SZGR2 - Beplay体育中心

Summary？

基因	675
象征	BRCA2
Synonyms	BRCC2\|BROVCA2\|FACD\|FAD\|FAD1\|FANCD\|FANCD1\|GLM3\|PNCA2\|XRCC11
Description	breast cancer 2
Reference	MIM：600185\|HGNC：HGNC：1101\|Ensembl:ENSG00000139618\|HPRD：02554\|Vega:OTTHUMG00000017411
基因类型	蛋白质编码
Map location	13q12.3
Pascal p-value	0.808
胎儿β	2.008

Gene in Data Sources

基因集名称	Method of gene set	Description	信息
CV:PGCnp	Genome-wide Association Study	GWAS
PMID：cooccur	High-throughput literature-search	PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击显示详细信息
GO_Annotation	将与神经相关的关键字映射到基因本体论注释	与神经相关的关键字的命中：1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0542

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0003697	single-stranded DNA binding	IEA		-
去：0005515	蛋白质结合	IPI		9774970\|10373512\|11597317 \|12242698\|15930293 \|15967112\|16099937 \|16275750\|17515903
去：0004402	组蛋白乙酰转移酶活性	IDA		9824164
GO：0016563	transcription activator activity	IDA		9619837
GO:0043015	γ-微管蛋白结合	IPI		17286961
生物过程	去学期	证据	神经关键字	PubMed ID
去：0007420	brain development	IEA	大脑（GO期限：7）	-
GO:0001556	卵母细胞成熟	IEA		-
GO:0000724	double-strand break repair via homologous recombination	IEA		-
GO:0001833	inner cell mass cell proliferation	IEA		-
去：0006355	调节转录，DNA依赖性的调节	我知道了		9619837
GO:0007141	男性减数分裂i	IEA		-
去：0006310	DNA recombination	IEA		-
去：0008585	female gonad development	IEA		-
去：0006289	nucleotide-excision repair	IMP		16845393
GO:0007283	spermatogenesis	IEA		-
GO:0007090	regulation of S phase of mitotic cell cycle	nas		9774970
GO:0010225	response to UV-C	IEA		-
GO:0010165	response to X-ray	IEA		-
GO:0010332	对伽马辐射的响应	IEA		-
GO：0048478	复制叉保护	IEA		-
去：0007569	cell aging	IEA		-
去：0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IEA		-
GO:0033595	response to genistein	IDA		16434996
去：0033600	乳腺上皮细胞增殖的阴性调节	IDA		15930293
GO:0033205	细胞周期中的细胞因子	IDA		17286961
GO：0042771	DNA损伤响应，p53类介体的信号转导导致凋亡诱导	IEA		-
GO:0043009	chordate embryonic development	IEA		-
GO:0051298	中心体重复	IDA		17286961
GO：0051276	染色体组织	IEA		-
GO：0045931	有丝分裂细胞周期的正调控	IEA		-
GO：0043627	response to estrogen stimulus	IDA		8895509
Cellular component	去学期	证据	神经关键字	PubMed ID
GO:0005813	centrosome	IDA		17286961
去：0005634	nucleus	IDA		9560268\|9774970\|17286961
去：0005654	核质	经验		12606939
去：0005737	cytoplasm	IEA		-
GO:0033593	BRCA2-MAGE-D1复合物	IDA		15930293
GO:0030141	分泌颗粒	IDA		8589722

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
ATM	AT1 \| ATA \| ATC \| ATD \| ATDC \| ATE \| DKFZp781A0353 \| MGC74674 \| TEL1 \| TELO1	ataxia telangiectasia mutated	重构的复合物	Biogrid	15199141
ATR	frp1 \|mec1 \|sckl \|SCKL1	ataxia telangiectasia and Rad3 related	蛋白质肽	Biogrid	10608806
Bard1	-	BRCA1相关环域1	共纯化重构的复合物	Biogrid	14636569
BCCIP	TOK-1 \| TOK1	BRCA2和CDKN1A相互作用蛋白	-	HPRD,BioGRID	11313963
BRCA1	Brcai \|BRCC1 \|虹膜\|PSCP \|RNF53	breast cancer 1, early onset	-	HPRD,BioGRID	9774970
BRCA1	Brcai \|BRCC1 \|虹膜\|PSCP \|RNF53	breast cancer 1, early onset	BRCA1 interacts with BRCA2.	绑定	9774970
BRCC3	BRCC36 \|C6.1A \|CXORF53	BRCA1/BRCA2-containing complex, subunit 3	Affinity Capture-MS 亲和力捕获 - 韦斯特恩共纯化	Biogrid	14636569
布雷	BRCC4 \|BRCC45	大脑和生殖器官表达（TNFRSF1A调节器）	Affinity Capture-MS 亲和力捕获 - 韦斯特恩共纯化	Biogrid	14636569
BUB1B	bub1beta \|bubr1 \|bub1a \|mad3l \|SSK1 \|HBUBR1	苯二咪唑1同源β（酵母）不受抑制的萌芽	-	HPRD,BioGRID	10749118
C11orf30	Emsy \|FLJ90741 \|GL002	chromosome 11 open reading frame 30	-	HPRD,BioGRID	14651845
CHEK2	CDS1 \| CHK2 \| HuCds1 \| LFS2 \| PP1425 \| RAD53	CHK2 checkpoint homolog (S. pombe)	亲和力捕获 - 韦斯特恩	Biogrid	17525332
FANCD2	DKFZP762A223 \|FA-D2 \|FA4 \|FACD \|时尚\|Fad2 \|fancd \|FLJ23826	Fanconi贫血，互补组D2	亲和力捕获 - 韦斯特恩共定位 Two-hybrid	Biogrid	15115758\|15199141
FANCD2	DKFZP762A223 \|FA-D2 \|FA4 \|FACD \|时尚\|Fad2 \|fancd \|FLJ23826	Fanconi贫血，互补组D2	FANCD2与BRCA2相互作用。	绑定	15115758
狂欢	脸\|fae	Fanconi贫血，互补小组E	亲和力捕获 - 韦斯特恩	Biogrid	15199141
粉丝	FAG \| XRCC9	Fanconi贫血，互补小组G	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	12915460
粉丝	FAG \| XRCC9	Fanconi贫血，互补小组G	Fancg与BRCA2相互作用。	绑定	12915460
flna	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	Filamin A，α（肌动蛋白结合蛋白280）	-	HPRD,BioGRID	11602572
flna	ABP-280 \| ABPX \| DKFZp434P031 \| FLN \| FLN1 \| FMD \| MNS \| NHBP \| OPD \| OPD1 \| OPD2	Filamin A，α（肌动蛋白结合蛋白280）	BRCA2 interacts with hsFLNa.	绑定	11602572
HMG20B	Braf25 \|Braf35 \|FLJ26127 \|HMGX2 \|PP7706 \|Smarce1r \|Soxl \|PP8857	高动力组20B	-	HPRD,BioGRID	11207365
kat2b	CAF \| P \| P/CAF \| PCAF	K（赖氨酸）乙酰转移酶2B	-	HPRD,BioGRID	9824164
PLK1	PLK \| STPK13	polo样激酶1（果蝇）	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	12815053\|14647413
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	Affinity Capture-MS 亲和力捕获 - 韦斯特恩共定位共纯化重构的复合物 Two-hybrid	Biogrid	9126738\|9405383 \|9523196\|9560268 \|9774970\|9811893 \|11313963\|11477095 \|12408834\|12442171 \|12815053\|14580352 \|14636569\|15065660
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	-	HPRD	9126738\|12619154
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	BRCA2与RAD51相互作用。	绑定	9774970
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	BRCA2 interacts with Rad51.	绑定	9774970
RAD51	BRCC5 \|hrad51 \|HSRAD51 \|HST16930 \|rad51a \|reca	RAD51homolog (RecA homolog, E. coli) (S. cerevisiae)	BRCA2 interacts with an unspecified isoform of RAD51.	绑定	15800615
RPA1	HSSB \|repa1 \|RF-A \|RP-A \|RPA70	复制蛋白A1，70KDA	亲和力捕获 - 韦斯特恩重构的复合物	Biogrid	12527904
SHFM1	DSS1 \|ECD \|SEM1 \|SHFD1 \|SHSF1 \|SHFDG1	手/脚畸形（近视）1型	-	HPRD,BioGRID	10373512\|12228710
SMAD2	JV18 \| JV18-1 \| MADH2 \| MADR2 \| MGC22139 \| MGC34440 \| hMAD-2 \| hSMAD2	SMAD家庭成员2	亲和力捕获 - 韦斯特恩	Biogrid	12165866
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD家庭成员3	SMAD3 interacts with BRCA2.	绑定	12165866
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD家庭成员3	-	HPRD,BioGRID	12165866
STAT5A	MGF \| STAT5	signal transducer and activator of transcription 5A	-	HPRD,BioGRID	12459499
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	肿瘤蛋白p53	-	HPRD,BioGRID	9811893

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
KEGG HOMOLOGOUS RECOMBINATION	28	17	All SZGR 2.0 genes in this pathway
癌症中的KEGG途径	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
Biocarta Atrbrca途径	21	12	All SZGR 2.0 genes in this pathway
PID FANCONI PATHWAY	47	28	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID ATR途径	39	25	All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY	40	30	All SZGR 2.0 genes in this pathway
PID DELTA NP63 PATHWAY	47	34	All SZGR 2.0 genes in this pathway
Reactome减数分裂	116	81	All SZGR 2.0 genes in this pathway
REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	17	11	All SZGR 2.0 genes in this pathway
Reactome Fanconi贫血途径	25	11	All SZGR 2.0 genes in this pathway
Reactome Double Strand Break修复	24	14	All SZGR 2.0 genes in this pathway
Reactome DNA修复	112	59	All SZGR 2.0 genes in this pathway
Reactome减数分裂重组	86	62	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血红斑dn	493	298	All SZGR 2.0 genes in this pathway
GAZDA钻石黑芬贫血祖先DN	66	42	All SZGR 2.0 genes in this pathway
Odonnell TFRC靶向DN	139	76	All SZGR 2.0 genes in this pathway
MYC和TFRC DN的ODONNELL目标	45	25	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
多德鼻咽癌DN	1375	806	All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性	722	443	All SZGR 2.0 genes in this pathway
Markey RB1慢性洛夫	115	78	All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN	228	137	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
Mathew Fanconi贫血基因	11	7	All SZGR 2.0 genes in this pathway
Schlosser血清反应	134	93	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
Pujana乳腺癌点燃int网络	101	73	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT网络	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络	1652	1023	All SZGR 2.0 genes in this pathway
Pujana BRCA2 PCC网络	423	265	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络	779	480	All SZGR 2.0 genes in this pathway
Pujana BRCA中心网络	117	72	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN	1024	594	All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标	230	156	All SZGR 2.0 genes in this pathway
Mir192和Mir215的Georges目标	893	528	All SZGR 2.0 genes in this pathway
Kauffmann DNA修复基因	230	137	All SZGR 2.0 genes in this pathway
Onder CDH1目标1 DN	169	102	All SZGR 2.0 genes in this pathway
黑川肝癌化学疗法DN	41	28	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
YU MYC TARGETS UP	42	26	All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS	50	33	All SZGR 2.0 genes in this pathway
Zhu CMV全部	120	89	All SZGR 2.0 genes in this pathway
CHIBA RESPONSE TO TSA DN	23	14	All SZGR 2.0 genes in this pathway
ZHU CMV 8 HR UP	47	39	All SZGR 2.0 genes in this pathway
由E2F4绑定的Marson未刺激	728	415	All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默	461	298	All SZGR 2.0 genes in this pathway
MATZUK精子细胞	72	55	All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码	323	240	All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP	1305	895	All SZGR 2.0 genes in this pathway
Chang Core血清反应	212	128	All SZGR 2.0 genes in this pathway
霍夫曼大到小淋巴细胞向上	163	102	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6	456	285	All SZGR 2.0 genes in this pathway
Yagi AML带有Inv 16易位	422	277	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
惠特菲尔德细胞周期文献	44	25	All SZGR 2.0 genes in this pathway
Browne HCMV感染30分钟DN	150	99	All SZGR 2.0 genes in this pathway
Dutertre雌二醇反应24小时	324	193	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向DN	553	343	All SZGR 2.0 genes in this pathway
ewsr1 fli1融合DN的TORCHIA目标	321	200	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP	570	339	All SZGR 2.0 genes in this pathway
ERBB2同工型的Pedersen转移7	403	240	All SZGR 2.0 genes in this pathway

Gene Page:BRCA2