Gene Page:TJP1
Summary？
| GeneID | 7082 |
| 象征 | TJP1 |
| Synonyms | ZO-1 |
| Description | 紧密连接蛋白1 |
| Reference | MIM：601009|HGNC:HGNC:11827|ENSEMBL：ENSG00000104067|HPRD：03002|Vega：Otthumg00000137397 |
| 基因类型 | 蛋白质编码 |
| Map location | 15q13 |
| Pascal p-value | 0.27 |
| Sherlock p-value | 0.002 |
| 胎儿β | -0.826 |
| DMG | 1(# studies) |
| 主持人 | 小脑 |
| Support | G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2CDB.HUMAN_BAYES-COLLINS-HUMAN-PSD-FULL G2CDB.HUMAN_BAYES-COLLINS-MOUSE-PSD-CONSUS G2CDB.HUMANNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet |
Gene in Data Sources
| 基因集名称 | Method of gene set | Description | 信息 |
|---|---|---|---|
| 简历：Gwascat | Genome-wide Association Studies | 该数据集包括与精神分裂症相关的560个SNP。总共将486个基因映射到50kb内的这些SNP。 | |
| CV:GWASdb | Genome-wide Association Studies | 精神分裂症的GWASDB记录 | |
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG：Wockner_2014 | 全基因组DNA甲基化分析 | 该数据集包括4641个差异甲基化探针，对应于精神分裂症患者（n = 24）和对照组（n = 24）之间的2929个独特基因。 | 1 |
| PMID：cooccur | High-throughput literature-search | PubMed中的系统搜索与SCZ关键字共发生的基因。总共包括3027个基因。 | |
| Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias | 点击显示详细信息 |
| GO_Annotation | 将与神经相关的关键字映射到基因本体论注释 | 与神经相关关键字的命中：2 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
Differentially methylated gene| Probe | 染色体 | 位置 | Nearest gene | p（dis） | Beta (dis) | fdr（dis） | 学习 |
|---|---|---|---|---|---|---|---|
| cg12400336 | 15 | 30114871 | TJP1 | 8.97E-5 | 0.486 | 0.027 | DMG：Wockner_2014 |
第二节。转录组注释
一般基因表达（GTEX）
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
时间变化的基因表达（brainspan）
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
相约: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
所示的栏表示表达分布的较低25％和上层25％。
大脑区域的顶级共表达基因
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MYLPF | 0.51 | 0.19 |
| MXRA7 | 0.51 | 0.55 |
| tesc | 0.50 | 0.68 |
| SPOCK3 | 0.47 | 0.61 |
| ACYP2 | 0.47 | 0.62 |
| C9orf103 | 0.47 | 0.53 |
| CPLX1 | 0.46 | 0.60 |
| FAM102A | 0.46 | 0.60 |
| PNLDC1 | 0.45 | 0.57 |
| HABP4 | 0.45 | 0.60 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KIAA1211 | -0.41 | -0.45 |
| AL033532.1 | -0.39 | -0.45 |
| ST8SIA2 | -0.39 | -0.45 |
| KIAA1949 | -0.38 | -0.50 |
| sema4g | -0.38 | -0.40 |
| PNPLA3 | -0.38 | -0.44 |
| Gmip | -0.38 | -0.41 |
| TTC28 | -0.38 | -0.38 |
| GJC1 | -0.38 | -0.46 |
| JUP | -0.38 | -0.42 |
第三节。基因本体论注释
| 分子功能 | 去学期 | 证据 | 神经关键字 | PubMed ID |
|---|---|---|---|---|
| 去：0005515 | 蛋白质结合 | IEA | - | |
| 去：0005515 | 蛋白质结合 | IPI | 11042084|12154091 | |
| 生物过程 | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0007043 | cell-cell junction assembly | TAS | 8486731 | |
| Cellular component | 去学期 | 证据 | 神经关键字 | PubMed ID |
| GO:0005923 | 紧密连接 | IEA | 大脑（GO期限：10） | - |
| GO:0005923 | 紧密连接 | TAS | 大脑（GO期限：10） | 8486731 |
| 去：0005737 | cytoplasm | IDA | 18029348 | |
| GO:0005913 | 细胞细胞粘附连接 | TAS | 8486731 | |
| 去：0005886 | plasma membrane | IDA | 18029348 | |
| 去：0005886 | plasma membrane | IEA | - | |
| GO：0016323 | 基底外侧质膜 | IDA | 16427635 | |
| GO:0030054 | cell junction | IDA | 18029348 | |
| GO:0030054 | cell junction | IEA | - |
Section IV. Protein-protein interaction annotation
| 互动者 | 别名b | 官方全名b | 实验 | Source | PubMed ID |
|---|---|---|---|---|---|
| CGN | DKFZp779N1112 | FLJ39281 | KIAA1319 | cingulin | - | HPRD,BioGRID | 10613913|12023291|11042084 |
| CGN | DKFZp779N1112 | FLJ39281 | KIAA1319 | cingulin | - | HPRD | 11042084 |
| CGN | DKFZp779N1112 | FLJ39281 | KIAA1319 | cingulin | Cingulin与ZO-1相互作用。 | 绑定 | 10613913 |
| cldn1 | CLD1 | ILVASC | SEMP1 | 克劳丁1 | - | HPRD,BioGRID | 10601346 |
| Cldn2 | - | 克劳丁2 | - | HPRD,BioGRID | 10601346 |
| Cldn3 | C7orf1 |CPE-R2 |cpetr2 |hrvp1 |RVP1 | 克劳丁3 | - | HPRD,BioGRID | 10601346 |
| cldn4 | CPE-R | CPER | CPETR | CPETR1 | WBSCR8 | hCPE-R | 克劳丁4 | - | HPRD,BioGRID | 10601346 |
| Cldn5 | awal |BEC1 |cpetrl1 |TMVCF | 克劳丁5 | - | HPRD,BioGRID | 10601346 |
| Cldn6 | - | 克劳丁6 | 重构的复合物 | Biogrid | 10601346 |
| Cldn7 | CEPTRL2 | CPETRL2 | Hs.84359 | claudin-1 | 克劳丁7 | - | HPRD,BioGRID | 10601346 |
| cldn8 | - | 克劳丁8 | - | HPRD,BioGRID | 10601346 |
| CTTN | EMS1 | FLJ34459 | cortactin | - | HPRD | 9792678 | 11018051 |
| egfr | ERBB |ERBB1 |her1 |PIG61 |梅纳 | 表皮生长因子受体（红细胞性白血病病毒（V-ERB-B）癌基因同源物，鸟类） | - | HPRD,BioGRID | 12708492 |
| F11r | CD321 | JAM | JAM-1 | JAM-A | JAM1 | JAMA | JCAM | KAT | PAM-1 | F11受体 | 亲和力捕获 - 韦斯特恩 重构的复合物 Two-hybrid |
Biogrid | 10856295|12953056 |
| GJA1 | CX43 | DFNB38 | GJAL | ODDD | 间隙连接蛋白，Alpha 1，43KDA | - | HPRD,BioGRID | 9707407 |
| GJA3 | CX46 | CZP3 | gap junction protein, alpha 3, 46kDa | - | HPRD,BioGRID | 12808044 |
| GJA8 | CAE |CAE1 |CX50 |CZP1 |MP70 | 间隙连接蛋白，Alpha 8，50KDA | - | HPRD,BioGRID | 12808044 |
| GJB3 | CX31 |DFNA2 |ekv |FLJ22486 |MGC102938 | 间隙连接蛋白，β3，31KDA | - | HPRD | 12154091 |
| GJC1 | CX45 | DKFZp686P0738 | GJA7 | 间隙连接蛋白，伽马1，45KDA | - | HPRD | 11557048|12064590|12064590 |
| GJC1 | CX45 | DKFZp686P0738 | GJA7 | 间隙连接蛋白，伽马1，45KDA | - | HPRD,BioGRID | 12064590 |
| GJD3 | CX31.9 |CX30.2 |GJA11 |GJC1 | 间隙连接蛋白，三角洲3，31.9kda | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 12154091 |
| GRIN1 | NMDA1 | NMDAR1 | NR1 | 谷氨酸受体，离子型，N-甲基D-天冬氨酸1 | - | HPRD | 10862698 |
| Grin2d | EB11 | NMDAR2D | 谷氨酸受体，离子型，N-甲基D-天冬氨酸2D | - | HPRD | 10862698 |
| jam2 | C21orf43 |CD322 |jam-b |jamb |Pro245 |ve-jam |Vejam | 连接粘附分子2 | - | HPRD,BioGRID | 12953056 |
| jam3 | FLJ14529 |jam-c |jamc | 连接粘附分子3 | - | HPRD,BioGRID | 12953056 |
| 柯雷尔 | FLJ10845 | MGC129542 | MGC129543 | NEPH1 | kin of IRRE like (Drosophila) | - | HPRD,BioGRID | 12578837|12865409 |
| mllt4 | AF-6 |AF6 |Afadin |FLJ34371 |RP3-431P23.3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | - | HPRD,BioGRID | 10334923 |
| NPHS1 | CNF |nphn | 肾脏病1，先天性，芬兰类型（肾素） | 重构的复合物 | Biogrid | 15331416 |
| OCLN | - | occludin | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 9792688|12169098 |
| OCLN | - | occludin | - | HPRD | 7798316|9792688 |10575001|10601346 |11700038|12169098 |
| PTPN14 | MGC126803 |pez |ptp36 | protein tyrosine phosphatase, non-receptor type 14 | - | HPRD,BioGRID | 12808048 |
| RAB8B | FLJ38125 | Rab8b，Ras Oncogene家族成员 | 亲和力捕获 - 韦斯特恩 | Biogrid | 12639940 |
| TJP2 | MGC26306 |x104 |ZO-2 |ZO2 | 紧密连接蛋白2（Zona occludens 2） | 亲和力捕获 - 韦斯特恩 重构的复合物 |
Biogrid | 9792688|One hundred.26224 |10575001 |
| TJP2 | MGC26306 |x104 |ZO-2 |ZO2 | 紧密连接蛋白2（Zona occludens 2） | - | HPRD | 7542259 |
| TJP3 | MGC119546 | ZO-3 | 紧密连接蛋白3（Zona Ouckludens 3） | 亲和力捕获 - 韦斯特恩 | Biogrid | 10575001 |
| TJP3 | MGC119546 | ZO-3 | 紧密连接蛋白3（Zona Ouckludens 3） | - | HPRD | 9531559 |
Section V. Pathway annotation
Section VI. microRNA annotation
| mirna家族 | Target position | miRNA ID | mirna seq | ||
|---|---|---|---|---|---|
| UTR开始 | UTR结束 | 匹配方法 | |||
| mir-101 | 741 | 747 | 1A | hsa-miR-101 | uacaguacugauaacugaag |
| miR-103/107 | 1178 | 1184 | 1A | hsa-miR-103brain | agcagcauuguacggcuauga |
| hsa-miR-107brain | AGCAGCAUUGUACAGGGCUAUCA | ||||
| miR-137 | 1096 | 1102 | 1A | HSA-MIR-137 | uauugcuuaagaauacgcguag |
| miR-142-3p | 1345 | 1351 | 1A | hsa-miR-142-3p | UGUAGUGUUUCCUACUUUAUGGA |
| miR-144 | 740 | 747 | 1A，M8 | HSA-MIR-144 | UACAGUAUAGAUGAUGUACUAG |
| miR-185 | 1056 | 1062 | M8 | HSA-MIR-185brain | UGGAGAGAAAGGCAGUUC |
| miR-191 | 297 | 304 | 1A，M8 | HSA-MIR-191brain | caacggaaucccaaaagcagcu |
| miR-193 | 313 | 319 | 1A | HSA-MIR-193A | AACUGGCCUACAAAGUCCCAG |
| HSA-MIR-193B | aacuggcccucaaagucccgcuuu | ||||
| miR-194 | 1163 | 1169 | 1A | HSA-MIR-194 | uguaacagcaacuccauga |
| mir-330 | 242 | 248 | M8 | hsa-miR-330brain | GCAAAGCACACGGCCUGCAGAGA |
| mir-335 | 1068 | 1074 | 1A | hsa-miR-335brain | UCAAGAGCAAUAACGAAAAAUGU |
| mir-455 | 1310 | 1316 | M8 | hsa-miR-455 | UAUGUGCCUUUGGACUACAUCG |
| miR-493-5p | 488 | 494 | M8 | HSA-MIR-493-5p | uuguacaugguaggcuuucauu |