SZGR2 - Beplay体育中心

Summary?

基因	7068
Symbol	thrb
同义词	c-erba-2 \| c-erba-beta \| erba2 \| grth \| nr1a2 \| prth \| thr1 \| thrb1 \| thrb2
描述	甲状腺激素受体β
参考	MIM：190160\|HGNC：HGNC：11799\|ENSEMBL：ENSG00000151090\|HPRD:07521\|Vega:OTTHUMG00000130478
基因type	protein-coding
地图位置	3P24.2
Pascal P值	1.81E-5
Fetal beta	-1.834
DMG	1（＃研究）

基因in Data Sources

基因set name	基因组方法	描述	Info
简历：PGCNP	全基因组协会研究	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
GSMA_I	基因组扫描荟萃分析	Psr: 0.006
网络	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0385

Section I. Genetics and epigenetics annotation

差异甲基化基因

探测	Chromosome	Position	最近的基因	P (dis)	beta（dis）	FDR (dis)	Study
CG19763108	3	24187579	thrb	7.93e-5	0.596	0.025	DMG:Wockner_2014

Section II. Transcriptome annotation

基因ral gene expression (GTEx)

Devlopment期间的基因表达（BrainCloud）

Footnote:
总共绘制了269个时间点，n = 38个胎儿样品（x = 1：38）。每个三角形代表一个时间点。

基因expression of temporal and spatial changes (BrainSpan)

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

前10个积极共表达的基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
SATB2	0.83	0.81
nkain2	0.82	0.76
TDRD7	0.80	0.79
LPL	0.79	0.58
LGALS8	0.79	0.77
SLC44A5	0.79	0.66
CCBE1	0.79	0.62
ADAMTSL3	0.78	0.75
CHST15	0.77	0.79
RBM24	0.77	0.78

前10个负共表达基因
基因	皮尔逊的相关性	斯皮尔曼的相关性
HSD17B14	-0.56	-0.61
MT-CO2	-0.53	-0.53
AF347015.31	-0.52	-0.51
BDH2	-0.51	-0.55
MT-CYB	-0.51	-0.50
AF347015.8	-0.51	-0.51
AIFM3	-0.51	-0.50
C11orf67	-0.51	-0.54
AF347015.27	-0.50	-0.49
AF347015.2	-0.50	-0.51

Section III. Gene Ontology annotation

Molecular function	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0004887	甲状腺激素受体活性	塔斯		1618799
去：0003700	转录因子活性	NAS		1618799
去：0003707	类固醇激素受体活性	IEA		-
去：0003714	transcription corepressor activity	塔斯		1618799
GO:0005515	protein binding	新闻学会		7870181\|15100213\|15625236
去：0008270	锌离子结合	IEA		-
GO：0046872	金属离子结合	IEA		-
GO：0043565	序列特异性DNA结合	IEA		-
生物过程	去的术语	Evidence	Neuro keywords	PubMed ID
去：0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0009887	器官形态发生	IEA		-
去：0008016	regulation of heart contraction	IEA		-
GO:0007605	声音的感官感知	IEA		-
GO:0016481	negative regulation of transcription	IEA		-
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IEA		-
细胞分量	去的术语	Evidence	Neuro keywords	PubMed ID
GO:0005634	核	塔斯		1618799

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
Anp32a	C15orf1 \|i1pp2a \|lanp \|mapm \|MGC119787 \|MGC150373 \|phap1 \|phapi \|pp32	酸性（富含亮氨酸）核磷蛋白32家族，成员A	tr-beta与pp32相互作用。	BIND	15308690
BRD8	SMAP \| SMAP2 \| p120	含有8的溴结构域	Reconstituted Complex Two-hybrid	BioGRID	9368056
BTG1	-	B-cell translocation gene 1, anti-proliferative	BTG1与THRB相互作用（TR-BETA-1）。这种相互作用是基于未指定物种的人类BTG1和TR-BETA-1之间的相互作用进行建模的。	BIND	15674337
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	Cyclin D1	Affinity Capture-Western Reconstituted Complex	BioGRID	12048199
COPS2	ALIEN \| CSN2 \| SGN2 \| TRIP15	COP9本构型显微类同源亚基2（拟南芥）	-	HPRD，Biogrid	7776974\|10207062
CTCF	-	CCCTC-binding factor (zinc finger protein)	TR interacts with CTCF.	BIND	10625678
EIF3I	EIF3S2 \| PRO2242 \| TRIP-1 \| TRIP1 \| eIF3-beta \| eIF3-p36	eukaryotic translation initiation factor 3, subunit I	Two-hybrid	BioGRID	9368056
HDAC3	HD3 \| RPD3 \| RPD3-2	组蛋白脱乙酰基酶3	-	HPRD	10944117
JMJD1C	DKFZP761F0118 \|FLJ14374 \|KIAA1380 \|RP11-10C13.2 \|Trip8	jumonji domain containing 1C	-	HPRD	7776974
MECR	CGI-63 \| FASN2B \| NRBF1	线粒体trans-2-烯烃还原酶	-	HPRD	9795230
MED1	CRSP1 \| CRSP200 \| DRIP205 \| DRIP230 \| MGC71488 \| PBP \| PPARBP \| PPARGBP \| RB18A \| TRAP220 \| TRIP2	mediator complex subunit 1	-	HPRD	9325263
MED21	SRB7 \| SURB7	中介复合体亚基21	Tr-beta与HSRB7相互作用。	BIND	15249124
MPG	AAG \| APNG \| CRA36.1 \| MDG \| Mid1 \| PIG11 \| PIG16 \| anpg	N-甲基丁胺-DNA糖基化酶	MPGinteracts with THRB (TR-beta). This interaction was modeled on a demonstrated interaction between MPG from an unspecified species and THRB from an unspecified species.	BIND	14761960
NCOA1	F-SRC-1 \|kat13a \|MGC129719 \|MGC129720 \|NCOA-1 \|RIP160 \|SRC-1 \|src1 \|Bhlhe42	nuclear receptor coactivator 1	-	HPRD，Biogrid	9171239
NCOA1	F-SRC-1 \|kat13a \|MGC129719 \|MGC129720 \|NCOA-1 \|RIP160 \|SRC-1 \|src1 \|Bhlhe42	nuclear receptor coactivator 1	SRC-1 interacts with THR-beta. This interaction was modelled on a demonstrated interaction between human SRC-1 and rat TR-beta.	BIND	9346901
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	-	HPRD，Biogrid	11518802
NCOA2	GRIP1 \| KAT13C \| MGC138808 \| NCoA-2 \| TIF2	nuclear receptor coactivator 2	GRIP1与Tr相互作用。这种相互作用是在小鼠grip1和人类TR之间证明的相互作用上建模的。	BIND	10454563
NCOA3	Actr \|AIB-1 \|AIB1 \|CAGH16 \|CTG26 \|kat13b \|MGC141848 \|Rac3 \|src3 \|TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	TRAM-1 interacts with TR-beta. This interaction was modelled on a demonstrated interaction between human TRAM-1 and rat TR-beta.	BIND	9346901
NCOA3	Actr \|AIB-1 \|AIB1 \|CAGH16 \|CTG26 \|kat13b \|MGC141848 \|Rac3 \|src3 \|TNRC14 \| TNRC16 \| TRAM-1 \| pCIP	nuclear receptor coactivator 3	ACTR与TR相互作用。	BIND	9267036
NCOA6	AIB3 \| ANTP \| ASC2 \| HOX1.1 \| HOXA7 \| KIAA0181 \| NRC \| PRIP \| RAP250 \| TRBP	nuclear receptor coactivator 6	Reconstituted Complex Two-hybrid	BioGRID	10567404\|10823961 \|11158331\|11773444
NCOR2	CTG26 \|SMRT \|Smrte \|smrte-tau \|TNRC14 \|TRAC-1 \|trac1	nuclear receptor co-repressor 2	Reconstituted Complex	BioGRID	9751500
NR2F6	EAR-2 \|ear2 \|ERBAL2	nuclear receptor subfamily 2, group F, member 6	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	10713182
NRBF2	COPR1 \| COPR2 \| DKFZp564C1664 \| FLJ30395 \| NRBF-2	nuclear receptor binding factor 2	-	HPRD，Biogrid	10786636
PPARGC1A	LEM6 \| PGC-1(alpha) \| PGC-1v \| PGC1 \| PGC1A \| PPARGC1	过氧化物酶体增殖物激活的受体伽马，共激活因子1 alpha	-	HPRD，Biogrid	11751919
PPARGC1B	errl1 \|Perc \|PGC-1（beta）\|PGC1B	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	Reconstituted Complex	BioGRID	11733490
PRMT1	ANM1 \| HCP1 \| HRMT1L2 \| IR1B4	protein arginine methyltransferase 1	Reconstituted Complex	BioGRID	11050077
PRMT2	HRMT1L1 \| MGC111373	protein arginine methyltransferase 2	PRMT2interacts with TR-beta.	BIND	12039952
PSMC3IP	GT198 \| HOP2 \| HUMGT198A \| TBPIP	PSMC3 interacting protein	-	HPRD	11739747
PSMC5	S8 \| SUG1 \| TBP10 \| TRIP1 \| p45 \| p45/SUG	蛋白酶体（Prosome，大蛋白）26S亚基，ATPase，5	Two-hybrid	BioGRID	7870181
rxra	FLJ00280 \|FLJ00318 \|FLJ16020 \|FLJ16733 \|MGC102720 \|NR2B1	类维生素X受体，α	Reconstituted Complex	BioGRID	9368056
RXRB	daudi6 \|H-2riibp \|MGC1831 \|NR2B2 \|RCOR-1	retinoid X receptor, beta	THR-beta interacts with RXR-beta. This interaction was modelled on a demonstrated interaction between rat TR-beta and mouse RXR-beta.	BIND	9346901
rxrg	NR2B3 \|rxrc	retinoid X receptor, gamma	-	HPRD	9794455
SRC	ASV \|src1 \|C-SRC \|P60-SRC	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	Reconstituted Complex	BioGRID	10454579
tbl1x	EBI \|SMAP55 \|TBL1	transducin (beta)-like 1X-linked	Reconstituted Complex	BioGRID	10809664
thrb	ERBA-BETA \| ERBA2 \| GRTH \| MGC126109 \| MGC126110 \| NR1A2 \| PRTH \| THR1 \| THRB1 \| THRB2	甲状腺激素受体，β（红细胞白血病病毒（V-ERB-A）癌基因同源物2，Avian）	Reconstituted Complex	BioGRID	9751500
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD，Biogrid	11258898
Trip12	KIAA0045 \| MGC138849 \| MGC138850	甲状腺激素受体相互作用12	-	HPRD	7776974
TRIP4	HST17391	甲状腺激素受体相互作用4	-	HPRD，Biogrid	7776974\|10454579
TSG101	TSG10 \|VPS23	肿瘤敏感性基因101	Two-hybrid	BioGRID	10508170

Section V. Pathway annotation

Pathway name	Pathway size	＃szgr 2.0基因	Info
KEGG神经活性配体受体相互作用	272	195	All SZGR 2.0 genes in this pathway
BIOCARTA EGFR SMRTE PATHWAY	11	11	All SZGR 2.0 genes in this pathway
PID RXR VDR途径	26	24	All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY	352	181	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	49	36	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS UP	137	94	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL UP	94	59	All SZGR 2.0 genes in this pathway
Senese HDAC1靶向DN	260	143	All SZGR 2.0 genes in this pathway
剑麻结肠直肠腺瘤DN	291	176	All SZGR 2.0 genes in this pathway
多德鼻咽癌	1821年	933	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD DN	150	93	All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 DN	65	45	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX DN	88	58	All SZGR 2.0 genes in this pathway
结肠癌DN中甲基化的甲基化	28	26	All SZGR 2.0 genes in this pathway
CHENG IMPRINTED BY ESTRADIOL	110	68	All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER LATE RECURRENCE DN	69	48	All SZGR 2.0 genes in this pathway
figueroa aml甲基化簇7	118	68	All SZGR 2.0 genes in this pathway
PURBEY CTBP1没有SATB1的目标	344	215	All SZGR 2.0 genes in this pathway
CTBP1的Purbey目标不是SATB1 DN	448	282	All SZGR 2.0 genes in this pathway
Krieg KDM3A靶向缺氧	208	107	All SZGR 2.0 genes in this pathway
前列腺癌模型中的Acevedo FGFR1靶标	289	184	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

miRNA family	目标位置			mirna id	miRNA seq
miRNA family	UTR start	UTR end	Match method	mirna id	miRNA seq
Let-7/98	764	770	1a	HSA-LET-7A^脑	UGAGGUAGUAGGUUGUAUAGUU
				HSA-LET-7B^脑	UGAGGUAGUAGGUUGUGUGGUU
				HSA-LET-7C^脑	ugagguaguagguuguaugguu
				HSA-LET-7D^脑	AGAGGUAGUAGGUUGCAUAGU
				HSA-LET-7E^脑	UGAGGUAGGAGGUUGUAUAGU
				HSA-LET-7F^脑	ugagguagauuguauauaguu
				HSA-MIR-98^脑	ugagguaaguuguauuguu
				HSA-LET-7G^SZ	ugagguaguuguuguacagu
				HSA-LET-7I^脑	UGAGGUAGUAGUUUGUGCUGU
miR-1/206	51	57	1a	HSA-MIR-1	Uggaauguaaagaaguaugua
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				HSA-MIR-613	aggaauguucuuugcc
miR-101	3770	3776	m8	HSA-MIR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	1472	1478	m8	HSA-MIR-124A	UUAAGGCACGCGGUGAAUGCCA
miR-124.1	1472	1478	m8	HSA-MIR-124A	UUAAGGCACGCGGUGAAUGCCA
mir-124/506	1472	1478	1a	HSA-MIR-506	uaaggcacccuucugugaguaga
mir-124/506	1472	1478	1a	HSA-MIR-124^脑	UAAGGCACGCGGUGAAUGCC
miR-128	3772	3778	1a	HSA-MIR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	3772	3778	1a	HSA-MIR-128b	UCACAGUGAACCGGUCUCUUUC
miR-135	1501	1508	1a,m8	HSA-MIR-135A	Uauggcuuuuuuuuccuauga
miR-135	1501	1508	1a,m8	HSA-MIR-135B	Uauggcuuuucauuccuaugug
miR-138	280	286	m8	HSA-MIR-138^脑	Agcugguuguguugaauc
miR-138	280	286	m8	HSA-MIR-138^脑	Agcugguuguguugaauc
mir-141/200a	4447	4454	1a,m8	HSA-MIR-141	uaacacugucugugugugugaugg
mir-141/200a	4447	4454	1a,m8	hsa-miR-200a	uaacacugucuguguguguaaacgaugu
mir-146	4321	4327	m8	HSA-MIR-146A	ugagaacugaauuccaugggug
mir-146	4321	4327	m8	HSA-MIR-146B^脑	UGAGAACUGAAUUCCAUAGGCU
mir-181	1410	1417	1a,m8	HSA-MIR-181a^脑	AACAUUCAACGCUGUCGGUGAGU
				HSA-MIR-181b^SZ	aacauucauugcugucggggg
				HSA-MIR-181c^脑	aacauucaaccugucggugagu
				HSA-MIR-181d^脑	aacauucauuguugucggggguggguu
mir-21	4632	4638	m8	HSA-MIR-21^脑	UAGCUUAUCAGACUGAUGUUGA
mir-21	4632	4638	m8	hsa-miR-590	GAGCUUAUUCAUAAAAGUGCAG
mir-218	4167	4173	1a	HSA-MIR-218^脑	uugugcuugaucuaaccaugu
mir-219	4108	4115	1a,m8	HSA-MIR-219^脑	ugauuguccaaacgcaauucu
mir-27	3772	3778	m8	hsa-miR-27a^脑	UUCACAGUGGCUAAGUUCCGC
mir-27	3772	3778	m8	hsa-miR-27b^脑	uucacaguggcuaaguucugc
miR-329	3813	3820	1a,m8	hsa-miR-329^脑	aacacaccugguaaccucuuu
miR-34b	1470	1476	m8	hsa-miR-34b	uaggcagugucauagcugauug
mir-381	4543	4549	1a	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-431	4105	4111	1a	HSA-MIR-431	UGUCUUGCAGGCCGUCAUGCA
miR-452	4441	4448	1a,m8	HSA-MIR-452	UGUUUGCAGAGGAAACUGAGAC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Clickhere查看与SZ相关的miRNA列表。
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Clickhereto see the list of brain related miRNAs.

基因页：thrb