Gene Page:TAF5

概括?
基因 6877
Symbol TAF5
Synonyms TAF(II)100|TAF2D|TAFII-100|TAFII100
Description TATA-box binding protein associated factor 5
Reference MIM:601787|HGNC:HGNC:11539|Ensembl:ENSG00000148835|HPRD:11876|Vega：Otthumg0000000018985
Gene type protein-coding
Map location 10q24-q25.2
Pascal p-value 0.002
Fetal beta 1.193
eGene Myers' cis & trans

数据源中的基因
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
LK:YES Genome-wide Association Study 该数据集包括映射到22个区域的99个基因。CV：RIPKE_2013中还包括24个领先的SNP

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs7860423 chr9 140955546 TAF5 6877 0.15 trans
rs17650385 chr13 87104244 TAF5 6877 0.03 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

脚注：
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

脚注：
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
Rab10 0.91 0.92
ABCD3 0.90 0.91
RAD21 0.90 0.91
ASCC1 0.90 0.88
C5orf43 0.89 0.88
COPB1 0.89 0.88
PPP1CC 0.89 0.92
IFIT5 0.89 0.91
ZNF271 0.89 0.88
STAG2 0.89 0.89
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MT-CO2 -0.66 -0.76
FXYD1 -0.65 -0.75
AC018755.7 -0.63 -0.71
IFI27 -0.63 -0.73
AF347015.8 -0.63 -0.74
AF347015.33 -0.63 -0.72
AF347015.21 -0.62 -0.72
AF347015.31 -0.62 -0.71
AF347015.27 -0.61 -0.70
MT-CYB -0.61 -0.71

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
CPSF1 CPSF160 | HSU37012 | P / cl.18 cleavage and polyadenylation specific factor 1, 160kDa in vitro BioGRID 9311784
GTF2F2 BTF4 | RAP30 | TF2F2 | TFIIF general transcription factor IIF, polypeptide 2, 30kDa - HPRD 8758937
MYC bHLHe39 | c-Myc v-myc myelocytomatosis viral oncogene homolog (avian) Reconstituted Complex BioGRID 12660246
SUPT3H SPT3 | SPT3L suppressor of Ty 3 homolog (S. cerevisiae) Affinity Capture-Western BioGRID 11406595
TAF1 BA2R | CCG1 | CCGS | DYT3 | KAT4 | N-TAF1 | NSCL2 | OF | P250 | TAF2A | TAFII250 TAF1RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa - HPRD,BioGRID 9045704
TAF11 MGC:15243 | PRO2134 | TAF2I | TAFII28 TAF11 RNA聚合酶II, TATA box binding protein (TBP)-associated factor, 28kDa - HPRD,BioGRID 9045704
TAF12 TAF2J | TAFII20 TAF12RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa - HPRD,BioGRID 9045704
TAF15 Npl3 | RBP56 | TAF2N | TAFII68 | hTAFII68 TAF15RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa Affinity Capture-Western
Reconstituted Complex		 BioGRID 9488465
TAF4 FLJ41943 | TAF2C | TAF2C1 | TAF4A | TAFII130 | TAFII135 TAF4RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa Affinity Capture-Western BioGRID 11406595
TAF6 DKFZp781E21155 | MGC:8964 | TAF2E | TAFII70 | TAFII80 | TAFII85 TAF6RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa - HPRD,BioGRID 9045704
TAF7 TAF2F | TAFII55 TAF7RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa Affinity Capture-Western BioGRID 9045704
TAF9 AD-004 | AK6 | CGI-137 | CINAP | CIP | MGC1603 | MGC3647 | MGC5067 | MGC:1603 | MGC:3647 | MGC:5067 | TAF2G | TAFII31 | TAFII32 | TAFIID32 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa - HPRD,BioGRID 9045704
TBP gtf2d |GTF2D1 |MGC117320 |MGC126054 |MGC126055 |SCA17 |tfiid TATA box binding protein - HPRD,BioGRID 9045704


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG BASAL TRANSCRIPTION FACTORS 36 24 该途径中的所有SZGR 2.0基因
REACTOME RNA POL II TRANSCRIPTION 105 54 该途径中的所有SZGR 2.0基因
REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING 41 21 该途径中的所有SZGR 2.0基因
REACTOME TRANSCRIPTION 210 127 该途径中的所有SZGR 2.0基因
REACTOME RNA POL II PRE TRANSCRIPTION EVENTS 61 32 该途径中的所有SZGR 2.0基因
REACTOME HIV INFECTION 207 122 该途径中的所有SZGR 2.0基因
REACTOME HIV LIFE CYCLE 125 69 该途径中的所有SZGR 2.0基因
REACTOME LATE PHASE OF HIV LIFE CYCLE 104 61 该途径中的所有SZGR 2.0基因
ODONNELL TFRC TARGETS DN 139 76 该途径中的所有SZGR 2.0基因
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 该途径中的所有SZGR 2.0基因
KIM WT1 TARGETS DN 459 276 该途径中的所有SZGR 2.0基因
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 该途径中的所有SZGR 2.0基因
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800 473 该途径中的所有SZGR 2.0基因
PEREZ TP53 TARGETS 1174 695 该途径中的所有SZGR 2.0基因
PEREZ TP63 TARGETS 355 243 该途径中的所有SZGR 2.0基因
PEREZ TP53 AND TP63 TARGETS 205 145 该途径中的所有SZGR 2.0基因
NAGY TFTC组件人类 19 11 该途径中的所有SZGR 2.0基因
FARMER BREAST CANCER APOCRINE VS BASAL 330 217 该途径中的所有SZGR 2.0基因
AMUNDSON GENOTOXIC SIGNATURE 105 68 该途径中的所有SZGR 2.0基因
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 该途径中的所有SZGR 2.0基因
PUJANA BRCA1 PCC NETWORK 1652 1023 该途径中的所有SZGR 2.0基因
PUJANA ATM PCC NETWORK 1442 892 该途径中的所有SZGR 2.0基因
PUJANA CHEK2 PCC NETWORK 779 480 该途径中的所有SZGR 2.0基因
HOFMANN CELL LYMPHOMA UP 50 35 该途径中的所有SZGR 2.0基因
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 该途径中的所有SZGR 2.0基因
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314 201 该途径中的所有SZGR 2.0基因
BLALOCK ALZHEIMERS DISEASE UP 1691年 1088 该途径中的所有SZGR 2.0基因
BROWNE HCMV INFECTION 14HR UP 156 101 该途径中的所有SZGR 2.0基因
VERHAAK GLIOBLASTOMA PRONEURAL 177 132 该途径中的所有SZGR 2.0基因
LU EZH2 TARGETS DN 414 237 该途径中的所有SZGR 2.0基因
PILON KLF1 TARGETS DN 1972 1213 该途径中的所有SZGR 2.0基因
LEE BMP2 TARGETS DN 882 538 该途径中的所有SZGR 2.0基因
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 该途径中的所有SZGR 2.0基因
FOSTER KDM1A TARGETS DN 211 119 该途径中的所有SZGR 2.0基因
HOLLEMAN PREDNISOLONE RESISTANCE ALL UP 19 15 该途径中的所有SZGR 2.0基因