SZGR2 - Beplay体育中心

Summary?

基因	6776
象征	Stat5a
同义词	MGF\|STAT5
描述	信号换能器和转录5a激活剂
参考	MIM:601511\|HGNC：HGNC：11366\|Ensembl:ENSG00000126561\|HPRD:03301\|Vega:OTTHUMG00000150725
Gene type	protein-coding
地图位置	17q11.2
Pascal P值	0.527
Sherlock P值	0.077
Fetal beta	-0.912
DMG	1（＃研究）
eGene	Nucleus accumbens basal ganglia 迈尔斯的顺式和跨性别

Gene in Data Sources

Gene set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
网络	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.2058

Section I. Genetics and epigenetics annotation

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
CG12259792	17	40442580	Stat5a	4.685E-4	-0.275	0.046	DMG:Wockner_2014

EQTL注释

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	PVALUE	qvalue	TSS distance	eQTL type
rs9431457	chr1	221425020	Stat5a	6776		0.15		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

大脑区域没有共表达基因

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0004871	signal transducer activity	IEA		-
去：0003700	transcription factor activity	塔斯		7719937\|8631883
GO:0005509	calcium ion binding	IEA		-
GO:0005515	protein binding	新闻学会		16819511
生物过程	去的术语	Evidence	Neuro keywords	PubMed ID
去：0001553	luteinization	IEA		-
去：0001779	natural killer cell differentiation	IEA		-
去：0007259	Jak-Stat Cascade	塔斯		7719937
去：0007165	signal transduction	IEA		-
去：0008284	细胞增殖的阳性调节	IEA		-
去:0019915	脂质的隔离	IEA		-
去：0007595	lactation	IEA		-
去：0007565	female pregnancy	IEA		-
GO:0043066	凋亡的负调节	IEA		-
去：0030155	regulation of cell adhesion	IEA		-
GO：0042104	positive regulation of activated T cell proliferation	IEA		-
GO:0040018	多细胞生物生长的阳性调节	IEA		-
GO:0030879	乳腺发育	IEA		-
GO:0030856	调节上皮细胞分化	IEA		-
GO：0019218	类固醇代谢过程的调节	IEA		-
GO：0019221	细胞因子介导的信号通路	IEA		-
去：0043029	T细胞稳态	IEA		-
GO:0045579	B细胞分化的阳性调节	IEA		-
GO：0045647	negative regulation of erythrocyte differentiation	IEA		-
GO：0045885	positive regulation of survival gene product expression	IEA		-
GO:0045931	positive regulation of mitotic cell cycle	IEA		-
GO:0045944	积极的监管transcription from RNA polymerase II promoter	IEA		-
GO：0050729	炎症反应的积极调节	IEA		-
GO:0045086	positive regulation of interleukin-2 biosynthetic process	IEA		-
GO:0046543	development of secondary female sexual characteristics	IEA		-
GO:0046544	development of secondary male sexual characteristics	IEA		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005634	核	IEA		-
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BMX	ETK \| PSCTK2 \| PSCTK3	BMX非受体酪氨酸激酶	-	HPRD	9373245
BRCA1	BRCAI \| BRCC1 \| IRIS \| PSCP \| RNF53	乳腺癌1，早发	-	HPRD，Biogrid	12459499
BRCA2	BRCC2 \| FACD \| FAD \| FAD1 \| FANCB \| FANCD \| FANCD1	乳腺癌2，早发	-	HPRD，Biogrid	12459499
CCND2	KIAK0002 \| MGC102758	细胞周期蛋白D2	Stat5ainteracts with Cyclin D2 promoter.	BIND	15735688
CD247	CD3-ZETA \| CD3H \| CD3Q \| CD3Z \| T3Z \| TCRZ	CD247分子	-	HPRD，Biogrid	9880255
CEBPB	C/EBP-beta \|CRP2 \|IL6DBP \|圈\|MGC32080 \|nf-il6 \|TCF5	CCAAT/enhancer binding protein (C/EBP), beta	-	HPRD	11158330
CENPJ	BM032 \| CPAP \| LAP \| LIP1 \| MCPH6 \| MGC131581 \| MGC131582 \| MGC142222 \| MGC142224	Centromere蛋白J	-	HPRD	12198240
CRKL	-	v-crk sarcoma virus CT10 oncogene homolog (avian)-like	-	HPRD，Biogrid	9837784\|11167825
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	-	HPRD，Biogrid	10358079
EPOR	MGC138358	erythropoietin receptor	-	HPRD，Biogrid	8977232
ERBB4	her4 \|MGC138404 \|P180ERBB4	V-ERB-A红细胞白血病病毒癌基因同源物4（Avian）	Affinity Capture-MS Affinity Capture-Western	BioGRID	15534001\|16729043
ESR1	DKFZP686N23123 \|er \|ESR \|Esra \|时代\|NR3A1	estrogen receptor 1	ER-alpha interacts with STAT5a.	BIND	15304355
ESR1	DKFZP686N23123 \|er \|ESR \|Esra \|时代\|NR3A1	estrogen receptor 1	Reconstituted Complex	BioGRID	11682624
ESR2	ER-BETA \| ESR-BETA \| ESRB \| ESTRB \| Erb \| NR3A2	estrogen receptor 2 (ER beta)	-	HPRD，Biogrid	11682624
GHR	GHBP	growth hormone receptor	-	HPRD	8702683
IL2RB	CD122 \|P70-75	interleukin 2 receptor, beta	-	HPRD，Biogrid	10602027
IL2RG	CD132 \|IMD4 \|Scidx \|SCIDX1	interleukin 2 receptor, gamma (severe combined immunodeficiency)	-	HPRD	11418623
IL5	EDF \|IL-5 \|trf	白介素5（刺激因子，嗜酸性粒细胞）	Stat5ainteracts with IL-5 promoter.	BIND	15735688
IL9	HP40 \| IL-9 \| P40	interleukin 9	STAT5A与IL-9启动子相互作用。	BIND	15735688
JAK1	jak1a \|jak1b \|JTK3	Janus kinase 1 (a protein tyrosine kinase)	-	HPRD	11722592
JAK1	jak1a \|jak1b \|JTK3	Janus kinase 1 (a protein tyrosine kinase)	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	9047382
JAK2	JTK10	Janus激酶2（蛋白酪氨酸激酶）	-	HPRD，Biogrid	9575217
JAK3	jak-3 \|jak3_human \|jakl \|l-jak \|ljak	Janus激酶3（蛋白质酪氨酸激酶，白细胞）	-	HPRD，Biogrid	9047382\|10037026
Magea12	MAGE12	黑色素瘤抗原家族A，12	Two-hybrid	BioGRID	16189514
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	-	HPRD，Biogrid	10194762\|10996427
NCOR2	CTG26 \|SMRT \|Smrte \|smrte-tau \|TNRC14 \|TRAC-1 \|trac1	nuclear receptor co-repressor 2	-	HPRD	11726519
NMI	-	N-MYC（和STAT）交互器	Nmi interacts with Stat5a	BIND	9989503
NMI	-	N-MYC（和STAT）交互器	-	HPRD，Biogrid	9989503
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD	9528750
PPIB	CYP-S1 \|CYPB \|MGC14109 \|MGC2224 \|scylp	peptidylprolyl isomerase B (cyclophilin B)	-	HPRD	11997457
PRTFDC1	FLJ11888 \|HHGP	含1个	Two-hybrid	BioGRID	16189514
PTPN11	BPTP3 \| CFC \| MGC14433 \| NS1 \| PTP-1D \| PTP2C \| SH-PTP2 \| SH-PTP3 \| SHP2	protein tyrosine phosphatase, non-receptor type 11	-	HPRD，Biogrid	12060651
SHC1	FLJ26504 \|SHC \|SHCA	SHC (Src homology 2 domain containing) transforming protein 1	Affinity Capture-Western	BioGRID	10996427
src	ASV \|src1 \|C-SRC \|P60-SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	10358079
Stat5a	MGF \|Stat5	信号换能器和转录5a激活剂	磷酸化的STAT5A与磷酸化的Stat5a相互作用以形成二聚体。	BIND	10594041
Stat5a	MGF \|Stat5	信号换能器和转录5a激活剂	-	HPRD	9528750
Stat5b	Stat5	转录5b的信号换能器和激活因子	-	HPRD	9528750
Syk	dkfzp313n1010 \|FLJ25043 \|FLJ37489	spleen tyrosine kinase	-	HPRD	10825200
TSLP	-	thymic stromal lymphopoietin	-	HPRD	10570284\|11418668

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
kegg erbb信号通路	87	71	All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY	155	105	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG CHRONIC MYELOID LEUKEMIA	73	59	All SZGR 2.0 genes in this pathway
KEGG ACUTE MYELOID LEUKEMIA	60	47	All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY	45	35	All SZGR 2.0 genes in this pathway
BIOCARTA EGF PATHWAY	31	25	All SZGR 2.0 genes in this pathway
Biocarta EPO途径	19	13	All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY	28	22	All SZGR 2.0 genes in this pathway
BIOCARTA IL2 PATHWAY	22	16	All SZGR 2.0 genes in this pathway
BIOCARTA IL3 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
BIOCARTA IL10 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
Biocarta IL2RB途径	38	26	All SZGR 2.0 genes in this pathway
Biocarta IL22BP途径	16	12	All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY	17	14	All SZGR 2.0 genes in this pathway
BIOCARTA GLEEVEC PATHWAY	23	17	All SZGR 2.0 genes in this pathway
Biocarta PPARA途径	58	43	All SZGR 2.0 genes in this pathway
BIOCARTA PDGF PATHWAY	32	25	All SZGR 2.0 genes in this pathway
BIOCARTA TPO PATHWAY	24	17	All SZGR 2.0 genes in this pathway
PID ERBB4途径	38	32	All SZGR 2.0 genes in this pathway
PID GMCSF途径	37	31	All SZGR 2.0 genes in this pathway
PID IL4 2 Pathway	65	43	All SZGR 2.0 genes in this pathway
PID IL27 PATHWAY	26	20	All SZGR 2.0 genes in this pathway
PID CD40途径	31	26	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID IL12 2 Pathway	63	54	All SZGR 2.0 genes in this pathway
PID TCPTP通路	43	33	All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY	50	41	All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY	82	60	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID CXCR4途径	102	78	All SZGR 2.0 genes in this pathway
PID IL5 PATHWAY	14	11	All SZGR 2.0 genes in this pathway
PID IL3途径	27	19	All SZGR 2.0 genes in this pathway
PID PDGFRB途径	129	103	All SZGR 2.0 genes in this pathway
PID IL23途径	37	30	All SZGR 2.0 genes in this pathway
PID时代基因组途径	65	37	All SZGR 2.0 genes in this pathway
PID套件途径	52	40	All SZGR 2.0 genes in this pathway
PID EPO PATHWAY	34	29	All SZGR 2.0 genes in this pathway
PID IL2 STAT5途径	30	23	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
PID Rac1途径	54	37	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT	78	59	All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING	24	19	All SZGR 2.0 genes in this pathway
Reactome IL 7信号传导	11	9	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ERBB4	90	67	All SZGR 2.0 genes in this pathway
Reactome催乳素受体信号传导	14	11	All SZGR 2.0 genes in this pathway
REACTOME核信号BY ERBB4	38	30	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
FGFR1突变体的反应组信号传导	30	20	All SZGR 2.0 genes in this pathway
FGFR1融合突变体的反应组信号传导	19	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
PDGF的Reactome信号传导	122	93	All SZGR 2.0 genes in this pathway
Reactome下游信号转导	95	76	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
Reactome IL 3 5和GM CSF信号传导	43	34	All SZGR 2.0 genes in this pathway
Reactome IL 2信号传导	41	34	All SZGR 2.0 genes in this pathway
Reactome免疫系统	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN	242	165	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 DN	281	186	All SZGR 2.0 genes in this pathway
周的炎症反应fima	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
阿霉素DN的Graessmann凋亡	1781年	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
标记HDAC目标DN	15	11	All SZGR 2.0 genes in this pathway
dirmeier LMP1响应迟到	57	41	All SZGR 2.0 genes in this pathway
TSAI RESPONSE TO IONIZING RADIATION	149	101	All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK	101	73	All SZGR 2.0 genes in this pathway
PUJANA XPRSS INT NETWORK	168	103	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK	423	265	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
PUJANA BRCA CENTERED NETWORK	117	72	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发12小时	116	79	All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时	487	286	All SZGR 2.0 genes in this pathway
Sakai慢性肝炎与肝癌DN	36	24	All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 2	30	23	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN	66	47	All SZGR 2.0 genes in this pathway
OKUMURA INFLAMMATORY RESPONSE LPS	183	115	All SZGR 2.0 genes in this pathway
nguyen Notch1靶向	29	23	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
BRACHAT RESPONSE TO METHOTREXATE DN	27	19	All SZGR 2.0 genes in this pathway
Brachat对Camptothecin DN的反应	46	31	All SZGR 2.0 genes in this pathway
Gerhold脂肪形成	49	40	All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞DN	409	268	All SZGR 2.0 genes in this pathway
Rizki肿瘤侵入性2D	69	46	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN	101	65	All SZGR 2.0 genes in this pathway
王肿瘤的侵入性	374	247	All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C	69	49	All SZGR 2.0 genes in this pathway
Hinata NFKB靶向角质形成细胞	91	63	All SZGR 2.0 genes in this pathway
Meissner NPC HCP，含H3未甲基化	536	296	All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3	1069	729	All SZGR 2.0 genes in this pathway
ACOSTA PROLIFERATION INDEPENDENT MYC TARGETS DN	116	74	All SZGR 2.0 genes in this pathway
Pilon KLF1靶向DN	1972年	1213	All SZGR 2.0 genes in this pathway
Kasler HDAC7靶向1个	194	133	All SZGR 2.0 genes in this pathway
wakabayashi脂肪生成PPARG RXRA绑定8D	882	506	All SZGR 2.0 genes in this pathway
Wang MLL目标	289	188	All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL DN	428	246	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
mir-141/200a	1242	1248	m8	hsa-miR-141	uaacacugucugugugugugaugg
mir-141/200a	1242	1248	m8	hsa-miR-200a	uaacacugucuguguguguaaacgaugu

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击hereto see the list of brain related miRNAs.

基因页：Stat5a