Gene Page:TBCD
Summary?
| GeneID | 6904 |
| Symbol | TBCD |
| Synonyms | SSD-1|tfcD |
| Description | tubulin folding cofactor D |
| Reference | MIM:604649|HGNC:HGNC:11581|Ensembl:ENSG00000141556|HPRD:05227|Vega:OTTHUMG00000177878 |
| Gene type | protein-coding |
| Map location | 17q25.3 |
| Pascal p-value | 0.795 |
| Sherlock p-value | 0.794 |
| Fetal beta | -0.036 |
| DMG | 2 (# studies) |
| eGene | Cerebellum 元 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Montano_2016 | Genome-wide DNA methylation analysis | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 3 |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
| PMID:cooccur | High-throughput literature-search | 系统搜索PubMed基因有限公司-occurring with SCZ keywords. A total of 3027 genes were included. | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | Click to show details |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg09665571 | 17 | 80861008 | TBCD | 2.48E-4 | 0.006 | 0.17 | DMG:Montano_2016 |
| cg01799560 | 17 | 80846075 | TBCD | 1.12E-5 | 0.266 | 0.013 | DMG:Wockner_2014 |
| cg08811443 | 17 | 80819108 | TBCD | 2.987E-4 | 0.371 | 0.039 | DMG:Wockner_2014 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| RPL4 | 0.96 | 0.93 |
| ILF2 | 0.95 | 0.93 |
| BTF3 | 0.95 | 0.93 |
| APEX1 | 0.95 | 0.95 |
| RBM4 | 0.94 | 0.92 |
| IGBP1 | 0.94 | 0.93 |
| TUT1 | 0.94 | 0.92 |
| NUP88 | 0.94 | 0.91 |
| EIF3L | 0.94 | 0.92 |
| PHB2 | 0.94 | 0.95 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HLA-F | -0.69 | -0.77 |
| AF347015.27 | -0.68 | -0.84 |
| AIFM3 | -0.67 | -0.74 |
| AF347015.33 | -0.67 | -0.85 |
| AF347015.31 | -0.67 | -0.82 |
| MT-CYB | -0.67 | -0.85 |
| MT-CO2 | -0.67 | -0.83 |
| C5orf53 | -0.66 | -0.70 |
| HEPN1 | -0.66 | -0.74 |
| FBXO2 | -0.65 | -0.63 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME PROTEIN FOLDING | 53 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | 19 | 10 | All SZGR 2.0 genes in this pathway |
| REACTOME METABOLISM OF PROTEINS | 518 | 242 | All SZGR 2.0 genes in this pathway |
| DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LIVE DN | 384 | 220 | All SZGR 2.0 genes in this pathway |
| HOEBEKE LYMPHOID STEM CELL UP | 95 | 64 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 1 UP | 380 | 236 | All SZGR 2.0 genes in this pathway |
| MULLIGHAN MLL SIGNATURE 2 UP | 418 | 263 | All SZGR 2.0 genes in this pathway |
| PUJANA BRCA2 PCC NETWORK | 423 | 265 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 18HR DN | 178 | 121 | All SZGR 2.0 genes in this pathway |
| DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN | 287 | 208 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D | 882 | 506 | All SZGR 2.0 genes in this pathway |