Gene Page:TAP2

Summary?
GeneID 6891
Symbol TAP2
Synonyms ABC18|ABCB3|APT2|D6S217E|PSF-2|PSF2|RING11
Description transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Reference MIM:170261|HGNC:HGNC:44|Ensembl:ENSG00000204267|HPRD:01360|Vega:OTTHUMG00000031068
Gene type protein-coding
Map location 6p21.3
帕斯卡假定值 6.547E-7
Fetal beta -0.693
eGene Caudate basal ganglia
Cerebellar Hemisphere
Cerebellum
Cortex
Frontal Cortex BA9
Hippocampus
Nucleus accumbens basal ganglia
Putamen basal ganglia
Meta

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
PMID:cooccur High-throughput literature-search Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I Genome scan meta-analysis Psr: 0.033
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias Click to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2621366 6 32768980 TAP2 ENSG00000204267.9 7.641E-7 0 27831 gtex_brain_putamen_basal
rs2621362 6 32769536 TAP2 ENSG00000204267.9 7.641E-7 0 27275 gtex_brain_putamen_basal
rs2219893 6 32769663 TAP2 ENSG00000204267.9 7.641E-7 0 27148 gtex_brain_putamen_basal
rs2199874 6 32769926 TAP2 ENSG00000204267.9 7.641E-7 0 26885 gtex_brain_putamen_basal
rs199560253 6 32771452 TAP2 ENSG00000204267.9 4.706E-7 0 25359 gtex_brain_putamen_basal
rs375727133 6 32771847 TAP2 ENSG00000204267.9 1.241E-6 0 24964 gtex_brain_putamen_basal
rs2071473 6 32782605 TAP2 ENSG00000204267.9 1.077E-7 0 14206 gtex_brain_putamen_basal
rs2857106 6 32787570 TAP2 ENSG00000204267.9 1.18E-7 0 9241 gtex_brain_putamen_basal
rs2621323 6 32788707 TAP2 ENSG00000204267.9 7.433E-8 0 8104 gtex_brain_putamen_basal
rs2621322 6 32788712 TAP2 ENSG00000204267.9 1.18E-7 0 8099 gtex_brain_putamen_basal
rs2621321 6 32789480 TAP2 ENSG00000204267.9 5.991E-7 0 7331 gtex_brain_putamen_basal
rs2857104 6 32790167 TAP2 ENSG00000204267.9 5.991E-7 0 6644 gtex_brain_putamen_basal
rs2857103 6 32791299 TAP2 ENSG00000204267.9 3.09E-8 0 5512 gtex_brain_putamen_basal
rs2856993 6 32791403 TAP2 ENSG00000204267.9 1.18E-7 0 5408 gtex_brain_putamen_basal
rs13501 6 32793523 TAP2 ENSG00000204267.9 3.09E-8 0 3288 gtex_brain_putamen_basal
rs2857101 6 32794676 TAP2 ENSG00000204267.9 5.991E-7 0 2135 gtex_brain_putamen_basal
rs241456 6 32795965 TAP2 ENSG00000204267.9 1.55E-7 0 846 gtex_brain_putamen_basal
rs241455 6 32796019 TAP2 ENSG00000204267.9 1.55E-7 0 792 gtex_brain_putamen_basal
rs2071546 6 32796057 TAP2 ENSG00000204267.9 1.55E-7 0 754 gtex_brain_putamen_basal
rs2071545 6 32796058 TAP2 ENSG00000204267.9 1.5E-7 0 753 gtex_brain_putamen_basal
rs241454 6 32796144 TAP2 ENSG00000204267.9 1.55E-7 0 667 gtex_brain_putamen_basal
rs241453 6 32796226 TAP2 ENSG00000204267.9 3.845E-7 0 585 gtex_brain_putamen_basal
rs241452 6 32796346 TAP2 ENSG00000204267.9 1.55E-7 0 465 gtex_brain_putamen_basal
rs114247673 6 32796466 TAP2 ENSG00000204267.9 2.053E-7 0 345 gtex_brain_putamen_basal
rs241451 6 32796480 TAP2 ENSG00000204267.9 1.988E-8 0 331 gtex_brain_putamen_basal
rs17034 6 32796521 TAP2 ENSG00000204267.9 2.933E-7 0 290 gtex_brain_putamen_basal
rs241449 6 32796653 TAP2 ENSG00000204267.9 1.551E-7 0 158 gtex_brain_putamen_basal
rs241448 6 32796685 TAP2 ENSG00000204267.9 1.551E-7 0 126 gtex_brain_putamen_basal
rs241447 6 32796751 TAP2 ENSG00000204267.9 1.552E-7 0 60 gtex_brain_putamen_basal
rs241446 6 32796967 TAP2 ENSG00000204267.9 3.845E-7 0 -156 gtex_brain_putamen_basal
rs241445 6 32797072 TAP2 ENSG00000204267.9 3.845E-7 0 -261 gtex_brain_putamen_basal
rs241444 6 32797109 TAP2 ENSG00000204267.9 3.845E-7 0 -298 gtex_brain_putamen_basal
rs241443 6 32797115 TAP2 ENSG00000204267.9 6.193E-8 0 -304 gtex_brain_putamen_basal
rs241442 6 32797168 TAP2 ENSG00000204267.9 3.845E-7 0 -357 gtex_brain_putamen_basal
rs241441 6 32797297 TAP2 ENSG00000204267.9 4.055E-7 0 -486 gtex_brain_putamen_basal
rs241440 6 32797361 TAP2 ENSG00000204267.9 3.845E-7 0 -550 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0000166 nucleotide binding IEA -
GO:0005524 ATP binding IEA -
GO:0005524 ATP binding NAS 12047747
GO:0004409 homoaconitate hydratase activity NAS 1946428
GO:0005215 transporter activity IDA 10835348
GO:0005215 transporter activity IEA -
去:0015433 peptide antigen-transporting ATPase activity NAS 12047747
去:0016887 ATPase activity IEA -
GO:0042288 MHC class I protein binding NAS 12047747
GO:0042301 phosphate binding NAS 11532960
GO:0015198 oligopeptide transporter activity IEA -
GO:0015197 peptide transporter activity IEA -
GO:0042605 peptide antigen binding NAS 11133832
GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA -
GO:0046982 protein heterodimerization activity 新闻学会 11133832
GO:0046982 protein heterodimerization activity ISS -
GO:0046980 tapasin binding 新闻学会 12047747
GO:0046980 tapasin binding ISS -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006461 protein complex assembly NAS 12047747
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I NAS 11532960
GO:0006955 immune response IEA -
GO:0006857 oligopeptide transport IEA -
GO:0006886 intracellular protein transport IMP 11133832
GO:0006886 intracellular protein transport ISS -
GO:0015833 peptide transport IEA -
GO:0046967 cytosol to ER transport NAS 11133832
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005829 cytosol NAS 11133832
GO:0005788 endoplasmic reticulum lumen IMP 11133832
GO:0005788 endoplasmic reticulum lumen ISS -
GO:0005789 endoplasmic reticulum membrane IEA -
GO:0005634 nucleus IDA 18029348
GO:0005783 endoplasmic reticulum IDA 18029348
GO:0005783 endoplasmic reticulum IEA -
GO:0016020 membrane IEA -
GO:0016021 integral to membrane IEA -
GO:0016021 integral to membrane NAS 1946428
GO:0042825 TAP complex NAS 12202157

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ABC TRANSPORTERS 44 29 All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
KEGG PRIMARY IMMUNODEFICIENCY 35 28 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING CROSS PRESENTATION 76 48 All SZGR 2.0 genes in this pathway
REACTOME ER PHAGOSOME PATHWAY 61 40 All SZGR 2.0 genes in this pathway
REACTOME免疫系统 933 616 All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539 350 All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC 21 17 All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251 156 All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 DN 267 178 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460 312 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 104 59 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552 347 All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211 136 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL FLI1 9 8 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN 51 32 All SZGR 2.0 genes in this pathway
JAIN NFKB SIGNALING 75 44 All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF UP 12 10 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
RUAN RESPONSE TO TNF TROGLITAZONE UP 17 11 All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419 273 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 49 38 All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299 167 All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210 124 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 58 38 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS DN 414 237 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B 549 316 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS UP 149 96 All SZGR 2.0 genes in this pathway
HOLLEMAN ASPARAGINASE RESISTANCE ALL UP 22 14 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-370 1676 1682 m8 hsa-miR-370brain GCCUGCUGGGGUGGAACCUGG