.20 |
| GLIPR1L2 | -0.27 | -0.29 |
| TSR2 | -0.25 | -0.19 |
| SLCO1A2 | -0.24 | -0.20 |
| HDAC11 | -0.24 | -0.14 |
| C5orf53 | -0.24 | -0.20 |
| CCNI2 | -0.24 | -0.19 |
| 杂志 | -0.23 | -0.17 |
| GJC2 | -0.23 | -0.18 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| GO:0003779 | actin binding | IEA | - | |
| GO:0005178 | 整联蛋白结合 | IPI | 11375975 | |
| 去：0005509 | calcium ion binding | IEA | - | |
| 去：0005515 | 蛋白质结合 | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 17043677 | |
| GO:0005198 | structural molecule activity | IEA | - | |
| GO:0008022 | protein C-terminus binding | IPI | 11375975 | |
| GO:0008017 | 微管结合 | IEA | - | |
| 去：0051015 | actin filament binding | ISS | 8575775 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0008090 | retrograde axon cargo transport | IEA | 轴突（GO术语级别：9） | - |
| GO:0007155 | cell adhesion | IEA | - | |
| GO:0007229 | integrin-mediated signaling pathway | nas | 11375975 | |
| GO:0007010 | 细胞骨架组织 | TAS | 10428034 | |
| GO:0007050 | cell cycle arrest | IEA | - | |
| GO:0030036 | 肌动蛋白细胞骨架organization | ISS | 8575775 | |
| GO:0031110 | 微管聚合或解聚的调节 | IEA | - | |
| GO:0031122 | 细胞质微管组织 | IEA | - | |
| GO:0045104 | intermediate filament cytoskeleton organization | IEP | 11751855 | |
| GO:0045104 | intermediate filament cytoskeleton organization | ISS | - | |
| GO:0045104 | intermediate filament cytoskeleton organization | nas | 11375975 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO：0060053 | 神经丝细胞骨架 | IEA | neuron (GO term level: 10) | - |
| 去：0005856 | 细胞骨架 | IEA | - | |
| 去：0005604 | basement membrane | TAS | 2461961 | |
| 去：0005737 | cytoplasm | IDA | 11751855 | |
| 去：0005737 | cytoplasm | ISS | 8575775 | |
| 去:0016023 | 细胞质膜结合的囊泡 | IDA | 14581450 | |
| GO:0015630 | microtubule cytoskeleton | IEA | - | |
| GO:0015629 | 肌动蛋白细胞骨架 | IEA | - | |
| GO:0030056 | Hemidesmosom体 | IEA | - | |
| GO:0030056 | Hemidesmosom体 | TAS | 8575775|11375975 |
Section V. Pathway annotation
Section VI. microRNA annotation
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| let-7/98 | 345 | 351 | 1A | hsa-let-7abrain | ugagguaguaguauauaguu |
| hsa-let-7bbrain | ugagguaguagguuguguguguu | ||||
| hsa-let-7cbrain | UGAGGUAGUAGGUUGUAUGGUU | ||||
| hsa-let-7dbrain | AGAGGUAGUAGGUUGCAUAGU | ||||
| hsa-let-7ebrain | ugagguaggagguuauauagu | ||||
| hsa-let-7fbrain | UGAGGUAGUAGAUUGUAUAGUU | ||||
| hsa-miR-98brain | ugagguaaguuguauuguu | ||||
| hsa-let-7gSZ | UGAGGUAGUAGUUUGUACAGU | ||||
| hsa-let-7ibrain | ugagguaguugugugugugcugu | ||||
| miR-134 | 190 | 196 | 1A | HSA-MIR-134brain | ugugacuggugaccagaggg |
| miR-142-3p | 318 | 324 | 1A | hsa-miR-142-3p | UGUAGUGUUUCCUACUUUAUGGA |
| miR-496 | 56 | 62 | 1A | HSA-MIR-496 | AUUACAUGGCCAAUCUC |
| mir-539 | 873 | 880 | 1A，M8 | hsa-miR-539 | GGAGAAAUUAUCCUUGGUGUGU |