Gene Page:SRPK1

Summary?
GeneID 6732
Symbol SRPK1
Synonyms SFRSK1
Description SRSF protein kinase 1
Reference MIM:601939|HGNC:HGNC:11305|Ensembl:ENSG00000096063|HPRD:15992|Vega:OTTHUMG00000014583
Gene type protein-coding
Map location 6p21.31
Pascal p-value 0.087
Sherlock p-value 0.509
Fetal beta 0.999
DMG 1 (# studies)
eGene Cerebellar Hemisphere
Myers' cis & trans

Gene in Data Sources
基因本身t name Method of gene set Description Info
CV:PGCnp 全基因组关联研究 GWAS
DMG:vanEijk_2014 Genome-wide DNA methylation analysis This dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GSMA_I Genome scan meta-analysis Psr: 0.033
GSMA_IIE Genome scan meta-analysis (European-ancestry samples) Psr: 0.04433

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg09082921 6 35744226 SRPK1 0.002 -8 DMG:vanEijk_2014

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs9366911 chr6 36589339 SRPK1 6732 0.16 cis

Section II. Transcriptome annotation

General gene expression (GTEx)

不可用

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HERC6 0.88 0.72
MX1 0.80 0.55
IFIT3 0.78 0.44
IFIT1 0.77 0.51
ATPAF1 0.75 0.73
C1QB 0.75 0.58
CD59 0.75 0.65
PPT1 0.75 0.81
AC068989.2 0.75 0.61
HSD17B12 0.74 0.78
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
TMEM88 -0.41 -0.47
EGFL8 -0.40 -0.39
RP9P -0.38 -0.53
MYLK2 -0.36 -0.40
AC005921.3 -0.36 -0.47
AC011475.1 -0.36 -0.39
SLC38A5 -0.35 -0.40
AL022328.1 -0.34 -0.46
RAMP2 -0.34 -0.44
C1orf86 -0.34 -0.30

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0000287 magnesium ion binding IDA 11509566
GO:0005515 protein binding 新闻学会 10196197|11509566|17353931
GO:0005524 ATP binding IDA 11509566
GO:0005524 ATP binding IEA -
GO:0004674 protein serine/threonine kinase activity IDA 11509566
GO:0004674 protein serine/threonine kinase activity IEA -
GO:0016740 transferase activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0008380 RNA splicing TAS 8208298
GO:0006468 protein amino acid phosphorylation IDA 11509566
GO:0006468 protein amino acid phosphorylation IEA -
GO:0007243 protein kinase cascade IDA 11509566
GO:0007059 chromosome segregation IDA 15034300
GO:0030154 cell differentiation IEA -
GO:0050684 regulation of mRNA processing IDA 8208298
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IDA 11509566
GO:0005737 cytoplasm IDA 11509566

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CROP LUC7A | OA48-18 cisplatin resistance-associated overexpressed protein Biochemical Activity BioGRID 12565863
FERMT1 C20orf42 | DTGCU2 | FLJ20116 | FLJ23423 | KIND1 | UNC112A | URP1 fermitin family homolog 1 (Drosophila) - HPRD 9472028
LBR DHCR14B | FLJ43126 | LMN2R | MGC9041 | PHA lamin B receptor - HPRD 10049757|10390541
MBP MGC99675 myelin basic protein - HPRD 10390541
PRM1 P1 protamine 1 - HPRD,BioGRID 10390541
RNPS1 E5.1 | MGC117332 RNA binding protein S1, serine-rich domain Affinity Capture-MS BioGRID 17353931
SAFB DKFZp779C1727 | HAP | HET | SAFB1 scaffold attachment factor B - HPRD 11509566
SFRS1 ASF | MGC5228 | SF2 | SF2p33 | SRp30a splicing factor, arginine/serine-rich 1 - HPRD 8208298|8798720
|9472028|10390541
SFRS1 ASF | MGC5228 | SF2 | SF2p33 | SRp30a splicing factor, arginine/serine-rich 1 Affinity Capture-Western
Biochemical Activity
Far Western
Reconstituted Complex		 BioGRID 9472028|10196197
|12565863|17517895
SFRS12 DKFZp564B176 | MGC133045 | SRrp508 | SRrp86 splicing factor, arginine/serine-rich 12 - HPRD 14559993
SFRS2IP CASP11 | SIP1 | SRRP129 splicing factor, arginine/serine-rich 2, interacting protein - HPRD 8208298
SFRS3 SRp20 splicing factor, arginine/serine-rich 3 - HPRD 8208298|10390541
SFRS4 SRP75 splicing factor, arginine/serine-rich 4 - HPRD 8208298|10390541
SFRS5 HRS | SRP40 splicing factor, arginine/serine-rich 5 - HPRD 8208298|10390541
SFRS6 B52 | FLJ08061 | MGC5045 | SRP55 splicing factor, arginine/serine-rich 6 - HPRD 8208298|10340541
SNRNP70 RNPU1Z | RPU1 | SNRP70 | U170K | U1AP | U1RNP small nuclear ribonucleoprotein 70kDa (U1) Affinity Capture-Western
Biochemical Activity		 BioGRID 9472028|12417631
U2AF1 DKFZp313J1712 | FP793 | RN | RNU2AF1 | U2AF35 | U2AFBP U2 small nuclear RNA auxiliary factor 1 - HPRD 9472028
U2AF2 U2AF65 U2 small nuclear RNA auxiliary factor 2 - HPRD 9472028
YWHAG 14-3-3GAMMA tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide - HPRD 15324660


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265 158 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
OUELLET OVARIAN CANCER INVASIVE VS LMP UP 117 85 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER BASAL VS LULMINAL 330 215 All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN 47 34 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584 395 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
BENPORATH PROLIFERATION 147 80 All SZGR 2.0 genes in this pathway
SCHUHMACHER MYC TARGETS UP 80 57 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
NUMATA CSF3 SIGNALING VIA STAT3 22 17 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532 309 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS DN 141 92 All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491 310 All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022 619 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673 430 All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME RED 16 11 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973 570 All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863 514 All SZGR 2.0 genes in this pathway
PARK APL PATHOGENESIS DN 50 35 All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 81 66 All SZGR 2.0 genes in this pathway
YAMASHITA LIVER CANCER WITH EPCAM UP 53 25 All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2 277 172 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 72 53 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN 336 211 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337 236 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-137 1828 1835 1A,m8 保险公司-miR-137 UAUUGCUUAAGAAUACGCGUAG
miR-139 1695 1701 1A 保险公司-miR-139brain UCUACAGUGCACGUGUCU
miR-15/16/195/424/497 1181 1188 1A,m8 保险公司-miR-15abrain UAGCAGCACAUAAUGGUUUGUG
保险公司-miR-16brain UAGCAGCACGUAAAUAUUGGCG
保险公司-miR-15bbrain UAGCAGCACAUCAUGGUUUACA
保险公司-miR-195SZ UAGCAGCACAGAAAUAUUGGC
保险公司-miR-424 CAGCAGCAAUUCAUGUUUUGAA
保险公司-miR-497 CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d 1104 1110 m8 保险公司-miR-17-5p CAAAGUGCUUACAGUGCAGGUAGU
保险公司-miR-20abrain UAAAGUGCUUAUAGUGCAGGUAG
保险公司-miR-106a AAAAGUGCUUACAGUGCAGGUAGC
保险公司-miR-106bSZ UAAAGUGCUGACAGUGCAGAU
保险公司-miR-20bSZ CAAAGUGCUCAUAGUGCAGGUAG
保险公司-miR-519d CAAAGUGCCUCCCUUUAGAGUGU
miR-182 221 227 1A 保险公司-miR-182 UUUGGCAAUGGUAGAACUCACA
miR-186 2199 2205 m8 保险公司-miR-186 CAAAGAAUUCUCCUUUUGGGCUU
miR-26 1240 1246 m8 保险公司-miR-26abrain UUCAAGUAAUCCAGGAUAGGC
保险公司-miR-26bSZ UUCAAGUAAUUCAGGAUAGGUU
miR-485-5p 251 257 m8 保险公司-miR-485-5p AGAGGCUGGCCGUGAUGAAUUC
miR-503 1182 1188 1A 保险公司-miR-503 UAGCAGCGGGAACAGUUCUGCAG
miR-9 223 229 1A 保险公司-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA
miR-96 221 227 1A 保险公司-miR-96brain UUUGGCACUAGCACAUUUUUGC