Gene Page:THBS3

Summary?
GeneID 7059
Symbol THBS3
Synonyms TSP3
Description thrombospondin 3
Reference MIM:188062|HGNC:HGNC:11787|Ensembl:ENSG00000169231|HPRD:01767|Vega:OTTHUMG00000035710
Gene type protein-coding
Map location 1q21
Sherlock p-value 0.003
Fetal beta 0.229
eGene Cerebellar Hemisphere
Cerebellum

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GSMA_I Genome scan meta-analysis Psr: 0.0235
GSMA_IIA Genome scan meta-analysis (All samples) Psr: 0.00814

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
STIM1 0.87 0.91
PSAP 0.85 0.86
CTSA 0.85 0.86
ANXA7 0.84 0.85
TFE3 0.84 0.85
NPTN 0.84 0.82
PRNP 0.83 0.90
STAT6 0.83 0.82
ARHGEF4 0.83 0.85
SIRPA 0.83 0.87
Top 10 negatively co-expressed genes
Gene Pearson's Correlation Spearman's Correlation
RBMX2 -0.57 -0.57
BCL7C -0.55 -0.62
KIAA1949 -0.54 -0.36
TUBB2B -0.52 -0.42
EXOSC8 -0.52 -0.49
IGF2BP2 -0.52 -0.45
ZNF300 -0.52 -0.26
RPS8 -0.51 -0.54
CARHSP1 -0.51 -0.48
RPS19P3 -0.51 -0.60

Section III. Gene Ontology annotation

Molecular function 去的术语 Evidence Neuro keywords PubMed ID
GO:0005509 calcium ion binding TAS 8288588
GO:0005515 protein binding IEA -
GO:0005198 structural molecule activity IEA -
Biological process 去的术语 Evidence Neuro keywords PubMed ID
GO:0007160 cell-matrix adhesion TAS 8468055
GO:0007155 cell adhesion IEA -
Cellular component 去的术语 Evidence Neuro keywords PubMed ID
GO:0005576 extracellular region EXP 6338048
GO:0005576 extracellular region IEA -
GO:0031093 platelet alpha granule lumen EXP 6338048

Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG TGF BETA SIGNALING PATHWAY 86 64 All SZGR 2.0 genes in this pathway
KEGG FOCAL ADHESION 201 138 All SZGR 2.0 genes in this pathway
KEGG ECM RECEPTOR INTERACTION 84 53 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY PDGF 122 93 All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567 375 All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329 219 All SZGR 2.0 genes in this pathway
AUNG GASTRIC CANCER 54 20 All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 1Q21 AMPLICON 38 18 All SZGR 2.0 genes in this pathway
NIKOLSKY MUTATED AND AMPLIFIED IN BREAST CANCER 94 60 All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP 83 66 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504 323 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178 121 All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN 48 33 All SZGR 2.0 genes in this pathway
ZHANG GATA6 TARGETS DN 64 46 All SZGR 2.0 genes in this pathway
SARRIO EPITHELIAL MESENCHYMAL TRANSITION DN 154 101 All SZGR 2.0 genes in this pathway
GRADE COLON VS RECTAL CANCER DN 56 36 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA CHEMOTAXIS DN 457 302 All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668 419 All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3 718 401 All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3 445 257 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS UP 745 475 All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS DN 784 464 All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839 928 All SZGR 2.0 genes in this pathway
NABA ECM GLYCOPROTEINS 196 99 All SZGR 2.0 genes in this pathway
NABA CORE MATRISOME 275 148 All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028 559 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-183 227 233 1A hsa-miR-183 UAUGGCACUGGUAGAAUUCACUG