Gene Page:STAT2
概括?
| 基因 | 6773 |
| Symbol | STAT2 |
| Synonyms | IMD44 | ISGF-3 | P113 | Stat113 |
| Description | 转录2的信号换能器和激活剂2 |
| Reference | MIM:600556|HGNC:HGNC:11363|ENSEMBL：ENSG00000170581|HPRD:02778|Vega:OTTHUMG00000170760 |
| Gene type | protein-coding |
| Map location | 12q13.3 |
| Pascal p-value | 0.038 |
| Sherlock p-value | 0.577 |
| eGene | Myers' cis & trans |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
eQTL annotation| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs4436485 | chr10 | 103245360 | STAT2 | 6773 | 0.09 | trans | ||
| rs2796843 | chr13 | 51240181 | STAT2 | 6773 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PLCB2 | 0.64 | 0.57 |
| ARHGAP4 | 0.62 | 0.60 |
| MPPE1 | 0.59 | 0.52 |
| EXOC3L | 0.58 | 0.56 |
| LRRC56 | 0.57 | 0.59 |
| RRP7A | 0.56 | 0.58 |
| PPP1R16A | 0.56 | 0.63 |
| ACAP1 | 0.56 | 0.42 |
| DUSP15 | 0.55 | 0.47 |
| RFNG | 0.55 | 0.59 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.27 | -0.34 | -0.34 |
| MT-ATP8 | -0.34 | -0.35 |
| AF347015.31 | -0.34 | -0.32 |
| AF347015.2 | -0.32 | -0.34 |
| AF347015.21 | -0.31 | -0.30 |
| AF347015.8 | -0.31 | -0.30 |
| AF347015.33 | -0.31 | -0.31 |
| AL139819.3 | -0.30 | -0.34 |
| MT-CO2 | -0.29 | -0.29 |
| AF347015.15 | -0.29 | -0.30 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| CREBBP | CBP | KAT3A | RSTS | CREB binding protein | - | HPRD,BioGRID | 8848048|10464260 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | Reconstituted Complex | BioGRID | 10464260 |
| EP300 | KAT3B | p300 | E1A binding protein p300 | Stat2 interacts with p300. | BIND | 10464260 |
| IFNAR1 | AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC | interferon (alpha, beta and omega) receptor 1 | Affinity Capture-Western Reconstituted Complex |
BioGRID | 7559568|8605876 |9121453 |
| IFNAR1 | AVP | IFN-alpha-REC | IFNAR | IFNBR | IFRC | interferon (alpha, beta and omega) receptor 1 | - | HPRD | 7559568|8605876|11786546 |
| IFNAR2 | IFN-R | IFN-alpha-REC | IFNABR | IFNARB | interferon (alpha, beta and omega) receptor 2 | - | HPRD,BioGRID | 9121453|11786546 |
| IRF9 | IRF-9 | ISGF3 | ISGF3G | p48 | 干扰素调节因子9 | - | HPRD,BioGRID | 9242679 |
| IRF9 | IRF-9 | ISGF3 | ISGF3G | p48 | 干扰素调节因子9 | STAT2与P48相互作用。这种相互作用是基于未指定物种与人P48的STAT2之间的相互作用建模的。 | BIND | 8943351 |
| MED14 | CRSP150 | CRSP2 | CSRP | CXorf4 | DRIP150 | EXLM1 | MGC104513 | RGR1 | TRAP170 | mediator complex subunit 14 | - | HPRD,BioGRID | 12509459 |
| SMARCA4 | BAF190 |BRG1 |FLJ39786 |SNF2 |snf2-beta |snf2l4 |SNF2LB |swi2 |HSNF2B | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | - | HPRD,BioGRID | 12244326 |
| SMARCC1 | BAF155 | CRACC1 | Rsc8 | SRG3 | SWI3 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | Affinity Capture-Western | BioGRID | 12244326 |
| SMARCC2 | BAF170 | CRACC2 | Rsc8 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | Affinity Capture-Western | BioGRID | 12244326 |
| SMARCE1 | BAF57 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 | Affinity Capture-Western | BioGRID | 12244326 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | STAT1与STAT2交互。 | BIND | 15467722 |
| STAT1 | DKFZp686B04100 | ISGF-3 | STAT91 | signal transducer and activator of transcription 1, 91kDa | - | HPRD,BioGRID | 8621447|10446176 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CHEMOKINE SIGNALING PATHWAY | 190 | 128 | 该途径中的所有SZGR 2.0基因 |
| KEGG JAK STAT SIGNALING PATHWAY | 155 | 105 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA BIOPEPTIDES PATHWAY | 45 | 35 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA EGF PATHWAY | 31 | 25 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA IL10 PATHWAY | 17 | 14 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA IL22BP PATHWAY | 16 | 12 | 该途径中的所有SZGR 2.0基因 |
| BIOCARTA PDGF PATHWAY | 32 | 25 | 该途径中的所有SZGR 2.0基因 |
| ST TYPE I INTERFERON PATHWAY | 9 | 8 | 该途径中的所有SZGR 2.0基因 |
| PID IL27 PATHWAY | 26 | 20 | 该途径中的所有SZGR 2.0基因 |
| PID CXCR4 PATHWAY | 102 | 78 | 该途径中的所有SZGR 2.0基因 |
| REACTOME INTERFERON ALPHA BETA SIGNALING | 64 | 50 | 该途径中的所有SZGR 2.0基因 |
| IFNA信号的反应组调节 | 24 | 22 | 该途径中的所有SZGR 2.0基因 |
| REACTOME INTERFERON SIGNALING | 159 | 116 | 该途径中的所有SZGR 2.0基因 |
| REACTOME IMMUNE SYSTEM | 933 | 616 | 该途径中的所有SZGR 2.0基因 |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | 该途径中的所有SZGR 2.0基因 |
| BARRIER COLON CANCER RECURRENCE DN | 20 | 16 | 该途径中的所有SZGR 2.0基因 |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D UP | 182 | 110 | 该途径中的所有SZGR 2.0基因 |
| KINSEY TARGETS OF EWSR1 FLII FUSION DN | 329 | 219 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | 该途径中的所有SZGR 2.0基因 |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | 该途径中的所有SZGR 2.0基因 |
| STREICHER LSM1 TARGETS UP | 44 | 34 | 该途径中的所有SZGR 2.0基因 |
| AUNG GASTRIC CANCER | 54 | 20 | 该途径中的所有SZGR 2.0基因 |
| DAUER STAT3 TARGETS UP | 49 | 35 | 该途径中的所有SZGR 2.0基因 |
| YAN ESCAPE FROM ANOIKIS | 24 | 19 | 该途径中的所有SZGR 2.0基因 |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | 该途径中的所有SZGR 2.0基因 |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | 该途径中的所有SZGR 2.0基因 |
| GARCIA TARGETS OF FLI1 AND DAX1 UP | 57 | 34 | 该途径中的所有SZGR 2.0基因 |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | 该途径中的所有SZGR 2.0基因 |
| MARIADASON RESPONSE TO BUTYRATE SULINDAC 6 | 52 | 32 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | 该途径中的所有SZGR 2.0基因 |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | 该途径中的所有SZGR 2.0基因 |
| WORSCHECH TUMOR REJECTION UP | 56 | 32 | 该途径中的所有SZGR 2.0基因 |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | 该途径中的所有SZGR 2.0基因 |
| BOCHKIS FOXA2 TARGETS | 425 | 261 | 该途径中的所有SZGR 2.0基因 |
| QI PLASMACYTOMA DN | 100 | 63 | 该途径中的所有SZGR 2.0基因 |
| HOFMANN MYELODYSPLASTIC SYNDROM HIGH RISK DN | 20 | 13 | 该途径中的所有SZGR 2.0基因 |
| HOFMANN MYELODYSPLASTIC SYNDROM RISK DN | 23 | 12 | 该途径中的所有SZGR 2.0基因 |
| ZHAN MULTIPLE MYELOMA LB DN | 44 | 23 | 该途径中的所有SZGR 2.0基因 |
| CHANDRAN METASTASIS DN | 306 | 191 | 该途径中的所有SZGR 2.0基因 |
| WANG RESPONSE TO GSK3 INHIBITOR SB216763 UP | 397 | 206 | 该途径中的所有SZGR 2.0基因 |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | 该途径中的所有SZGR 2.0基因 |
| PURBEY联合体的目标1 NOT SATB1 UP | 344 | 215 | 该途径中的所有SZGR 2.0基因 |
| YANG BCL3 TARGETS UP | 364 | 236 | 该途径中的所有SZGR 2.0基因 |
| BOSCO INTERFERON INDUCED ANTIVIRAL MODULE | 78 | 48 | 该途径中的所有SZGR 2.0基因 |
| ALTEMEIER RESPONSE TO LPS WITH MECHANICAL VENTILATION | 128 | 81 | 该途径中的所有SZGR 2.0基因 |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | 该途径中的所有SZGR 2.0基因 |