Gene Page:SYP

Summary?
GeneID 6855
Symbol SYP
Synonyms MRX96|MRXSYP
Description synaptophysin
Reference MIM:313475|HGNC:HGNC:11506|Ensembl:ENSG00000102003|HPRD:02435|Vega:OTTHUMG00000034557
Gene type protein-coding
Map location Xp11.23-p11.22
Sherlock p-value 0.81
Fetal beta -2.266
Support EXOCYTOSIS
SEROTONIN
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature High-throughput literature-search 与精神分裂症Co-occurance关键词:schizophrenia,schizophrenic,schizophrenias Click to show details
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 6

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
POLD2 0.94 0.95
PPP4C 0.92 0.94
CLPP 0.92 0.92
PTOV1 0.92 0.92
AP4M1 0.91 0.92
MIIP 0.91 0.93
BCS1L 0.91 0.92
GNB2 0.91 0.92
PRMT1 0.91 0.94
TSEN34 0.91 0.91
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.27 -0.71 -0.82
AF347015.33 -0.71 -0.84
MT-CO2 -0.69 -0.80
MT-CYB -0.69 -0.82
AF347015.8 -0.69 -0.82
AF347015.31 -0.68 -0.79
AF347015.15 -0.68 -0.82
AF347015.2 -0.67 -0.83
AF347015.26 -0.66 -0.83
HLA-F -0.64 -0.69

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding NAS -
GO:0005515 protein binding NAS 10620806
GO:0005215 transporter activity IEA -
GO:0015485 cholesterol binding IDA 10620806
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0016188 synaptic vesicle maturation NAS Synap (GO term level: 8) 10620806
GO:0048499 synaptic vesicle membrane organization NAS Synap (GO term level: 5) 10620806
GO:0006810 transport IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0042734 presynaptic membrane IEA neuron, axon, Synap (GO term level: 5) -
GO:0008021 synaptic vesicle IEA Synap, Neurotransmitter (GO term level: 12) -
GO:0019717 synaptosome IEA Synap, Brain (GO term level: 7) -
GO:0030285 integral to synaptic vesicle membrane NAS Synap (GO term level: 14) 1975480
GO:0045202 synapse IEA neuron, Synap, Neurotransmitter, Glial (GO term level: 2) -
GO:0030054 cell junction IEA -
GO:0031410 cytoplasmic vesicle IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
MODY HIPPOCAMPUS POSTNATAL 63 50 All SZGR 2.0 genes in this pathway
WEIGEL OXIDATIVE STRESS BY HNE AND H2O2 39 29 All SZGR 2.0 genes in this pathway
MCCLUNG COCAINE REWARD 5D 79 62 All SZGR 2.0 genes in this pathway
MCCLUNG CREB1 TARGETS UP 100 72 All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS 69 45 All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210 725 All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 68 45 All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 80 53 All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3 UNMETHYLATED 63 31 All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228 119 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756 494 All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682 440 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-224 355 361 m8 hsa-miR-224 CAAGUCACUAGUGGUUCCGUUUA
miR-24 164 170 m8 hsa-miR-24SZ UGGCUCAGUUCAGCAGGAACAG