Gene Page:STRN
概括?
| 基因 | 6801 |
| 象征 | STRN |
| Synonyms | SG2NA |
| Description | striatin |
| Reference | MIM:614765|HGNC:HGNC:11424|Ensembl:ENSG00000115808|HPRD:18124|Vega:OTTHUMG00000100959 |
| Gene type | protein-coding |
| Map location | 2p22.2 |
| Pascal p-value | 3.16e-4 |
| Support | G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.humanPSD G2Cdb.humanPSP |
数据源中的基因
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| Network | 人蛋白蛋白质相互作用网络中核心基因的最短路径距离 | Contribution to shortest path in PPI network: 0.0585 |
第一节遗传学和表观遗传学注释
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26conception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
大脑区域没有共表达基因
Section III. Gene Ontology annotation
| 分子功能 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005516 | calmodulin binding | NAS | 9693043 | |
| 生物过程 | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0008150 | biological_process | nd | - | |
| Cellular component | 去的术语 | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | nd | - | |
| GO:0005737 | 细胞质 | IEA | - | |
| 去：0016020 | 膜 | IEA | - |
第四节。蛋白质蛋白相互作用注释
| 互动者 | Aliases B | Official full name B | Experimental | 资源 | PubMed ID |
|---|---|---|---|---|---|
| CAV1 | CAV | MSTP085 | VIP21 | caveolin 1, caveolae protein, 22kDa | - | HPRD | 11707266 |
| CCT2 | 99D8.1 | CCT-beta | CCTB | MGC142074 | MGC142076 | PRO1633 | TCP-1-beta | chaperonin containing TCP1, subunit 2 (beta) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT3 | CCT-gamma | CCTG | PIG48 | TCP-1-gamma | TRIC5 | chaperonin containing TCP1, subunit 3 (gamma) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT4 | cct-delta |CCTD |MGC126164 |MGC126165 |SRB | chaperonin containing TCP1, subunit 4 (delta) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT5 | CCT-epsilon | CCTE | KIAA0098 | TCP-1-epsilon | chaperonin containing TCP1, subunit 5 (epsilon) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT6A | CCT-zeta | CCT-zeta-1 | CCT6 | Cctz | HTR3 | MGC126214 | MGC126215 | MoDP-2 | TCP-1-zeta | TCP20 | TCPZ | TTCP20 | chaperonin containing TCP1, subunit 6A (zeta 1) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT6B | CCT-zeta-2 | CCTZ-2 | Cctz2 | TCP-1-zeta-2 | TSA303 | chaperonin containing TCP1, subunit 6B (zeta 2) | 亲和力捕获ms | BioGRID | 18782753 |
| CCT7 | CCT-ETA |CCTH |MGC110985 |NIP7-1 |TCP-1-ETA | 伴侣素含有TCP1，亚基7（ETA） | 亲和力捕获ms | BioGRID | 18782753 |
| CCT8 | C21orf112 | Cctq | D21S246 | KIAA0002 | PRED71 | 伴侣素含有TCP1，亚基8（Theta） | 亲和力捕获ms | BioGRID | 18782753 |
| CTTNBP2 | C7orf8 | CORTBP2 | FLJ34229 | KIAA1758 | MGC104579 | Orf4 | cortactin binding protein 2 | 亲和力捕获ms | BioGRID | 18782753 |
| CTTNBP2NL | DKFZp547A023 | FLJ13278 | CTTNBP2 N-terminal like | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| ESR1 | DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1 | 雌激素受体1 | - | HPRD | 15569929 |
| FAM40A | FLJ14743 |KIAA1761 |MGC148091 |RP4-773N10.1 | family with sequence similarity 40, member A | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| FAM40B | - | family with sequence similarity 40, member B | 亲和力捕获ms | BioGRID | 18782753 |
| FGFR1OP2 | DKFZP564O1863 |HSPC123 | FGFR1 oncogene partner 2 | 亲和力捕获ms | BioGRID | 18782753 |
| GNAI1 | Gi | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | - | HPRD | 15569929 |
| MCC | DKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1 | mutated in colorectal cancers | 亲和力捕获ms | BioGRID | 17353931 |
| mobkl3 | 2C4D | CGI-95 | MGC12264 | MOB1 | MOB3 | PREI3 | MOB1, Mps One Binder kinase activator-like 3 (yeast) | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| PDCD10 | CCM3 | MGC1212 | MGC24477 | TFAR15 | 程序性细胞死亡10 | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| PPP2CA | pp2ac |pp2ca |RP-C | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP2CA | pp2ac |pp2ca |RP-C | protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform | - | HPRD | 10681496 |
| PPP2CB | PP2CB | protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP2R1A | MGC786 | PR65A | protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform | 亲和力捕获ms | BioGRID | 18782753 |
| PPP2R1B | MGC26454 | PR65B | 蛋白质磷酸酶2（以前为2A），调节亚基A，β同工型 | 亲和力捕获ms | BioGRID | 18782753 |
| RP5-1000E10.4 | DKFZP686A0768 |FLJ21168 |西克 | suppressor of IKK epsilon | 亲和力捕获ms | BioGRID | 18782753 |
| RP6-213H19.1 | 面具|MST4 | serine/threonine protein kinase MST4 | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| SLMAP | FLJ42206 | KIAA1601 | MGC138760 | MGC138761 | SLAP | sarcolemma associated protein | 亲和力捕获ms | BioGRID | 18782753 |
| STK24 | MST-3 | MST3 | MST3B | STE20 | STK3 | 丝氨酸/苏氨酸激酶24（Ste20同源物，酵母） | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 17353931|18782753 |
| STK25 | DKFZp686J1430 | SOK1 | YSK1 | serine/threonine kinase 25 (STE20 homolog, yeast) | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
| strn3 | SG2NA | striatin, calmodulin binding protein 3 | 亲和力捕获ms | BioGRID | 18782753 |
| strn4 | FLJ35594 | ZIN | zinedin | striatin, calmodulin binding protein 4 | 亲和力捕获ms | BioGRID | 18782753 |
| TCP1 | CCT-alpha | CCT1 | CCTa | D6S230E | TCP-1-alpha | t-complex 1 | 亲和力捕获ms | BioGRID | 18782753 |
| TRAF3IP3 | DJ434O14.3 |FLJ44151 |MGC117354 |MGC163289 |T3JAM | TRAF3 interacting protein 3 | 亲和力捕获ms Affinity Capture-Western |
BioGRID | 18782753 |
V.途径注释
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID ER NONGENOMIC PATHWAY | 41 | 35 | 该途径中的所有SZGR 2.0基因 |
| 奥斯曼膀胱癌 | 404 | 246 | 该途径中的所有SZGR 2.0基因 |
| SENESE HDAC1 TARGETS UP | 457 | 269 | 该途径中的所有SZGR 2.0基因 |
| Senese HDAC3靶向 | 501 | 327 | 该途径中的所有SZGR 2.0基因 |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC UP | 722 | 443 | 该途径中的所有SZGR 2.0基因 |
| ENK UV RESPONSE EPIDERMIS UP | 293 | 179 | 该途径中的所有SZGR 2.0基因 |
| PUJANA BRCA1 PCC NETWORK | 1652 | 1023 | 该途径中的所有SZGR 2.0基因 |
| PUJANA ATM PCC NETWORK | 1442 | 892 | 该途径中的所有SZGR 2.0基因 |
| Benporath Nanog目标 | 988 | 594 | 该途径中的所有SZGR 2.0基因 |
| GOLDRATH HOMEOSTATIC PROLIFERATION | 171 | 102 | 该途径中的所有SZGR 2.0基因 |
| CUI TCF21 TARGETS 2 DN | 830 | 547 | 该途径中的所有SZGR 2.0基因 |
| HU GENOTOXIN ACTION DIRECT VS INDIRECT 24HR | 55 | 38 | 该途径中的所有SZGR 2.0基因 |
| Yoshimura mapk8靶向 | 1305 | 895 | 该途径中的所有SZGR 2.0基因 |
| 米利假足 | 518 | 299 | 该途径中的所有SZGR 2.0基因 |
| STAMBOLSKY RESPONSE TO VITAMIN D3 UP | 84 | 48 | 该途径中的所有SZGR 2.0基因 |
| PILON KLF1 TARGETS DN | 1972 | 1213 | 该途径中的所有SZGR 2.0基因 |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | 该途径中的所有SZGR 2.0基因 |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | 该途径中的所有SZGR 2.0基因 |
| RATTENBACHER BOUND BY CELF1 | 467 | 251 | 该途径中的所有SZGR 2.0基因 |
Section VI. microRNA annotation
| mirna家族 | Target position | mirna id | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-103/107 | 187 | 193 | 1A | HSA-MIR-103brain | AGCAGCAUUGUACAGGGCUAUGA |
| HSA-MIR-107brain | AGCAGCAUUGUACAGGGCUAUCA | ||||
| miR-141/200a | 500 | 507 | 1A,m8 | hsa-miR-141 | uaacacugucugugugugugaugg |
| HSA-MIR-200A | UAACACUGUCUGGUAACGAUGU | ||||
| mir-25/32/92/363/367 | 591 | 597 | 1A | HSA-MIR-25brain | Cauugcacuugucucggucuga |
| hsa-miR-32 | UAUUGCACAUUACUAAGUUGC | ||||
| hsa-miR-92 | UAUUGCACUUGUCCCGGCCUG | ||||
| hsa-miR-367 | Aauugcacuuuagcaaugga | ||||
| hsa-miR-92bSZ | UAUUGCACUCGUCCCGGCCUC | ||||
| mir-495 | 175 | 181 | m8 | hsa-miR-495brain | AAACAAACAUGGUGCACUUCUUU |