Gene Page:SRC
Summary?
GeneID | 6714 |
Symbol | SRC |
Synonyms | ASV|SRC1|c-SRC|p60-Src |
Description | SRC原始癌基因,非受体酪氨酸激酶 |
Reference | MIM:190090|HGNC:HGNC:11283|运用:ENSG00000197122|HPRD:01819|Vega:OTTHUMG00000032417 |
Gene type | protein-coding |
Map location | 20q12-Q13 |
Pascal p-value | 0.228 |
Sherlock p-value | 0.968 |
Fetal beta | 0.082 |
Support | 代谢性谷氨酸受体 G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanNRC COMPOSITESET Potential synaptic genes |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
PMID:cooccur | High-throughput literature-search | Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included. | |
文学 | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias | Click to show details |
Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 14.4947 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/SRC_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
脚注:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
RASAL1 | 0.79 | 0.78 |
RASGEF1A | 0.77 | 0.82 |
SLC7A4 | 0.76 | 0.83 |
syn1 | 0.75 | 0.81 |
PRKCG | 0.75 | 0.82 |
syn2 | 0.75 | 0.81 |
SLC30A3 | 0.75 | 0.77 |
CHRM1 | 0.75 | 0.77 |
TMEM130 | 0.75 | 0.81 |
PNMAL2 | 0.74 | 0.77 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
RBMX2 | -0.39 | -0.45 |
KIAA1949 | -0.38 | -0.26 |
CSRP2 | -0.37 | -0.43 |
SLA | -0.37 | -0.02 |
TUBB2B | -0.37 | -0.36 |
SH2D2A | -0.37 | -0.41 |
FABP7 | -0.36 | -0.39 |
ZNF435 | -0.36 | -0.24 |
DACT1 | -0.36 | 0.00 |
MYCN | -0.36 | -0.03 |
Section III. Gene Ontology annotation
Molecular function | 去的术语 | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0000166 | nucleotide binding | IEA | - | |
GO:0005070 | SH3/SH2 adaptor activity | TAS | 9020193 | |
GO:0005515 | protein binding | IPI | 8681387|9763511 | |
GO:0005524 | ATP binding | IEA | - | |
去:0004715 | non-membrane spanning protein tyrosine kinase activity | IEA | - | |
GO:0016740 | transferase activity | IEA | - | |
GO:0042169 | SH2 domain binding | IPI | 8070403 | |
Biological process | 去的术语 | Evidence | Neuro keywords | PubMed ID |
GO:0007172 | 信号复合物组件 | TAS | 9924018 | |
GO:0006468 | protein amino acid phosphorylation | IEA | - | |
GO:0007265 | Ras protein signal transduction | EXP | 11520933 | |
GO:0007243 | protein kinase cascade | TAS | 9020193 | |
GO:0044419 | interspecies interaction between organisms | IEA | - | |
Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
去:0005829 | cytosol | EXP | 10858437|11124251 | |
GO:0005901 | caveola | IDA | 17848177 | |
GO:0005886 | plasma membrane | EXP | 8845374|9028946|11124251 |12506110|12907686 |15574420 |
Section IV. Protein-protein interaction annotation
Interactors | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
---|---|---|---|---|---|
ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | c-Abl interacts with Src. This interaction was modeled on a demonstrated interaction between human c-Abl and v-Src from the Rous Sarcoma virus. | BIND | 1383690 |
ADAM12 | MCMP | MCMPMltna | MLTN | MLTNA | ADAM metallopeptidase domain 12 | - | HPRD | 11127814 |
ADAM15 | MDC15 | ADAM metallopeptidase domain 15 | - | HPRD | 11741929 |
ADRB2 | ADRB2R | ADRBR | B2AR | BAR | BETA2AR | adrenergic, beta-2-, receptor, surface | Affinity Capture-Western | BioGRID | 11013230 |
ADRB3 | BETA3AR | adrenergic, beta-3-, receptor | - | HPRD,BioGRID | 11013230 |
ADRBK1 | BARK1 | BETA-ARK1 | FLJ16718 | GRK2 | adrenergic, beta, receptor kinase 1 | - | HPRD,BioGRID | 12624098 |
AFAP1 | AFAP | AFAP-110 | FLJ56849 | actin filament associated protein 1 | - | HPRD,BioGRID | 9655255 |
AHR | - | aryl hydrocarbon receptor | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 12024042 |
ANKRD11 | ANCO-1 |lz16 |T13 | ankyrin repeat domain 11 | - | HPRD | 15184363 |
ANXA2 | ANX2 | ANX2L4 | CAL1H | LIP2 | LPC2 | LPC2D | P36 | PAP-IV | annexin A2 | - | HPRD,BioGRID | 11106497 |
AR | AIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFM | 雄性激素受体 | Affinity Capture-Western Two-hybrid |
BioGRID | 11032808|15027889 |15466214 |
ARHGAP1 | CDC42GAP | RHOGAP | RHOGAP1 | p50rhoGAP | Rho GTPase activating protein 1 | - | HPRD,BioGRID | 8253717 |
ARHGAP17 | DKFZp564A1363 | FLJ37567 | FLJ43368 | MGC87805 | MST066 | MST110 | MSTP038 | MSTP066 | MSTP110 | NADRIN | RICH1 | WBP15 | Rho GTPase activating protein 17 | Reconstituted Complex | BioGRID | 11431473 |
ARNT | HIF-1beta | HIF1B | HIF1BETA | TANGO | bHLHe2 | aryl hydrocarbon receptor nuclear translocator | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 12024042 |
ARR3 | ARRX | arrestin 3, retinal (X-arrestin) | - | HPRD,BioGRID | 11877451 |
ASAP1 | AMAP1 | CENTB4 | DDEF1 | KIAA1249 | PAG2 | PAP | ZG14P | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | - | HPRD,BioGRID | 9819391 |
ASAP2 | Amap2 |Centb3 |ddef2 |FLJ42910 |KIAA0400 |pag3 |PAP |pap-alpha |shag1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | Affinity Capture-Western | BioGRID | 10022920 |
AXL | JTK11 | UFO | AXL receptor tyrosine kinase | - | HPRD,BioGRID | 9178760 |
BCAR1 | CAS | CAS1 | CASS1 | CRKAS | P130Cas | breast cancer anti-estrogen resistance 1 | c-Src interacts with CAS. | BIND | 9148935 |
BCAR1 | CAS | CAS1 | CASS1 | CRKAS | P130Cas | breast cancer anti-estrogen resistance 1 | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 10085298|10487518 |10739664|11514617 |12397603|12615911 |
BCR | ALL | BCR-ABL1 | BCR1 | CML | D22S11 | D22S662 | FLJ16453 | PHL | breakpoint cluster region | BCR与SRC相互作用。这种相互作用是根据来自Rous肉瘤病毒的未指定来源和SRC之间的BCR之间的相互作用进行了建模的。 | BIND | 1383690 |
BMX | ETK | PSCTK2 | PSCTK3 | BMX non-receptor tyrosine kinase | - | HPRD,BioGRID | 10688651 |
CAV1 | CAV | MSTP085 | VIP21 | caveolin 1, caveolae protein, 22kDa | - | HPRD,BioGRID | 8910575 |
CAV2 | CAV | MGC12294 | caveolin 2 | Reconstituted Complex | BioGRID | 12091389 |
CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | - | HPRD | 8635998 |
CBL | C-CBL | CBL2 | RNF55 | Cas-Br-M (murine) ecotropic retroviral transforming sequence | Cbl interacts with Src. This interaction was modeled on a demonstrated interaction between human Cbl and Src from unspecified species. | BIND | 15135048 |
CD2AP | CMS |DKFZP586H0519 | CD2-associated protein | - | HPRD | 10339567 |
CD36 | CHDS7 | FAT | GP3B | GP4 | GPIV | PASIV | SCARB3 | CD36 molecule (thrombospondin receptor) | - | HPRD | 7521304 |
CD44 | CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 | CD44 molecule (Indian blood group) | Affinity Capture-Western Reconstituted Complex |
BioGRID | 11084024 |
CD46 | MCP | MGC26544 | MIC10 | TLX | TRA2.10 | CD46 molecule, complement regulatory protein | - | HPRD,BioGRID | 10657632 |
CD59 | 16.3A5 | 1F5 | EJ16 | EJ30 | EL32 | FLJ38134 | FLJ92039 | G344 | HRF-20 | HRF20 | MAC-IP | MACIF | MEM43 | MGC2354 | MIC11 | MIN1 | MIN2 | MIN3 | MIRL | MSK21 | p18-20 | CD59 molecule, complement regulatory protein | - | HPRD | 12219031 |
CDC37 | P50CDC37 | cell division cycle 37 homolog (S. cerevisiae) | Reconstituted Complex | BioGRID | 11085988 |
CDCP1 | CD318 | SIMA135 | TRASK | CUB domain containing protein 1 | Src interacts with CDCP1. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human CDCP1. | BIND | 15851033 |
CDH1 | Arc-1 | CD324 | CDHE | ECAD | LCAM | UVO | cadherin 1, type 1, E-cadherin (epithelial) | Affinity Capture-Western | BioGRID | 10744074 |
CEACAM3 | CD66D | CEA | CGM1 | MGC119875 | W264 | W282 | carcinoembryonic antigen-related cell adhesion molecule 3 | - | HPRD | 11708798 |
CRK | CRKII | v-crk sarcoma virus CT10 oncogene homolog (avian) | Affinity Capture-Western | BioGRID | 12615911 |
CSF1R | C-FMS | CD115 | CSFR | FIM2 | FMS | colony stimulating factor 1 receptor | Affinity Capture-Western | BioGRID | 7681396 |
CSK | MGC117393 | c-src tyrosine kinase | - | HPRD,BioGRID | 7513429 |
CTNND1 | CAS | CTNND | KIAA0384 | P120CAS | P120CTN | p120 | catenin (cadherin-associated protein), delta 1 | Affinity Capture-Western | BioGRID | 12640114 |
DAB2 | DOC-2 | DOC2 | FLJ26626 | disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) | - | HPRD,BioGRID | 12473651 |
DAG1 | 156DAG | A3a | AGRNR | DAG | dystroglycan 1 (dystrophin-associated glycoprotein 1) | Affinity Capture-Western Biochemical Activity Reconstituted Complex |
BioGRID | 11724572 |
DDR2 | MIG20a | NTRKR3 | TKT | TYRO10 | discoidin domain receptor tyrosine kinase 2 | - | HPRD,BioGRID | 11884411 |
DOCK1 | DOCK180 | ced5 | dedicator of cytokinesis 1 | Affinity Capture-Western | BioGRID | 12615911 |
DOK1 | MGC117395 | MGC138860 | P62DOK | docking protein 1, 62kDa (downstream of tyrosine kinase 1) | Reconstituted Complex | BioGRID | 11071635 |
DOK4 | FLJ10488 | 对接蛋白4 | - | HPRD | 12730241 |
DOK4 | FLJ10488 | 对接蛋白4 | IRS5/DOK4 interacts with Src. This interaction was modelled on a demonstrated interaction between human IRS5/DOK4 and hamster Src. | BIND | 12730241 |
DRD4 | D4DR | dopamine receptor D4 | D4.4与C-SRC相互作用。这种相互作用是在人类D4.4和Chicken C-SRC之间证明的相互作用上建模的。 | BIND | 9843378 |
DTNA | D18S892E | DRP3| DTN | FLJ96209 | LVNC1 | dystrobrevin, alpha | - | HPRD | 9701558 |
E2F4 | E2F-4 | E2F transcription factor 4, p107/p130-binding | E2F4 interacts with SRC enhancer. | BIND | 15782160 |
EFNB1 | CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782 | ephrin-B1 | - | HPRD,BioGRID | 8878483 |
EGFR | ERBB | ERBB1 | HER1 | PIG61 | mENA | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | - | HPRD,BioGRID | 10971656 |
EP300 | KAT3B | p300 | E1A binding protein p300 | Reconstituted Complex | BioGRID | 10973497 |
EPHB2 | CAPB | DRT | EPHT3 | ERK | Hek5 | MGC87492 | PCBC | Tyro5 | EPH receptor B2 | - | HPRD,BioGRID | 9632142 |
EPS8 | - | epidermal growth factor receptor pathway substrate 8 | - | HPRD,BioGRID | 10395945 |
ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | V-ERB-B2红细胞白血病病毒性癌基因同源2,神经/胶质母细胞瘤衍生的癌基因同源物(Avian) | - | HPRD | 7542762 |
ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | V-ERB-B2红细胞白血病病毒性癌基因同源2,神经/胶质母细胞瘤衍生的癌基因同源物(Avian) | Reconstituted Complex | BioGRID | 11940572 |
ERBB2 | CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1 | V-ERB-B2红细胞白血病病毒性癌基因同源2,神经/胶质母细胞瘤衍生的癌基因同源物(Avian) | SRC (SRC-1) interacts with the ERBB2 (HER2) promoter. | BIND | 15788656 |
ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | 雌激素受体1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10454579|11032808 |11564893 |
ESR2 | ER-BETA | ESR-BETA | ESRB | ESTRB | Erb | NR3A2 | estrogen receptor 2 (ER beta) | Affinity Capture-Western | BioGRID | 11032808 |
ETS1 | ETS-1 | EWSR2 | FLJ10768 | v-ets erythroblastosis virus E26 oncogene homolog 1 (avian) | SRC (SRC-1) interacts with ETS1. | BIND | 15788656 |
ETS2 | ETS2IT1 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) | SRC (SRC-1) interacts with ETS2. | BIND | 15788656 |
EVL | RNB6 | Enah/Vasp-like | - | HPRD,BioGRID | 10945997 |
FARP2 | FIR | FRG | KIAA0793 | PLEKHC3 | FERM, RhoGEF and pleckstrin domain protein 2 | - | HPRD | 12771149 |
FASLG | APT1LG1 | CD178 | CD95L | FASL | TNFSF6 | Fas ligand (TNF superfamily, member 6) | - | HPRD | 11741599 |
FOXO1 | FKH1 | FKHR | FOXO1A | forkhead box O1 | - | HPRD,BioGRID | 10973497 |
FYN | MGC45350 |SLK |syn | FYN oncogene related to SRC, FGR, YES | Protein-peptide | BioGRID | 9169421 |
GAB2 | KIAA0571 | GRB2-associated binding protein 2 | - | HPRD,BioGRID | 10391903 |
GAB3 | - | GRB2-associated binding protein 3 | - | HPRD,BioGRID | 11739737 |
GFAP | FLJ45472 | glial fibrillary acidic protein | - | HPRD | 11379820 |
GIT1 | - | G protein-coupled receptor kinase interacting ArfGAP 1 | - | HPRD | 14523024 |
GJA1 | CX43 | DFNB38 | GJAL | ODDD | gap junction protein, alpha 1, 43kDa | - | HPRD | 9278444 |
GJA1 | CX43 | DFNB38 | GJAL | ODDD | gap junction protein, alpha 1, 43kDa | Cx43 interacts with v-Src. This interaction was modelled on a demonstrated interaction between rat Cx43 and human v-Src. | BIND | 9278444 |
GJB1 | CMTX | CMTX1 | CX32 | gap junction protein, beta 1, 32kDa | GJB1 (connexin32) interacts with and prevents the activation of Src. | BIND | 15782139 |
GNB2L1 | Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1 | guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 | - | HPRD,BioGRID | 9584165 |
GRB10 | GRB-IR | Grb-10 | IRBP | KIAA0207 | MEG1 | RSS | growth factor receptor-bound protein 10 | Biochemical Activity | BioGRID | 10871840 |
GRB2 | ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084 | growth factor receptor-bound protein 2 | - | HPRD,BioGRID | 11964172 |
GRIN2A | NMDAR2A | NR2A | 谷氨酸受体,ionotropic N-methyl D-aspartate 2A | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10458595|12932824 |
GRIN2A | NMDAR2A | NR2A | 谷氨酸受体,ionotropic N-methyl D-aspartate 2A | - | HPRD | 10458595|10884433 |12932824 |
GRIN2B | MGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3 | 谷氨酸受体,ionotropic N-methyl D-aspartate 2B | - | HPRD | 10884433 |
GSN | DKFZp313L0718 | gelsolin (amyloidosis, Finnish type) | Affinity Capture-Western | BioGRID | 11577104 |
HNF1A | HNF1 | LFB1 | MODY3 | TCF1 | HNF1 homeobox A | - | HPRD,BioGRID | 10777539 |
HNRNPK | CSBP | FLJ41122 | HNRPK | TUNP | heterogeneous nuclear ribonucleoprotein K | Src interacts with hnRNPK. This interaction was modeled on a demonstrated interaction between Src from an unspecified source and human hnRNPK. | BIND | 8810341 |
HSP90AA1 | FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | - | HPRD,BioGRID | 1310678 |
IL6R | CD126 | IL-6R-1 | IL-6R-alpha | IL6RA | MGC104991 | interleukin 6 receptor | - | HPRD | 10462375 |
ITK | EMT | LYK | MGC126257 | MGC126258 | PSCTK2 | IL2-inducible T-cell kinase | Reconstituted Complex | BioGRID | 10636929 |
KCNQ5 | Kv7.5 | potassium voltage-gated channel, KQT-like subfamily, member 5 | - | HPRD | 15304482 |
KHDRBS1 | FLJ34027 |SAM68 |p62 | KH domain containing, RNA binding, signal transduction associated 1 | - | HPRD,BioGRID | 1545818|8766817 |10467411 |
KHDRBS1 | FLJ34027 |SAM68 |p62 | KH domain containing, RNA binding, signal transduction associated 1 | c-Src SH3 domain interacts with Sam68 proline-rich region. This interaction was modelled on a demonstrated interaction between c-Src from an unspecified source and human Sam68. | BIND | 7537265 |
KIFAP3 | FLJ22818 | KAP3 | SMAP | Smg-GDS | dJ190I16.1 | kinesin-associated protein 3 | - | HPRD,BioGRID | 8900189 |
LRP1 | A2MR | APOER | APR | CD91 | FLJ16451 | IGFBP3R | LRP | MGC88725 | TGFBR5 | low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor) | Biochemical Activity | BioGRID | 11854294 |
LYN | FLJ26625 | JTK8 | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | Protein-peptide | BioGRID | 9169421 |
MAP2 | DKFZp686I2148 | MAP2A | MAP2B | MAP2C | microtubule-associated protein 2 | Reconstituted Complex | BioGRID | 10781592 |
MAPK15 | ERK7 |ERK8 | mitogen-activated protein kinase 15 | - | HPRD | 11875070 |
MAPK8IP3 | DKFZp762N1113 | FLJ00027 | JIP3 | JSAP1 | KIAA1066 | SYD2 | mitogen-activated protein kinase 8 interacting protein 3 | Biochemical Activity | BioGRID | 12226752 |
MATK | CHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101 | megakaryocyte-associated tyrosine kinase | - | HPRD,BioGRID | 7530249 |
MET | AUTS9 | HGFR | RCCP2 | c-Met | met proto-oncogene (hepatocyte growth factor receptor) | - | HPRD,BioGRID | 9837958 |
MICAL1 | DKFZp434B1517 | FLJ11937 | FLJ21739 | MICAL | MICAL-1 | NICAL | microtubule associated monoxygenase, calponin and LIM domain containing 1 | Reconstituted Complex | BioGRID | 11827972 |
MPZL1 | FLJ21047 | PZR | PZR1b | PZRa | PZRb | myelin protein zero-like 1 | - | HPRD,BioGRID | 11751924 |
MST1R | CD136 |CDW136 |ptk8 |罗恩 | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | - | HPRD | 8918464 |
MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | MUC1interacts with c-Src. | BIND | 11483589 |
MUC1 | CD227 | EMA | H23AG | MAM6 | PEM | PEMT | PUM | mucin 1, cell surface associated | - | HPRD,BioGRID | 11152665|11483589 |
MYLK | DKFZp686I10125 | FLJ12216 | KRP | MLCK | MLCK1 | MLCK108 | MLCK210 | MSTP083 | MYLK1 | smMLCK | myosin light chain kinase | - | HPRD,BioGRID | 10362724 |
NCOA6 | AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBP | nuclear receptor coactivator 6 | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 10567404|10847592 |11158331|12482968 |
ND2 | MTND2 | NADH dehydrogenase, subunit 2 (complex I) | Affinity Capture-Western Reconstituted Complex Two-hybrid |
BioGRID | 15069201 |
NPHS1 | CNF | NPHN | nephrosis 1, congenital, Finnish type (nephrin) | - | HPRD | 12846735 |
pde4d | DPDE3 | HSPDE4D | PDE4DN2 | STRK1 | 磷酸二酯酶4D,营地特异性(磷酸二酯酶E3 Dunce同源物,果蝇) | pde4d4 interacts with Src SH3 domain. | BIND | 10571082 |
pde6g | DKFZp686C0587 | MGC125749 | PDEG | phosphodiesterase 6G, cGMP-specific, rod, gamma | - | HPRD,BioGRID | 12624098 |
PDGFRB | CD140B |JTK12 |PDGF-R-BETA |PDGFR |PDGFR1 | platelet-derived growth factor receptor, beta polypeptide | PDGFR interacts with Src. This interaction was modelled on a demonstrated interaction between rat PDGFR and Src from an unknown species. | BIND | 2173144 |
PECAM1 | CD31 | PECAM-1 | platelet/endothelial cell adhesion molecule | - | HPRD,BioGRID | 10858437 |
PELP1 | HMX3 | MNAR | P160 | proline, glutamate and leucine rich protein 1 | Affinity Capture-Western | BioGRID | 15466214 |
PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | - | HPRD | 12210743 |
PIK3R1 | GRB1 | p85 | p85-ALPHA | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Affinity Capture-Western | BioGRID | 10487518 |
PKD1 | PBP | polycystic kidney disease 1 (autosomal dominant) | - | HPRD | 11113628 |
PLCG1 | PLC-II | PLC1 | PLC148 | PLCgamma1 | phospholipase C, gamma 1 | - | HPRD,BioGRID | 7510703 |
PLD1 | - | phospholipase D1, phosphatidylcholine-specific | Biochemical Activity | BioGRID | 12697812 |
PLD2 | - | phospholipase D2 | Affinity Capture-Western Biochemical Activity Reconstituted Complex |
BioGRID | 12697812 |
PLSCR1 | MMTRA1B | 磷脂cramblase 1 | Biochemical Activity | BioGRID | 12871937 |
PRKCE | MGC125656 | MGC125657 | PKCE | nPKC-epsilon | protein kinase C, epsilon | - | HPRD | 11834516 |
PRKCZ | PKC-ZETA | PKC2 | protein kinase C, zeta | - | HPRD,BioGRID | 10527887 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | c-Src interacts with FAK. This interaction was modeled on a demonstrated interaction between human c-Src and mouse FAK. | BIND | 9148935 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 10085298|11980671 |12387730|12558988 |12615911 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | - | HPRD | 7529876|8054685 |10931187 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | - | HPRD | 7529876|8054685 |
PTK2 | FADK | FAK | FAK1 | pp125FAK | PTK2 protein tyrosine kinase 2 | Src interacts with tyrosine autophosphorylated FAK. This interaction was modeled on a demonstrated interaction between human Src and avian FAK. | BIND | 7515480 |
PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | - | HPRD | 8849729|10777553 |
PTK2B | CADTK | CAKB | FADK2 | FAK2 | FRNK | PKB | PTK | PYK2 | RAFTK | PTK2B protein tyrosine kinase 2 beta | Affinity Capture-Western Reconstituted Complex |
BioGRID | 8849729|10521452 |10777553 |
PTPN2 | ptpt |TC-PTP |tcellptp |TCPTP | protein tyrosine phosphatase, non-receptor type 2 | PTPN2 (TCPTP) interacts with Src. This interaction was modelled on a demonstrated interaction between human PTPN2 and chicken Src. | BIND | 15696169 |
PTPN21 | PTPD1 | PTPRL10 | protein tyrosine phosphatase, non-receptor type 21 | - | HPRD,BioGRID | 7519780 |
PTPRA | HEPTP | HLPR | HPTPA | HPTPalpha | LRP | PTPA | PTPRL2 | R-PTP-alpha | RPTPA | protein tyrosine phosphatase, receptor type, A | Affinity Capture-Western | BioGRID | 11923305 |
PXN | FLJ16691 | paxillin | Reconstituted Complex | BioGRID | 10085298 |
PXN | FLJ16691 | paxillin | - | HPRD | 7534286 |
RAF1 | CRAF | NS5 | Raf-1 | c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 | - | HPRD,BioGRID | 7517401 |
RARA | NR1B1 | RAR | retinoic acid receptor, alpha | Reconstituted Complex | BioGRID | 10454579 |
rasa1 | CM-AVM | CMAVM | DKFZp434N071 | GAP | PKWS | RASA | RASGAP | p120GAP | p120RASGAP | RAS p21 protein activator (GTPase activating protein) 1 | - | HPRD,BioGRID | 1717825 |
RET | CDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51 | ret proto-oncogene | - | HPRD,BioGRID | 10070972 |
RGS16 | A28-RGS14 | A28-RGS14P | RGS-R | regulator of G-protein signaling 16 | SRC磷酸化RGS16。这种相互作用是基于未指定物种与人RSG16的SRC之间的相互作用进行建模的。 | BIND | 12588871 |
RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | - | HPRD,BioGRID | 12454018 |
RICS | GC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAP | Rho GTPase-activating protein | SRC与GC-GAP相互作用。这种相互作用是基于未指定物种与人GC间隙的SRC之间的相互作用建模的。 | BIND | 12819203 |
RPL10 | DKFZP686J1851 |DXS648 |DXS648E |FLJ23544 |FLJ27072 |十一月|QM | ribosomal protein L10 | Reconstituted Complex | BioGRID | 12138090 |
RPS6KB1 | PS6K | S6K | S6K1 | STK14A | p70(S6K)-alpha | p70-S6K | p70-alpha | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | Biochemical Activity | BioGRID | 16640565 |
RPS6KB2 | KLS | P70-beta | P70-beta-1 | P70-beta-2 | S6K-beta2 | S6K2 | SRK | STK14B | p70(S6K)-beta | p70S6Kb | ribosomal protein S6 kinase, 70kDa, polypeptide 2 | Biochemical Activity | BioGRID | 16640565 |
RXRA | FLJ00280 |FLJ00318 |FLJ16020 |FLJ16733 |MGC102720 |NR2B1 | retinoid X receptor, alpha | Reconstituted Complex | BioGRID | 10517671 |
SH3BP1 | - | SH3-domain结合蛋白1 | - | HPRD,BioGRID | 1379745 |
SH3PXD2A | FISH | SH3MD1 | SH3 and PX domains 2A | - | HPRD | 9687503 |
SHB | RP11-3J10.8 |BA3J10.2 | Src homology 2 domain containing adaptor protein B | Shb interacts with Src. This interaction was modelled on a demonstrated interaction between human Shb and chicken Src. | BIND | 7537362 |
SHB | RP11-3J10.8 |BA3J10.2 | Src homology 2 domain containing adaptor protein B | - | HPRD,BioGRID | 7537362 |
SHC1 | FLJ26504 | SHC | SHCA | SHC (Src homology 2 domain containing) transforming protein 1 | Src interacts with Shc. This interaction was modelled on demonstrated interactions between human Src and rat Shc, and between Src from unspecified species and human Shc. | BIND | 7515480|8939605 |
SKAP1 | SCAP1 | SKAP55 | src kinase associated phosphoprotein 1 | - | HPRD,BioGRID | 9195899 |
SLC9A2 | NHE2 | solute carrier family 9 (sodium/hydrogen exchanger), member 2 | - | HPRD,BioGRID | 10187839 |
SMARCB1 | BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFS | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 | - | HPRD | 12145209 |
SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | - | HPRD | 12145209 |
SNURF | - | SNRPN upstream reading frame | Phenotypic Enhancement | BioGRID | 11696545 |
SRC | ASV |src1 |C-SRC |P60-SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | Tyrosine phophorylated c-Src interacts with Src SH2 domain. | BIND | 7683128 |
SRC | ASV |src1 |C-SRC |P60-SRC | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | - | HPRD | 9174343 |
SRF | MCM1 | serum response factor (c-fos serum response element-binding transcription factor) | - | HPRD,BioGRID | 9786846 |
STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD,BioGRID | 9344858 |
STAT3 | APRF | FLJ20882 | HIES | MGC16063 | signal transducer and activator of transcription 3 (acute-phase response factor) | - | HPRD,BioGRID | 8657134 |
STAT5A | MGF | STAT5 | signal transducer and activator of transcription 5A | - | HPRD | 10358079 |
SYK | DKFZp313N1010 | FLJ25043 | FLJ37489 | spleen tyrosine kinase | - | HPRD,BioGRID | 7513017 |
syn1 | syn1a | SYN1b | SYNI | synapsin I | - | HPRD,BioGRID | 10899172 |
thrb | Erba-Beta |erba2 |Grth |MGC126109 |MGC126110 |NR1A2 |prth |thr1 |thrb1 |thrb2 | thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) | Reconstituted Complex | BioGRID | 10454579 |
TIAM1 | FLJ36302 | T-cell lymphoma invasion and metastasis 1 | - | HPRD | 12810717 |
TNFSF11 | CD254 | ODF | OPGL | OPTB2 | RANKL | TRANCE | hRANKL2 | sOdf | tumor necrosis factor (ligand) superfamily, member 11 | Affinity Capture-Western | BioGRID | 10635328 |
TRAF1 | EBI6 | MGC:10353 | TNF receptor-associated factor 1 | Affinity Capture-Western | BioGRID | 10635328 |
TRAF3 | CAP-1 | CD40bp | CRAF1 | LAP1 | TNF receptor-associated factor 3 | Affinity Capture-Western | BioGRID | 10635328 |
TRAF6 | MGC:3310 |RNF85 | TNF receptor-associated factor 6 | - | HPRD,BioGRID | 10635328 |
TRIP4 | HsT17391 | thyroid hormone receptor interactor 4 | Affinity Capture-Western | BioGRID | 10454579 |
TRIP6 | MGC10556 | MGC10558 | MGC29959 | MGC3837 | MGC4423 | OIP1 | ZRP-1 | thyroid hormone receptor interactor 6 | - | HPRD,BioGRID | 14688263 |
TRPC6 | FLJ11098 | FLJ14863 | FSGS2 | TRP6 | transient receptor potential cation channel, subfamily C, member 6 | - | HPRD,BioGRID | 14761972 |
TRPV4 | OTRPC4 | TRP12 | VR-OAC | VRL-2 | VRL2 | VROAC | transient receptor potential cation channel, subfamily V, member 4 | - | HPRD,BioGRID | 12538589 |
TUB | rd5 | tubby homolog (mouse) | - | HPRD | 10455176 |
TYRO3 | BYK | Brt | Dtk | FLJ16467 | RSE | Sky | Tif | TYRO3 protein tyrosine kinase | - | HPRD,BioGRID | 7537495 |
WAS | IMD2 | THC | WASP | Wiskott-Aldrich syndrome (eczema-thrombocytopenia) | - | HPRD,BioGRID | 8805332 |
WBP11 | DKFZP779M1063 |NPWBP |SIPP1 | WW domain binding protein 11 | - | HPRD | 11375989 |
YTHDC1 | KIAA1966 |YT521 |YT521-B | YTH domain containing 1 | - | HPRD | 15175272 |
YWHAB | GW128 | HS1 | KCIP-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | - | HPRD | 8702721 |
YWHAE | 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | - | HPRD | 8702721 |
YWHAG | 14-3-3GAMMA | 酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白,伽马多肽 | - | HPRD | 8702721 |
YWHAH | YWHA1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide | - | HPRD | 8702721 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
桶G ERBB SIGNALING PATHWAY | 87 | 71 | All SZGR 2.0 genes in this pathway |
桶G ENDOCYTOSIS | 183 | 132 | All SZGR 2.0 genes in this pathway |
桶G VEGF SIGNALING PATHWAY | 76 | 53 | All SZGR 2.0 genes in this pathway |
桶G FOCAL ADHESION | 201 | 138 | All SZGR 2.0 genes in this pathway |
kegg粘附交界处 | 75 | 53 | All SZGR 2.0 genes in this pathway |
桶G TIGHT JUNCTION | 134 | 86 | All SZGR 2.0 genes in this pathway |
桶G GAP JUNCTION | 90 | 68 | All SZGR 2.0 genes in this pathway |
桶G GNRH SIGNALING PATHWAY | 101 | 77 | All SZGR 2.0 genes in this pathway |
桶G EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION | 68 | 44 | All SZGR 2.0 genes in this pathway |
BIOCARTA SRCRPTP PATHWAY | 11 | 9 | All SZGR 2.0 genes in this pathway |
Biocarta AGR途径 | 36 | 31 | All SZGR 2.0 genes in this pathway |
BIOCARTA AT1R PATHWAY | 36 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA SPPA PATHWAY | 22 | 18 | All SZGR 2.0 genes in this pathway |
BIOCARTA CBL PATHWAY | 13 | 10 | All SZGR 2.0 genes in this pathway |
BIOCARTA CELL2CELL PATHWAY | 14 | 11 | All SZGR 2.0 genes in this pathway |
BIOCARTA ECM PATHWAY | 24 | 17 | All SZGR 2.0 genes in this pathway |
BIOCARTA ERK PATHWAY | 28 | 22 | All SZGR 2.0 genes in this pathway |
BIOCARTA GABA PATHWAY | 10 | 10 | All SZGR 2.0 genes in this pathway |
BIOCARTA MPR PATHWAY | 34 | 28 | All SZGR 2.0 genes in this pathway |
BIOCARTA INTEGRIN PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
BIOCARTA PYK2 PATHWAY | 31 | 24 | All SZGR 2.0 genes in this pathway |
BIOCARTA EDG1 PATHWAY | 27 | 24 | All SZGR 2.0 genes in this pathway |
BIOCARTA RHO PATHWAY | 32 | 23 | All SZGR 2.0 genes in this pathway |
BIOCARTA ACH PATHWAY | 16 | 13 | All SZGR 2.0 genes in this pathway |
BIOCARTA BARRESTIN SRC PATHWAY | 15 | 14 | All SZGR 2.0 genes in this pathway |
Biocarta遇到了途径 | 37 | 30 | All SZGR 2.0 genes in this pathway |
BIOCARTA SPRY PATHWAY | 18 | 15 | All SZGR 2.0 genes in this pathway |
BIOCARTA UCALPAIN PATHWAY | 18 | 11 | All SZGR 2.0 genes in this pathway |
ST DIFFERENTIATION PATHWAY IN PC12 CELLS | 45 | 35 | All SZGR 2.0 genes in this pathway |
St GA12途径 | 23 | 16 | All SZGR 2.0 genes in this pathway |
ST G ALPHA S PATHWAY | 16 | 11 | All SZGR 2.0 genes in this pathway |
ST G ALPHA I PATHWAY | 35 | 29 | All SZGR 2.0 genes in this pathway |
ST ADRENERGIC | 36 | 29 | All SZGR 2.0 genes in this pathway |
ST INTEGRIN SIGNALING PATHWAY | 82 | 62 | All SZGR 2.0 genes in this pathway |
ST STAT3 PATHWAY | 11 | 10 | All SZGR 2.0 genes in this pathway |
ST INTERLEUKIN 4 PATHWAY | 26 | 18 | All SZGR 2.0 genes in this pathway |
PID ENDOTHELIN PATHWAY | 63 | 52 | All SZGR 2.0 genes in this pathway |
PID PRL SIGNALING EVENTS PATHWAY | 23 | 17 | All SZGR 2.0 genes in this pathway |
PID LYSOPHOSPHOLIPID PATHWAY | 66 | 53 | All SZGR 2.0 genes in this pathway |
PID NFKAPPAB ATYPICAL PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
PID GLYPICAN 1PATHWAY | 27 | 20 | All SZGR 2.0 genes in this pathway |
PID ER NONGENOMIC PATHWAY | 41 | 35 | All SZGR 2.0 genes in this pathway |
PID MET PATHWAY | 80 | 60 | All SZGR 2.0 genes in this pathway |
PID PTP1B PATHWAY | 52 | 40 | All SZGR 2.0 genes in this pathway |
PID S1P S1P3 PATHWAY | 29 | 24 | All SZGR 2.0 genes in this pathway |
PID EPHB FWD PATHWAY | 40 | 38 | All SZGR 2.0 genes in this pathway |
PID NECTIN PATHWAY | 30 | 20 | All SZGR 2.0 genes in this pathway |
PID p38 alpha beta途径 | 31 | 25 | All SZGR 2.0 genes in this pathway |
PID CDC42 PATHWAY | 70 | 51 | All SZGR 2.0 genes in this pathway |
PID RET PATHWAY | 39 | 29 | All SZGR 2.0 genes in this pathway |
PID ARF6 PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
PID TCPTP PATHWAY | 43 | 33 | All SZGR 2.0 genes in this pathway |
PID FAS PATHWAY | 38 | 29 | All SZGR 2.0 genes in this pathway |
PID TXA2PATHWAY | 57 | 43 | All SZGR 2.0 genes in this pathway |
PID NETRIN PATHWAY | 32 | 27 | All SZGR 2.0 genes in this pathway |
PID INTEGRIN A9B1 PATHWAY | 25 | 18 | All SZGR 2.0 genes in this pathway |
PID CXCR4途径 | 102 | 78 | All SZGR 2.0 genes in this pathway |
PID ERBB1 RECEPTOR PROXIMAL PATHWAY | 35 | 29 | All SZGR 2.0 genes in this pathway |
PID PI3KCI PATHWAY | 49 | 40 | All SZGR 2.0 genes in this pathway |
PID AJDISS 2PATHWAY | 48 | 38 | All SZGR 2.0 genes in this pathway |
PID AR TF PATHWAY | 53 | 38 | All SZGR 2.0 genes in this pathway |
PID ECADHERIN NASCENT AJ PATHWAY | 39 | 33 | All SZGR 2.0 genes in this pathway |
PID AMB2 NEUTROPHILS PATHWAY | 41 | 32 | All SZGR 2.0 genes in this pathway |
PID AVB3 INTEGRIN PATHWAY | 75 | 53 | All SZGR 2.0 genes in this pathway |
PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | All SZGR 2.0 genes in this pathway |
PID UPA UPAR PATHWAY | 42 | 30 | All SZGR 2.0 genes in this pathway |
PID ERBB2 ERBB3 PATHWAY | 44 | 35 | All SZGR 2.0 genes in this pathway |
PID EPHA FWDPATHWAY | 34 | 29 | All SZGR 2.0 genes in this pathway |
PID ECADHERIN KERATINOCYTE PATHWAY | 21 | 19 | All SZGR 2.0 genes in this pathway |
PID PDGFRB PATHWAY | 129 | 103 | All SZGR 2.0 genes in this pathway |
PID AR NONGENOMIC PATHWAY | 31 | 27 | All SZGR 2.0 genes in this pathway |
PID ERBB1 INTERNALIZATION PATHWAY | 41 | 35 | All SZGR 2.0 genes in this pathway |
PID CXCR3 PATHWAY | 43 | 34 | All SZGR 2.0 genes in this pathway |
PID VEGFR1 2 PATHWAY | 69 | 57 | All SZGR 2.0 genes in this pathway |
PID SYNDECAN 2 PATHWAY | 33 | 27 | All SZGR 2.0 genes in this pathway |
PID PI3KCI AKT PATHWAY | 35 | 30 | All SZGR 2.0 genes in this pathway |
PID SYNDECAN 3 PATHWAY | 17 | 15 | All SZGR 2.0 genes in this pathway |
PID EPHRINB REV PATHWAY | 30 | 25 | All SZGR 2.0 genes in this pathway |
PID PI3K PLC TRK PATHWAY | 36 | 31 | All SZGR 2.0 genes in this pathway |
PID EPHA2 FWD PATHWAY | 19 | 16 | All SZGR 2.0 genes in this pathway |
PID ALPHA SYNUCLEIN PATHWAY | 33 | 25 | All SZGR 2.0 genes in this pathway |
PID FGF PATHWAY | 55 | 37 | All SZGR 2.0 genes in this pathway |
PID整合素A4B1途径 | 33 | 24 | All SZGR 2.0 genes in this pathway |
PID FAK PATHWAY | 59 | 45 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING BY NGF | 217 | 167 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY SCF KIT | 78 | 59 | All SZGR 2.0 genes in this pathway |
REACTOME DEVELOPMENTAL BIOLOGY | 396 | 292 | All SZGR 2.0 genes in this pathway |
FGF信号的Reactome Spry调节 | 14 | 9 | All SZGR 2.0 genes in this pathway |
REACTOME CELL CELL COMMUNICATION | 120 | 77 | All SZGR 2.0 genes in this pathway |
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING | 37 | 24 | All SZGR 2.0 genes in this pathway |
REACTOME REGULATION OF KIT SIGNALING | 17 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME MEMBRANE TRAFFICKING | 129 | 74 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY ERBB2 | 101 | 78 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY EGFR IN CANCER | 109 | 80 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING TO RAS | 27 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | 91 | 65 | All SZGR 2.0 genes in this pathway |
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE | 137 | 105 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALLING TO ERKS | 36 | 30 | All SZGR 2.0 genes in this pathway |
Reactome P38MAPK事件 | 13 | 12 | All SZGR 2.0 genes in this pathway |
FGFR在疾病中的反应组信号传导 | 127 | 88 | All SZGR 2.0 genes in this pathway |
REACTOME PECAM1 INTERACTIONS | 10 | 7 | All SZGR 2.0 genes in this pathway |
REACTOME GAB1 SIGNALOSOME | 38 | 29 | All SZGR 2.0 genes in this pathway |
REACTOME INTEGRIN CELL SURFACE INTERACTIONS | 79 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | 15 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | 15 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING | 27 | 17 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY PDGF | 122 | 93 | All SZGR 2.0 genes in this pathway |
REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | 95 | 76 | All SZGR 2.0 genes in this pathway |
REACTOME AXON GUIDANCE | 251 | 188 | All SZGR 2.0 genes in this pathway |
REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | 64 | 49 | All SZGR 2.0 genes in this pathway |
REACTOME ADP SIGNALLING THROUGH P2RY1 | 25 | 16 | All SZGR 2.0 genes in this pathway |
REACTOME CD28 CO STIMULATION | 32 | 26 | All SZGR 2.0 genes in this pathway |
REACTOME COSTIMULATION BY THE CD28 FAMILY | 63 | 48 | All SZGR 2.0 genes in this pathway |
REACTOME CTLA4 INHIBITORY SIGNALING | 21 | 15 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNAL AMPLIFICATION | 31 | 19 | All SZGR 2.0 genes in this pathway |
REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | 32 | 20 | All SZGR 2.0 genes in this pathway |
REACTOME L1CAM INTERACTIONS | 86 | 62 | All SZGR 2.0 genes in this pathway |
REACTOME NETRIN1 SIGNALING | 41 | 30 | All SZGR 2.0 genes in this pathway |
REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | 13 | 11 | All SZGR 2.0 genes in this pathway |
REACTOME RECYCLING PATHWAY OF L1 | 27 | 15 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | 12 | 10 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET AGGREGATION PLUG FORMATION | 36 | 23 | All SZGR 2.0 genes in this pathway |
REACTOME HEMOSTASIS | 466 | 331 | All SZGR 2.0 genes in this pathway |
REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION | 208 | 138 | All SZGR 2.0 genes in this pathway |
REACTOME SIGNALING BY FGFR | 112 | 80 | All SZGR 2.0 genes in this pathway |
Fulcher炎症反应凝集素与LPS | 579 | 346 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP | 35 | 22 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 1 DN | 242 | 165 | All SZGR 2.0 genes in this pathway |
MULLIGHAN MLL SIGNATURE 2 DN | 281 | 186 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE FIMA UP | 544 | 308 | All SZGR 2.0 genes in this pathway |
ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
DODD NASOPHARYNGEAL CARCINOMA DN | 1375 | 806 | All SZGR 2.0 genes in this pathway |
由阿霉素GRAESSMANN细胞凋亡 | 1142 | 669 | All SZGR 2.0 genes in this pathway |
MATTIOLI MULTIPLE MYELOMA WITH 14Q32 TRANSLOCATIONS | 36 | 25 | All SZGR 2.0 genes in this pathway |
SCHEIDEREIT IKK INTERACTING PROTEINS | 58 | 45 | All SZGR 2.0 genes in this pathway |
HEIDENBLAD AMPLIFIED IN SOFT TISSUE CANCER | 13 | 7 | All SZGR 2.0 genes in this pathway |
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
STARK PREFRONTAL CORTEX 22Q11 DELETION UP | 195 | 138 | All SZGR 2.0 genes in this pathway |
ZHAN MULTIPLE MYELOMA CD2 UP | 45 | 32 | All SZGR 2.0 genes in this pathway |
AFFAR YY1 TARGETS UP | 214 | 133 | All SZGR 2.0 genes in this pathway |
FAELT B CLL WITH VH3 21 UP | 44 | 30 | All SZGR 2.0 genes in this pathway |
BILD SRC ONCOGENIC SIGNATURE | 62 | 38 | All SZGR 2.0 genes in this pathway |
FOSTER TOLERANT MACROPHAGE DN | 409 | 268 | All SZGR 2.0 genes in this pathway |
Mitsiades对aplidin的反应 | 439 | 257 | All SZGR 2.0 genes in this pathway |
MATZUK EARLY ANTRAL FOLLICLE | 13 | 11 | All SZGR 2.0 genes in this pathway |
MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
JUBAN TARGETS OF SPI1 AND FLI1 UP | 115 | 73 | All SZGR 2.0 genes in this pathway |
DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
DELACROIX RAR BOUND ES | 462 | 273 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | mirna id | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-137 | 1620 | 1626 | 1A | hsa-miR-137 | UAUUGCUUAAGAAUACGCGUAG |
miR-141/200a | 1867 | 1873 | m8 | hsa-miR-141 | UAACACUGUCUGGUAAAGAUGG |
hsa-miR-200a | UAACACUGUCUGGUAACGAUGU | ||||
miR-149 | 1651年 | 1657年 | m8 | hsa-miR-149脑 | UCUGGCUCCGUGUCUUCACUCC |
miR-153 | 1891 | 1897年 | m8 | hsa-miR-153 | Uugcauagucacaaaaguga |
miR-203.1 | 1594 | 1601 | 1A,m8 | hsa-miR-203 | UGAAAUGUUUAGGACCACUAG |
hsa-miR-203 | UGAAAUGUUUAGGACCACUAG | ||||
miR-378 | 764 | 770 | 1A | hsa-miR-378 | CUCCUGACUCCAGGUCCUGUGU |
miR-9 | 419 | 425 | 1A | hsa-miR-9SZ | UCUUUGGUUAUCUAGCUGUAUGA |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click这里to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click这里to see the list of brain related miRNAs.