Gene Page:TBX15

Summary?
GeneID 6913
Symbol TBX15
Synonyms TBX14
Description T-box 15
Reference MIM:604127|HGNC:HGNC:11594|Ensembl:ENSG00000092607|HPRD:16035|Vega:OTTHUMG00000012263
Gene type protein-coding
Map location 1p11.1
Pascal p-value 0.502
Fetal beta 0.062
DMG 2 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:GWASdb Genome-wide Association Studies GWASdb records for schizophrenia
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Wockner_2014 Genome-wide DNA methylation analysis This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg14565725 1 119532044 TBX15 4.497E-4 -0.476 0.045 DMG:Wockner_2014
cg27262412 1 119530702 TBX15 9.05E-8 -0.019 2.07E-5 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26所示postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0003700 transcription factor activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0006355 regulation of transcription, DNA-dependent IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005634 nucleus IEA -

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
BERENJENO TRANSFORMED BY RHOA DN 394 258 All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN 514 319 All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069 729 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 DN 170 105 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE EARLY LATE 317 190 All SZGR 2.0 genes in this pathway
WANG MLL TARGETS 289 188 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-205 173 179 1A hsa-miR-205 UCCUUCAUUCCACCGGAGUCUG
miR-218 1648 1654 m8 hsa-miR-218brain UUGUGCUUGAUCUAACCAUGU
miR-431 805 811 m8 hsa-miR-431 UGUCUUGCAGGCCGUCAUGCA
miR-485-3p 1587 1594 1A,m8 hsa-miR-485-3p GUCAUACACGGCUCUCCUCUCU
miR-496 1577 1583 1A hsa-miR-496 AUUACAUGGCCAAUCUC
miR-500 1411 1417 1A hsa-miR-500 AUGCACCUGGGCAAGGAUUCUG
miR-96 1643 1649 m8 hsa-miR-96brain UUUGGCACUAGCACAUUUUUGC