Gene Page:SPN
Summary?
| GeneID | 6693 |
| Symbol | SPN |
| Synonyms | CD43|GALGP|GPL115|LSN |
| Description | sialophorin |
| Reference | MIM: 182160|HGNC:HGNC:11249|Ensembl:ENSG00000197471|HPRD:06770| |
| Gene type | protein-coding |
| Map location | 16p11.2 |
| Pascal p-value | 0.425 |
| Fetal beta | 0.197 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CNV:YES | Copy number variation studies | Manual curation | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.01775 | |
| Literature | High-throughput literature-search | Co-occurance与精神分裂症患者phrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DNM1L | 0.94 | 0.93 |
| NKRF | 0.93 | 0.93 |
| PJA2 | 0.93 | 0.96 |
| SLC30A9 | 0.93 | 0.92 |
| UCHL5 | 0.93 | 0.92 |
| ACTR2 | 0.93 | 0.92 |
| SERINC1 | 0.92 | 0.91 |
| PAFAH1B1 | 0.92 | 0.93 |
| CLTC | 0.92 | 0.93 |
| UBQLN1 | 0.92 | 0.90 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| FXYD1 | -0.73 | -0.66 |
| HIGD1B | -0.70 | -0.65 |
| MT-CO2 | -0.69 | -0.62 |
| GSDMD | -0.69 | -0.67 |
| AP002478.3 | -0.68 | -0.67 |
| AF347015.21 | -0.68 | -0.59 |
| AF347015.31 | -0.67 | -0.61 |
| ACSF2 | -0.67 | -0.65 |
| EIF4EBP3 | -0.66 | -0.68 |
| RAB34 | -0.66 | -0.72 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004888 | transmembrane receptor activity | TAS | 1683685 | |
| GO:0008367 | bacterial binding | IDA | 10899905 | |
| GO:0005515 | protein binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0001562 | response to protozoan | IEA | - | |
| GO:0001808 | negative regulation of type IV hypersensitivity | IEA | - | |
| GO:0007162 | negative regulation of cell adhesion | TAS | 10753822 | |
| GO:0006968 | cellular defense response | TAS | 1683685 | |
| GO:0007166 | cell surface receptor linked signal transduction | IEA | - | |
| GO:0007163 | establishment or maintenance of cell polarity | TAS | 10753822 | |
| GO:0006935 | chemotaxis | TAS | 10753822 | |
| GO:0008624 | induction of apoptosis by extracellular signals | IEA | - | |
| GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | IDA | 10899905 | |
| GO:0042130 | negative regulation of T cell proliferation | IEA | - | |
| GO:0042102 | positive regulation of T cell proliferation | IEA | - | |
| GO:0042742 | defense response to bacterium | IDA | 10899905 | |
| GO:0031295 | T cell costimulation | IEA | - | |
| GO:0050688 | regulation of defense response to virus | IEA | - | |
| GO:0050776 | regulation of immune response | IEA | - | |
| GO:0045060 | negative thymic T cell selection | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0001931 | uropod | IEA | Synap (GO term level: 5) | - |
| GO:0005604 | basement membrane | IEA | - | |
| GO:0005615 | extracellular space | IDA | 10899905 | |
| GO:0016020 | membrane | IEA | - | |
| GO:0009897 | external side of plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 2023632 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CELL ADHESION MOLECULES CAMS | 134 | 93 | All SZGR 2.0 genes in this pathway |
| SA MMP CYTOKINE CONNECTION | 15 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 91 | 65 | All SZGR 2.0 genes in this pathway |
| REACTOME BASIGIN INTERACTIONS | 30 | 23 | All SZGR 2.0 genes in this pathway |
| REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING DN | 46 | 29 | All SZGR 2.0 genes in this pathway |
| FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN | 463 | 290 | All SZGR 2.0 genes in this pathway |
| KIM WT1 TARGETS DN | 459 | 276 | All SZGR 2.0 genes in this pathway |
| EBAUER TARGETS OF PAX3 FOXO1 FUSION UP | 207 | 128 | All SZGR 2.0 genes in this pathway |
| TARTE PLASMA CELL VS B LYMPHOCYTE UP | 78 | 51 | All SZGR 2.0 genes in this pathway |
| KANG IMMORTALIZED BY TERT DN | 102 | 67 | All SZGR 2.0 genes in this pathway |
| IVANOVA HEMATOPOIESIS EARLY PROGENITOR | 532 | 309 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 14HR DN | 298 | 200 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 8HR DN | 47 | 31 | All SZGR 2.0 genes in this pathway |
| SPIRA SMOKERS LUNG CANCER DN | 22 | 11 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 1HR DN | 222 | 147 | All SZGR 2.0 genes in this pathway |
| MARTENS BOUND BY PML RARA FUSION | 456 | 287 | All SZGR 2.0 genes in this pathway |
| MARTENS TRETINOIN RESPONSE DN | 841 | 431 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |