Gene Page:SUPT5H
Summary?
| GeneID | 6829 |
| Symbol | SUPT5H |
| Synonyms | SPT5|SPT5H|Tat-CT1 |
| Description | SPT5 homolog, DSIF elongation factor subunit |
| Reference | MIM:602102|HGNC:HGNC:11469|Ensembl:ENSG00000196235|HPRD:03655|Vega:OTTHUMG00000182973 |
| Gene type | protein-coding |
| Map location | 19q13.2 |
| Pascal p-value | 0.016 |
| Sherlock p-value | 0.998 |
| Fetal beta | -0.443 |
| DMG | 1 (# studies) |
| eGene | Nucleus accumbens basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg22494492 | 19 | 39936032 | SUPT5H | 4.81E-8 | -0.011 | 1.29E-5 | DMG:Jaffe_2016 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| DRD1 | 0.82 | 0.70 |
| CHRM4 | 0.76 | 0.56 |
| ADCY5 | 0.76 | 0.79 |
| SLC5A7 | 0.76 | 0.40 |
| AC020658.1 | 0.75 | 0.69 |
| PDE10A | 0.75 | 0.66 |
| GPR149 | 0.74 | 0.56 |
| DRD2 | 0.74 | 0.49 |
| FAM40B | 0.73 | 0.35 |
| KLF5 | 0.72 | 0.62 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.21 | -0.32 | -0.54 |
| LGALS3 | -0.32 | -0.51 |
| AF347015.31 | -0.32 | -0.52 |
| SYCP3 | -0.32 | -0.54 |
| MT-CO2 | -0.32 | -0.54 |
| AF347015.2 | -0.32 | -0.48 |
| HIGD1B | -0.30 | -0.50 |
| AL139819.3 | -0.30 | -0.51 |
| AF347015.8 | -0.29 | -0.50 |
| CSAG1 | -0.29 | -0.50 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME RNA POL II TRANSCRIPTION | 105 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA CAPPING | 30 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME MRNA PROCESSING | 161 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSCRIPTION | 210 | 127 | All SZGR 2.0 genes in this pathway |
| REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX | 45 | 19 | All SZGR 2.0 genes in this pathway |
| REACTOME ELONGATION ARREST AND RECOVERY | 32 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | 61 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV LIFE CYCLE | 125 | 69 | All SZGR 2.0 genes in this pathway |
| REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT | 23 | 7 | All SZGR 2.0 genes in this pathway |
| REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX | 34 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME LATE PHASE OF HIV LIFE CYCLE | 104 | 61 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| BARRIER CANCER RELAPSE NORMAL SAMPLE DN | 31 | 19 | All SZGR 2.0 genes in this pathway |
| SUZUKI AMPLIFIED IN ORAL CANCER | 16 | 12 | All SZGR 2.0 genes in this pathway |
| SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC | 108 | 74 | All SZGR 2.0 genes in this pathway |
| HEIDENBLAD AMPLIFIED IN PANCREATIC CANCER | 31 | 19 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP | 479 | 299 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| KOYAMA SEMA3B TARGETS UP | 292 | 168 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| BENPORATH ES CORE NINE CORRELATED | 100 | 68 | All SZGR 2.0 genes in this pathway |
| KAUFFMANN DNA REPLICATION GENES | 147 | 87 | All SZGR 2.0 genes in this pathway |
| KUUSELO PANCREATIC CANCER 19Q13 AMPLIFICATION | 35 | 22 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| YAGI AML WITH 11Q23 REARRANGED | 351 | 238 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 UP | 430 | 288 | All SZGR 2.0 genes in this pathway |