基因Page:BRAF

Summary?
基因ID 673
Symbol BRAF
Synonyms B-RAF1|BRAF1|NS7|RAFB1
Description B-Raf proto-oncogene, serine/threonine kinase
Reference MIM:164757|HGNC:HGNC:1097|Ensembl:ENSG00000157764|HPRD:01264|Vega:OTTHUMG00000157457
基因type protein-coding
Map location 7q34
Pascal p-value 0.068
Fetal beta 0.15
DMG 1 (# studies)
Support CANABINOID
DOPAMINE
SEROTONIN

基因in Data Sources
基因set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0286

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg08428486 7 140452281 BRAF 3.34E-4 -0.363 0.041 DMG:Wockner_2014


Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Not available

基因expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
ZFP36L2 0.85 0.87
SOX9 0.83 0.73
FBXL7 0.83 0.85
SLC2A10 0.81 0.80
PALLD 0.79 0.75
NR2E1 0.78 0.76
CRB2 0.78 0.75
YAP1 0.77 0.83
NFATC4 0.77 0.71
SIX5 0.77 0.64
Top 10 negatively co-expressed genes
基因 Pearson's Correlation Spearman's Correlation
SYCP3 -0.24 -0.26
ZBTB8OS -0.22 -0.28
USMG5 -0.21 -0.30
THOC7 -0.21 -0.25
AF347015.21 -0.21 -0.15
AL050337.1 -0.21 -0.27
DDTL -0.20 -0.30
BEX5 -0.20 -0.15
GNRHR -0.20 -0.26
FABP3 -0.20 -0.12

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005057 receptor signaling protein activity IEA -
GO:0005515 protein binding 新闻学会 17353931
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0016740 transferase activity IEA -
GO:0008270 zinc ion binding IEA -
GO:0019992 diacylglycerol binding IEA -
GO:0046872 metal ion binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006468 protein amino acid phosphorylation TAS 2284096
GO:0009887 organ morphogenesis TAS 9207797
GO:0007264 small GTPase mediated signal transduction EXP 10712923
GO:0006916 anti-apoptosis TAS 9207797
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 18029348
GO:0005737 cytoplasm IEA -
GO:0005886 plasma membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
AKT1 AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 - HPRD,BioGRID 10869359
HRAS C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog - HPRD,BioGRID 7706312
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 MEK1 interacts with B-Raf. BIND 8621729
MAP2K1 MAPKK1 | MEK1 | MKK1 | PRKMK1 mitogen-activated protein kinase kinase 1 - HPRD 7731720
MAP2K2 FLJ26075 | MAPKK2 | MEK2 | MKK2 | PRKMK2 mitogen-activated protein kinase kinase 2 - HPRD 8668348
MAPK3 ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3 mitogen-activated protein kinase 3 Phenotypic Enhancement BioGRID 10869359
MRAS FLJ42964 | M-RAs | R-RAS3 | RRAS3 muscle RAS oncogene homolog - HPRD,BioGRID 12138204
OIP5 5730547N13Rik | LINT-25 | MIS18beta Opa interacting protein 5 B-RAF interacts with OIP5. BIND 12620389
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 B-RAF interacts with C-RAF. This interaction was modelled on a demonstrated interaction between human B-RAF and monkey C-RAF . BIND 15035987
RAF1 CRAF | NS5 | Raf-1 | c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 - HPRD,BioGRID 11325826
RAP1A KREV-1 | KREV1 | RAP1 | SMGP21 RAP1A, member of RAS oncogene family Reconstituted Complex BioGRID 10454553
RAP1GAP KIAA0474 | RAP1GA1 | Rap1GAP1 | rap1GAPII RAP1 GTPase activating protein Reconstituted Complex BioGRID 11278445
SFN YWHAS stratifin Affinity Capture-MS BioGRID 15778465
TIMM50 MGC102733 | TIM50 | TIM50L translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) B-RAF interacts with TIMM50. BIND 12620389
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide BRAF (B-Raf) interacts with an unspecified isoform of YWHAB (14-3-3-beta). BIND 12620389
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide B-RAF interacts with 14-3-3-beta. BIND 12620389
YWHAB GW128 | HS1 | KCIP-1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide - HPRD,BioGRID 10931830
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide Affinity Capture-MS BioGRID 17353931
YWHAH YWHA1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide - HPRD 8668348
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide - HPRD 8668348
YWHAQ 14-3-3 | 1C5 | HS1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide Affinity Capture-MS BioGRID 17353931
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide Affinity Capture-MS BioGRID 17353931
YWHAZ KCIP-1 | MGC111427 | MGC126532 | MGC138156 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide - HPRD 8668348


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG MAPK SIGNALING PATHWAY 267 205 All SZGR 2.0 genes in this pathway
KEGG ERBB SIGNALING PATHWAY 87 71 All SZGR 2.0 genes in this pathway
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG MTOR SIGNALING PATHWAY 52 40 All SZGR 2.0 genes in this pathway
KEGG VASCULAR SMOOTH MUSCLE CONTRACTION 115 81 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY 137 92 All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 70 57 All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY 126 103 All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 70 53 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137 103 All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 86 59 All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328 259 All SZGR 2.0 genes in this pathway
KEGG COLORECTAL CANCER 62 47 All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 70 60 All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER 70 56 All SZGR 2.0 genes in this pathway
KEGG ENDOMETRIAL CANCER 52 45 All SZGR 2.0 genes in this pathway
KEGG GLIOMA 65 56 All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 89 75 All SZGR 2.0 genes in this pathway
KEGG THYROID CANCER 29 26 All SZGR 2.0 genes in this pathway
KEGG MELANOMA 71 57 All SZGR 2.0 genes in this pathway
KEGG BLADDER CANCER 42 33 All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA 73 59 All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA 60 47 All SZGR 2.0 genes in this pathway
KEGG NON SMALL CELL LUNG CANCER 54 47 All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY 87 68 All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 45 35 All SZGR 2.0 genes in this pathway
ST ERK1 ERK2 MAPK PATHWAY 32 25 All SZGR 2.0 genes in this pathway
ST G ALPHA S PATHWAY 16 11 All SZGR 2.0 genes in this pathway
ST G ALPHA I PATHWAY 35 29 All SZGR 2.0 genes in this pathway
ST ADRENERGIC 36 29 All SZGR 2.0 genes in this pathway
ST INTEGRIN SIGNALING PATHWAY 82 62 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY 69 55 All SZGR 2.0 genes in this pathway
PID TCR RAS PATHWAY 14 14 All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY 105 78 All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY 129 103 All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 69 57 All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY 34 31 All SZGR 2.0 genes in this pathway
PID CD8 TCR DOWNSTREAM PATHWAY 65 56 All SZGR 2.0 genes in this pathway
PID FAK PATHWAY 59 45 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME SPRY REGULATION OF FGF SIGNALING 14 9 All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING 37 24 All SZGR 2.0 genes in this pathway
REACTOME ARMS MEDIATED ACTIVATION 17 17 All SZGR 2.0 genes in this pathway
REACTOME PROLONGED ERK ACTIVATION EVENTS 19 18 All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE 137 105 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS 36 30 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE 127 88 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO P38 VIA RIT AND RIN 15 14 All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137 110 All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS 37 32 All SZGR 2.0 genes in this pathway
REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS 27 23 All SZGR 2.0 genes in this pathway
REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS 33 28 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR 112 80 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS DN 411 249 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 16HR UP 225 139 All SZGR 2.0 genes in this pathway
SU TESTIS 76 53 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND TBH 60 42 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 10HR UP 101 69 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 111 68 All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER UP 73 53 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175 125 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN 157 106 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP 344 215 All SZGR 2.0 genes in this pathway