Gene Page:BUB1B

Summary?
GeneID 701
Symbol BUB1B
Synonyms BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1
Description BUB1有丝分裂检查点丝氨酸/苏氨酸激酶B
Reference MIM:602860|HGNC:HGNC:1149|Ensembl:ENSG00000156970|HPRD:04176|Vega:OTTHUMG00000129877
Gene type protein-coding
Map location 15q15
Pascal p-value 0.1
Fetal beta 2.26
DMG 1 (# studies)

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Jaffe_2016 Genome-wide DNA methylation analysis This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20259534 15 40453036 BUB1B 1.42E-8 -0.012 5.5E-6 DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC:分皮质区域;感觉器官SM:注册ions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
PRCC 0.95 0.95
PSMD3 0.95 0.94
C7orf26 0.94 0.95
UCK2 0.94 0.94
BAT3 0.94 0.95
DGCR14 0.94 0.94
CHMP7 0.94 0.95
RIC8A 0.94 0.94
DEDD 0.94 0.93
FTSJ1 0.94 0.93
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.81 -0.89
AF347015.27 -0.81 -0.91
MT-CO2 -0.81 -0.89
AF347015.33 -0.80 -0.90
AF347015.8 -0.79 -0.91
MT-CYB -0.78 -0.88
AF347015.15 -0.76 -0.88
FXYD1 -0.76 -0.86
AF347015.2 -0.75 -0.88
S100B -0.75 -0.85

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANAPC7 APC7 anaphase promoting complex subunit 7 - HPRD 10477750
AP2B1 ADTB2 | AP105B | AP2-BETA | CLAPB1 | DKFZp781K0743 adaptor-related protein complex 2, beta 1 subunit - HPRD,BioGRID 12419313
APC BTPS2 | DP2 | DP2.5 | DP3 | GS adenomatous polyposis coli Biochemical Activity BioGRID 11283619
BRCA2 BRCC2 | FACD | FAD | FAD1 | FANCB | FANCD | FANCD1 breast cancer 2, early onset - HPRD,BioGRID 10749118
BUB3 BUB3L | hBUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) - HPRD,BioGRID 9660858
CDC16 APC6 cell division cycle 16 homolog (S. cerevisiae) - HPRD,BioGRID 10477750
CDC20 CDC20A | MGC102824 | bA276H19.3 | p55CDC cell division cycle 20 homolog (S. cerevisiae) BubR1 interacts with Cdc20. BIND 15525512
CDC20 CDC20A | MGC102824 | bA276H19.3 | p55CDC cell division cycle 20 homolog (S. cerevisiae) - HPRD,BioGRID 11030144|11274370
|11535616|11907259
CDC27 APC3 | CDC27Hs | D0S1430E | D17S978E | HNUC cell division cycle 27 homolog (S. cerevisiae) - HPRD,BioGRID 10477750
CENPE KIF10 centromere protein E, 312kDa - HPRD,BioGRID 9763420|10477750
HDAC1 DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1 histone deacetylase 1 Affinity Capture-Western
Co-purification		 BioGRID 15388328
MAD2L1 HSMAD2 | MAD2 MAD2 mitotic arrest deficient-like 1 (yeast) Affinity Capture-Western
Co-purification		 BioGRID 11535616
SNCG BCSG1 | SR synuclein, gamma (breast cancer-specific protein 1) - HPRD,BioGRID 14576821


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CELL CYCLE 128 84 All SZGR 2.0 genes in this pathway
PID PLK1 PATHWAY 46 25 All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS 24 12 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE 421 253 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC 325 185 All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE CHECKPOINTS 124 70 All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MITOTIC CELL CYCLE 85 46 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC M M G1 PHASES 172 98 All SZGR 2.0 genes in this pathway
REACTOME DNA REPLICATION 192 110 All SZGR 2.0 genes in this pathway
REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS 73 40 All SZGR 2.0 genes in this pathway
REACTOME MITOTIC PROMETAPHASE 87 51 All SZGR 2.0 genes in this pathway
REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A 28 12 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 151 84 All SZGR 2.0 genes in this pathway
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 UP 146 86 All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663 425 All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305 185 All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN 310 188 All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244 153 All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290 177 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER EARLY UP 430 232 All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS TURQUOISE DN 53 25 All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362 238 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 139 76 All SZGR 2.0 genes in this pathway
ODONNELL TARGETS OF MYC AND TFRC DN 45 25 All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR UP 557 331 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278 748 All SZGR 2.0 genes in this pathway
SCIBETTA KDM5B TARGETS DN 81 55 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459 276 All SZGR 2.0 genes in this pathway
GRAHAM CML DIVIDING VS NORMAL QUIESCENT UP 181 101 All SZGR 2.0 genes in this pathway
GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING DN 87 49 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722 443 All SZGR 2.0 genes in this pathway
MISSIAGLIA REGULATED BY METHYLATION DN 122 67 All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584 356 All SZGR 2.0 genes in this pathway
KONG E2F3 TARGETS 97 58 All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER CLUSTER 2 33 17 All SZGR 2.0 genes in this pathway
ROSTY CERVICAL CANCER PROLIFERATION CLUSTER 140 73 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
AMUNDSON GENOTOXIC SIGNATURE 105 68 All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 101 73 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423 265 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779 480 All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795 478 All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539 324 All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379 235 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
BENPORATH OCT4 TARGETS 290 172 All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734 436 All SZGR 2.0 genes in this pathway
BENPORATH NOS TARGETS 179 105 All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES 648 385 All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215 893 528 All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 110 69 All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT DN 185 111 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163 115 All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR UP 45 20 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD UP 131 87 All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS DN 234 137 All SZGR 2.0 genes in this pathway
PETROVA PROX1 TARGETS UP 28 16 All SZGR 2.0 genes in this pathway
SU TESTIS 76 53 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298 200 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR DN 101 70 All SZGR 2.0 genes in this pathway
KANG DOXORUBICIN RESISTANCE UP 54 33 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318 220 All SZGR 2.0 genes in this pathway
DAZARD UV RESPONSE CLUSTER G6 153 112 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P6 91 44 All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED 728 415 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210 123 All SZGR 2.0 genes in this pathway
AMUNDSON GAMMA RADIATION RESPONSE 40 25 All SZGR 2.0 genes in this pathway
FINETTI BREAST CANCER KINOME RED 16 11 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
RIGGI EWING SARCOMA PROGENITOR DN 191 123 All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249 165 All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C 463 262 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE 72 55 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN 70 43 All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342 220 All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299 189 All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323 240 All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305 895 All SZGR 2.0 genes in this pathway
CHANG CYCLING GENES 148 83 All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP 107 59 All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER POOR SURVIVAL A6 456 285 All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR DN 277 166 All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION DN 98 69 All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN 72 47 All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288 168 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G23 UP 52 35 All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION UP 178 108 All SZGR 2.0 genes in this pathway
KOBAYASHI EGFR SIGNALING 24HR DN 251 151 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
CHIARETTI T ALL RELAPSE PROGNOSIS 19 15 All SZGR 2.0 genes in this pathway
WONG EMBRYONIC STEM CELL CORE 335 193 All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE LITERATURE 44 25 All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243 155 All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN 374 217 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR UP 324 193 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570 339 All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882 506 All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211 119 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway