SZGR2 - Beplay体育中心

Summary？

基因	71
象征	ACTG1
Synonyms	ACT\|ACTG\|BRWS2\|DFNA20\|DFNA26\|HEL-176
Description	肌动伽玛1
Reference	MIM:102560\|HGNC：HGNC：144\|ENSEMBL：ENSG00000184009\|HPRD：00017\|Vega:OTTHUMG00000177955
基因类型	蛋白质编码
Map location	17Q25
Pascal p-value	0.006
Sherlock p-value	0.996
DEG P值	DEG:Sanders_2014:DS1_p=0.142:DS1_beta=0.049700:DS2_p=8.57e-01:DS2_beta=0.009:DS2_FDR=9.36e-01
胎儿β	1.813
Support	结构可塑性

Gene in Data Sources

基因集名称	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
DEG:Sanders_2013	微阵列	使用微阵列在413例和446例对照中使用微阵列（LCLS）上的微阵列进行全基因组基因表达谱。
Network	Shortest path distance of core genes in the Human protein-protein interaction network	PPI网络中最短路径的贡献：0.083

Section I. Genetics and epigenetics annotation

第二节。转录组注释

一般基因表达（GTEX）

Devlopment期间的基因表达（BrainCloud）

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

时间变化的基因表达（brainspan）

Footnote:
SC：亚皮质区域；SM：感觉运动区域；FC：额叶皮层；和TP：颞顶皮层
ST1：胎儿（13-26个概念后周），ST2：婴儿早期至童年（4个月至11年）和ST3：青春期至成年期（13-23年）
所示的栏表示表达分布的较低25％和上层25％。

No co-expressed genes in brain regions

第三节。基因本体论注释

分子功能	去学期	证据	神经关键字	PubMed ID
去：0000166	nucleotide binding	IEA		-
去：0005524	ATP binding	IEA		-
去：0005200	细胞骨架的结构成分	我知道了		16130169
GO：0042802	identical protein binding	IPI		16189514
生物过程	去学期	证据	神经关键字	PubMed ID
去：0007605	声音的感官感知	IEA		-
GO:0006928	细胞运动	TAS		16130169
Cellular component	去学期	证据	神经关键字	PubMed ID
去：0005856	细胞骨架	TAS		16130169
去：0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

互动者	别名b	官方全名b	实验	Source	PubMed ID
动作	PS1TP5BP1	Actin，Beta	Two-hybrid	Biogrid	16189514
ACTG1	行为\|ACTG \|DFNA20 \|DFNA26	肌动蛋白，伽马1	Two-hybrid	Biogrid	16189514
anxa5	Anx5 \|enx2 \|PP4	annexin A5	-	HPRD	10903505
BCAP31	6c6-ag \|BAP31 \|CDM \|DXS1357E	B细胞受体相关蛋白31	-	HPRD,BioGRID	10958671
CAP1	CAP \| CAP1-PEN	CAP, adenylate cyclase-associated protein 1 (yeast)	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	8761950
CAP2	-	CAP, adenylate cyclase-associated protein, 2 (yeast)	-	HPRD,BioGRID	8761950
CAPZA3	CAPPA3 \| Gsg3	上限蛋白（肌动蛋白丝）肌肉z线，alpha 3	-	HPRD	12029070
CDH1	Arc-1 \| CD324 \| CDHE \| ECAD \| LCAM \| UVO	cadherin 1, type 1, E-cadherin (epithelial)	亲和力捕获 - 韦斯特恩	Biogrid	9535896
CFL1	CFL	Cofilin 1（非肌肉）	Two-hybrid	Biogrid	16189514
CFL2	NEM7	cofilin 2 (muscle)	亲和力捕获 - 韦斯特恩 Two-hybrid	Biogrid	16189514
ctnnd1	CAS \| CTNND \| KIAA0384 \| P120CAS \| P120CTN \| p120	catenin (cadherin-associated protein), delta 1	亲和力捕获 - 韦斯特恩	Biogrid	12835311
DNASE1	DKFZp686H0155 \| DNL1 \| DRNI \| FLJ38093 \| FLJ44902	脱氧核糖核酸酶i	-	HPRD	11474115
DSTN	actdp \|ADF \|BA462D18.2	destrin (actin depolymerizing factor)	-	HPRD	8399167
DSTN	actdp \|ADF \|BA462D18.2	destrin (actin depolymerizing factor)	Two-hybrid	Biogrid	16189514
dynll1	DLC1 \| DLC8 \| DNCL1 \| DNCLC1 \| LC8 \| LC8a \| MGC126137 \| MGC126138 \| PIN \| hdlc1	Dynein，轻链，LC8型1	-	HPRD	14760703
EIF6	2 \| CAB \| EIF3A \| ITGB4BP \| b \| b(2)gcn \| gcn \| p27BBP	真核翻译initiation factor 6	Two-hybrid	Biogrid	16169070
EPS8L1	drc3 \|EPS8R1 \|FLJ20258 \|MGC23164 \|MGC4642 \|PP10566	EPS8样1	亲和力捕获 - 韦斯特恩	Biogrid	14565974
EPS8L2	EPS8R2 \| FLJ16738 \| FLJ21935 \| FLJ22171 \| MGC126530 \| MGC3088	EPS8样2	亲和力捕获 - 韦斯特恩	Biogrid	14565974
EPS8L3	EPS8R3 \|FLJ21522 \|MGC16817	EPS8样3	亲和力捕获 - 韦斯特恩	Biogrid	14565974
Fez1	-	fasciculation and elongation protein zeta 1 (zygin I)	亲和力捕获 - 韦斯特恩	Biogrid	12874605
FHOD1	FHOS	formin homology 2 domain containing 1	亲和力捕获 - 韦斯特恩	Biogrid	14576350
LGALS13	gal13 \|plac8 \|pp13	凝集素，半乳糖苷结合，可溶性，13	-	HPRD	15009185
MAP3K7	TAK1 \| TGF1a	有丝分裂原激活的蛋白激酶激酶激酶7	-	HPRD	14743216
MDK	FLJ27379 \|Mk \|negf2	Midkine（神经突生长因子2）	Affinity Capture-MS	Biogrid	10772929
myo1a	BBMI \|DFNA48 \|mihc \|myhl	myosin IA	-	HPRD	11474115
PFN2	D3S1319E \|PFL	profilin 2	Two-hybrid	Biogrid	16169070
PLG	DKFZP779M0222	纤溶酶原	PLGinteracts with ACTG1 (G-actin). This interaction was modelled on a demonstrated interaction between human PLG and bovine ACTG1.	绑定	15746964
PPP1R9A	FLJ20068 \| KIAA1222 \| NRB1 \| NRBI \| Neurabin-I	protein phosphatase 1, regulatory (inhibitor) subunit 9A	-	HPRD	9362513\|12052877
PRSS23	MGC5107 \| SIG13 \| SPUVE \| ZSIG13	protease, serine, 23	Two-hybrid	Biogrid	16169070
RBX1	BA554C12.1 \|MGC13357 \|MGC1481 \|RNF75 \|ROC1	ring-box 1	Affinity Capture-MS	Biogrid	12481031
SCIN	KIAA1905	Scinderin	-	HPRD	1331119
SH3GL2	CNSA2 \| EEN-B1 \| FLJ20276 \| FLJ25015 \| SH3D2A \| SH3P4	SH3-domain GRB2-like 2	Two-hybrid	Biogrid	16169070
ST3GAL3	siat6 \|st3galii \|st3galiii \|ST3N	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Two-hybrid	Biogrid	16169070
TMSB4X	fx \|PTMB4 \|tb4x \|TMSB4	胸腺素β4，X连接	-	HPRD	8617195\|8630056 \|9153421\|10848969 \|15163409
TMSB4X	fx \|PTMB4 \|tb4x \|TMSB4	胸腺素β4，X连接	共晶结构重构的复合物	Biogrid	8617195\|15163409
传统	HS.89862 \|MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
WASF1	FLJ31482 \| KIAA0269 \| SCAR1 \| WAVE \| WAVE1	WAS protein family, member 1	Wave-1与G-肌动蛋白相互作用。这种相互作用是建立在人波-1和大鼠G-肌动蛋白之间的相互作用上的模型。	绑定	10970852

Section V. Pathway annotation

路径名	路径大小	# SZGR 2.0 genes in pathway	信息
kegg焦点粘附	201	138	All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION	75	53	All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION	134	86	All SZGR 2.0 genes in this pathway
kegg白细胞跨内皮迁移	118	78	All SZGR 2.0 genes in this pathway
肌动蛋白细胞骨架的KEGG调节	216	144	All SZGR 2.0 genes in this pathway
Kegg Vibrio霍乱感染	56	32	All SZGR 2.0 genes in this pathway
KEGG PATHOGENIC ESCHERICHIA COLI INFECTION	59	36	All SZGR 2.0 genes in this pathway
KEGG肥厚性心肌病HCM	85	65	All SZGR 2.0 genes in this pathway
KEGG心律失常右心肌病ARVC	76	59	All SZGR 2.0 genes in this pathway
KEGG扩张心肌病	92	68	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
Biocarta Hivnef途径	58	43	All SZGR 2.0 genes in this pathway
Rho GTPases对肌动蛋白细胞骨架的SIG调节	35	25	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
迪亚兹慢性巨型性白血病DN	116	79	All SZGR 2.0 genes in this pathway
乳腺癌腔与间充质DN	460	312	All SZGR 2.0 genes in this pathway
Wang LMO4靶向	372	227	All SZGR 2.0 genes in this pathway
Dittmer PTHLH靶向DN	73	51	All SZGR 2.0 genes in this pathway
Tien肠益生菌24小时DN	214	133	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
Spielman淋巴细胞欧洲vs亚洲	479	299	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
Benporath MYC带Ebox的目标	230	156	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON	335	181	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc Up	54	30	All SZGR 2.0 genes in this pathway
Lee Liver Cancer Myc TGFA UP	61	40	All SZGR 2.0 genes in this pathway
CHEN LUNG CANCER SURVIVAL	28	22	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 UP	56	34	All SZGR 2.0 genes in this pathway
费尔南德斯（Fernandez）由迈克（Myc）约束	182	116	All SZGR 2.0 genes in this pathway
Flechner活检肾脏移植OK vs捐助者	555	346	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 UP	62	35	All SZGR 2.0 genes in this pathway
GALINDO IMMUNE RESPONSE TO ENTEROTOXIN	85	67	All SZGR 2.0 genes in this pathway
Iglesias E2F目标	151	103	All SZGR 2.0 genes in this pathway
zamora nos2靶向	69	41	All SZGR 2.0 genes in this pathway
MODY HIPPOCAMPUS NEONATAL	35	25	All SZGR 2.0 genes in this pathway
Browne HCMV感染48小时DN	504	323	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN	91	64	All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN	128	93	All SZGR 2.0 genes in this pathway
MMS小鼠淋巴高4小时	36	20	All SZGR 2.0 genes in this pathway
贝尔德糖尿病性肾病DN	434	302	All SZGR 2.0 genes in this pathway
旺波剂量	21	9	All SZGR 2.0 genes in this pathway
Weng Por靶向肝脏	41	29	All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN	49	34	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
级结肠癌	871	505	All SZGR 2.0 genes in this pathway
西肾上腺皮质肿瘤DN	546	362	All SZGR 2.0 genes in this pathway
Podar对Ahaphostin DN的反应	18	16	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
Yoshimura MAPK8目标DN	366	257	All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK	1210	725	All SZGR 2.0 genes in this pathway
Hsiao家政基因	389	245	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
由MYC约束	1103	714	All SZGR 2.0 genes in this pathway
Karlsson TGFB1靶向	127	78	All SZGR 2.0 genes in this pathway
马滕斯三维诺蛋白响应DN	841	431	All SZGR 2.0 genes in this pathway
Kim所有疾病少突胶质细胞编号corr up	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 UP	140	94	All SZGR 2.0 genes in this pathway
棕熊UVC响应迟到	1137	655	All SZGR 2.0 genes in this pathway
双龙雷帕霉素通过TSC1和TSC2敏感	73	37	All SZGR 2.0 genes in this pathway
Krieg缺氧不是通过KDM3A	770	480	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP	146	75	All SZGR 2.0 genes in this pathway

第六节。microRNA注释

mirna家族	Target position			miRNA ID	mirna seq
mirna家族	UTR开始	UTR结束	匹配方法	miRNA ID	mirna seq
miR-10	358	364	1a	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	358	364	1a	hsa-miR-10b	uacccuguagaaccgaauuugu
mir-103/107	26	32	1a	hsa-miR-103^brain	agcagcauuguacggcuauga
mir-103/107	26	32	1a	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-145	96	103	1A，M8	HSA-MIR-145	guccaguuucccaggaaucccuu
miR-186	610	616	M8	HSA-MIR-186	caaagaauuuugggcuu
miR-199	151	157	1a	HSA-MIR-199A	CCCAGUGUUCAGACUACCUGUUC
miR-199	151	157	1a	HSA-MIR-199B	cccaguguuuagacuaucuuc
miR-361	140	146	M8	HSA-MIR-361^brain	uuaucagaaucuccagggguac
miR-381	184	190	M8	HSA-MIR-381	uauacaagggcaagcucucugu
miR-381	184	190	M8	HSA-MIR-381	uauacaagggcaagcucucugu
miR-485-5p	86	92	1a	hsa-miR-485-5p	aggcuggccgugaugauuc

SZ：在精神分裂症患者的脑皮质中差异表达的miRNA与使用微阵列进行对照样品进行比较。点击hereto see the list of SZ related miRNAs.
大脑：基于miRNA微阵列表达研究在大脑中表达的miRNA。点击here查看与大脑相关的miRNA列表。

Gene Page:ACTG1