Gene Page:TCF3
Summary?
基因 | 6929 |
象征 | TCF3 |
Synonyms | E2A|E47|ITF1|TCF-3|VDIR|bHLHb21 |
Description | transcription factor 3 |
Reference | MIM:147141|HGNC:HGNC:11633|Ensembl:ENSG0000000071564|HPRD:00918|Vega:Otthumg00000180031 |
基因类型 | 蛋白质编码 |
Map location | 19p13.3 |
Pascal p-value | 0.012 |
胎儿β | 0.472 |
DMG | 2(# studies) |
Gene in Data Sources
基因集名称 | Method of gene set | Description | 信息 |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
DMG:Montano_2016 | 全基因组DNA甲基化分析 | This dataset includes 172 replicated associations between CpGs with schizophrenia. | 2 |
DMG:vanEijk_2014 | 全基因组DNA甲基化分析 | 这个数据集包括甲醇432不同d CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). | 2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Probe | 染色体 | 位置 | Nearest gene | p(dis) | Beta (dis) | fdr(dis) | 学习 |
---|---|---|---|---|---|---|---|
cg23009327 | 19 | 1630248 | TCF3 | 1.32E-6 | 0.01 | 0.017 | DMG:Montano_2016 |
CG21030400 | 19 | 2052564 | TCF3 | 2.31E-4 | -3.744 | DMG:vanEijk_2014 |
第二节。转录组注释
一般基因表达(GTEX)
![Not available](http://www.tjghsg.com/bioinfo/SZGR/GeneImg/TCF3_DE_GTEx.png)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达(brainspan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1:胎儿(13-26个概念后周),ST2:婴儿早期至童年(4个月至11年)和ST3:青春期至成年期(13-23年)
所示的栏表示表达分布的较低25%和上层25%。
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
---|---|---|---|---|---|
ASCL3 | HASH3 | SGN1 | bHLHa42 | achaete-scute complex homolog 3 (Drosophila) | - | HPRD | 11784080 |
BHLHB8 | MIST1 | bHLHa15 | basic helix-loop-helix domain containing, class B, 8 | - | HPRD | 9073453 |
CALM1 | CALML2 | CAMI | DD132 | PHKD | 钙调蛋白1(磷酸化酶激酶,三角洲) | - | HPRD,BioGRID | 10757985 |
CALM3 | PHKD | PHKD3 | calmodulin 3 (phosphorylase kinase, delta) | - | HPRD | 10757985 |
CBFA2T3 | ETO2 | MTG16 | MTGR2 | ZMYND4 | 核心结合因子,runt域,α亚基2;易位到3 | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 16407974 |
克雷布 | CBP | KAT3A | RSTS | CREB结合蛋白 | - | HPRD,BioGRID | 12435739 |
CTNNB1 | ctnnb |DKFZP686D02253 |FLJ25606 |FLJ37923 | Catenin(cadherin相关蛋白),β1,88KDA | - | HPRD | 12107263 |
ELK3 | ERP | NET | SAP2 | ELK3, ETS-domain protein (SRF accessory protein 2) | - | HPRD,BioGRID | 8918463 |
EP300 | kat3b |P300 | E1A binding protein p300 | - | HPRD,BioGRID | 12435739 |
FERD3L | MGC119861 |n twist |北约3 |ntwist | FER3样(果蝇) | - | HPRD | 12217327 |
Garnl1 | DKFZp566D133 | DKFZp667F074 | GRIPE | KIAA0884 | TULIP1 | GTPase激活RAP/RANGAP域名1 | - | HPRD,BioGRID | 12200424 |
手1 | Hxt | Thing1 | bHLHa27 | eHand | 心脏和神经rest衍生物表达1 | - | HPRD | 10924525|11802795 |
手2 | DHAND2 | FLJ16260 | Hed | MGC125303 | MGC125304 | Thing2 | bHLHa26 | dHand | 心脏和神经rest衍生物表达2 | - | HPRD,BioGRID | 11812799 |
ID1 | ID | bHLHb24 | DNA结合1的抑制剂,显性负螺旋 - 环螺旋蛋白 | Two-hybrid | Biogrid | 9242638 |
ID2 | GIG8 | ID2A | ID2H | MGC26389 | bHLHb26 | DNA结合2的抑制剂,显性负螺旋 - 环螺旋蛋白 | - | HPRD,BioGRID | 9242638 |
ID3 | HEIR-1 | bHLHb25 | DNA结合3的抑制剂,显性负螺旋 - 环螺旋蛋白 | - | HPRD | 8759016|9525934 |
ID3 | HEIR-1 | bHLHb25 | DNA结合3的抑制剂,显性负螺旋 - 环螺旋蛋白 | 重构的复合物 Two-hybrid |
Biogrid | 9242638|9525934 |
kat2b | CAF | P | P/CAF | PCAF | K(赖氨酸)乙酰转移酶2B | - | HPRD,BioGRID | 12435739 |
LDB1 | 攀登2 |Nli | 林域结合1 | 亲和力捕获 - 韦斯特恩 | Biogrid | 16407974 |
LMX1A | LMX-1 |LMX1 |LMX1.1 |MGC87616 | LIM homeobox transcription factor 1, alpha | 重构的复合物 Two-hybrid |
Biogrid | 9199284 |
LYL1 | BHLHA18 | lymphoblastic leukemia derived sequence 1 | - | HPRD,BioGRID | 8628307 |
MAPKAPK2 | MK2 | 有丝分裂原激活的蛋白激酶激活的蛋白激酶2 | - | HPRD,BioGRID | 10781029 |
MAPKAPK3 | 3pk |MAPKAP3 | 有丝分裂原激活的蛋白激酶激活的蛋白激酶3 | - | HPRD,BioGRID | 10781029 |
MSC | ABF-1 | ABF1 | MYOR | bHLHa22 | 肌肉蛋白(活化的B细胞因子1) | - | HPRD | 9584154 |
MYF5 | BHLHC2 | myogenic factor 5 | Two-hybrid | Biogrid | 9242638 |
MYF6 | MRF4 | bHLHc4 | 肌原因子6(巨蛋白) | Two-hybrid | Biogrid | 9242638 |
MYOD1 | MYF3 | MYOD | PUM | bHLHc1 | myogenic differentiation 1 | - | HPRD | 1649701|9001211 |9184158 |
MYOD1 | MYF3 | MYOD | PUM | bHLHc1 | myogenic differentiation 1 | 体外 in vivo 重构的复合物 Two-hybrid |
Biogrid | 1649701|9184158 |9242638 |
myog | myf4 |肌蛋白|BHLHC3 | 肌原(肌原因子4) | 体外 in vivo Two-hybrid |
Biogrid | 1325437|2163343 |9242638 |
myog | myf4 |肌蛋白|BHLHC3 | 肌原(肌原因子4) | - | HPRD | 1649701 |
NEDD9 | CAS-L |cas2 |卡斯尔|Cass2 |hef1 |DJ49G10.2 |DJ761I2.1 | 神经前体细胞表达,发育下调9 | - | HPRD | 10502414 |
NHLH1 | Hen1 |NSCL |NSCL1 |BHLHA35 | Nescient Helix Loop Helix 1 | Two-hybrid | Biogrid | 12878195 |
PDX1 | GSF |IDX-1 |IPF1 |IUF1 |Mody4 |PDX-1 |STF-1 | pancreatic and duodenal homeobox 1 | - | HPRD,BioGRID | 10636926 |
PSMD4 | AF | AF-1 | ASF | MCB1 | Rpn10 | S5A | pUB-R5 | 蛋白酶体(Prosome,大蛋白)26S亚基,非ATPase,4 | - | HPRD,BioGRID | 9235903 |
PSMD9 | MGC8644 | Rpn4 | p27 | 蛋白酶体(Prosome,大蛋白)26S亚基,非ATPase,9 | - | HPRD | 10567574 |
PTF1A | PTF1-p48 | bHLHa29 | 胰比转录因子,1A | - | HPRD,BioGRID | 1720355|10768861 |
runx1t1 | AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2 | 与RUNT相关的转录因子1;易位为1(Cyclin D相关) | ETO与E2A相互作用。 | 绑定 | 15333839 |
SKP2 | fbl1 |fbxl1 |flb1 |MGC1366 | S期激酶相关蛋白2(P45) | - | HPRD,BioGRID | 14592976 |
tal1 | SCL |TCL5 |BHLHA17 |TAL-1 | T-cell acute lymphocytic leukemia 1 | - | HPRD | 8159721 | 9507011 |
tal1 | SCL |TCL5 |BHLHA17 |TAL-1 | T-cell acute lymphocytic leukemia 1 | Affinity Capture-MS 亲和力捕获 - 韦斯特恩 体外 in vivo 重构的复合物 Two-hybrid |
Biogrid | 8159721|16407974 |
TAL2 | BHLHA19 | T-cell acute lymphocytic leukemia 2 | - | HPRD | 8152805 |
TCF12 | HEB | HTF4 | HsT17266 | bHLHb20 | transcription factor 12 | - | HPRD,BioGRID | 1446075|12566462 |
TCF3 | E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21 | 转录因子3(E2A免疫球蛋白增强子结合因子E12/E47) | 共同分级 | Biogrid | 12435739 |
TCF3 | E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21 | 转录因子3(E2A免疫球蛋白增强子结合因子E12/E47) | - | HPRD | 2503252|7623842 |
TCF4 | E2-2 |itf2 |MGC149723 |MGC149724 |pths |sef2 |sef2-1 |SEF2-1A |sef2-1b |BHLHB19 | transcription factor 4 | - | HPRD | 8999959 |
TFPT | FB1 |INO80F |阿米达 | TCF3 (E2A) fusion partner (in childhood Leukemia) | - | HPRD | 10086727 |
TWIST1 | ACS3 | BPES2 | BPES3 | SCS | TWIST | bHLHa38 | 扭曲同源1(果蝇) | - | HPRD,BioGRID | 10749989 |
UBE2I | C358B7.1 | P18 | UBC9 | ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) | 重构的复合物 Two-hybrid |
Biogrid | 10497239 |