Gene Page:TIAM1

Summary?
GeneID 7074
Symbol TIAM1
Synonyms -
Description T-cell lymphoma invasion and metastasis 1
Reference MIM:600687|HGNC:HGNC:11805|Ensembl:ENSG00000156299|HPRD:02820|Vega:OTTHUMG00000084869
Gene type protein-coding
Map location 21q22.11
Pascal p-value 0.005
eGene Cerebellum
Putamen basal ganglia
Support CompositeSet
Darnell FMRP targets
Ascano FMRP targets
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene set Description Info
CV:PGCnp Genome-wide Association Study GWAS
GO_Annotation Mapping neuro-related keywords to Gene Ontology annotations Hits with neuro-related keywords: 1
Network Shortest path distance of core genes in the Human protein-protein interaction network Contribution to shortest path in PPI network: 0.0476

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP ID Chromosome Position eGene Gene Entrez ID pvalue qvalue TSS distance eQTL type
rs60443735 21 32709836 TIAM1 ENSG00000156299.8 4.25748E-6 0.05 222454 gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
死神:胎儿(13 - 26 postconception周),ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular function GO term Evidence Neuro keywords PubMed ID
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA -
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 10835422
GO:0005085 guanyl-nucleotide交换因素活动 IEA -
GO:0005057 receptor signaling protein activity IEA -
GO:0005543 phospholipid binding IEA -
GO:0005515 protein binding IEA -
GO:0046875 ephrin receptor binding IEA -
Biological process GO term Evidence Neuro keywords PubMed ID
GO:0050772 positive regulation of axonogenesis IEA axon, neurogenesis (GO term level: 14) -
GO:0007165 signal transduction IEA -
GO:0048013 ephrin receptor signaling pathway IEA -
GO:0007264 small GTPase mediated signal transduction IEA -
GO:0035023 regulation of Rho protein signal transduction IEA -
Cellular component GO term Evidence Neuro keywords PubMed ID
GO:0005622 intracellular IEA -
GO:0005886 plasma membrane IEA -

Section IV. Protein-protein interaction annotation

Interactors Aliases B Official full name B Experimental Source PubMed ID
ANK1 ANK | SPH1 | SPH2 ankyrin 1, erythrocytic - HPRD,BioGRID 10893266
ANK3 ANKYRIN-G | FLJ45464 ankyrin 3, node of Ranvier (ankyrin G) Affinity Capture-Western BioGRID 10893266
CAMK2G CAMK | CAMK-II | CAMKG | FLJ16043 | MGC26678 calcium/calmodulin-dependent protein kinase II gamma - HPRD 10212259
CD44 CDW44 | CSPG8 | ECMR-III | HCELL | IN | LHR | MC56 | MDU2 | MDU3 | MGC10468 | MIC4 | MUTCH-I | Pgp1 CD44 molecule (Indian blood group) - HPRD,BioGRID 10636882
GRIN1 NMDA1 | NMDAR1 | NR1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 Tiam1 interacts with NMDA subunit NR1. This interaction was modelled on a demonstrated interaction between human Tiam1 and NR1 from an unspecified species. BIND 15721239
HRAS C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 v-Ha-ras Harvey rat sarcoma viral oncogene homolog - HPRD,BioGRID 12134164
MAPK8IP1 IB1 | JIP-1 | JIP1 | PRKM8IP mitogen-activated protein kinase 8 interacting protein 1 - HPRD,BioGRID 12024021
MAPK8IP2 IB2 | JIP2 | PRKM8IPL mitogen-activated protein kinase 8 interacting protein 2 Affinity Capture-Western BioGRID 12024021
MYC bHLHe39 | c-Myc v-myc myelocytomatosis viral oncogene homolog (avian) - HPRD,BioGRID 12446731
NME1 AWD | GAAD | NB | NBS | NDPK-A | NDPKA | NM23 | NM23-H1 non-metastatic cells 1, protein (NM23A) expressed in - HPRD,BioGRID 11274357
PPP1R9B FLJ30345 | PPP1R6 | PPP1R9 | SPINO | Spn protein phosphatase 1, regulatory (inhibitor) subunit 9B - HPRD,BioGRID 12531897
PRKCA AAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACA protein kinase C, alpha - HPRD,BioGRID 10212259
PRKCB MGC41878 | PKC-beta | PKCB | PRKCB1 | PRKCB2 protein kinase C, beta Biochemical Activity BioGRID 10212259
PRKCD MAY1 | MGC49908 | PKCD | nPKC-delta protein kinase C, delta - HPRD,BioGRID 10212259
PRKCE MGC125656 | MGC125657 | PKCE | nPKC-epsilon protein kinase C, epsilon - HPRD,BioGRID 10212259
PRKCG MGC57564 | PKC-gamma | PKCC | PKCG | SCA14 protein kinase C, gamma - HPRD,BioGRID 10212259
PRKCZ PKC-ZETA | PKC2 protein kinase C, zeta Biochemical Activity BioGRID 10212259
RAC1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) The GTPase Rac1 specifically interacts with Dbl-homology domain of the nucleotide exchange factor TIAM1. This interaction is modelled on a demonstrated interaction between mouse TIAM1 and human Rac1. BIND 11130063
RAC1 MGC111543 | MIG5 | TC-25 | p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) - HPRD,BioGRID 11130063|11595749
SRC ASV | SRC1 | c-SRC | p60-Src v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) - HPRD 12810717


Section V. Pathway annotation

Pathway name Pathway size # SZGR 2.0 genes in pathway Info
KEGG CHEMOKINE SIGNALING PATHWAY 190 128 All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON 216 144 All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 66 53 All SZGR 2.0 genes in this pathway
PID CDC42 PATHWAY 70 51 All SZGR 2.0 genes in this pathway
PID ARF6 DOWNSTREAM PATHWAY 15 14 All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 48 38 All SZGR 2.0 genes in this pathway
PID ECADHERIN NASCENT AJ PATHWAY 39 33 All SZGR 2.0 genes in this pathway
PID TRKR PATHWAY 62 48 All SZGR 2.0 genes in this pathway
PID RAC1 REG PATHWAY 38 25 All SZGR 2.0 genes in this pathway
PID EPHRINB REV PATHWAY 30 25 All SZGR 2.0 genes in this pathway
PID EPHA2 FWD PATHWAY 19 16 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY RHO GTPASES 113 81 All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF 217 167 All SZGR 2.0 genes in this pathway
REACTOME NRAGE SIGNALS DEATH THROUGH JNK 43 33 All SZGR 2.0 genes in this pathway
REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE 60 43 All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING 81 61 All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920 449 All SZGR 2.0 genes in this pathway
REACTOME G ALPHA1213 SIGNALLING EVENTS 74 56 All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805 368 All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP 579 346 All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN 320 184 All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN 241 146 All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372 227 All SZGR 2.0 genes in this pathway
VECCHI GASTRIC CANCER ADVANCED VS EARLY UP 175 120 All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157 104 All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS UP 456 228 All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP 214 155 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP DN 199 124 All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER GRADES 1 2 DN 67 43 All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP 443 294 All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 UP 150 93 All SZGR 2.0 genes in this pathway
WANG ESOPHAGUS CANCER VS NORMAL DN 101 66 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855 609 All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483 336 All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK 1442 892 All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514 330 All SZGR 2.0 genes in this pathway
SCHAEFFER SOX9 TARGETS IN PROSTATE DEVELOPMENT DN 45 33 All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988 594 All SZGR 2.0 genes in this pathway
ASTON MAJOR DEPRESSIVE DISORDER DN 160 110 All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP 398 262 All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 66 47 All SZGR 2.0 genes in this pathway
BECKER TAMOXIFEN RESISTANCE DN 52 37 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS UP 126 84 All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION UP 87 67 All SZGR 2.0 genes in this pathway
马丁尼回应TRABECTEDIN 50 32 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 20HR UP 240 152 All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156 101 All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 8HR 39 31 All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C5 46 36 All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE 246 153 All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528 324 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER T4 94 69 All SZGR 2.0 genes in this pathway
GAVIN FOXP3 TARGETS CLUSTER P4 100 62 All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS 212 121 All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC 58 43 All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409 268 All SZGR 2.0 genes in this pathway
JI CARCINOGENESIS BY KRAS AND STK11 UP 12 7 All SZGR 2.0 genes in this pathway
MASSARWEH TAMOXIFEN RESISTANCE DN 258 160 All SZGR 2.0 genes in this pathway
FUJII YBX1 TARGETS DN 202 132 All SZGR 2.0 genes in this pathway
POS HISTAMINE RESPONSE NETWORK 32 22 All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510 309 All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN 252 155 All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 122 84 All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP 47 30 All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435 289 All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS KERATINOCYTE UP 91 63 All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES UP 32 25 All SZGR 2.0 genes in this pathway
MARSON FOXP3 TARGETS UP 66 43 All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS 85 55 All SZGR 2.0 genes in this pathway
STEIN ESTROGEN RESPONSE NOT VIA ESRRA 18 12 All SZGR 2.0 genes in this pathway
LI INDUCED T TO NATURAL KILLER UP 307 182 All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548 370 All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229 149 All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 5 DN 50 31 All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 1972 1213 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS NOT VIA AKT1 UP 211 131 All SZGR 2.0 genes in this pathway
BHAT ESR1 TARGETS VIA AKT1 UP 281 183 All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP D 280 158 All SZGR 2.0 genes in this pathway
LINSLEY MIR16 TARGETS 206 127 All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882 538 All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN 553 343 All SZGR 2.0 genes in this pathway
KATSANOU ELAVL1 TARGETS DN 148 88 All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 151 86 All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516 308 All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family Target position miRNA ID miRNA seq
UTR start UTR end Match method
miR-10 1163 1170 1A,m8 hsa-miR -10a UACCCUGUAGAUCCGAAUUUGUG
hsa-miR -10b UACCCUGUAGAACCGAAUUUGU
miR-141/200a 745 752 1A,m8 hsa-miR -141 UAACACUGUCUGGUAAAGAUGG
hsa-miR -200a UAACACUGUCUGGUAACGAUGU
miR-142-5p 1448 1455 1A,m8 hsa-miR -142-5p CAUAAAGUAGAAAGCACUAC
miR-17-5p/20/93.mr/106/519.d 1235 1241 m8 hsa-miR -17-5p CAAAGUGCUUACAGUGCAGGUAGU
hsa-miR -20abrain UAAAGUGCUUAUAGUGCAGGUAG
hsa-miR -106a AAAAGUGCUUACAGUGCAGGUAGC
hsa-miR -106bSZ UAAAGUGCUGACAGUGCAGAU
hsa-miR -20bSZ CAAAGUGCUCAUAGUGCAGGUAG
hsa-miR -519d CAAAGUGCCUCCCUUUAGAGUGU
miR-183 1795 1801 m8 hsa-miR -183 UAUGGCACUGGUAGAAUUCACUG
miR-21 1861 1867 m8 hsa-miR -21brain UAGCUUAUCAGACUGAUGUUGA
hsa-miR -590 GAGCUUAUUCAUAAAAGUGCAG
miR-29 1780 1786 m8 hsa-miR -29aSZ UAGCACCAUCUGAAAUCGGUU
hsa-miR -29bSZ UAGCACCAUUUGAAAUCAGUGUU
hsa-miR -29cSZ UAGCACCAUUUGAAAUCGGU
miR-320 1625 1631 1A hsa-miR -320 AAAAGCUGGGUUGAGAGGGCGAA
hsa-miR -320 AAAAGCUGGGUUGAGAGGGCGAA
miR-329 26 32 1A hsa-miR -329brain AACACACCUGGUUAACCUCUUU
miR-376c 1830 1836 m8 hsa-miR -376c AACAUAGAGGAAAUUCCACG
miR-410 1846 1852 1A hsa-miR -410 AAUAUAACACAGAUGGCCUGU
miR-93.hd/291-3p/294/295/302/372/373/520 1234 1240 m8 hsa-miR -93brain AAAGUGCUGUUCGUGCAGGUAG
hsa-miR -302a UAAGUGCUUCCAUGUUUUGGUGA
hsa-miR -302b UAAGUGCUUCCAUGUUUUAGUAG
hsa-miR -302c UAAGUGCUUCCAUGUUUCAGUGG
hsa-miR -302d UAAGUGCUUCCAUGUUUGAGUGU
hsa-miR -372 AAAGUGCUGCGACAUUUGAGCGU
hsa-miR -373 GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR -520e AAAGUGCUUCCUUUUUGAGGG
hsa-miR -520a AAAGUGCUUCCCUUUGGACUGU
hsa-miR -520b AAAGUGCUUCCUUUUAGAGGG
hsa-miR -520c AAAGUGCUUCCUUUUAGAGGGUU
hsa-miR -520d AAAGUGCUUCUCUUUGGUGGGUU