Gene Page:TFCP2

Summary?
GeneID 7024
Symbol TFCP2
Synonyms LBP1C|LSF|LSF1D|SEF|TFCP2C
Description transcription factor CP2
Reference MIM:189889|HGNC:HGNC:11748|Ensembl:ENSG00000135457|HPRD:01790|Vega:OTTHUMG00000169621
Gene type protein-coding
Map location 12q13
Pascal p-value 0.393
Sherlock p-value 0.925
Fetal beta 0.065
DMG 1 (# studies)
eGene Myers' cis & trans
元

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
DMG:Nishioka_2013 Genome-wide DNA methylation analysis The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe Chromosome Position Nearest gene P (dis) Beta (dis) FDR (dis) Study
cg20927059 12 51567112 TFCP2 -0.027 0.26 DMG:Nishioka_2013

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs12304878 chr12 51353850 TFCP2 7024 1.676E-5 cis
rs12304921 chr12 51357541 TFCP2 7024 7.043E-4 cis
rs224446 chr12 51381717 TFCP2 7024 1.917E-5 cis
rs2018022 chr12 51475352 TFCP2 7024 0.01 cis
rs3751275 chr12 51518786 TFCP2 7024 7.568E-4 cis
rs12304878 chr12 51353850 TFCP2 7024 0 trans
rs12304921 chr12 51357541 TFCP2 7024 0.05 trans
rs224446 chr12 51381717 TFCP2 7024 0 trans
rs3751275 chr12 51518786 TFCP2 7024 0.06 trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),圣2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
STRN4 0.90 0.93
KLHL22 0.89 0.90
ZMYND19 0.89 0.90
DTX3 0.88 0.90
RANBP3 0.88 0.89
CXXC1 0.88 0.90
ZNF513 0.87 0.89
NLE1 0.87 0.87
EVL 0.87 0.90
RIC8A 0.87 0.88
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
AF347015.31 -0.77 -0.81
MT-CO2 -0.77 -0.81
AF347015.27 -0.75 -0.81
AF347015.8 -0.74 -0.79
MT-CYB -0.74 -0.79
AF347015.21 -0.73 -0.83
AF347015.33 -0.73 -0.78
AF347015.2 -0.71 -0.79
AF347015.15 -0.71 -0.78
AF347015.26 -0.68 -0.75

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
PID HDAC CLASSI PATHWAY 66 50 All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382 904 All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375 806 All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358 245 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS UP 424 268 All SZGR 2.0 genes in this pathway
SASAKI ADULT T CELL LEUKEMIA 176 122 All SZGR 2.0 genes in this pathway
URS ADIPOCYTE DIFFERENTIATION UP 74 51 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR DN 47 31 All SZGR 2.0 genes in this pathway
ZHENG IL22 SIGNALING DN 42 26 All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294 199 All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER DN 238 145 All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422 277 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254 158 All SZGR 2.0 genes in this pathway