SZGR2 - Beplay体育中心

Summary?

基因ID	6774
象征	STAT3
同义词s	Admio \| Aprf \| Hies
Description	signal transducer and activator of transcription 3 (acute-phase response factor)
Reference	MIM:102582\|HGNC：HGNC：11364\|ENSEMBL：ENSG00000168610\|HPRD：00026\|Vega：Otthumg00000150645
基因类型	protein-coding
Map location	17q21.31
Pascal P值	0.128
Sherlock p-value	0.172
Fetal beta	-1.162
DMG	1 (# studies)
eGene	Myers' cis & trans

基因in Data Sources

基因set name	基因组方法	Description	Info
简历：PGCNP	Genome-wide Association Study	GWAS
简历：Phewas	Phenome-wide association studies (PheWAS)	157个与精神分裂症相关的SNP	1
DMG：Vaneijk_2014	Genome-wide DNA methylation analysis	该数据集包括432个差异甲基化的CpG位点，对应于精神分裂症患者（n = 260）和未受影响的对照（n = 250）之间的391个独特的转录本。	2
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	点击to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	与神经相关的关键字的命中：1
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.046

Section I. Genetics and epigenetics annotation

简历：Phewas

SNP ID	Chromosome	位置	等位基因	P	Function	基因	Up/Down Distance
RS744166	17	40514201	无效的	1.495	STAT3	无效的

Differentially methylated gene

Probe	Chromosome	位置	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg13053608	17	40345673	STAT3	1.15e-5	-3.526		DMG：Vaneijk_2014
cg25687894	17	40075716	STAT3	3.09E-5	-5.732		DMG：Vaneijk_2014

eQTL annotation

SNP ID	Chromosome	位置	eGene	基因Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs16859370	CHR2	172240162	STAT3	6774		0.13		trans

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
基因	皮尔逊的相关性	斯皮尔曼的相关性
SPG20	0.87	0.82
ATG4C	0.87	0.85
RNF13	0.87	0.85
LAMP2	0.85	0.85
LIPA	0.85	0.85
MOSPD2	0.85	0.77
REEP3	0.84	0.78
TTC35	0.84	0.88
KIAA0494	0.83	0.82
GCLC	0.82	0.82

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
SH2B2	-0.51	-0.57
SH3BP2	-0.50	-0.54
HYAL2	-0.49	-0.56
traf4	-0.47	-0.51
CCDC28B	-0.46	-0.53
KIAA1949	-0.46	-0.39
C21orf30	-0.46	-0.38
WDR86	-0.46	-0.47
ISLR2	-0.45	-0.28
PAFAH1B3	-0.45	-0.43

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	IEA		-
GO:0003700	transcription factor activity	IEA		-
GO:0003700	transcription factor activity	TAS		7512451\|8675499
GO:0005062	hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity	TAS		7512451
GO:0005509	calcium ion binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0008134	transcription factor binding	IPI		15664994
Biological process	去的术语	Evidence	Neuro keywords	PubMed ID
去：0007399	nervous system development	TAS	神经突（GO期限：5）	10205054
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS		8675499
去：0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0007259	JAK-STAT cascade	TAS		15664994
去：0007165	signal transduction	IEA		-
去：0007165	signal transduction	TAS		7512451\|10205054
GO:0006928	细胞运动	TAS		9670957
GO:0019221	细胞因子介导的信号通路	nas		15664994
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	艾达		12444102
GO:0005634	nucleus	IEA		-
GO:0005730	nucleolus	艾达		18029348
GO:0005737	cytoplasm	TAS		7512451

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	Experimental	Source	PubMed ID
A2M	CPAMD5 \| DKFZp779B086 \| FWP007 \| S863-7	alpha-2-macroglobulin	STAT3的未指定同工型结合APRE。	BIND	15950906
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	-	HPRD,BioGRID	11751884
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	基本的螺旋 - 环螺旋域，包含B类，2	-	HPRD	15223310
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	基本的螺旋 - 环螺旋域，包含B类，2	STRA13 interacts with STAT3-beta.	BIND	15223310
BHLHB2	DEC1 \| SHARP-2 \| STRA13 \| Stra14 \| bHLHe40	基本的螺旋 - 环螺旋域，包含B类，2	STRA13 interacts with STAT3-alpha.	BIND	15223310
BMX	ETK \| PSCTK2 \| PSCTK3	BMX非受体酪氨酸激酶	-	HPRD,BioGRID	10688651
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	breast cancer 1, early onset	-	HPRD	11163768
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	Cyclin D1	An unspecified isoform of STAT3 binds to Cyclin D1 promoter.	BIND	15950906
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	Cyclin D1	-	HPRD,BioGRID	11279133
CCR2	CC-CKR-2 \| CCR2A \| CCR2B \| CD192 \| CKR2 \| CKR2A \| CKR2B \| CMKBR2 \| MCP-1-R	趋化因子（C-C基序）受体2	Affinity Capture-Western	BioGRID	11350939
CCR5	CC-CKR-5 \| CCCKR5 \| CD195 \| CKR-5 \| CKR5 \| CMKBR5	趋化因子（C-C基序）受体5	Affinity Capture-Western	BioGRID	11350939
CDKN1A	CAP20 \| CDKN1 \| CIP1 \| MDA-6 \| P21 \| SDI1 \| WAF1 \| p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	-	HPRD,BioGRID	10764767
CREBBP	CBP \|kat3a \|RST	CREB binding protein	Affinity Capture-Western	BioGRID	11239394
CREBBP	CBP \|kat3a \|RST	CREB binding protein	STAT3通过CBP乙酰化。这种相互作用是根据未指定物种的人类STAT3和CBP之间的相互作用进行建模的。	BIND	15653507
EGFR	ERBB \|ERBB1 \|her1 \|PIG61 \|梅纳	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-Western	BioGRID	10358079\|15485908
EGFR	ERBB \|ERBB1 \|her1 \|PIG61 \|梅纳	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Tyrosine phophorylated EGFR interacts with STAT3.	BIND	12873986
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD,BioGRID	11350938
ELP2	FLJ10879 \|Shinc-2 \|Statip1 \|Stip	elongation protein 2 homolog (S. cerevisiae)	-	HPRD,BioGRID	10954736
EP300	kat3b \|P300	E1A binding protein p300	STAT3与P300相互作用。	BIND	15653507
EP300	kat3b \|P300	E1A binding protein p300	-	HPRD,BioGRID	10205054
EPHA5	Cek7 \|EHK1 \|hek7 \|Tyro4	EPH receptor A5	Affinity Capture-Western	BioGRID	15485908
ERBB2	CD340 \|her-2 \|her-2/neu \|her2 \|neu \|ngl \|TKR1	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	Affinity Capture-Western	BioGRID	11940572
ESR1	DKFZp686N23123 \| ER \| ESR \| ESRA \| Era \| NR3A1	estrogen receptor 1	Affinity Capture-Western	BioGRID	11429412
FER	tyk3	fer (fps/fes related) tyrosine kinase	-	HPRD	10878010
FER	tyk3	fer (fps/fes related) tyrosine kinase	-	HPRD	10878010\|12738762
FES	FPS	feline sarcoma oncogene	-	HPRD,BioGRID	9714332
FOS	AP-1 \| C-FOS	V-FOS FBJ鼠骨肉瘤病毒性癌基因同源物	An unspecified isoform of STAT3 binds to c-fos promoter.	BIND	15950906
FOXM1	FKHL16 \| FOXM1B \| HFH-11 \| HFH11 \| HNF-3 \| INS-1 \| MPHOSPH2 \| MPP-2 \| MPP2 \| PIG29 \| TGT3 \| TRIDENT	forkhead box M1	-	HPRD	11861839
frap1	FLJ44809 \| FRAP \| FRAP2 \| MTOR \| RAFT1 \| RAPT1	FK506 binding protein 12-rapamycin associated protein 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10660304\|15522880
GHR	GHBP	生长激素受体	-	HPRD,BioGRID	8923468
gtf2i	BAP-135 \| BAP135 \| BTKAP1 \| DIWS \| FLJ38776 \| FLJ56355 \| IB291 \| SPIN \| TFII-I \| WBS \| WBSCR6	general transcription factor II, i	-	HPRD,BioGRID	9584171
HDAC1	DKFZp686H12203 \| GON-10 \| HD1 \| RPD3 \| RPD3L1	histone deacetylase 1	Stat3 interacts with HDAC1.	BIND	15653507
HDAC2	RPD3 \|YAF1	histone deacetylase 2	Stat3 interacts with HDAC2.	BIND	15653507
HDAC3	HD3 \|RPD3 \|RPD3-2	histone deacetylase 3	Stat3 interacts with HDAC3.	BIND	15653507
HNF1A	HNF1 \|LFB1 \|Mody3 \|TCF1	HNF1 homeobox A	-	HPRD,BioGRID	11134330
HSP90AA1	FLJ31884 \|HSP86 \|HSP89A \|HSP90A \|HSP90N \|HSPC1 \|HSPCA \|HSPCAL1 \|HSPCAL4 \|HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	-	HPRD,BioGRID	12559950
IFNAR1	AVP \| IFN-alpha-REC \| IFNAR \| IFNBR \| IFRC	interferon (alpha, beta and omega) receptor 1	-	HPRD,BioGRID	8626489
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	白介素1受体配件蛋白	-	HPRD,BioGRID	9923604
IL23R	-	白介素23受体	-	HPRD	12023369
IL2RA	CD25 \| IDDM10 \| IL2R \| TCGFR	白介素2受体，α	-	HPRD	10602027
IL2RB	CD122 \| P70-75	interleukin 2 receptor, beta	-	HPRD,BioGRID	10602027
IL6R	CD126 \| IL-6R-1 \| IL-6R-alpha \| IL6RA \| MGC104991	interleukin 6 receptor	-	HPRD,BioGRID	10982829
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	-	HPRD,BioGRID	12361954
IL6ST	CD130 \| CDw130 \| GP130 \| GP130-RAPS \| IL6R-beta	interleukin 6 signal transducer (gp130, oncostatin M receptor)	gp130 interacts with an unspecified isoform of Stat3.	BIND	12361954
JAK1	JAK1A \| JAK1B \| JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD,BioGRID	11722592
JAK2	JTK10	Janus kinase 2 (a protein tyrosine kinase)	-	HPRD	10925297
JAK3	jak-3 \|jak3_human \|jakl \|l-jak \|ljak	Janus kinase 3 (a protein tyrosine kinase, leukocyte)	-	HPRD,BioGRID	10037026
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	10490649
Kat5	esa1 \|htatip \|htatip1 \|plip \|提示\|TIP60 \|CPLA2	K(lysine) acetyltransferase 5	-	HPRD,BioGRID	12551922
KHDRBS1	FLJ34027 \| Sam68 \| p62	KH结构域含有RNA结合，信号转导相关1	-	HPRD,BioGRID	11585385
LCK	YT16 \| p56lck \| pp58lck	淋巴细胞特异性蛋白酪氨酸激酶	-	HPRD	10825200
LEP	FLJ94114 \| OB \| OBS	瘦素	Reconstituted Complex	BioGRID	12824284
LEPR	CD295 \| OBR	瘦素receptor	-	HPRD	8608603
MET	AUTS9 \| HGFR \| RCCP2 \| c-Met	met proto-oncogene (hepatocyte growth factor receptor)	-	HPRD,BioGRID	9440692
MYOD1	MYF3 \| MYOD \| PUM \| bHLHc1	myogenic differentiation 1	-	HPRD,BioGRID	12947115
NCOA1	F-SRC-1 \| KAT13A \| MGC129719 \| MGC129720 \| NCoA-1 \| RIP160 \| SRC-1 \| SRC1 \| bHLHe42	nuclear receptor coactivator 1	-	HPRD,BioGRID	11773079
NDUFA13	B16.6 \| CDA016 \| CGI-39 \| GRIM-19 \| GRIM19	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	GRIM-19 interacts with Stat3.	BIND	12628925
NDUFA13	B16.6 \| CDA016 \| CGI-39 \| GRIM-19 \| GRIM19	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13	-	HPRD,BioGRID	12867595
NFKB1	DKFZp686C01211 \| EBP-1 \| KBF1 \| MGC54151 \| NF-kappa-B \| NFKB-p105 \| NFKB-p50 \| p105	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	-	HPRD,BioGRID	12057007
NLK	DKFZp761G1211 \| FLJ21033	nemo-like kinase	-	HPRD	15764709
NMI	-	N-myc (and STAT) interactor	Nmi interacts with Stat3	BIND	9989503
NMI	-	N-myc (and STAT) interactor	-	HPRD,BioGRID	9989503
NR3C1	GCCR \| GCR \| GR \| GRL	核受体亚科3，C组，成员1（糖皮质激素受体）	-	HPRD,BioGRID	9388192\|14522952
PDIA3	ER60 \| ERp57 \| ERp60 \| ERp61 \| GRP57 \| GRP58 \| HsT17083 \| P58 \| PI-PLC	蛋白质二硫化物异构酶家族A，成员3	-	HPRD,BioGRID	12060494
PIAS3	FLJ14651 \| ZMIZ5	活化统计的蛋白质抑制剂3	-	HPRD	11429412\|12804609
PIAS3	FLJ14651 \| ZMIZ5	活化统计的蛋白质抑制剂3	-	HPRD,BioGRID	11429412
PML	MYL \| PP8675 \| RNF71 \| TRIM19	Promyelocytic白血病	-	HPRD,BioGRID	12506013
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	An unspecified isoform of PKC-beta interacts with Stat3.	BIND	10446219
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	PKC-delta interacts with Stat3.	BIND	10446219
PTK2	Fadk \|fak \|fak1 \|pp125fak	PTK2 protein tyrosine kinase 2	Affinity Capture-Western	BioGRID	10925297
PTPN11	bptp3 \|CFC \|MGC14433 \|NS1 \|PTP-1D \|PTP2C \|SH-PTP2 \|sh-ptp3 \|SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD,BioGRID	11594781
PTPN2	PTPT \| TC-PTP \| TCELLPTP \| TCPTP	蛋白质酪氨酸磷酸酶，非受体2型	-	HPRD,BioGRID	12359225
RAC1	MGC111543 \| MIG5 \| TC-25 \| p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	-	HPRD,BioGRID	11021801
RELA	MGC131774 \| NFKB3 \| p65	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	-	HPRD,BioGRID	12057007
RET	CDHF12 \|HSCR1 \|men2a \|men2b \|mtc1 \|PTC \|ret-ele1 \|RET51	ret proto-oncogene	-	HPRD,BioGRID	11536047\|12637586 \|15485908
RPA2	repa2 \|RPA32	复制蛋白A2, 32 kda	-	HPRD,BioGRID	10875894
SMAD1	BSP1 \| JV4-1 \| JV41 \| MADH1 \| MADR1	SMAD family member 1	Affinity Capture-Western	BioGRID	10205054
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	8657134
STAP2	bks \|FLJ20234	signal transducing adaptor family member 2	-	HPRD	12540842
STAT1	DKFZp686B04100 \| ISGF-3 \| STAT91	signal transducer and activator of transcription 1, 91kDa	-	HPRD,BioGRID	12070153
STAT3	APRF \| FLJ20882 \| HIES \| MGC16063	signal transducer and activator of transcription 3 (acute-phase response factor)	Stat3 interacts with itself to form a homodimer.	BIND	15653507
SYK	DKFZp313N1010 \| FLJ25043 \| FLJ37489	spleen tyrosine kinase	-	HPRD	10825200
Trip10	CIP4 \| HSTP \|小公牛\| STP	thyroid hormone receptor interactor 10	Affinity Capture-Western Reconstituted Complex	BioGRID	15163742
TSHR	chng1 \|lgr3 \|MGC75129 \|htshr-i	甲状腺刺激激素受体	-	HPRD,BioGRID	10809230
TSLP	-	thymic stromal lymphopoietin	-	HPRD	10570284\|11418668
ZNF467	EZI \| Zfp467	锌指蛋白467	-	HPRD	12426389

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY	67	57	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG PANCREATIC CANCER	70	56	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
BIOCARTA ERK PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IL6 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
BIOCARTA IL22BP PATHWAY	16	12	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
Biocarta Her2途径	22	17	All SZGR 2.0 genes in this pathway
BIOCARTA MET PATHWAY	37	30	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
st g alpha i路径	35	29	All SZGR 2.0 genes in this pathway
ST STAT3 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
PID GMCSF PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY	26	20	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID IL12 2 Pathway	63	54	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID HDAC Classi途径	66	50	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY	35	29	All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY	40	34	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID ERBB2 ERBB3途径	44	35	All SZGR 2.0 genes in this pathway
PID IL6 7途径	47	40	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY	62	48	All SZGR 2.0 genes in this pathway
PID IL23途径	37	30	All SZGR 2.0 genes in this pathway
PID套件途径	52	40	All SZGR 2.0 genes in this pathway
PID RAC1 PATHWAY	54	37	All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY	48	39	All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY	33	29	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	19	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS	30	20	All SZGR 2.0 genes in this pathway
FGFR1融合突变体的反应组信号传导	19	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导	122	93	All SZGR 2.0 genes in this pathway
Reactome下游信号转导	95	76	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL 6 SIGNALING	11	9	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
钟对偶氮替丁的反应和tsa	183	119	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
乳腺癌腔与基础DN	455	304	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
奥斯曼膀胱癌DN	406	230	All SZGR 2.0 genes in this pathway
HUMMEL BURKITTS LYMPHOMA DN	15	10	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS UP	293	179	All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 DN	51	35	All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶标C向上	170	114	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN	394	258	All SZGR 2.0 genes in this pathway
Johansson神经胶质作用是PDGFB	58	44	All SZGR 2.0 genes in this pathway
NUNODA RESPONSE TO DASATINIB IMATINIB UP	29	20	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP	181	108	All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP	88	58	All SZGR 2.0 genes in this pathway
Rashi对电离辐射2的响应2	127	92	All SZGR 2.0 genes in this pathway
Schlosser血清反应	134	93	All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS UP	49	35	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲DN	584	395	All SZGR 2.0 genes in this pathway
ozen mir125b1靶标	25	15	All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS	988	594	All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS	290	172	All SZGR 2.0 genes in this pathway
Benporath SOX2目标	734	436	All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS	179	105	All SZGR 2.0 genes in this pathway
UEDA中央时钟	88	62	All SZGR 2.0 genes in this pathway
brocke凋亡由IL6逆转	144	98	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP	555	346	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP	87	67	All SZGR 2.0 genes in this pathway
ABBUD LIF SIGNALING 1 UP	46	29	All SZGR 2.0 genes in this pathway
kaab失败的心房DN	141	99	All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER	49	30	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART VENTRICLE DN	41	28	All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS DN	96	71	All SZGR 2.0 genes in this pathway
Gerhold脂肪形成	49	40	All SZGR 2.0 genes in this pathway
Hillion HMGA1目标	90	71	All SZGR 2.0 genes in this pathway
Hillion HMGA1B目标	92	68	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞DN	409	268	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY UV	62	43	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
Sarrio上皮间质转变DN	154	101	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
OUYANG PROSTATE CANCER PROGRESSION UP	20	14	All SZGR 2.0 genes in this pathway
MATZUK CENTRAL FOR FEMALE FERTILITY	29	25	All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟C	69	49	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS DN	207	139	All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP	242	159	All SZGR 2.0 genes in this pathway
Gabriely miR21靶标	289	187	All SZGR 2.0 genes in this pathway
CARD MIR302A TARGETS	77	62	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN	116	74	All SZGR 2.0 genes in this pathway
Kasler HDAC7靶向1个	194	133	All SZGR 2.0 genes in this pathway
FEVR CTNNB1靶向	682	433	All SZGR 2.0 genes in this pathway
PEDRIOLI MIR31 TARGETS UP	221	120	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL	160	106	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	目标位置			miRNA ID	miRNA seq
mirna家族	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-124.1	1209	1215	M8	HSA-MIR-124A	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	1208	1215	1A,m8	HSA-MIR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	1208	1215	1A,m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-125/351	1438	1445	1A,m8	hsa-miR-125b^brain	UCCCUGAGACCCUAACUUGUGA
miR-125/351	1438	1445	1A,m8	hsa-miR-125a^brain	ucccugagacccuuaaccugug
mir-17-5p/20/93.mr/106/519.D	448	454	M8	HSA-MIR-17-5P	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	caaagugcuugugcagguag
				hsa-miR-519d	caaagugccucccuuuagugugu
miR-21	1946	1952	M8	hsa-miR-21^brain	UAGCUUAUCAGACUGAUGUUGA
miR-21	1946	1952	M8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
miR-410	2405	2412	1A,m8	hsa-miR-410	aauauaacacagauggcugu

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击hereto see the list of brain related miRNAs.

基因Page:STAT3