Gene Page:TAPBP

Summary?
GeneID 6892
Symbol TAPBP
Synonyms NGS17|TAPA|TPN|TPSN
Description TAP binding protein (tapasin)
Reference MIM:601962|HGNC:HGNC:11566|Ensembl:ENSG00000231925|HPRD:09061|Vega:OTTHUMG00000031090
Gene type protein-coding
Map location 6p21.3
Pascal p-value 1.602E-7
Sherlock p-value 0.006
Fetal beta -1.69
DMG 1 (# studies)

基因数据来源
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
GSMA_I Genome scan meta-analysis Psr: 0.033

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg18797229 6 33267523 TAPBP 1.22E-8 -0.021 4.99E-6 DMG:Jaffe_2016
cg10007189 6 33281536 TAPBP 2.3E-8 -0.008 7.61E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CCDC135 0.73 0.29
RFX2 0.72 0.60
CCDC114 0.71 0.46
RIBC1 0.71 0.34
CCDC11 0.70 0.28
C1orf92 0.70 0.28
MYLK3 0.69 0.29
FAM179A 0.69 0.30
GLB1L 0.69 0.42
NEK5 0.68 0.30
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
EPHX4 -0.24 -0.22
ABCC12 -0.22 -0.23
KRT17 -0.21 -0.19
SPHAR -0.21 -0.29
SLC26A4 -0.21 -0.22
KMO -0.20 -0.19
CARD16 -0.20 -0.21
HSPB3 -0.20 -0.21
SERPINB2 -0.20 -0.21
RGS4 -0.20 -0.10

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
去:0015433 peptide antigen-transporting ATPase activity TAS 9238042
GO:0042288 MHC class I protein binding TAS 12788224
GO:0051082 unfolded protein binding TAS 12788224
GO:0042605 peptide antigen binding TAS 12788224
GO:0046979 TAP2 binding TAS 12788224
GO:0046978 TAP1 binding TAS 12788224
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006461 protein complex assembly TAS 9271576
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA -
GO:0006955 immune response TAS 9271576
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 11884415
GO:0050823 peptide antigen stabilization ISS -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0000139 Golgi membrane IDA 11884415
GO:0005792 microsome NAS 11884415
GO:0005789 endoplasmic reticulum membrane IDA 11884415
GO:0005783 endoplasmic reticulum TAS 9238042|9271576
GO:0016020 membrane IEA -
GO:0016021 integral to membrane TAS 9238042
GO:0042824 MHC class I peptide loading complex NAS 12788224

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG ANTIGEN PROCESSING AND PRESENTATION 89 65 All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL DN 634 384 All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP 783 507 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS UP 306 188 All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS UP 269 146 All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404 246 All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER 20Q13 AMPLIFICATION DN 180 101 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF UP 215 137 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142 669 All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
AUNG GASTRIC CANCER 54 20 All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP 134 93 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037 673 All SZGR 2.0 genes in this pathway
LIU NASOPHARYNGEAL CARCINOMA 70 38 All SZGR 2.0 genes in this pathway
MORI LARGE PRE BII LYMPHOCYTE DN 58 39 All SZGR 2.0 genes in this pathway
MORI IMMATURE B LYMPHOCYTE UP 53 35 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185 114 All SZGR 2.0 genes in this pathway
WIELAND UP BY HBV INFECTION 101 66 All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 83 56 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555 346 All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN 85 67 All SZGR 2.0 genes in this pathway
阿布得生活信号1 46 29 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL LONG TERM 302 191 All SZGR 2.0 genes in this pathway
LINDVALL IMMORTALIZED BY TERT UP 78 48 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 1691 1088 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8 86 57 All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C4 18 12 All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS DN 135 88 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434 302 All SZGR 2.0 genes in this pathway
KIM LRRC3B TARGETS 30 24 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE DN 373 196 All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 49 38 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS DN 145 93 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL DN 102 65 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 107 67 All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D UP 131 79 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP 221 150 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222 141 All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP 59 44 All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 UP 430 288 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898 516 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137 655 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 PARTIAL 160 106 All SZGR 2.0 genes in this pathway