Gene Page:TGFBI

Summary？
基因 7045
象征 TGFBI
Synonyms bigh3 | cdb1 | cdg2 | cdgg1 | csd | csd1 | csd2 | csd3 | ebmd | lcd1
Description 反式forming growth factor beta induced
Reference MIM：601692|HGNC:HGNC:11771|Ensembl：ENSG00000120708|HPRD：03409|Vega:OTTHUMG00000163213
基因类型 蛋白质编码
Map location 5Q31
Pascal p-value 0.678
Sherlock p-value 0.23
胎儿β -0.872
DMG 1(# studies)
主持人 Myers' cis & trans

Gene in Data Sources
基因集名称 Method of gene set Description 信息
CV:GWASdb Genome-wide Association Studies 精神分裂症的GWASDB记录
CV:PGCnp Genome-wide Association Study GWAS
DMG：Wockner_2014 全基因组DNA甲基化分析 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 1
PMID：cooccur High-throughput literature-search PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。
GSMA_I Genome scan meta-analysis PSR：0.0032
Literature High-throughput literature-search Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias 点击显示详细信息

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

Probe 染色体 位置 Nearest gene p（dis） Beta (dis) fdr（dis） 学习
CG05838308 5 135367668 TGFBI 2.37E-5 0.46 0.017 DMG：Wockner_2014

@eQTL annotation

SNP ID 染色体 位置 主持人 Gene Entrez ID pvalue QVALUE TSS距离 EQTL类型
RS1404184 CHR2 149268502 TGFBI 7045 0.16 反式
rs1996630 CHR3 21781970 TGFBI 7045 0.19 反式
rs17004962 CHR4 81563338 TGFBI 7045 0.01 反式
rs11225017 Chr11 101687729 TGFBI 7045 0.08 反式
rs7311343 CHR12 21228780 TGFBI 7045 0.05 反式
RS1197137 Chrx 95591388 TGFBI 7045 0.01 反式

第二节。转录组注释

一般基因表达（GTEX）

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

大脑区域的顶级共表达基因

前10个积极共表达的基因
Gene Pearson's Correlation 斯皮尔曼的相关性
ZNF710 0.84 0.86
CAD 0.83 0.84
GRK5 0.82 0.83
NFRKB 0.81 0.85
Men1 0.81 0.82
TMTC4 0.81 0.82
SNRNP200 0.81 0.83
DCAKD 0.81 0.84
ptgfrn 0.80 0.80
ZFP64 0.80 0.83
Top 10 negatively co-expressed genes
Gene Pearson's Correlation 斯皮尔曼的相关性
AF347015.31 -0.62 -0.73
MT-CO2 -0.61 -0.73
AF347015.27 -0.60 -0.72
C5orf53 -0.60 -0.63
AF347015.33 -0.59 -0.70
AF347015.21 -0.59 -0.79
mt-cyb -0.58 -0.70
ifi27 -0.58 -0.67
AF347015.8 -0.58 -0.71
S100B -0.56 -0.64

第三节。基因本体论注释

分子功能 去学期 证据 神经关键字 PubMed ID
GO:0005178 整联蛋白结合 TAS 1388724
去：0005515 蛋白质结合 IEA -
生物过程 去学期 证据 神经关键字 PubMed ID
GO:0007162 细胞粘附的负调控 TAS 8024701
GO:0008283 cell proliferation TAS 1388724
去：0007601 visual perception TAS 9463327
GO：0050896 对刺激的反应 IEA -
Cellular component 去学期 证据 神经关键字 PubMed ID
去：0005576 细胞外区域 IEA -
去：0005578 proteinaceous extracellular matrix IEA -
去：0005615 细胞外空间 TAS 1388724

Section V. Pathway annotation

路径名 路径大小 # SZGR 2.0 genes in pathway 信息
PID Integin1途径 66 44 All SZGR 2.0 genes in this pathway
PID Integin3途径 43 25 All SZGR 2.0 genes in this pathway
PID Integin2途径 29 18 All SZGR 2.0 genes in this pathway
REACTOME AMYLOIDS 83 63 All SZGR 2.0 genes in this pathway
中村肿瘤区周围与中央 285 181 All SZGR 2.0 genes in this pathway
Schuetz乳腺癌导管侵入性 351 230 All SZGR 2.0 genes in this pathway
Fulcher炎症反应凝集素与LPS DN 463 290 All SZGR 2.0 genes in this pathway
迪亚兹慢性巨型性白血病DN 116 79 All SZGR 2.0 genes in this pathway
LIU CMYB TARGETS UP 165 106 All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455 304 All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN 460 312 All SZGR 2.0 genes in this pathway
SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP 158 103 All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合3D DN的Takeda目标 31 19 All SZGR 2.0 genes in this pathway
NUP98 HOXA9融合8D DN的Takeda目标 205 127 All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 142 90 All SZGR 2.0 genes in this pathway
runx1 runx1t1融合HSC DN的TONKS目标 187 115 All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN 260 143 All SZGR 2.0 genes in this pathway
Lee神经Crest干细胞向上 146 99 All SZGR 2.0 genes in this pathway
sabates结直肠腺瘤 141 75 All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA UP 171 112 All SZGR 2.0 genes in this pathway
DMOG的Elvidge缺氧 130 85 All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226 132 All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781 465 All SZGR 2.0 genes in this pathway
ENK UV响应表皮DN 508 354 All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 70 43 All SZGR 2.0 genes in this pathway
Chiaradonna肿瘤转化KRAS CDC25 UP 58 39 All SZGR 2.0 genes in this pathway
Markey RB1急性lof 215 137 All SZGR 2.0 genes in this pathway
Gaussmann MLL AF4融合靶向E 97 60 All SZGR 2.0 genes in this pathway
兰迪斯ERBB2乳房肿瘤324 DN 149 93 All SZGR 2.0 genes in this pathway
Schramm Inhba目标 7 7 All SZGR 2.0 genes in this pathway
KANG GIST WITH PDGFRA UP 50 27 All SZGR 2.0 genes in this pathway
OXFORD RALA AND RALB TARGETS DN 9 5 All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS DN 47 33 All SZGR 2.0 genes in this pathway
Hatada甲基化在肺癌中 390 236 All SZGR 2.0 genes in this pathway
Sheth肝癌与TXNIP损失PAM4 261 153 All SZGR 2.0 genes in this pathway
Nuytten EZH2靶向 1037 673 All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS DN 64 41 All SZGR 2.0 genes in this pathway
Buytaert光动力疗法应力DN 637 377 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发12小时DN 57 45 All SZGR 2.0 genes in this pathway
Schaeffer前列腺开发48小时DN 428 306 All SZGR 2.0 genes in this pathway
Koyama Sema3b靶向 292 168 All SZGR 2.0 genes in this pathway
WU细胞迁移 184 114 All SZGR 2.0 genes in this pathway
Colin Pilocytic星形胶质细胞瘤与胶质母细胞瘤DN 28 21 All SZGR 2.0 genes in this pathway
ROSS AML WITH CBFB MYH11 FUSION 52 32 All SZGR 2.0 genes in this pathway
甜蜜的克拉斯靶向 84 51 All SZGR 2.0 genes in this pathway
马纳洛缺氧 207 145 All SZGR 2.0 genes in this pathway
棕色髓样细胞的发育 165 100 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366 238 All SZGR 2.0 genes in this pathway
LEI MYB目标 318 215 All SZGR 2.0 genes in this pathway
HOXA9和MEIS1 DN的HESS目标 77 48 All SZGR 2.0 genes in this pathway
PETROVA ENDOTHELIUM LYMPHATIC VS BLOOD DN 162 102 All SZGR 2.0 genes in this pathway
Affar YY1靶向DN 234 137 All SZGR 2.0 genes in this pathway
NPM1突变DN的Verhaak AML 246 180 All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408 274 All SZGR 2.0 genes in this pathway
Chen LVAD支持失败的心脏DN 42 32 All SZGR 2.0 genes in this pathway
麦克道尔急性肺损伤 45 29 All SZGR 2.0 genes in this pathway
Sesto对UV C6的反应 39 27 All SZGR 2.0 genes in this pathway
PAL PRMT5靶向 203 135 All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS DN 57 42 All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN 504 323 All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 67 45 All SZGR 2.0 genes in this pathway
HAN JNK SINGALING UP 35 21 All SZGR 2.0 genes in this pathway
tseng irs1靶向DN 135 88 All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487 303 All SZGR 2.0 genes in this pathway
CUI TCF21目标2向上 428 266 All SZGR 2.0 genes in this pathway
伯顿成生7 51 34 All SZGR 2.0 genes in this pathway
Tseng脂肪势DN 46 28 All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS UP 280 183 All SZGR 2.0 genes in this pathway
Durchdewald皮肤致癌DN 264 168 All SZGR 2.0 genes in this pathway
LEIN CHOROID PLEXUS MARKERS 103 61 All SZGR 2.0 genes in this pathway
促进耐受巨噬细胞 156 92 All SZGR 2.0 genes in this pathway
coates巨噬细胞M1 vs M2向上 81 52 All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543 317 All SZGR 2.0 genes in this pathway
Martinez TP53靶向 602 364 All SZGR 2.0 genes in this pathway
Martinez RB1和TP53靶向 601 369 All SZGR 2.0 genes in this pathway
OSADA ASCL1 TARGETS DN 24 20 All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS DN 36 21 All SZGR 2.0 genes in this pathway
级结肠癌 871 505 All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285 167 All SZGR 2.0 genes in this pathway
HUANG DASATINIB RESISTANCE UP 81 53 All SZGR 2.0 genes in this pathway
冬季缺氧metagene 242 168 All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374 247 All SZGR 2.0 genes in this pathway
Boylan多发性骨髓瘤C D DN 252 155 All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP 71 49 All SZGR 2.0 genes in this pathway
Lindstedt树突状细胞成熟D 68 44 All SZGR 2.0 genes in this pathway
Schraets MLL靶向DN 33 24 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491 316 All SZGR 2.0 genes in this pathway
甜Kras致癌签名 89 56 All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP 395 249 All SZGR 2.0 genes in this pathway
Han Satb1靶向DN 442 275 All SZGR 2.0 genes in this pathway
CROONQUIST STROMAL STIMULATION UP 60 42 All SZGR 2.0 genes in this pathway
Croonquist NRA与基质刺激DN 99 65 All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 9 35 26 All SZGR 2.0 genes in this pathway
Mikkelsen MCV6 HCP带有H3K27ME3 435 318 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA1 UP 101 66 All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 68 50 All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS UP 13 11 All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA MESENCHYMAL 216 130 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505 328 All SZGR 2.0 genes in this pathway
PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 UP 134 85 All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3靶向 387 225 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
Johnstone Parvb目标3 430 288 All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到 1137 655 All SZGR 2.0 genes in this pathway
Kim Glis2靶向 84 61 All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 DN 39 21 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682 433 All SZGR 2.0 genes in this pathway
Smad2或Smad3的Koinuma目标 824 528 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 148 88 All SZGR 2.0 genes in this pathway
杨Bcl3靶向 364 236 All SZGR 2.0 genes in this pathway
Wang MLL目标 289 188 All SZGR 2.0 genes in this pathway
DURAND STROMA S UP 297 194 All SZGR 2.0 genes in this pathway
WARTERS对IR皮肤的反应 83 44 All SZGR 2.0 genes in this pathway
NABA ECM糖蛋白 196 99 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族 Target position miRNA ID mirna seq
UTR开始 UTR结束 匹配方法
miR-181 74 80 M8 HSA-MIR-181Abrain AACAUUCAACGCUGUCGGUGAGU
HSA-MIR-181BSZ AACAUUCAUUGCUGUCGGUGGG
HSA-MIR-181Cbrain AACAUUCAACCUGUCGGUGAGU
HSA-MIR-181Dbrain AACAUUCAUUGUUGUCGGUGGGUU
miR-21 425 432 1A，M8 hsa-miR-21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR-590 gagcuuauucauaaaaagugcag
mir-543 75 81 M8 hsa-miR-543 aaacauucgcggugcacuucu
mir-9 579 586 1A，M8 hsa-miR-9SZ UCUUUGGUUAUCUAGCUGUAUGA