Gene Page:PRDX2

Summary?
GeneID 7001
Symbol PRDX2
Synonyms HEL-S-2a|NKEF-B|NKEFB|PRP|PRX2|PRXII|PTX1|TDPX1|TPX1|TSA
Description peroxiredoxin 2
Reference MIM:600538|HGNC:HGNC:9353|Ensembl:ENSG00000167815|HPRD:02763|Vega:OTTHUMG00000134285
Gene type protein-coding
Map location 19p13.2
Pascal p-value 0.045
Sherlock p-value 0.611
Fetal beta 0.361
DMG 1 (# studies)
eGene Myers' cis & trans
Support CELL METABOLISM
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS
G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL
G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS
G2Cdb.human_clathrin
G2Cdb.human_Synaptosome
G2Cdb.human_TAP-PSD-95-CORE
G2Cdb.humanNRC
G2Cdb.humanPSD
G2Cdb.humanPSP
CompositeSet

基因数据来源
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg23467004 19 12912244 PRDX2 1.99E-9 0.008 1.64E-6 DMG:Jaffe_2016

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs2105242 chr1 163568328 PRDX2 7001 0.19 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
MAP4 0.50 0.57
TRAF1 0.49 0.56
TENC1 0.47 0.58
PPFIBP2 0.46 0.56
CSDAP1 0.44 0.41
SERPING1 0.44 0.54
BCL3 0.43 0.45
PLAUR 0.43 0.46
ADAMTSL3 0.43 0.34
C1orf38 0.42 0.55
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RGS6 -0.25 -0.19
SEC62 -0.25 -0.25
QRFPR -0.23 -0.28
COX6A1 -0.22 -0.24
LIN7A -0.22 -0.21
CDH7 -0.22 -0.12
TCERG1L -0.22 -0.12
DOK6 -0.21 -0.12
CDH18 -0.21 -0.11
IGSF9B -0.21 -0.15

Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0008379 thioredoxin peroxidase activity IDA 8144038
GO:0016209 antioxidant activity IEA -
GO:0016491 oxidoreductase activity IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0006979 response to oxidative stress IMP 12943237
GO:0006979 response to oxidative stress NAS 11904290
GO:0006916 anti-apoptosis TAS 16130169
GO:0042981 regulation of apoptosis IMP 12943237
GO:0045454 cell redox homeostasis IEA -
GO:0055114 oxidation reduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005737 cytoplasm TAS 16130169

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN 16 12 All SZGR 2.0 genes in this pathway
JAEGER METASTASIS DN 258 141 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 143 83 All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 86 59 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
GRAHAM CML QUIESCENT VS NORMAL QUIESCENT UP 87 45 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
HAHTOLA MYCOSIS FUNGOIDES CD4 DN 116 71 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508 354 All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530 342 All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF DN 118 78 All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228 137 All SZGR 2.0 genes in this pathway
WANG HCP PROSTATE CANCER 111 69 All SZGR 2.0 genes in this pathway
JAZAG TGFB1 SIGNALING UP 108 69 All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP 479 299 All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957 597 All SZGR 2.0 genes in this pathway
LIU COMMON CANCER GENES 79 47 All SZGR 2.0 genes in this pathway
RAHMAN TP53 TARGETS PHOSPHORYLATED 21 18 All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN 261 155 All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION DN 517 309 All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 120 MCF10A 43 28 All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 81 51 All SZGR 2.0 genes in this pathway
HOUSTIS ROS 36 29 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL CIS 128 77 All SZGR 2.0 genes in this pathway
CHESLER BRAIN QTL CIS 75 51 All SZGR 2.0 genes in this pathway
BYSTRYKH造血干细胞和大脑QTL CIS 65 38 All SZGR 2.0 genes in this pathway
CHESLER BRAIN HIGHEST GENETIC VARIANCE 37 21 All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546 351 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 126 84 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
TAKAO RESPONSE TO UVB RADIATION UP 86 55 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN 371 218 All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 71 49 All SZGR 2.0 genes in this pathway
ZHANG PROLIFERATING VS QUIESCENT 51 41 All SZGR 2.0 genes in this pathway
ZHOU TNF SIGNALING 30MIN 54 36 All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP 428 266 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317 208 All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN 78 44 All SZGR 2.0 genes in this pathway
SAGIV CD24 TARGETS UP 23 15 All SZGR 2.0 genes in this pathway
SAGIV CD24 TARGETS DN 46 26 All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN 45 31 All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871 505 All SZGR 2.0 genes in this pathway
MOOTHA PGC 420 269 All SZGR 2.0 genes in this pathway
CHIARETTI T ALL REFRACTORY TO THERAPY 30 18 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 13 172 107 All SZGR 2.0 genes in this pathway
BAUS TFF2 TARGETS DN 11 7 All SZGR 2.0 genes in this pathway
NIELSEN LEIOMYOSARCOMA DN 18 11 All SZGR 2.0 genes in this pathway
BAE BRCA1 TARGETS UP 75 47 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
PECE乳腺干细胞 146 75 All SZGR 2.0 genes in this pathway