基因页：SPOCK1

Summary？
基因 6695
象征 SPOCK1
同义词 spock | testican | tic1
Description Sparc/osteotin，CWCV和Kazal样域蛋白聚糖（睾丸）1
Reference MIM:602264|HGNC：HGNC：11251|ENSEMBL：ENSG00000152377|HPRD:11887|Vega:OTTHUMG00000129157
基因类型 蛋白质编码
地图位置 5q31.2
Pascal P值 0.007
Sherlock p-value 0.006
胎儿β -0.707
主持人 Putamen basal ganglia

Gene in Data Sources
基因集名称 基因组方法 Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
简历：PGCNP 全基因组协会研究 GWAS
GSMA_I Genome scan meta-analysis PSR：0.0032
go_annotation 将与神经相关的关键字映射到基因本体论注释 与神经相关的关键字的命中：1

Section I. Genetics and epigenetics annotation

@EQTL注释

SNP ID 染色体 位置 主持人 Gene Entrez ID PVALUE QVALUE TSS距离 EQTL类型
RS17600276 5 136433386 SPOCK1 ENSG00000152377.8 2.66E-6 0.01 500682 gtex_brain_putamen_basal
RS201543316 5 136436560 SPOCK1 ENSG00000152377.8 3.473E-6 0.01 497508 gtex_brain_putamen_basal
RS965166 5 136439130 SPOCK1 ENSG00000152377.8 1.641E-6 0.01 494938 gtex_brain_putamen_basal
RS965167 5 136439139 SPOCK1 ENSG00000152377.8 1.664E-6 0.01 494929 gtex_brain_putamen_basal
RS28567576 5 136440247 SPOCK1 ENSG00000152377.8 1.405E-6 0.01 493821 gtex_brain_putamen_basal
RS66472723 5 136440304 SPOCK1 ENSG00000152377.8 3.621E-6 0.01 493764 gtex_brain_putamen_basal
rs1468293 5 136441222 SPOCK1 ENSG00000152377.8 3.575E-6 0.01 492846 gtex_brain_putamen_basal
rs17522016 5 136447232 SPOCK1 ENSG00000152377.8 1.911E-6 0.01 486836 gtex_brain_putamen_basal
rs68027902 5 136448540 SPOCK1 ENSG00000152377.8 2.408E-6 0.01 485528 gtex_brain_putamen_basal
RS757423 5 136449299 SPOCK1 ENSG00000152377.8 2.976E-6 0.01 484769 gtex_brain_putamen_basal
RS2905968 5 136457836 SPOCK1 ENSG00000152377.8 3.267E-6 0.01 476232 gtex_brain_putamen_basal
RS757424 5 136459562 SPOCK1 ENSG00000152377.8 9.726E-7 0.01 474506 gtex_brain_putamen_basal
RS916980 5 136460641 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 473427 gtex_brain_putamen_basal
RS2905971 5 136461551 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 472517 gtex_brain_putamen_basal
RS2905973 5 136462383 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 471685 gtex_brain_putamen_basal
rs2966729 5 136462509 SPOCK1 ENSG00000152377.8 1.762E-6 0.01 471559 gtex_brain_putamen_basal
rs2966730 5 136464224 SPOCK1 ENSG00000152377.8 1.762E-6 0.01 469844 gtex_brain_putamen_basal
RS2905976 5 136464933 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 469135 gtex_brain_putamen_basal
RS2905978 5 136466480 SPOCK1 ENSG00000152377.8 5.449E-6 0.01 467588 gtex_brain_putamen_basal
rs2240223 5 136466581 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 467487 gtex_brain_putamen_basal
rs2240224 5 136466764 SPOCK1 ENSG00000152377.8 9.745E-7 0.01 467304 gtex_brain_putamen_basal
rs6596366 5 136467795 SPOCK1 ENSG00000152377.8 1.095E-6 0.01 466273 gtex_brain_putamen_basal
RS13186295 5 136468871 SPOCK1 ENSG00000152377.8 2.66E-6 0.01 465197 gtex_brain_putamen_basal
RS34812669 5 136481759 SPOCK1 ENSG00000152377.8 5.449E-6 0.01 452309 gtex_brain_putamen_basal
RS1434662 5 136489133 SPOCK1 ENSG00000152377.8 1.343E-6 0.01 444935 gtex_brain_putamen_basal
RS565009222 5 136496186 SPOCK1 ENSG00000152377.8 5.712E-6 0.01 437882 gtex_brain_putamen_basal
RS7713012 5 136502945 SPOCK1 ENSG00000152377.8 1.343E-6 0.01 431123 gtex_brain_putamen_basal
RS6882509 5 136504046 SPOCK1 ENSG00000152377.8 4.451E-7 0.01 430022 gtex_brain_putamen_basal
RS35890961 5 136505153 SPOCK1 ENSG00000152377.8 1.343E-6 0.01 428915 gtex_brain_putamen_basal
RS68178906 5 136512226 SPOCK1 ENSG00000152377.8 1.482E-6 0.01 421842 gtex_brain_putamen_basal

第二节。转录组注释

一般基因表达（GTEX）

无法使用

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions


第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0005509 calcium ion binding IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0007399 nervous system development TAS 神经突（GO期限：5） 9181134
去：0007155 cell adhesion TAS 8389704
GO:0008283 cell proliferation TAS 8389704
GO:0006928 细胞运动 TAS 8389704
去：0007275 多细胞生物发育 TAS 8389704
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IEA -
去：0005578 proteinaceous extracellular matrix IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
中村肿瘤区周围与中央DN 634 384 All SZGR 2.0 genes in this pathway
Bertucci髓质与导管乳腺癌DN 169 118 All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性 351 230 All SZGR 2.0 genes in this pathway
vecchi胃癌先进与早期 175 120 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 8D的Takeda目标 157 91 All SZGR 2.0 genes in this pathway
NUP98 HOXA9 Fusion 10D的Takeda目标 194 122 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧 130 85 All SZGR 2.0 genes in this pathway
Elvidge HIF1A和HIF2A靶向DN 104 72 All SZGR 2.0 genes in this pathway
甲状腺癌 443 294 All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇3 DN 229 142 All SZGR 2.0 genes in this pathway
Mahadevan伊马替尼抵抗 23 15 All SZGR 2.0 genes in this pathway
Mahadevan GIST形态开关 15 11 All SZGR 2.0 genes in this pathway
Seitz肿瘤转化通过8p删除 73 47 All SZGR 2.0 genes in this pathway
Wood EBV EBNA1目标DN 47 33 All SZGR 2.0 genes in this pathway
Mohankumar TLX1靶向DN 193 112 All SZGR 2.0 genes in this pathway
COLIN PILOCYTIC ASTROCYTOMA VS GLIOBLASTOMA UP 35 32 All SZGR 2.0 genes in this pathway
Onder CDH1目标2向上 256 159 All SZGR 2.0 genes in this pathway
通过CTNNB1发出的CDH1信号传导 83 58 All SZGR 2.0 genes in this pathway
阿斯顿主要抑郁症DN 160 110 All SZGR 2.0 genes in this pathway
Chesler Brain QTL顺式 75 51 All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向 84 51 All SZGR 2.0 genes in this pathway
马纳洛缺氧 207 145 All SZGR 2.0 genes in this pathway
KAAB心脏心房和心室UP 249 170 All SZGR 2.0 genes in this pathway
Yamazaki TCEB3靶向 175 116 All SZGR 2.0 genes in this pathway
Browne HCMV感染8小时 105 73 All SZGR 2.0 genes in this pathway
JI对FSH DN的响应 58 43 All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN 434 302 All SZGR 2.0 genes in this pathway
Wang Smarce1靶向 280 183 All SZGR 2.0 genes in this pathway
约瑟夫对丁酸钠的反应 31 21 All SZGR 2.0 genes in this pathway
Kondo EZH2目标 245 148 All SZGR 2.0 genes in this pathway
Bonome卵巢癌的生存次优秀 510 309 All SZGR 2.0 genes in this pathway
Boquest干细胞向上 260 174 All SZGR 2.0 genes in this pathway
Mirlet7a3 DN的Brueckner目标 78 49 All SZGR 2.0 genes in this pathway
Yauch刺猬信号传导旁分泌 149 85 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 DN 315 201 All SZGR 2.0 genes in this pathway
Rutella对HGF DN的响应 235 144 All SZGR 2.0 genes in this pathway
Rutella对HGF与CSF2RB和IL4 DN的响应 245 150 All SZGR 2.0 genes in this pathway
Meissner NPC HCP带有H3K4ME2 491 319 All SZGR 2.0 genes in this pathway
Mikkelsen MEF HCP带有H3K27ME3 590 403 All SZGR 2.0 genes in this pathway
Chicas RB1目标汇合 567 365 All SZGR 2.0 genes in this pathway
STAT3的Azare肿瘤转化 121 70 All SZGR 2.0 genes in this pathway
ERBB2同工4的PEDERSEN转移4 110 66 All SZGR 2.0 genes in this pathway
杨Bcl3靶向 364 236 All SZGR 2.0 genes in this pathway
前列腺癌模型DN中的Acevedo FGFR1靶标 308 187 All SZGR 2.0 genes in this pathway
anastassiou癌症间充质过渡特征 64 40 All SZGR 2.0 genes in this pathway
NABA PROTEOGLYCANS 35 23 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 目标位置 miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
mir-124.1 566 572 1a HSA-MIR-124A UUAAGGCACGCGGUGAAUGCCA
miR-135 944 950 M8 HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
HSA-MIR-135A UAUGGCUUUUUAUUCCUAUGUGA
HSA-MIR-135B Uauggcuuuucauuccuaugug
miR-139 429 435 1a HSA-MIR-139brain ucuacagugcacgugucu
mir-23 3260 3267 1A，M8 HSA-MIR-23Abrain AUCACAUUGCCAGGGAUUUCC
HSA-MIR-23Bbrain aucacauugccagggauuacc
mir-323 3260 3266 1a hsa-miR-323brain gcacauuacggucgaccucu
mir-326 150 156 M8 hsa-miR-326 CCUCUGGGCCCUUCCUCCAG
miR-375 2144 2150 1a HSA-MIR-375 uuuguucguucggcucgcguga