Gene Page:VAMP2

Summary?
GeneID 6844
Symbol VAMP2
Synonyms SYB2|VAMP-2
Description vesicle associated membrane protein 2
Reference MIM:185881|HGNC:HGNC:12643|Ensembl:ENSG00000220205|HPRD:01717|Vega:OTTHUMG00000150254
Gene type protein-coding
Map location 17p13.1
Pascal p-value 0.361
Sherlock p-value 0.801
DEG p-value DEG:Maycox_2009:CC_BA10_fold_change=-1.11:CC_BA10_disease_P=0.0403:HBB_BA9_fold_change=-1.28:HBB_BA9_disease_P=0.0379
Fetal beta -1.939
Support EXOCYTOSIS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_mGluR5
G2Cdb.human_TAP-PSD-95-CORE
CompositeSet
Darnell FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
DEG:Maycox_2009 Microarray to determine the expression of over 30000 mRNA transcripts in post-mortem tissue We included 51 genes whose expression changes are common between two schizophrenia cohorts.
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance柯ywords: schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations 支安打与neuro-related关键词:1

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
DNAJC28 0.74 0.69
FBXO9 0.73 0.64
TTC35 0.69 0.67
C2orf74 0.69 0.61
KRT222P 0.68 0.58
NMNAT1 0.68 0.70
C13orf1 0.68 0.59
C1D 0.67 0.60
SGTB 0.66 0.56
TYW3 0.66 0.57
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
HYAL2 -0.44 -0.44
OLFM2 -0.41 -0.38
SEMA4B -0.40 -0.35
SH3BP2 -0.39 -0.39
AC006276.1 -0.39 -0.34
NAPRT1 -0.39 -0.33
SH2B2 -0.39 -0.41
SPNS1 -0.38 -0.32
SLC38A5 -0.38 -0.40
WDR86 -0.38 -0.37

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005515 protein binding 新闻学会 9920726
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0016192 vesicle-mediated transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0019717 synaptosome IEA Synap, Brain (GO term level: 7) -
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0016020 membrane IEA -
GO:0005887 integral to plasma membrane TAS 1976629
GO:0030054 cell junction IEA -
GO:0031410 cytoplasmic vesicle IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
BCAP31 6C6-AG | BAP31 | CDM | DXS1357E B-cell receptor-associated protein 31 Reconstituted Complex BioGRID 9396746
CPLX1 CPX-I | CPX1 complexin 1 - HPRD,BioGRID 11832227
DNAJC5 CSP | DKFZp434N1429 | DKFZp761N1221 | DNAJC5A | FLJ00118 | FLJ13070 DnaJ (Hsp40) homolog, subfamily C, member 5 Csp1 interacts with VAMP2. This interaction was modeled on a demonstrated interaction between cow Csp1, and human VAMP2. BIND 15610015
NAPA SNAPA N-ethylmaleimide-sensitive factor attachment protein, alpha Reconstituted Complex BioGRID 7622514
RABAC1 PRA1 | PRAF1 | YIP3 Rab acceptor 1 (prenylated) - HPRD,BioGRID 9341137
SNAP23 HsT17016 | SNAP23A | SNAP23B synaptosomal-associated protein, 23kDa SNAP23 interacts with VAMP2. BIND 15610015
SNAP23 HsT17016 | SNAP23A | SNAP23B synaptosomal-associated protein, 23kDa - HPRD,BioGRID 10713150
SNAP25 FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2 synaptosomal-associated protein, 25kDa - HPRD 7961655
SNAP25 FLJ23079 | RIC-4 | RIC4 | SEC9 | SNAP | SNAP-25 | bA416N4.2 | dJ1068F16.2 synaptosomal-associated protein, 25kDa Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
Two-hybrid		 BioGRID 9030619|11524423
|11832227
STX11 FHL4 | HLH4 | HPLH4 syntaxin 11 - HPRD,BioGRID 10036234
STX1A HPC-1 | STX1 | p35-1 syntaxin 1A (brain) Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
Two-hybrid		 BioGRID 7553862|9030619
|10100611|10449403
|11832227|12093152
STX1B STX1B1 | STX1B2 syntaxin 1B - HPRD,BioGRID 12093152
STX2 EPIM | EPM | MGC51014 | STX2A | STX2B | STX2C syntaxin 2 Two-hybrid BioGRID 12828989
STX3 STX3A syntaxin 3 Two-hybrid BioGRID 12828989
STX4 STX4A | p35-2 syntaxin 4 Affinity Capture-Western
Two-hybrid		 BioGRID 8760387|10194441
|10820264|12517971
STX4 STX4A | p35-2 syntaxin 4 - HPRD 8760387|12417022
|12517971|8770861
STXBP2 Hunc18b | MUNC18-2 | UNC18-2 | UNC18B | pp10122 syntaxin binding protein 2 - HPRD 12773094
STXBP3 MUNC18-3 | MUNC18C | PSP | UNC-18C syntaxin binding protein 3 Reconstituted Complex BioGRID 12832401
SYPL1 H-SP1 | SYPL synaptophysin-like 1 - HPRD 10370136
TRPC3 TRP3 transient receptor potential cation channel, subfamily C, member 3 - HPRD 15327778
TRPC3 TRP3 transient receptor potential cation channel, subfamily C, member 3 TRPC3 interacts with VAMP2. BIND 15327778
UNC13B MGC133279 | MGC133280 | MUNC13 | UNC13 | Unc13h2 | hmunc13 unc-13 homolog B (C. elegans) Co-fractionation BioGRID 8999968
VAMP3 CEB vesicle-associated membrane protein 3 (cellubrevin) Reconstituted Complex BioGRID 12130530
VAMP8 EDB vesicle-associated membrane protein 8 (endobrevin) Reconstituted Complex BioGRID 12130530
VAPA MGC3745 | VAP-33 | VAP-A | VAP33 | hVAP-33 VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa - HPRD,BioGRID 9657962
VAPB ALS8 | VAMP-B | VAMP-C | VAP-B | VAP-C VAMP (vesicle-associated membrane protein)-associated protein B and C - HPRD,BioGRID 9920726


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG SNARE INTERACTIONS IN VESICULAR TRANSPORT 38 25 All SZGR 2.0 genes in this pathway
KEGG VASOPRESSIN REGULATED WATER REABSORPTION 44 30 All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY 26 24 All SZGR 2.0 genes in this pathway
意图CTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
意图CTOME BOTULINUM NEUROTOXICITY 19 14 All SZGR 2.0 genes in this pathway
意图CTOME TRANS GOLGI NETWORK VESICLE BUDDING 60 31 All SZGR 2.0 genes in this pathway
意图CTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS 17 12 All SZGR 2.0 genes in this pathway
意图CTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE 15 13 All SZGR 2.0 genes in this pathway
意图CTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186 155 All SZGR 2.0 genes in this pathway
意图CTOME NEURONAL SYSTEM 279 221 All SZGR 2.0 genes in this pathway
意图CTOME NEUROTRANSMITTER RELEASE CYCLE 34 30 All SZGR 2.0 genes in this pathway
意图CTOME INTEGRATION OF ENERGY METABOLISM 120 84 All SZGR 2.0 genes in this pathway
意图CTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE 11 11 All SZGR 2.0 genes in this pathway
意图CTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE 10 9 All SZGR 2.0 genes in this pathway
意图CTOME DIABETES PATHWAYS 133 91 All SZGR 2.0 genes in this pathway
意图CTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE 10 10 All SZGR 2.0 genes in this pathway
意图CTOME INSULIN SYNTHESIS AND PROCESSING 21 15 All SZGR 2.0 genes in this pathway
意图CTOME REGULATION OF INSULIN SECRETION 93 65 All SZGR 2.0 genes in this pathway
意图CTOME LYSOSOME VESICLE BIOGENESIS 23 11 All SZGR 2.0 genes in this pathway
意图CTOME GOLGI ASSOCIATED VESICLE BIOGENESIS 53 27 All SZGR 2.0 genes in this pathway
意图CTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION 17 16 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473 314 All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP 276 187 All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 5 147 89 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
BENPORATH MYC TARGETS WITH EBOX 230 156 All SZGR 2.0 genes in this pathway
STARK HYPPOCAMPUS 22Q11 DELETION UP 53 40 All SZGR 2.0 genes in this pathway
LEE TARGETS OF PTCH1 AND SUFU DN 83 69 All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182 116 All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL 254 164 All SZGR 2.0 genes in this pathway
RAMPON ENRICHED LEARNING ENVIRONMENT EARLY UP 15 12 All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 109 63 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439 257 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546 362 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221 150 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103 714 All SZGR 2.0 genes in this pathway
ZEMBUTSU SENSITIVITY TO DOXORUBICIN 17 10 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448 282 All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467 251 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-1/206 946 952 m8 hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
hsa-miR-1 UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZ UGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613 AGGAAUGUUCCUUCUUUGCC
miR-127 98 104 m8 hsa-miR-127brain UCGGAUCCGUCUGAGCUUGGCU
miR-133 912 918 1A hsa-miR-133a UUGGUCCCCUUCAACCAGCUGU
hsa-miR-133b UUGGUCCCCUUCAACCAGCUA
miR-135 70 76 1A hsa-miR-135a UAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135b UAUGGCUUUUCAUUCCUAUGUG
miR-150 522 528 m8 hsa-miR-150 UCUCCCAACCCUUGUACCAGUG
miR-153 325 332 1A,m8 hsa-miR-153 UUGCAUAGUCACAAAAGUGA
miR-25/32/92/363/367 328 334 1A hsa-miR-25brain CAUUGCACUUGUCUCGGUCUGA
hsa-miR-32 UAUUGCACAUUACUAAGUUGC
hsa-miR-92 UAUUGCACUUGUCCCGGCCUG
hsa-miR-367 AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZ UAUUGCACUCGUCCCGGCCUC
miR-28 1234 1240 m8 hsa-miR-28brain AAGGAGCUCACAGUCUAUUGAG
miR-30-3p 1185 1192 1A,m8 hsa-miR-30a-3p CUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3p CUUUCAGUCGGAUGUUUACAGC
miR-325 202 208 1A hsa-miR-325 CCUAGUAGGUGUCCAGUAAGUGU
miR-338 1553 1560 1A,m8 hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
hsa-miR-338brain UCCAGCAUCAGUGAUUUUGUUGA
miR-34/449 1226 1232 m8 hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
hsa-miR-34abrain UGGCAGUGUCUUAGCUGGUUGUU
hsa-miR-34c AGGCAGUGUAGUUAGCUGAUUGC
hsa-miR-449 UGGCAGUGUAUUGUUAGCUGGU
hsa-miR-449b AGGCAGUGUAUUGUUAGCUGGC
miR-34b 1100 1106 m8 hsa-miR-34b UAGGCAGUGUCAUUAGCUGAUUG
miR-369-3p 169 175 1A hsa-miR-369-3p AAUAAUACAUGGUUGAUCUUU
miR-374 169 175 m8 hsa-miR-374 UUAUAAUACAACCUGAUAAGUG
miR-377 1534 1540 1A hsa-miR-377 AUCACACAAAGGCAACUUUUGU
miR-409-5p 1688 1694 1A hsa-miR-409-5p AGGUUACCCGAGCAACUUUGCA
miR-410 171 177 1A hsa-miR-410 AAUAUAACACAGAUGGCCUGU
miR-448 326 332 1A hsa-miR-448 UUGCAUAUGUAGGAUGUCCCAU
miR-491 1481 1487 1A hsa-miR-491brain AGUGGGGAACCCUUCCAUGAGGA
miR-493-5p 1666 1673 1A,m8 hsa-miR-493-5p UUGUACAUGGUAGGCUUUCAUU