Gene Page:TECTB
Summary?
| GeneID | 6975 |
| Symbol | TECTB |
| Synonyms | - |
| Description | tectorin beta |
| Reference | MIM:602653|HGNC:HGNC:11721|Ensembl:ENSG00000119913|HPRD:16005|Vega:OTTHUMG00000019056 |
| Gene type | protein-coding |
| Map location | 10q25-q26 |
| Pascal p-value | 0.027 |
| Fetal beta | -0.617 |
| DMG | 1 (# studies) |
| eGene | Caudate basal ganglia Cortex Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 3 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg00357221 | 10 | 114043412 | TECTB | 6.5E-5 | -0.431 | 0.024 | DMG:Wockner_2014 |
| cg10343314 | 10 | 114043305 | TECTB | 3.605E-4 | -0.391 | 0.042 | DMG:Wockner_2014 |
| cg09925467 | 10 | 114043123 | TECTB | 5.739E-4 | -0.601 | 0.049 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs76586435 | 10 | 113994235 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -49258 | gtex_brain_putamen_basal |
| rs12358126 | 10 | 113995337 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -48156 | gtex_brain_putamen_basal |
| rs115729793 | 10 | 114000610 | TECTB | ENSG00000119913.4 | 1.675E-6 | 0.03 | -42883 | gtex_brain_putamen_basal |
| rs116034828 | 10 | 114000634 | TECTB | ENSG00000119913.4 | 1.675E-6 | 0.03 | -42859 | gtex_brain_putamen_basal |
| rs79446367 | 10 | 114002449 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -41044 | gtex_brain_putamen_basal |
| rs11195852 | 10 | 114009165 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -34328 | gtex_brain_putamen_basal |
| rs12356568 | 10 | 114010837 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -32656 | gtex_brain_putamen_basal |
| rs200724102 | 10 | 114011226 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -32267 | gtex_brain_putamen_basal |
| rs7072514 | 10 | 114011803 | TECTB | ENSG00000119913.4 | 4.143E-6 | 0.03 | -31690 | gtex_brain_putamen_basal |
| rs12355144 | 10 | 114012876 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -30617 | gtex_brain_putamen_basal |
| rs200296484 | 10 | 114016039 | TECTB | ENSG00000119913.4 | 1.705E-6 | 0.03 | -27454 | gtex_brain_putamen_basal |
| rs77615791 | 10 | 114017356 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -26137 | gtex_brain_putamen_basal |
| rs117765391 | 10 | 114018097 | TECTB | ENSG00000119913.4 | 2.018E-6 | 0.03 | -25396 | gtex_brain_putamen_basal |
| rs11815425 | 10 | 114022661 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -20832 | gtex_brain_putamen_basal |
| rs17672268 | 10 | 114023390 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -20103 | gtex_brain_putamen_basal |
| rs12358434 | 10 | 114025839 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -17654 | gtex_brain_putamen_basal |
| rs11817654 | 10 | 114026723 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -16770 | gtex_brain_putamen_basal |
| rs12358863 | 10 | 114026909 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -16584 | gtex_brain_putamen_basal |
| rs7895527 | 10 | 114030652 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -12841 | gtex_brain_putamen_basal |
| rs11195861 | 10 | 114032654 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -10839 | gtex_brain_putamen_basal |
| rs11195864 | 10 | 114035837 | TECTB | ENSG00000119913.4 | 4.258E-6 | 0.03 | -7656 | gtex_brain_putamen_basal |
| rs11195869 | 10 | 114041244 | TECTB | ENSG00000119913.4 | 4.013E-6 | 0.03 | -2249 | gtex_brain_putamen_basal |
| rs11195870 | 10 | 114043240 | TECTB | ENSG00000119913.4 | 3.94E-6 | 0.03 | -253 | gtex_brain_putamen_basal |
| rs7905078 | 10 | 114047059 | TECTB | ENSG00000119913.4 | 2.431E-6 | 0.03 | 3566 | gtex_brain_putamen_basal |
| rs199812500 | 10 | 114048104 | TECTB | ENSG00000119913.4 | 4.142E-6 | 0.03 | 4611 | gtex_brain_putamen_basal |
| rs11195875 | 10 | 114048105 | TECTB | ENSG00000119913.4 | 4.133E-6 | 0.03 | 4612 | gtex_brain_putamen_basal |
| rs74848039 | 10 | 114049630 | TECTB | ENSG00000119913.4 | 4.007E-6 | 0.03 | 6137 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| MCCLUNG COCAIN REWARD 4WK | 75 | 47 | All SZGR 2.0 genes in this pathway |
| NABA ECM GLYCOPROTEINS | 196 | 99 | All SZGR 2.0 genes in this pathway |
| NABA CORE MATRISOME | 275 | 148 | All SZGR 2.0 genes in this pathway |
| NABA MATRISOME | 1028 | 559 | All SZGR 2.0 genes in this pathway |