Gene Page:SPIB

Summary?
GeneID 6689
Symbol SPIB
Synonyms SPI-B
Description Spi-B transcription factor
Reference MIM:606802|HGNC:HGNC:11242|Ensembl:ENSG00000269404|Vega:OTTHUMG00000183039
Gene type protein-coding
Map location 19q13.33
Pascal p-value 0.016
Fetal beta 0.309
Support CompositeSet

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DNM:Xu_2012 Whole Exome Sequencing analysis De novo mutations of 4 genes were identified by exome sequencing of 795 samples in this study

Section I. Genetics and epigenetics annotation

@DNM table

Gene Chromosome Position Ref Alt Transcript AA change Mutation type Sift CG46 Trait Study
SPIB chr19 50925796 G A NM_001243998
NM_001243999
NM_001244000
NM_003121		 .
p.40A>T
.
p.40A>T		 silent
missense
silent
missense		 Schizophrenia DNM:Xu_2012


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PRPF18 0.90 0.90
SCFD1 0.90 0.88
C11orf58 0.90 0.86
CUL2 0.89 0.89
RAB1A 0.89 0.88
TERF1 0.89 0.88
GGNBP2 0.89 0.91
GPBP1 0.89 0.88
CUL3 0.89 0.90
DDX1 0.89 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.72 -0.69
AF347015.31 -0.70 -0.70
IFI27 -0.69 -0.70
AF347015.33 -0.69 -0.67
AF347015.21 -0.68 -0.63
FXYD1 -0.68 -0.68
AF347015.2 -0.68 -0.69
AF347015.8 -0.68 -0.66
HIGD1B -0.68 -0.67
MT-CYB -0.67 -0.65

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CSNK2A1 CK2A1 | CKII casein kinase 2, alpha 1 polypeptide - HPRD,BioGRID 8632909
E2F1 E2F-1 | RBAP1 | RBBP3 | RBP3 E2F transcription factor 1 Two-hybrid BioGRID 12748276
E2F2 E2F-2 E2F transcription factor 2 Two-hybrid BioGRID 12748276
E2F3 DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598 E2F transcription factor 3 Two-hybrid BioGRID 12748276
E2F4 E2F-4 E2F transcription factor 4, p107/p130-binding Two-hybrid BioGRID 12748276
IRF4 LSIRF | MUM1 interferon regulatory factor 4 - HPRD 10196196
JUN AP-1 | AP1 | c-Jun jun oncogene - HPRD,BioGRID 10196196
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 mitogen-activated protein kinase 3 - HPRD,BioGRID 8632909
MAPK8 JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1 mitogen-activated protein kinase 8 - HPRD,BioGRID 8632909
RB1 OSRC | RB | p105-Rb | pRb | pp110 retinoblastoma 1 - HPRD 10196196
SPI1 OF | PU.1 | SFPI1 | SPI-1 | SPI-A spleen focus forming virus (SFFV) proviral integration oncogene spi1 - HPRD,BioGRID 10196196
SPIB SPI-B Spi-B transcription factor (Spi-1/PU.1 related) - HPRD,BioGRID 10196196
TBP GTF2D | GTF2D1 | MGC117320 | MGC126054 | MGC126055 | SCA17 | TFIID TATA box binding protein - HPRD,BioGRID 10196196


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
SENGUPTA NASOPHARYNGEAL CARCINOMA WITH LMP1 UP 408 247 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
SABATES COLORECTAL ADENOMA DN 291 176 All SZGR 2.0 genes in this pathway
RIZ ERYTHROID DIFFERENTIATION 12HR 43 35 All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION 45 34 All SZGR 2.0 genes in this pathway
DIRMEIER LMP1 RESPONSE LATE UP 57 41 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
RICKMAN HEAD AND NECK CANCER A 100 63 All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775 494 All SZGR 2.0 genes in this pathway
BENPORATH ES CORE NINE CORRELATED 100 68 All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 9 19 13 All SZGR 2.0 genes in this pathway
MORI PLASMA CELL DN 33 20 All SZGR 2.0 genes in this pathway
KLEIN PRIMARY EFFUSION LYMPHOMA DN 58 42 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157 105 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 55 38 All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246 180 All SZGR 2.0 genes in this pathway
KUMAR TARGETS OF MLL AF9 FUSION 405 264 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390 242 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
KAAB FAILED HEART ATRIUM UP 38 30 All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268 157 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING DN 39 27 All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282 183 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461 298 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER RELAPSE IN BONE DN 315 197 All SZGR 2.0 genes in this pathway
乳腺癌萧述三腔的DN 564 326 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476 285 All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648 398 All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259 185 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C UP 47 29 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
ZHAN EARLY DIFFERENTIATION GENES DN 42 29 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 1 28 19 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway