Gene Page:TFRC

Summary？
基因 7037
象征 TFRC
Synonyms CD71|IMD46|T9|TFR|TFR1|TR|TRFR|p90
Description 转铁蛋白受体
Reference MIM：190010|HGNC:HGNC:11763|Ensembl:ENSG00000072274|HPRD:01812|Vega:OTTHUMG00000155714
基因类型 蛋白质编码
Map location 3Q29
Pascal p-value 0.703
Sherlock p-value 0.285
胎儿β -0.561
主持人 小脑

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CNV:YES Copy number variation studies Manual curation
CV:PGCnp Genome-wide Association Study GWAS
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
Literature High-throughput literature-search 与精神分裂症关键词共同存在：精神分裂症，精神分裂症，精神分裂症，精神分裂症 点击显示详细信息
Network Shortest path distance of core genes in the Human protein-protein interaction network PPI网络中最短路径的贡献：0.0069

Section I. Genetics and epigenetics annotation


第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
NTN1 0.78 0.46
FZD5 0.77 0.49
ZNF503 0.76 0.45
AC010997.1 0.75 0.45
最好3 0.75 0.10
LHX6 0.74 0.62
DLX6 0.74 0.67
VAX1 0.74 0.58
SIX3 0.74 0.40
MADCAM1 0.72 0.31
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
CDADC1 -0.17 0.02
INPP1 -0.15 0.10
CHPT1 -0.15 -0.21
mgll -0.15 -0.10
RTN4RL2 -0.15 0.26
BCAP29 -0.14 0.04
SLC26A4 -0.14 0.07
ST3GAL6 -0.14 0.09
C1 -0.14 -0.18
PPP2R5A -0.14 0.04

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
去：0004998 转铁蛋白受体activity nas 1871153
GO:0004872 receptor activity IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
去：0006897 内吞作用 IEA -
去：0006879 细胞铁离子稳态 nas 1871153
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IDA 1871153
去：0005768 endosome IDA 14612438
GO：0016023 细胞质膜结合的囊泡 IDA 15229288
去：0005886 plasma membrane IEA -
去：0005887 integral to plasma membrane TAS 6090955
GO：0048471 细胞质的核周区 IEA -
GO:0042470 melanosome IEA -

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
KEGG内吞作用 183 132 All SZGR 2.0 genes in this pathway
KEGG造血细胞谱系 88 60 All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 79 62 All SZGR 2.0 genes in this pathway
PID HNF3B途径 45 37 All SZGR 2.0 genes in this pathway
PID HIF1 TFPathway 66 52 All SZGR 2.0 genes in this pathway
REACTOME MEMBRANE TRAFFICKING 129 74 All SZGR 2.0 genes in this pathway
Reactome Trans Golgi网络囊泡芽 60 31 All SZGR 2.0 genes in this pathway
小分子的反应组跨膜转运 413 270 All SZGR 2.0 genes in this pathway
Reactome Golgi相关囊泡生物发生 53 27 All SZGR 2.0 genes in this pathway
Reactome铁吸收和运输 36 18 All SZGR 2.0 genes in this pathway
REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING 25 10 All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294 178 All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431 263 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨态性白血病 1382 904 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
Odonnell TFRC靶向DN 139 76 All SZGR 2.0 genes in this pathway
MYC和TFRC DN的ODONNELL目标 45 25 All SZGR 2.0 genes in this pathway
Senese HDAC1靶向 457 269 All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS UP 238 144 All SZGR 2.0 genes in this pathway
SENESE HDAC2目标了 114 66 All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS UP 501 327 All SZGR 2.0 genes in this pathway
Bidus转移 214 134 All SZGR 2.0 genes in this pathway
多德鼻咽癌DN 1375 806 All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633 376 All SZGR 2.0 genes in this pathway
甲状腺癌的甲状腺癌间变性 722 443 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
Lindgren膀胱癌簇1 DN 378 231 All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 3 UP 329 196 All SZGR 2.0 genes in this pathway
环氧素DN的浓凋亡 172 112 All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 1781 1082 All SZGR 2.0 genes in this pathway
Graessmann对MC和阿霉素DN的反应 770 415 All SZGR 2.0 genes in this pathway
berenjeno由Rhoa Up Troment 536 340 All SZGR 2.0 genes in this pathway
McBryan Pubertal乳房4 5WK DN 196 131 All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE UP 38 26 All SZGR 2.0 genes in this pathway
myllykangas放大热点7 8 6 All SZGR 2.0 genes in this pathway
Hernandez异常有丝分裂由Docetacel 4NM DN 7 6 All SZGR 2.0 genes in this pathway
Teramoto OPN目标群集1 13 10 All SZGR 2.0 genes in this pathway
Martoriati MDM4靶向胎儿肝DN 514 319 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM1 229 137 All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC网络 1652 1023 All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC网络 779 480 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 UP 209 139 All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA HIF1A UP 77 49 All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS DN 1024 594 All SZGR 2.0 genes in this pathway
LOCKWOOD AMPLIFIED IN LUNG CANCER 214 139 All SZGR 2.0 genes in this pathway
带有E盒的WEI MYCN目标 795 478 All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP 33 20 All SZGR 2.0 genes in this pathway
Caffarel对THC 24小时5的响应 34 23 All SZGR 2.0 genes in this pathway
Colin Pilocytic星形胶质细胞瘤与胶质母细胞瘤DN 28 21 All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标 230 156 All SZGR 2.0 genes in this pathway
Benporath增殖 147 80 All SZGR 2.0 genes in this pathway
Stark Hyppocampus 22Q11删除 53 40 All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464 276 All SZGR 2.0 genes in this pathway
ONDER CDH1 SIGNALING VIA CTNNB1 83 58 All SZGR 2.0 genes in this pathway
Welch GATA1目标 22 12 All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc TGFA UP 61 40 All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION DN 187 122 All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 121 65 All SZGR 2.0 genes in this pathway
tarte浆细胞与Plasmablast DN 309 206 All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束 182 116 All SZGR 2.0 genes in this pathway
Flechner PBL肾脏移植OK vs捐助者 151 100 All SZGR 2.0 genes in this pathway
SCHUHMACHER MYC目标了 80 57 All SZGR 2.0 genes in this pathway
SANA对IFNG DN的回应 85 56 All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882 572 All SZGR 2.0 genes in this pathway
Coller MYC的目标 25 19 All SZGR 2.0 genes in this pathway
SHIPP DLBCL VS FOLLICULAR LYMPHOMA UP 45 30 All SZGR 2.0 genes in this pathway
Sasaki成人T细胞白血病 176 122 All SZGR 2.0 genes in this pathway
彭雷帕霉素反应dn 245 154 All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337 230 All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475 313 All SZGR 2.0 genes in this pathway
NUMATA CSF3通过STAT3发出信号传导 22 17 All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 114 84 All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS 126 90 All SZGR 2.0 genes in this pathway
Browne HCMV感染20小时 240 152 All SZGR 2.0 genes in this pathway
Browne HCMV感染16小时 225 139 All SZGR 2.0 genes in this pathway
伊万诺娃造血晚期祖先 544 307 All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237 837 All SZGR 2.0 genes in this pathway
哈里斯缺氧 81 64 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP 105 73 All SZGR 2.0 genes in this pathway
Delaserna Myod的目标 89 51 All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215 132 All SZGR 2.0 genes in this pathway
EHRLICH ICF SYNDROM DN 15 13 All SZGR 2.0 genes in this pathway
Sesto对UV C0的反应 107 72 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN 88 58 All SZGR 2.0 genes in this pathway
葡萄病毒感染DN的Debiasi凋亡DN 287 208 All SZGR 2.0 genes in this pathway
SEMENZA HIF1 TARGETS 36 32 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 6小时DN的响应 911 527 All SZGR 2.0 genes in this pathway
Krige对Tosedostat 24小时DN的反应 1011 592 All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393 244 All SZGR 2.0 genes in this pathway
霍林引用1个目标1 dn 37 22 All SZGR 2.0 genes in this pathway
Hillion HMGA1目标 90 71 All SZGR 2.0 genes in this pathway
Sansom APC MYC目标 217 138 All SZGR 2.0 genes in this pathway
Heller HDAC靶向被甲基化的沉默 461 298 All SZGR 2.0 genes in this pathway
马丁内斯RB1靶向 673 430 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601 369 All SZGR 2.0 genes in this pathway
阿塞维多肝肿瘤与正常的相邻组织向上 863 514 All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP 425 253 All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 108 68 All SZGR 2.0 genes in this pathway
BHATI G2M ARREST BY 2METHOXYESTRADIOL UP 125 68 All SZGR 2.0 genes in this pathway
Podar对Ahaphostin DN的反应 18 16 All SZGR 2.0 genes in this pathway
CUI葡萄糖剥夺 60 44 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
格雷希克癌症复制号码 323 240 All SZGR 2.0 genes in this pathway
Mootha PGC 420 269 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP 139 95 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
LUDWICZEK TREATING IRON OVERLOAD 7 5 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟C 69 49 All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN 366 257 All SZGR 2.0 genes in this pathway
炎症反应和胆固醇 58 38 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338 225 All SZGR 2.0 genes in this pathway
Rutella对HGF的反应 418 282 All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP 408 276 All SZGR 2.0 genes in this pathway
甜肺癌Kras DN 435 289 All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G23 UP 52 35 All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP 605 377 All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC UP 72 53 All SZGR 2.0 genes in this pathway
DANG MYC TARGETS UP 143 100 All SZGR 2.0 genes in this pathway
由MYC约束 1103 714 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 8 49 36 All SZGR 2.0 genes in this pathway
YAO对孕酮簇的时间反应11 103 68 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR UP 61 44 All SZGR 2.0 genes in this pathway
Browne HCMV感染4小时 55 41 All SZGR 2.0 genes in this pathway
Wang对GSK3抑制剂SB216763 DN的响应 374 217 All SZGR 2.0 genes in this pathway
DEMAGALHAES AGING DN 16 10 All SZGR 2.0 genes in this pathway
Bruins通过TP53组B响应UVC响应 549 316 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 2 UP 15 12 All SZGR 2.0 genes in this pathway
Lee BMP2靶向DN 882 538 All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 72 52 All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL UP 289 184 All SZGR 2.0 genes in this pathway
Zwang 3类由EGF瞬时诱导 222 159 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-124/506 949 955 M8 hsa-miR-506 UAAGGCACCCUUCUGAGUAGA
HSA-MIR-124brain UAAGGCACGCGGUGAAUGCC
miR-141/200a 1463 1469 M8 HSA-MIR-141 uaacacugucugugugugugaugg
hsa-miR-200a UAACACUGUCUGGUAACGAUGU
miR-144 973 979 M8 HSA-MIR-144 UACAGUAUAGAUGAUGUACUAG
miR-145 1028 1034 1A HSA-MIR-145 guccaguuucccaggaaucccuu
mir-148/152 864 870 1A hsa-miR-148a ucagugcacuacaacuuugu
HSA-MIR-152brain UCAGUGCAUGACACUUGGG
hsa-miR-148b ucagugcaucacacaacuuugu
miR-194 1430 1436 1A HSA-MIR-194 uguaacagcaacuccauga
miR-31 528 535 1A，M8 hsa-miR-31 Aggcaagaugcuggcauagcug
mir-320 147 153 M8 hsa-miR-320 aaaagcugggugagaggggcgaa
miR-542-3p 1323 1329 1A hsa-miR-542-3p UGUGACAGAUUGAUAACUGAAA
mir-7 1355 1362 1A，M8 hsa-miR-7SZ UGGAAGACUAGUGAUUUUGUUG
mir-9 653 659 1A hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA